Associations between serum uric acid levels and the incidence of nonfatal stroke: a nationwide community-based cohort study

Background Hyperuricemia is an established risk factor for cardiovascular events and mortality. This study investigated the association between serum uric acid and the incidence of nonfatal stroke in a Japanese community-based population. Methods We used a nationwide database of 155,322 subjects (ag...

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Bibliographic Details
Published in:Clinical and experimental nephrology 2017-06, Vol.21 (3), p.497-503
Main Authors: Kamei, Keita, Konta, Tsuneo, Hirayama, Atsushi, Ichikawa, Kazunobu, Kubota, Isao, Fujimoto, Shouichi, Iseki, Kunitoshi, Moriyama, Toshiki, Yamagata, Kunihiro, Tsuruya, Kazuhiko, Narita, Ichiei, Kondo, Masahide, Shibagaki, Yugo, Kasahara, Masato, Asahi, Koichi, Watanabe, Tsuyoshi
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Biomarkers - blood
Cardiovascular diseases
Chi-Square Distribution
Cohort analysis
Databases, Factual
Female
Health risk assessment
Humans
Hyperuricemia
Hyperuricemia - blood
Hyperuricemia - diagnosis
Hyperuricemia - epidemiology
Incidence
Japan - epidemiology
Kidney stones
Logistic Models
Longitudinal Studies
Male
Medicine
Medicine & Public Health
Middle Aged
Mortality
Multivariate Analysis
Nephrology
Odds Ratio
Original Article
Regression analysis
Renal function
Risk Factors
Sex
Stroke
Stroke - blood
Stroke - diagnosis
Stroke - epidemiology
Time Factors
Uric acid
Uric Acid - blood
Urology
Women
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Summary:Background Hyperuricemia is an established risk factor for cardiovascular events and mortality. This study investigated the association between serum uric acid and the incidence of nonfatal stroke in a Japanese community-based population. Methods We used a nationwide database of 155,322 subjects (aged 40–73, male 39 %) who participated in the annual “Specific Health Check and Guidance in Japan” checkup from 2008 to 2010. We examined the relationship between the quintiles of serum uric acid levels at baseline and the incidence of nonfatal stroke during a 2-year study period using self-reported data. Results The crude incidence of nonfatal stroke was significantly associated with serum uric acid levels at baseline, showing the lowest values in subjects with the 3rd quintile (Q3: men, 5.0–5.6; women, 3.8–4.3) of uric acid levels (mg/dL) and the highest values in subjects with the highest quintile (Q5: men ≥7.1, women ≥5.5) both in men and women ( P  
ISSN:1342-1751
1437-7799
DOI:10.1007/s10157-016-1311-7