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Use of similarity scoring in the development of oral solid dosage forms
[Display omitted] In the oral solid dosage form space, material physical properties have a strong impact on the behaviour of the formulation during processing. The ability to identify materials with similar characteristics (and thus expected to exhibit similar behaviour) within the company’s portfol...
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| Published in: | International journal of pharmaceutics 2016-12, Vol.514 (2), p.335-340 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c365t-9d64db46e4d851853bf7541a593c6455ef92c4757975e5bd8e51729d9443fddc3 |
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| cites | cdi_FETCH-LOGICAL-c365t-9d64db46e4d851853bf7541a593c6455ef92c4757975e5bd8e51729d9443fddc3 |
| container_end_page | 340 |
| container_issue | 2 |
| container_start_page | 335 |
| container_title | International journal of pharmaceutics |
| container_volume | 514 |
| creator | Ferreira, Ana P. Olusanmi, Dolapo Sprockel, Omar Abebe, Admassu Nikfar, Faranak Tobyn, Mike |
| description | [Display omitted]
In the oral solid dosage form space, material physical properties have a strong impact on the behaviour of the formulation during processing. The ability to identify materials with similar characteristics (and thus expected to exhibit similar behaviour) within the company’s portfolio can help accelerate drug development by enabling early assessment and prediction of potential challenges associated with the powder properties of a new active pharmaceutical ingredient. Such developments will aid the production of robust dosage forms, in an efficient manner.
Similarity scoring metrics are widely used in a number of scientific fields. This study proposes a practical implementation of this methodology within pharmaceutical development. The developed similarity metrics is based on the Mahalanobis distance. Scanning electron microscopy was used to confirm morphological similarity between the reference material and the closest matches identified by the metrics proposed. The results show that the metrics proposed are able to successfully identify material with similar physical properties. |
| doi_str_mv | 10.1016/j.ijpharm.2015.09.046 |
| format | article |
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In the oral solid dosage form space, material physical properties have a strong impact on the behaviour of the formulation during processing. The ability to identify materials with similar characteristics (and thus expected to exhibit similar behaviour) within the company’s portfolio can help accelerate drug development by enabling early assessment and prediction of potential challenges associated with the powder properties of a new active pharmaceutical ingredient. Such developments will aid the production of robust dosage forms, in an efficient manner.
Similarity scoring metrics are widely used in a number of scientific fields. This study proposes a practical implementation of this methodology within pharmaceutical development. The developed similarity metrics is based on the Mahalanobis distance. Scanning electron microscopy was used to confirm morphological similarity between the reference material and the closest matches identified by the metrics proposed. The results show that the metrics proposed are able to successfully identify material with similar physical properties.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2015.09.046</identifier><identifier>PMID: 26423176</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administration, Oral ; Chemistry, Pharmaceutical - methods ; Chemistry, Pharmaceutical - statistics & numerical data ; Dosage Forms - standards ; Knowledge management ; Microscopy, Electron, Scanning ; Quality by design ; Robustness ; Similarity scoring ; Solid oral dosage form ; Surrogate</subject><ispartof>International journal of pharmaceutics, 2016-12, Vol.514 (2), p.335-340</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-9d64db46e4d851853bf7541a593c6455ef92c4757975e5bd8e51729d9443fddc3</citedby><cites>FETCH-LOGICAL-c365t-9d64db46e4d851853bf7541a593c6455ef92c4757975e5bd8e51729d9443fddc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26423176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferreira, Ana P.</creatorcontrib><creatorcontrib>Olusanmi, Dolapo</creatorcontrib><creatorcontrib>Sprockel, Omar</creatorcontrib><creatorcontrib>Abebe, Admassu</creatorcontrib><creatorcontrib>Nikfar, Faranak</creatorcontrib><creatorcontrib>Tobyn, Mike</creatorcontrib><title>Use of similarity scoring in the development of oral solid dosage forms</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
In the oral solid dosage form space, material physical properties have a strong impact on the behaviour of the formulation during processing. The ability to identify materials with similar characteristics (and thus expected to exhibit similar behaviour) within the company’s portfolio can help accelerate drug development by enabling early assessment and prediction of potential challenges associated with the powder properties of a new active pharmaceutical ingredient. Such developments will aid the production of robust dosage forms, in an efficient manner.
Similarity scoring metrics are widely used in a number of scientific fields. This study proposes a practical implementation of this methodology within pharmaceutical development. The developed similarity metrics is based on the Mahalanobis distance. Scanning electron microscopy was used to confirm morphological similarity between the reference material and the closest matches identified by the metrics proposed. The results show that the metrics proposed are able to successfully identify material with similar physical properties.</description><subject>Administration, Oral</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Chemistry, Pharmaceutical - statistics & numerical data</subject><subject>Dosage Forms - standards</subject><subject>Knowledge management</subject><subject>Microscopy, Electron, Scanning</subject><subject>Quality by design</subject><subject>Robustness</subject><subject>Similarity scoring</subject><subject>Solid oral dosage form</subject><subject>Surrogate</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkD1PwzAQhi0EoqXwE0AeWRLs-CuZEKqgIFViobOV2JfWURIXO63Uf0-qFlamW5733rsHoXtKUkqofGpS12w3ZejSjFCRkiIlXF6gKc0VSxhX8hJNCVN5IqhiE3QTY0MIkRll12iSSZ4xquQULVYRsK9xdJ1ry-CGA47GB9evsevxsAFsYQ-t33bQD0fQh7LF0bfOYutjuQZc-9DFW3RVl22Eu_OcodXb69f8PVl-Lj7mL8vEMCmGpLCS24pL4DYXNBesqpXgtBQFM5ILAXWRGa6EKpQAUdkcxvOzwhacs9paw2bo8bR3G_z3DuKgOxcNtG3Zg99FTfNMSk65ykZUnFATfIwBar0NrivDQVOijw51o88O9dGhJoUeHY65h3PFrurA_qV-pY3A8wmA8dG9g6CjcdAbsC6AGbT17p-KHyn0hL4</recordid><startdate>20161205</startdate><enddate>20161205</enddate><creator>Ferreira, Ana P.</creator><creator>Olusanmi, Dolapo</creator><creator>Sprockel, Omar</creator><creator>Abebe, Admassu</creator><creator>Nikfar, Faranak</creator><creator>Tobyn, Mike</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161205</creationdate><title>Use of similarity scoring in the development of oral solid dosage forms</title><author>Ferreira, Ana P. ; Olusanmi, Dolapo ; Sprockel, Omar ; Abebe, Admassu ; Nikfar, Faranak ; Tobyn, Mike</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-9d64db46e4d851853bf7541a593c6455ef92c4757975e5bd8e51729d9443fddc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Oral</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Chemistry, Pharmaceutical - statistics & numerical data</topic><topic>Dosage Forms - standards</topic><topic>Knowledge management</topic><topic>Microscopy, Electron, Scanning</topic><topic>Quality by design</topic><topic>Robustness</topic><topic>Similarity scoring</topic><topic>Solid oral dosage form</topic><topic>Surrogate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferreira, Ana P.</creatorcontrib><creatorcontrib>Olusanmi, Dolapo</creatorcontrib><creatorcontrib>Sprockel, Omar</creatorcontrib><creatorcontrib>Abebe, Admassu</creatorcontrib><creatorcontrib>Nikfar, Faranak</creatorcontrib><creatorcontrib>Tobyn, Mike</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferreira, Ana P.</au><au>Olusanmi, Dolapo</au><au>Sprockel, Omar</au><au>Abebe, Admassu</au><au>Nikfar, Faranak</au><au>Tobyn, Mike</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of similarity scoring in the development of oral solid dosage forms</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2016-12-05</date><risdate>2016</risdate><volume>514</volume><issue>2</issue><spage>335</spage><epage>340</epage><pages>335-340</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>[Display omitted]
In the oral solid dosage form space, material physical properties have a strong impact on the behaviour of the formulation during processing. The ability to identify materials with similar characteristics (and thus expected to exhibit similar behaviour) within the company’s portfolio can help accelerate drug development by enabling early assessment and prediction of potential challenges associated with the powder properties of a new active pharmaceutical ingredient. Such developments will aid the production of robust dosage forms, in an efficient manner.
Similarity scoring metrics are widely used in a number of scientific fields. This study proposes a practical implementation of this methodology within pharmaceutical development. The developed similarity metrics is based on the Mahalanobis distance. Scanning electron microscopy was used to confirm morphological similarity between the reference material and the closest matches identified by the metrics proposed. The results show that the metrics proposed are able to successfully identify material with similar physical properties.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26423176</pmid><doi>10.1016/j.ijpharm.2015.09.046</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2016-12, Vol.514 (2), p.335-340 |
| issn | 0378-5173 1873-3476 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Administration, Oral Chemistry, Pharmaceutical - methods Chemistry, Pharmaceutical - statistics & numerical data Dosage Forms - standards Knowledge management Microscopy, Electron, Scanning Quality by design Robustness Similarity scoring Solid oral dosage form Surrogate |
| title | Use of similarity scoring in the development of oral solid dosage forms |
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