In Vivo Evaluation of Zinc-Containing Nanostructured Carbonated Hydroxyapatite

The hydroxyapatite (HA) is a biocompatible and bioactive biomaterial used as bone substitute, however, the high crystallinity of HA and consequently its low solubility may be a limitation for its clinical use. In order to improve the biosorption of HA, the partial substitutions in the chemical struc...

Full description

Saved in:
Bibliographic Details
Published in:Key Engineering Materials 2016-05, Vol.696, p.223-229
Main Authors: Granjeiro, J.M., Uzeda, Marcelo, Pesce, Giovana, Alves, Adriana Terezinha, Ribeiro, Simone, Miguel, Fulvio, Santos, Silvia Albuquerque, Sartoretto, Suelen Cristina, Resende, Rodrigo, Rossi, Alexandre Malta, Calasans-Maia, Mônica Diuana
Format: Article
Language:English
Subjects:
Biocompatibility
Biomaterials
Biomedical materials
Carbonation
Engineering
Hydroxyapatite
Mice
Nanostructure
Skin & tissue grafts
Surgical implants
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c3043-d58636de2ce18b94d2f0bb9418898b3194e4b1b2360acfe49b0fcf2af97f196e3
cites
container_end_page 229
container_issue
container_start_page 223
container_title Key Engineering Materials
container_volume 696
creator Granjeiro, J.M.
Uzeda, Marcelo
Pesce, Giovana
Alves, Adriana Terezinha
Ribeiro, Simone
Miguel, Fulvio
Santos, Silvia Albuquerque
Sartoretto, Suelen Cristina
Resende, Rodrigo
Rossi, Alexandre Malta
Calasans-Maia, Mônica Diuana
description The hydroxyapatite (HA) is a biocompatible and bioactive biomaterial used as bone substitute, however, the high crystallinity of HA and consequently its low solubility may be a limitation for its clinical use. In order to improve the biosorption of HA, the partial substitutions in the chemical structure and doping with small amounts of impurities have been study. The objective of this study was to evaluate the biocompatibility of 3% Zinc-containing nanostructured carbonated hydroxyapatite (ZncHA) compared with the carbonated hydroxyapatite (cHA), both synthesized at 37°C and non-sintered, using as control the stoichiometric HA microspheres in subcutaneous of mice. The X-ray Diffraction (XRD) and Vibrational Spectroscopy in Infra Red Fourier Transform (FTIR) were used to characterize the biomaterials. In vivo test was performed in BALB/c mice by implanting of HA, cHA and ZncHA spheres in the subcutaneous tissue for 1, and 9 weeks (n=5). The negative control consisted in incision without material implantation (Sham group). The samples were histological processed to descriptive analysis of biological effect. The microscopic analysis showed a similar granulation reaction between groups at the first experimental period. In 9 weeks there was a time dependent biosorption of cHA compared with other groups. In conclusion, the biomaterials tested were biocompatible and cHA group showed a significant biosorption in comparison with HA and ZncHA groups. The doping of zinc did not influence the biocompatibility of biomaterial, however, change the biosorption response
doi_str_mv 10.4028/www.scientific.net/KEM.696.223
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1825512128</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1825512128</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3043-d58636de2ce18b94d2f0bb9418898b3194e4b1b2360acfe49b0fcf2af97f196e3</originalsourceid><addsrcrecordid>eNqNkMlKBDEQhoMLuL5DgyBeus3SnU4uogyjM7hd1IOXkE4nGhmTMUk7ztsbGUHx5KkK6qu_ig-AQwSrGmJ2vFgsqqisdskaqyqn0_Hl-LqinFYYkzWwjSjFJW95sw72ecsIJE2LYA3JRp5BRErOMN0COzG-QEgQQ802uJm64sG--2L8LmeDTNa7wpvi0TpVjrxL0jrrnoob6XxMYVBpCLovRjJ03smU28myD_5jKed5N-k9sGnkLOr977oL7s_Hd6NJeXV7MR2dXZWKwJqUfcMoob3GSiPW8brHBna5IsY46wjita471GFCoVRG17yDRhksDW8N4lSTXXC0yp0H_zbomMSrjUrPZtJpP0SBGG4ahBFmGT34g774Ibj8nUAtxw3HvCGZOllRKvgYgzZiHuyrDEuBoPjSL7J-8aNfZP0i6xdZv8j6c8DpKiAF6WLS6vnXnf9FfAKVw5Sh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1792592953</pqid></control><display><type>article</type><title>In Vivo Evaluation of Zinc-Containing Nanostructured Carbonated Hydroxyapatite</title><source>Scientific.net Journals</source><creator>Granjeiro, J.M. ; Uzeda, Marcelo ; Pesce, Giovana ; Alves, Adriana Terezinha ; Ribeiro, Simone ; Miguel, Fulvio ; Santos, Silvia Albuquerque ; Sartoretto, Suelen Cristina ; Resende, Rodrigo ; Rossi, Alexandre Malta ; Calasans-Maia, Mônica Diuana</creator><creatorcontrib>Granjeiro, J.M. ; Uzeda, Marcelo ; Pesce, Giovana ; Alves, Adriana Terezinha ; Ribeiro, Simone ; Miguel, Fulvio ; Santos, Silvia Albuquerque ; Sartoretto, Suelen Cristina ; Resende, Rodrigo ; Rossi, Alexandre Malta ; Calasans-Maia, Mônica Diuana</creatorcontrib><description>The hydroxyapatite (HA) is a biocompatible and bioactive biomaterial used as bone substitute, however, the high crystallinity of HA and consequently its low solubility may be a limitation for its clinical use. In order to improve the biosorption of HA, the partial substitutions in the chemical structure and doping with small amounts of impurities have been study. The objective of this study was to evaluate the biocompatibility of 3% Zinc-containing nanostructured carbonated hydroxyapatite (ZncHA) compared with the carbonated hydroxyapatite (cHA), both synthesized at 37°C and non-sintered, using as control the stoichiometric HA microspheres in subcutaneous of mice. The X-ray Diffraction (XRD) and Vibrational Spectroscopy in Infra Red Fourier Transform (FTIR) were used to characterize the biomaterials. In vivo test was performed in BALB/c mice by implanting of HA, cHA and ZncHA spheres in the subcutaneous tissue for 1, and 9 weeks (n=5). The negative control consisted in incision without material implantation (Sham group). The samples were histological processed to descriptive analysis of biological effect. The microscopic analysis showed a similar granulation reaction between groups at the first experimental period. In 9 weeks there was a time dependent biosorption of cHA compared with other groups. In conclusion, the biomaterials tested were biocompatible and cHA group showed a significant biosorption in comparison with HA and ZncHA groups. The doping of zinc did not influence the biocompatibility of biomaterial, however, change the biosorption response</description><identifier>ISSN: 1013-9826</identifier><identifier>ISSN: 1662-9795</identifier><identifier>ISBN: 9783035710403</identifier><identifier>ISBN: 3035710406</identifier><identifier>EISSN: 1662-9795</identifier><identifier>DOI: 10.4028/www.scientific.net/KEM.696.223</identifier><language>eng</language><publisher>Zurich: Trans Tech Publications Ltd</publisher><subject>Biocompatibility ; Biomaterials ; Biomedical materials ; Carbonation ; Engineering ; Hydroxyapatite ; Mice ; Nanostructure ; Skin &amp; tissue grafts ; Surgical implants</subject><ispartof>Key Engineering Materials, 2016-05, Vol.696, p.223-229</ispartof><rights>2016 Trans Tech Publications Ltd</rights><rights>Copyright Trans Tech Publications Ltd. May 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3043-d58636de2ce18b94d2f0bb9418898b3194e4b1b2360acfe49b0fcf2af97f196e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttps://www.scientific.net/Image/TitleCover/4028?width=600</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Granjeiro, J.M.</creatorcontrib><creatorcontrib>Uzeda, Marcelo</creatorcontrib><creatorcontrib>Pesce, Giovana</creatorcontrib><creatorcontrib>Alves, Adriana Terezinha</creatorcontrib><creatorcontrib>Ribeiro, Simone</creatorcontrib><creatorcontrib>Miguel, Fulvio</creatorcontrib><creatorcontrib>Santos, Silvia Albuquerque</creatorcontrib><creatorcontrib>Sartoretto, Suelen Cristina</creatorcontrib><creatorcontrib>Resende, Rodrigo</creatorcontrib><creatorcontrib>Rossi, Alexandre Malta</creatorcontrib><creatorcontrib>Calasans-Maia, Mônica Diuana</creatorcontrib><title>In Vivo Evaluation of Zinc-Containing Nanostructured Carbonated Hydroxyapatite</title><title>Key Engineering Materials</title><description>The hydroxyapatite (HA) is a biocompatible and bioactive biomaterial used as bone substitute, however, the high crystallinity of HA and consequently its low solubility may be a limitation for its clinical use. In order to improve the biosorption of HA, the partial substitutions in the chemical structure and doping with small amounts of impurities have been study. The objective of this study was to evaluate the biocompatibility of 3% Zinc-containing nanostructured carbonated hydroxyapatite (ZncHA) compared with the carbonated hydroxyapatite (cHA), both synthesized at 37°C and non-sintered, using as control the stoichiometric HA microspheres in subcutaneous of mice. The X-ray Diffraction (XRD) and Vibrational Spectroscopy in Infra Red Fourier Transform (FTIR) were used to characterize the biomaterials. In vivo test was performed in BALB/c mice by implanting of HA, cHA and ZncHA spheres in the subcutaneous tissue for 1, and 9 weeks (n=5). The negative control consisted in incision without material implantation (Sham group). The samples were histological processed to descriptive analysis of biological effect. The microscopic analysis showed a similar granulation reaction between groups at the first experimental period. In 9 weeks there was a time dependent biosorption of cHA compared with other groups. In conclusion, the biomaterials tested were biocompatible and cHA group showed a significant biosorption in comparison with HA and ZncHA groups. The doping of zinc did not influence the biocompatibility of biomaterial, however, change the biosorption response</description><subject>Biocompatibility</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Carbonation</subject><subject>Engineering</subject><subject>Hydroxyapatite</subject><subject>Mice</subject><subject>Nanostructure</subject><subject>Skin &amp; tissue grafts</subject><subject>Surgical implants</subject><issn>1013-9826</issn><issn>1662-9795</issn><issn>1662-9795</issn><isbn>9783035710403</isbn><isbn>3035710406</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkMlKBDEQhoMLuL5DgyBeus3SnU4uogyjM7hd1IOXkE4nGhmTMUk7ztsbGUHx5KkK6qu_ig-AQwSrGmJ2vFgsqqisdskaqyqn0_Hl-LqinFYYkzWwjSjFJW95sw72ecsIJE2LYA3JRp5BRErOMN0COzG-QEgQQ802uJm64sG--2L8LmeDTNa7wpvi0TpVjrxL0jrrnoob6XxMYVBpCLovRjJ03smU28myD_5jKed5N-k9sGnkLOr977oL7s_Hd6NJeXV7MR2dXZWKwJqUfcMoob3GSiPW8brHBna5IsY46wjita471GFCoVRG17yDRhksDW8N4lSTXXC0yp0H_zbomMSrjUrPZtJpP0SBGG4ahBFmGT34g774Ibj8nUAtxw3HvCGZOllRKvgYgzZiHuyrDEuBoPjSL7J-8aNfZP0i6xdZv8j6c8DpKiAF6WLS6vnXnf9FfAKVw5Sh</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Granjeiro, J.M.</creator><creator>Uzeda, Marcelo</creator><creator>Pesce, Giovana</creator><creator>Alves, Adriana Terezinha</creator><creator>Ribeiro, Simone</creator><creator>Miguel, Fulvio</creator><creator>Santos, Silvia Albuquerque</creator><creator>Sartoretto, Suelen Cristina</creator><creator>Resende, Rodrigo</creator><creator>Rossi, Alexandre Malta</creator><creator>Calasans-Maia, Mônica Diuana</creator><general>Trans Tech Publications Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>L6V</scope><scope>M7S</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope></search><sort><creationdate>20160501</creationdate><title>In Vivo Evaluation of Zinc-Containing Nanostructured Carbonated Hydroxyapatite</title><author>Granjeiro, J.M. ; Uzeda, Marcelo ; Pesce, Giovana ; Alves, Adriana Terezinha ; Ribeiro, Simone ; Miguel, Fulvio ; Santos, Silvia Albuquerque ; Sartoretto, Suelen Cristina ; Resende, Rodrigo ; Rossi, Alexandre Malta ; Calasans-Maia, Mônica Diuana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3043-d58636de2ce18b94d2f0bb9418898b3194e4b1b2360acfe49b0fcf2af97f196e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biocompatibility</topic><topic>Biomaterials</topic><topic>Biomedical materials</topic><topic>Carbonation</topic><topic>Engineering</topic><topic>Hydroxyapatite</topic><topic>Mice</topic><topic>Nanostructure</topic><topic>Skin &amp; tissue grafts</topic><topic>Surgical implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Granjeiro, J.M.</creatorcontrib><creatorcontrib>Uzeda, Marcelo</creatorcontrib><creatorcontrib>Pesce, Giovana</creatorcontrib><creatorcontrib>Alves, Adriana Terezinha</creatorcontrib><creatorcontrib>Ribeiro, Simone</creatorcontrib><creatorcontrib>Miguel, Fulvio</creatorcontrib><creatorcontrib>Santos, Silvia Albuquerque</creatorcontrib><creatorcontrib>Sartoretto, Suelen Cristina</creatorcontrib><creatorcontrib>Resende, Rodrigo</creatorcontrib><creatorcontrib>Rossi, Alexandre Malta</creatorcontrib><creatorcontrib>Calasans-Maia, Mônica Diuana</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science &amp; Engineering Database (Proquest)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology &amp; Engineering</collection><collection>Engineering Research Database</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><jtitle>Key Engineering Materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Granjeiro, J.M.</au><au>Uzeda, Marcelo</au><au>Pesce, Giovana</au><au>Alves, Adriana Terezinha</au><au>Ribeiro, Simone</au><au>Miguel, Fulvio</au><au>Santos, Silvia Albuquerque</au><au>Sartoretto, Suelen Cristina</au><au>Resende, Rodrigo</au><au>Rossi, Alexandre Malta</au><au>Calasans-Maia, Mônica Diuana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vivo Evaluation of Zinc-Containing Nanostructured Carbonated Hydroxyapatite</atitle><jtitle>Key Engineering Materials</jtitle><date>2016-05-01</date><risdate>2016</risdate><volume>696</volume><spage>223</spage><epage>229</epage><pages>223-229</pages><issn>1013-9826</issn><issn>1662-9795</issn><eissn>1662-9795</eissn><isbn>9783035710403</isbn><isbn>3035710406</isbn><notes>Selected, peer reviewed papers from BIOCERAMICS 27, 27th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, October 27-29, 2015, Bali, Indonesia</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The hydroxyapatite (HA) is a biocompatible and bioactive biomaterial used as bone substitute, however, the high crystallinity of HA and consequently its low solubility may be a limitation for its clinical use. In order to improve the biosorption of HA, the partial substitutions in the chemical structure and doping with small amounts of impurities have been study. The objective of this study was to evaluate the biocompatibility of 3% Zinc-containing nanostructured carbonated hydroxyapatite (ZncHA) compared with the carbonated hydroxyapatite (cHA), both synthesized at 37°C and non-sintered, using as control the stoichiometric HA microspheres in subcutaneous of mice. The X-ray Diffraction (XRD) and Vibrational Spectroscopy in Infra Red Fourier Transform (FTIR) were used to characterize the biomaterials. In vivo test was performed in BALB/c mice by implanting of HA, cHA and ZncHA spheres in the subcutaneous tissue for 1, and 9 weeks (n=5). The negative control consisted in incision without material implantation (Sham group). The samples were histological processed to descriptive analysis of biological effect. The microscopic analysis showed a similar granulation reaction between groups at the first experimental period. In 9 weeks there was a time dependent biosorption of cHA compared with other groups. In conclusion, the biomaterials tested were biocompatible and cHA group showed a significant biosorption in comparison with HA and ZncHA groups. The doping of zinc did not influence the biocompatibility of biomaterial, however, change the biosorption response</abstract><cop>Zurich</cop><pub>Trans Tech Publications Ltd</pub><doi>10.4028/www.scientific.net/KEM.696.223</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1013-9826
ispartof Key Engineering Materials, 2016-05, Vol.696, p.223-229
issn 1013-9826
1662-9795
1662-9795
language eng
recordid cdi_proquest_miscellaneous_1825512128
source Scientific.net Journals
subjects Biocompatibility
Biomaterials
Biomedical materials
Carbonation
Engineering
Hydroxyapatite
Mice
Nanostructure
Skin & tissue grafts
Surgical implants
title In Vivo Evaluation of Zinc-Containing Nanostructured Carbonated Hydroxyapatite
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T15%3A29%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20Vivo%20Evaluation%20of%20Zinc-Containing%20Nanostructured%20Carbonated%20Hydroxyapatite&rft.jtitle=Key%20Engineering%20Materials&rft.au=Granjeiro,%20J.M.&rft.date=2016-05-01&rft.volume=696&rft.spage=223&rft.epage=229&rft.pages=223-229&rft.issn=1013-9826&rft.eissn=1662-9795&rft.isbn=9783035710403&rft.isbn_list=3035710406&rft_id=info:doi/10.4028/www.scientific.net/KEM.696.223&rft_dat=%3Cproquest_cross%3E1825512128%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3043-d58636de2ce18b94d2f0bb9418898b3194e4b1b2360acfe49b0fcf2af97f196e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1792592953&rft_id=info:pmid/&rfr_iscdi=true