Lipoprotein(a) in patients with hepatocellular carcinoma and portal vein thrombosis

Background The mechanism for hypercoagulability in malignancy is not entirely understood. Although several studies report contrasting finding about the link between elevated plasma levels of the lipoprotein(a) [Lp(a)] and the possible recurrence of venous thromboembolism, we perform a study to evalu...

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Bibliographic Details
Published in:Aging clinical and experimental research 2017-02, Vol.29 (Suppl 1), p.185-190
Main Authors: Malaguarnera, Giulia, Catania, Vito Emanuele, Francaviglia, Antonio, Malaguarnera, Michele, Drago, Filippo, Motta, Massimo, Latteri, Saverio
Format: Article
Language:English
Subjects:
Aged
Atherosclerosis
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - complications
Carcinoma, Hepatocellular - pathology
Female
Geriatrics/Gerontology
Health risk assessment
Humans
Lipoprotein(a) - analysis
Lipoprotein(a) - blood
Lipoproteins
Liver cancer
Liver Neoplasms - blood
Liver Neoplasms - complications
Liver Neoplasms - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Portal Vein - diagnostic imaging
Predictive Value of Tests
Statistics as Topic
Thromboembolism
Ultrasonography, Doppler - methods
Venous Thrombosis - blood
Venous Thrombosis - diagnosis
Venous Thrombosis - etiology
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Summary:Background The mechanism for hypercoagulability in malignancy is not entirely understood. Although several studies report contrasting finding about the link between elevated plasma levels of the lipoprotein(a) [Lp(a)] and the possible recurrence of venous thromboembolism, we perform a study to evaluate the impact of the Lp(a) in the development of portal vein thromboembolism (PVT) in patients with HCC. Methods We compared 44 PVT patients with 50 healthy subjects and 50 HCC patients. Results The comparison between PVT patients and HCC showed in the former the mean value of serum lipoprotein levels was higher than 37.3 mg/dl ( p  = 0.000). The comparison between PVT versus healthy controls showed that in the former, mean value of serum lipoprotein levels was higher than 75 mg/dl ( p  = 0.000). The predictive value test of serum lipoprotein(a) on PVT was 0.72 and on HCC was 0.83. The odds ratio of lipoprotein(a) was 9.21 on PVT and 6.33 on HCC. Conclusion Patients with PVT and HCC showed a statistical significant serum lipoprotein(a) level higher than the subjects with HCC and no PVT or the healthy subject. So we assume a role of lipoprotein(a) as predictor of venous thromboembolism in neoplastic patients.
ISSN:1720-8319
1594-0667
1720-8319
DOI:10.1007/s40520-016-0653-z