Label-free quantification in clinical proteomics

Nowadays, proteomic studies no longer focus only on identifying as many proteins as possible in a given sample, but aiming for an accurate quantification of them. Especially in clinical proteomics, the investigation of variable protein expression profiles can yield useful information on pathological...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2013-08, Vol.1834 (8), p.1581-1590
Main Authors: Megger, Dominik A., Bracht, Thilo, Meyer, Helmut E., Sitek, Barbara
Format: Article
Language:English
Subjects:
biomarkers
Biomarkers - analysis
Clinical proteomics
Disease biomarker
drugs
Humans
Label-free proteomics
protein synthesis
proteins
Proteins - metabolism
Proteome - analysis
Proteomics
quantitative analysis
Quantitative proteomics
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Summary:Nowadays, proteomic studies no longer focus only on identifying as many proteins as possible in a given sample, but aiming for an accurate quantification of them. Especially in clinical proteomics, the investigation of variable protein expression profiles can yield useful information on pathological pathways or biomarkers and drug targets related to a particular disease. Over the time, many quantitative proteomic approaches have been established allowing researchers in the field of proteomics to refer to a comprehensive toolbox of different methodologies. In this review we will give an overview of different methods of quantitative proteomics with focus on label-free proteomics and its use in clinical proteomics.
ISSN:1570-9639
0006-3002
1878-1454
1878-2434
DOI:10.1016/j.bbapap.2013.04.001