Loading…
Abnormal structure and functional connectivity of the anterior insula at pain-free periovulation is associated with perceived pain during menstruation
Neuroimaging studies have demonstrated the critical role of the insula in pain pathways and its close relation with the perceived intensity of nociceptive stimuli. We aimed to identify the structural and functional characteristics of the insula during periovulatory phase in women with primary dysmen...
Saved in:
| Published in: | Brain imaging and behavior 2017-12, Vol.11 (6), p.1787-1795 |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c372t-b0e21055b80e5a38d497dc407bd41eb444c9f95d93687c062eaeb5b4a210cadb3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c372t-b0e21055b80e5a38d497dc407bd41eb444c9f95d93687c062eaeb5b4a210cadb3 |
| container_end_page | 1795 |
| container_issue | 6 |
| container_start_page | 1787 |
| container_title | Brain imaging and behavior |
| container_volume | 11 |
| creator | Dun, Wang-huan Yang, Jing Yang, Ling Ding, Dun Ma, Xue-ying Liang, Feng-Li von Deneen, Karen M. Ma, Shao-hui Xu, Xiao-ling Liu, Jixin Zhang, Ming |
| description | Neuroimaging studies have demonstrated the critical role of the insula in pain pathways and its close relation with the perceived intensity of nociceptive stimuli. We aimed to identify the structural and functional characteristics of the insula during periovulatory phase in women with primary dysmenorrhea (PDM), and further investigate its association with the intensity of perceived pain during menstruation. Optimized voxel-based morphometry and functional connectivity (FC) analyses were applied by using 3-dimensional T1-weighted and resting functional magnetic resonance imaging (fMRI) in 36 patients at the peri-ovulation phase and 29 age-, education-, and gender-matched healthy controls (HC). A visual analogue scale (VAS) was used to examine the intensity of the abdominal pain at periovulation and menstruation. In our results, PDM patients had significant higher VAS-rating during menstruaion than periovulation. Compared with the HC, PDM patients had lower gray matter density in the left anterior insula (aINS). Taken the left aINS as a seed region, we further found hypoconnectivity between aINS and medial prefrontal cortex (mPFC), which showed negative relation with the VAS during menstruation. As the aINS is a key site of the salience network (SN) and the mPFC is a critical region in the default mode network (DMN), it’s implicated a trait-related central-alteration that communications between pain attention and perception networks were disrupted without the ongoing menstrual pain. Moreover, result of correlation analysis, at least in part, suggested a possible role of altered FC (pain-free period) in predicting pain perception (menstruation). |
| doi_str_mv | 10.1007/s11682-016-9646-y |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1839117542</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1970203055</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-b0e21055b80e5a38d497dc407bd41eb444c9f95d93687c062eaeb5b4a210cadb3</originalsourceid><addsrcrecordid>eNp1kc9uFSEUxonR2Fp9ADeGxI2bUWBgGJZNU_8kTdzomgBzxtLMwAjMNfdFfF7BWxtj4goO5_d9nJwPoZeUvKWEyHeZ0mFkHaFDpwY-dMdH6JyqnnZSDOLxw13IM_Qs5ztCBB8VfYrOmBx7xrk6Rz8vbYhpNQvOJe2u7AmwCROe9-CKj6E2XAwBanHw5YjjjMttQwokHxP2Ie-LwabgzfjQzQkAb611qM_NAPuMTc7ReVNgwj98uW2AA3-oZRPhaU8-fMMrhDbDb9Vz9GQ2S4YX9-cF-vr--svVx-7m84dPV5c3neslK50lwCgRwo4EhOnHiSs5OU6knTgFyzl3alZiUv0wSkcGBgassNxUlTOT7S_Qm5PvluL3HXLRq88OlsUEiHvWdOwVpVJwVtHX_6B3cU91QZVSkjDS10EqRU-USzHnBLPekl9NOmpKdAtNn0LTNTTdQtPHqnl177zbFaYHxZ-UKsBOQN7apiD99fV_XX8B-Wqmug</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1970203055</pqid></control><display><type>article</type><title>Abnormal structure and functional connectivity of the anterior insula at pain-free periovulation is associated with perceived pain during menstruation</title><source>Springer Link</source><creator>Dun, Wang-huan ; Yang, Jing ; Yang, Ling ; Ding, Dun ; Ma, Xue-ying ; Liang, Feng-Li ; von Deneen, Karen M. ; Ma, Shao-hui ; Xu, Xiao-ling ; Liu, Jixin ; Zhang, Ming</creator><creatorcontrib>Dun, Wang-huan ; Yang, Jing ; Yang, Ling ; Ding, Dun ; Ma, Xue-ying ; Liang, Feng-Li ; von Deneen, Karen M. ; Ma, Shao-hui ; Xu, Xiao-ling ; Liu, Jixin ; Zhang, Ming</creatorcontrib><description>Neuroimaging studies have demonstrated the critical role of the insula in pain pathways and its close relation with the perceived intensity of nociceptive stimuli. We aimed to identify the structural and functional characteristics of the insula during periovulatory phase in women with primary dysmenorrhea (PDM), and further investigate its association with the intensity of perceived pain during menstruation. Optimized voxel-based morphometry and functional connectivity (FC) analyses were applied by using 3-dimensional T1-weighted and resting functional magnetic resonance imaging (fMRI) in 36 patients at the peri-ovulation phase and 29 age-, education-, and gender-matched healthy controls (HC). A visual analogue scale (VAS) was used to examine the intensity of the abdominal pain at periovulation and menstruation. In our results, PDM patients had significant higher VAS-rating during menstruaion than periovulation. Compared with the HC, PDM patients had lower gray matter density in the left anterior insula (aINS). Taken the left aINS as a seed region, we further found hypoconnectivity between aINS and medial prefrontal cortex (mPFC), which showed negative relation with the VAS during menstruation. As the aINS is a key site of the salience network (SN) and the mPFC is a critical region in the default mode network (DMN), it’s implicated a trait-related central-alteration that communications between pain attention and perception networks were disrupted without the ongoing menstrual pain. Moreover, result of correlation analysis, at least in part, suggested a possible role of altered FC (pain-free period) in predicting pain perception (menstruation).</description><identifier>ISSN: 1931-7557</identifier><identifier>EISSN: 1931-7565</identifier><identifier>DOI: 10.1007/s11682-016-9646-y</identifier><identifier>PMID: 27832449</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Attention ; Biomedical and Life Sciences ; Biomedicine ; Brain Mapping ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - pathology ; Cerebral Cortex - physiopathology ; Correlation analysis ; Dysmenorrhea - diagnostic imaging ; Dysmenorrhea - pathology ; Dysmenorrhea - physiopathology ; Female ; Functional magnetic resonance imaging ; Humans ; Magnetic Resonance Imaging ; Medical imaging ; Menstruation ; Menstruation - physiology ; Morphometry ; Neural networks ; Neural Pathways - diagnostic imaging ; Neural Pathways - pathology ; Neural Pathways - physiopathology ; Neuroimaging ; Neurology ; Neuropsychology ; Neuroradiology ; Neurosciences ; Original Research ; Ovulation ; Ovulation - physiology ; Pain ; Pain perception ; Pain Perception - physiology ; Patients ; Perception ; Perceptions ; Prefrontal cortex ; Prospective Studies ; Psychiatry ; Rest ; Structure-function relationships ; Substantia grisea ; Visual cortex ; Young Adult</subject><ispartof>Brain imaging and behavior, 2017-12, Vol.11 (6), p.1787-1795</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Brain Imaging and Behavior is a copyright of Springer, (2016). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-b0e21055b80e5a38d497dc407bd41eb444c9f95d93687c062eaeb5b4a210cadb3</citedby><cites>FETCH-LOGICAL-c372t-b0e21055b80e5a38d497dc407bd41eb444c9f95d93687c062eaeb5b4a210cadb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27832449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dun, Wang-huan</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Yang, Ling</creatorcontrib><creatorcontrib>Ding, Dun</creatorcontrib><creatorcontrib>Ma, Xue-ying</creatorcontrib><creatorcontrib>Liang, Feng-Li</creatorcontrib><creatorcontrib>von Deneen, Karen M.</creatorcontrib><creatorcontrib>Ma, Shao-hui</creatorcontrib><creatorcontrib>Xu, Xiao-ling</creatorcontrib><creatorcontrib>Liu, Jixin</creatorcontrib><creatorcontrib>Zhang, Ming</creatorcontrib><title>Abnormal structure and functional connectivity of the anterior insula at pain-free periovulation is associated with perceived pain during menstruation</title><title>Brain imaging and behavior</title><addtitle>Brain Imaging and Behavior</addtitle><addtitle>Brain Imaging Behav</addtitle><description>Neuroimaging studies have demonstrated the critical role of the insula in pain pathways and its close relation with the perceived intensity of nociceptive stimuli. We aimed to identify the structural and functional characteristics of the insula during periovulatory phase in women with primary dysmenorrhea (PDM), and further investigate its association with the intensity of perceived pain during menstruation. Optimized voxel-based morphometry and functional connectivity (FC) analyses were applied by using 3-dimensional T1-weighted and resting functional magnetic resonance imaging (fMRI) in 36 patients at the peri-ovulation phase and 29 age-, education-, and gender-matched healthy controls (HC). A visual analogue scale (VAS) was used to examine the intensity of the abdominal pain at periovulation and menstruation. In our results, PDM patients had significant higher VAS-rating during menstruaion than periovulation. Compared with the HC, PDM patients had lower gray matter density in the left anterior insula (aINS). Taken the left aINS as a seed region, we further found hypoconnectivity between aINS and medial prefrontal cortex (mPFC), which showed negative relation with the VAS during menstruation. As the aINS is a key site of the salience network (SN) and the mPFC is a critical region in the default mode network (DMN), it’s implicated a trait-related central-alteration that communications between pain attention and perception networks were disrupted without the ongoing menstrual pain. Moreover, result of correlation analysis, at least in part, suggested a possible role of altered FC (pain-free period) in predicting pain perception (menstruation).</description><subject>Attention</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain Mapping</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - pathology</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Correlation analysis</subject><subject>Dysmenorrhea - diagnostic imaging</subject><subject>Dysmenorrhea - pathology</subject><subject>Dysmenorrhea - physiopathology</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical imaging</subject><subject>Menstruation</subject><subject>Menstruation - physiology</subject><subject>Morphometry</subject><subject>Neural networks</subject><subject>Neural Pathways - diagnostic imaging</subject><subject>Neural Pathways - pathology</subject><subject>Neural Pathways - physiopathology</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Neuropsychology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Research</subject><subject>Ovulation</subject><subject>Ovulation - physiology</subject><subject>Pain</subject><subject>Pain perception</subject><subject>Pain Perception - physiology</subject><subject>Patients</subject><subject>Perception</subject><subject>Perceptions</subject><subject>Prefrontal cortex</subject><subject>Prospective Studies</subject><subject>Psychiatry</subject><subject>Rest</subject><subject>Structure-function relationships</subject><subject>Substantia grisea</subject><subject>Visual cortex</subject><subject>Young Adult</subject><issn>1931-7557</issn><issn>1931-7565</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kc9uFSEUxonR2Fp9ADeGxI2bUWBgGJZNU_8kTdzomgBzxtLMwAjMNfdFfF7BWxtj4goO5_d9nJwPoZeUvKWEyHeZ0mFkHaFDpwY-dMdH6JyqnnZSDOLxw13IM_Qs5ztCBB8VfYrOmBx7xrk6Rz8vbYhpNQvOJe2u7AmwCROe9-CKj6E2XAwBanHw5YjjjMttQwokHxP2Ie-LwabgzfjQzQkAb611qM_NAPuMTc7ReVNgwj98uW2AA3-oZRPhaU8-fMMrhDbDb9Vz9GQ2S4YX9-cF-vr--svVx-7m84dPV5c3neslK50lwCgRwo4EhOnHiSs5OU6knTgFyzl3alZiUv0wSkcGBgassNxUlTOT7S_Qm5PvluL3HXLRq88OlsUEiHvWdOwVpVJwVtHX_6B3cU91QZVSkjDS10EqRU-USzHnBLPekl9NOmpKdAtNn0LTNTTdQtPHqnl177zbFaYHxZ-UKsBOQN7apiD99fV_XX8B-Wqmug</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Dun, Wang-huan</creator><creator>Yang, Jing</creator><creator>Yang, Ling</creator><creator>Ding, Dun</creator><creator>Ma, Xue-ying</creator><creator>Liang, Feng-Li</creator><creator>von Deneen, Karen M.</creator><creator>Ma, Shao-hui</creator><creator>Xu, Xiao-ling</creator><creator>Liu, Jixin</creator><creator>Zhang, Ming</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20171201</creationdate><title>Abnormal structure and functional connectivity of the anterior insula at pain-free periovulation is associated with perceived pain during menstruation</title><author>Dun, Wang-huan ; Yang, Jing ; Yang, Ling ; Ding, Dun ; Ma, Xue-ying ; Liang, Feng-Li ; von Deneen, Karen M. ; Ma, Shao-hui ; Xu, Xiao-ling ; Liu, Jixin ; Zhang, Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-b0e21055b80e5a38d497dc407bd41eb444c9f95d93687c062eaeb5b4a210cadb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Attention</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain Mapping</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Cerebral Cortex - pathology</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Correlation analysis</topic><topic>Dysmenorrhea - diagnostic imaging</topic><topic>Dysmenorrhea - pathology</topic><topic>Dysmenorrhea - physiopathology</topic><topic>Female</topic><topic>Functional magnetic resonance imaging</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical imaging</topic><topic>Menstruation</topic><topic>Menstruation - physiology</topic><topic>Morphometry</topic><topic>Neural networks</topic><topic>Neural Pathways - diagnostic imaging</topic><topic>Neural Pathways - pathology</topic><topic>Neural Pathways - physiopathology</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Neuropsychology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Research</topic><topic>Ovulation</topic><topic>Ovulation - physiology</topic><topic>Pain</topic><topic>Pain perception</topic><topic>Pain Perception - physiology</topic><topic>Patients</topic><topic>Perception</topic><topic>Perceptions</topic><topic>Prefrontal cortex</topic><topic>Prospective Studies</topic><topic>Psychiatry</topic><topic>Rest</topic><topic>Structure-function relationships</topic><topic>Substantia grisea</topic><topic>Visual cortex</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dun, Wang-huan</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Yang, Ling</creatorcontrib><creatorcontrib>Ding, Dun</creatorcontrib><creatorcontrib>Ma, Xue-ying</creatorcontrib><creatorcontrib>Liang, Feng-Li</creatorcontrib><creatorcontrib>von Deneen, Karen M.</creatorcontrib><creatorcontrib>Ma, Shao-hui</creatorcontrib><creatorcontrib>Xu, Xiao-ling</creatorcontrib><creatorcontrib>Liu, Jixin</creatorcontrib><creatorcontrib>Zhang, Ming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Brain imaging and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dun, Wang-huan</au><au>Yang, Jing</au><au>Yang, Ling</au><au>Ding, Dun</au><au>Ma, Xue-ying</au><au>Liang, Feng-Li</au><au>von Deneen, Karen M.</au><au>Ma, Shao-hui</au><au>Xu, Xiao-ling</au><au>Liu, Jixin</au><au>Zhang, Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal structure and functional connectivity of the anterior insula at pain-free periovulation is associated with perceived pain during menstruation</atitle><jtitle>Brain imaging and behavior</jtitle><stitle>Brain Imaging and Behavior</stitle><addtitle>Brain Imaging Behav</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>11</volume><issue>6</issue><spage>1787</spage><epage>1795</epage><pages>1787-1795</pages><issn>1931-7557</issn><eissn>1931-7565</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Neuroimaging studies have demonstrated the critical role of the insula in pain pathways and its close relation with the perceived intensity of nociceptive stimuli. We aimed to identify the structural and functional characteristics of the insula during periovulatory phase in women with primary dysmenorrhea (PDM), and further investigate its association with the intensity of perceived pain during menstruation. Optimized voxel-based morphometry and functional connectivity (FC) analyses were applied by using 3-dimensional T1-weighted and resting functional magnetic resonance imaging (fMRI) in 36 patients at the peri-ovulation phase and 29 age-, education-, and gender-matched healthy controls (HC). A visual analogue scale (VAS) was used to examine the intensity of the abdominal pain at periovulation and menstruation. In our results, PDM patients had significant higher VAS-rating during menstruaion than periovulation. Compared with the HC, PDM patients had lower gray matter density in the left anterior insula (aINS). Taken the left aINS as a seed region, we further found hypoconnectivity between aINS and medial prefrontal cortex (mPFC), which showed negative relation with the VAS during menstruation. As the aINS is a key site of the salience network (SN) and the mPFC is a critical region in the default mode network (DMN), it’s implicated a trait-related central-alteration that communications between pain attention and perception networks were disrupted without the ongoing menstrual pain. Moreover, result of correlation analysis, at least in part, suggested a possible role of altered FC (pain-free period) in predicting pain perception (menstruation).</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27832449</pmid><doi>10.1007/s11682-016-9646-y</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1931-7557 |
| ispartof | Brain imaging and behavior, 2017-12, Vol.11 (6), p.1787-1795 |
| issn | 1931-7557 1931-7565 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1839117542 |
| source | Springer Link |
| subjects | Attention Biomedical and Life Sciences Biomedicine Brain Mapping Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Cerebral Cortex - physiopathology Correlation analysis Dysmenorrhea - diagnostic imaging Dysmenorrhea - pathology Dysmenorrhea - physiopathology Female Functional magnetic resonance imaging Humans Magnetic Resonance Imaging Medical imaging Menstruation Menstruation - physiology Morphometry Neural networks Neural Pathways - diagnostic imaging Neural Pathways - pathology Neural Pathways - physiopathology Neuroimaging Neurology Neuropsychology Neuroradiology Neurosciences Original Research Ovulation Ovulation - physiology Pain Pain perception Pain Perception - physiology Patients Perception Perceptions Prefrontal cortex Prospective Studies Psychiatry Rest Structure-function relationships Substantia grisea Visual cortex Young Adult |
| title | Abnormal structure and functional connectivity of the anterior insula at pain-free periovulation is associated with perceived pain during menstruation |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-23T06%3A37%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Abnormal%20structure%20and%20functional%20connectivity%20of%20the%20anterior%20insula%20at%20pain-free%20periovulation%20is%20associated%20with%20perceived%20pain%20during%20menstruation&rft.jtitle=Brain%20imaging%20and%20behavior&rft.au=Dun,%20Wang-huan&rft.date=2017-12-01&rft.volume=11&rft.issue=6&rft.spage=1787&rft.epage=1795&rft.pages=1787-1795&rft.issn=1931-7557&rft.eissn=1931-7565&rft_id=info:doi/10.1007/s11682-016-9646-y&rft_dat=%3Cproquest_cross%3E1970203055%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c372t-b0e21055b80e5a38d497dc407bd41eb444c9f95d93687c062eaeb5b4a210cadb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1970203055&rft_id=info:pmid/27832449&rfr_iscdi=true |