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Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens
Eosinophils remain among the most enigmatic of cells, as our appreciation of their detrimental activities—e.g., asthma and allergic disease—far outweighs our understanding of their beneficial effects. Among the major secretory effector proteins of eosinophils are the ribonucleases eosinophil‐derived...
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| Published in: | Journal of leukocyte biology 2001-11, Vol.70 (5), p.691-698 |
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| cites | cdi_FETCH-LOGICAL-c3901-752ddf523230572e7d175dff42a709ee31ce8974b3a410e06f26e598e8f3d4403 |
| container_end_page | 698 |
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| container_title | Journal of leukocyte biology |
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| creator | Rosenberg, Helene F. Domachowske, Joseph B. |
| description | Eosinophils remain among the most enigmatic of cells, as our appreciation of their detrimental activities—e.g., asthma and allergic disease—far outweighs our understanding of their beneficial effects. Among the major secretory effector proteins of eosinophils are the ribonucleases eosinophil‐derived neurotoxin (EDN) and eosinophil cationic protein (ECP) in primates and their orthologs, the eosinophil‐associated ribonucleases (EARs) in rodents. The rapid diversification observed among these ribonucleases suggested that the ultimate target(s) might be similarly efficient at generating sequence diversity while maintaining an unalterable susceptibility to ribonucleolytic cleavage. This has prompted us to consider a role for these proteins and by extension, for eosinophils, in host defense against single‐stranded RNA virus pathogens. We detail our studies of the antiviral activity of eosinophils and eosinophil ribonucleases against respiratory syncytial virus (RSV) in vitro and the related, natural rodent pathogen, pneumonia virus of mice (PVM), in vivo, and consider the possibility that antiviral host defense and the dysregulated responses leading to asthma represent opposing sides of an eosinophil‐mediated double‐edged sword. |
| doi_str_mv | 10.1189/jlb.70.5.691 |
| format | article |
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Among the major secretory effector proteins of eosinophils are the ribonucleases eosinophil‐derived neurotoxin (EDN) and eosinophil cationic protein (ECP) in primates and their orthologs, the eosinophil‐associated ribonucleases (EARs) in rodents. The rapid diversification observed among these ribonucleases suggested that the ultimate target(s) might be similarly efficient at generating sequence diversity while maintaining an unalterable susceptibility to ribonucleolytic cleavage. This has prompted us to consider a role for these proteins and by extension, for eosinophils, in host defense against single‐stranded RNA virus pathogens. We detail our studies of the antiviral activity of eosinophils and eosinophil ribonucleases against respiratory syncytial virus (RSV) in vitro and the related, natural rodent pathogen, pneumonia virus of mice (PVM), in vivo, and consider the possibility that antiviral host defense and the dysregulated responses leading to asthma represent opposing sides of an eosinophil‐mediated double‐edged sword.</description><identifier>ISSN: 0741-5400</identifier><identifier>EISSN: 1938-3673</identifier><identifier>DOI: 10.1189/jlb.70.5.691</identifier><identifier>PMID: 11698487</identifier><language>eng</language><publisher>United States: Society for Leukocyte Biology</publisher><subject>Animals ; Asthma - etiology ; Asthma - immunology ; Blood Proteins - physiology ; Chemotaxis ; Child ; Cytoplasmic Granules - enzymology ; Disease Susceptibility ; Eosinophil Granule Proteins ; eosinophil ribonuclease ; Eosinophil-Derived Neurotoxin ; Eosinophils - enzymology ; Eosinophils - physiology ; Evolution, Molecular ; Humans ; Infant ; major basic protein ; Mice ; Murine pneumonia virus - immunology ; pneumonia virus of mice ; Pneumovirus Infections - immunology ; Pneumovirus Infections - virology ; Primates ; Pulmonary Eosinophilia - immunology ; Pulmonary Eosinophilia - virology ; Recombinant Proteins - pharmacology ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - immunology ; Respiratory Tract Infections - immunology ; Respiratory Tract Infections - virology ; Ribonucleases - genetics ; Ribonucleases - pharmacology ; Ribonucleases - physiology ; Rodentia ; Species Specificity ; Virus Diseases - immunology</subject><ispartof>Journal of leukocyte biology, 2001-11, Vol.70 (5), p.691-698</ispartof><rights>2001 Society for Leukocyte Biology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3901-752ddf523230572e7d175dff42a709ee31ce8974b3a410e06f26e598e8f3d4403</citedby><cites>FETCH-LOGICAL-c3901-752ddf523230572e7d175dff42a709ee31ce8974b3a410e06f26e598e8f3d4403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1189%2Fjlb.70.5.691$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1189%2Fjlb.70.5.691$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11698487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosenberg, Helene F.</creatorcontrib><creatorcontrib>Domachowske, Joseph B.</creatorcontrib><title>Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens</title><title>Journal of leukocyte biology</title><addtitle>J Leukoc Biol</addtitle><description>Eosinophils remain among the most enigmatic of cells, as our appreciation of their detrimental activities—e.g., asthma and allergic disease—far outweighs our understanding of their beneficial effects. Among the major secretory effector proteins of eosinophils are the ribonucleases eosinophil‐derived neurotoxin (EDN) and eosinophil cationic protein (ECP) in primates and their orthologs, the eosinophil‐associated ribonucleases (EARs) in rodents. The rapid diversification observed among these ribonucleases suggested that the ultimate target(s) might be similarly efficient at generating sequence diversity while maintaining an unalterable susceptibility to ribonucleolytic cleavage. This has prompted us to consider a role for these proteins and by extension, for eosinophils, in host defense against single‐stranded RNA virus pathogens. We detail our studies of the antiviral activity of eosinophils and eosinophil ribonucleases against respiratory syncytial virus (RSV) in vitro and the related, natural rodent pathogen, pneumonia virus of mice (PVM), in vivo, and consider the possibility that antiviral host defense and the dysregulated responses leading to asthma represent opposing sides of an eosinophil‐mediated double‐edged sword.</description><subject>Animals</subject><subject>Asthma - etiology</subject><subject>Asthma - immunology</subject><subject>Blood Proteins - physiology</subject><subject>Chemotaxis</subject><subject>Child</subject><subject>Cytoplasmic Granules - enzymology</subject><subject>Disease Susceptibility</subject><subject>Eosinophil Granule Proteins</subject><subject>eosinophil ribonuclease</subject><subject>Eosinophil-Derived Neurotoxin</subject><subject>Eosinophils - enzymology</subject><subject>Eosinophils - physiology</subject><subject>Evolution, Molecular</subject><subject>Humans</subject><subject>Infant</subject><subject>major basic protein</subject><subject>Mice</subject><subject>Murine pneumonia virus - immunology</subject><subject>pneumonia virus of mice</subject><subject>Pneumovirus Infections - immunology</subject><subject>Pneumovirus Infections - virology</subject><subject>Primates</subject><subject>Pulmonary Eosinophilia - immunology</subject><subject>Pulmonary Eosinophilia - virology</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections - immunology</subject><subject>Respiratory Tract Infections - immunology</subject><subject>Respiratory Tract Infections - virology</subject><subject>Ribonucleases - genetics</subject><subject>Ribonucleases - pharmacology</subject><subject>Ribonucleases - physiology</subject><subject>Rodentia</subject><subject>Species Specificity</subject><subject>Virus Diseases - immunology</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNp9kDFv2zAQRokiRe2k3ToHXJIpUo6kJEpjYyRtAgNd0pmgpZPFgBYVUqrgf18WMtyt0-HDvfsOeIR8ZZAyVlb3b3aXSkjztKjYB7JmlSgTUUhxQdYgM5bkGcCKXIbwBgCCF_CJrBgrqjIr5ZqYRxdM74bO2HBH8RyoNzvXT7VFHTBudN_QsUPjqXcWqelp58JIG2yxD0j1Xps-Zo9hMF6Pzh_pb-OnQAc9dm4foc_kY6ttwC-neUV-PT2-bn4k25_fnzfftkktKmCJzHnTtDkXXEAuOcqGybxp24xrCRWiYDWWlcx2QmcMEIqWF5hXJZataLIMxBW5XXoH794nDKM6mFCjtbpHNwXFSs64kDKCdwtYexeCx1YN3hy0PyoG6q9aFdUqCSpXUW3Er0-90-6AzT_45DICbAFmY_H43zL1sn2ApfRmuenMvpuNRxUO2tr4gqt5ns_P_wB0fJKm</recordid><startdate>200111</startdate><enddate>200111</enddate><creator>Rosenberg, Helene F.</creator><creator>Domachowske, Joseph B.</creator><general>Society for Leukocyte Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>200111</creationdate><title>Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens</title><author>Rosenberg, Helene F. ; Domachowske, Joseph B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3901-752ddf523230572e7d175dff42a709ee31ce8974b3a410e06f26e598e8f3d4403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Asthma - etiology</topic><topic>Asthma - immunology</topic><topic>Blood Proteins - physiology</topic><topic>Chemotaxis</topic><topic>Child</topic><topic>Cytoplasmic Granules - enzymology</topic><topic>Disease Susceptibility</topic><topic>Eosinophil Granule Proteins</topic><topic>eosinophil ribonuclease</topic><topic>Eosinophil-Derived Neurotoxin</topic><topic>Eosinophils - enzymology</topic><topic>Eosinophils - physiology</topic><topic>Evolution, Molecular</topic><topic>Humans</topic><topic>Infant</topic><topic>major basic protein</topic><topic>Mice</topic><topic>Murine pneumonia virus - immunology</topic><topic>pneumonia virus of mice</topic><topic>Pneumovirus Infections - immunology</topic><topic>Pneumovirus Infections - virology</topic><topic>Primates</topic><topic>Pulmonary Eosinophilia - immunology</topic><topic>Pulmonary Eosinophilia - virology</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory Syncytial Virus Infections - immunology</topic><topic>Respiratory Tract Infections - immunology</topic><topic>Respiratory Tract Infections - virology</topic><topic>Ribonucleases - genetics</topic><topic>Ribonucleases - pharmacology</topic><topic>Ribonucleases - physiology</topic><topic>Rodentia</topic><topic>Species Specificity</topic><topic>Virus Diseases - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosenberg, Helene F.</creatorcontrib><creatorcontrib>Domachowske, Joseph B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of leukocyte biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosenberg, Helene F.</au><au>Domachowske, Joseph B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens</atitle><jtitle>Journal of leukocyte biology</jtitle><addtitle>J Leukoc Biol</addtitle><date>2001-11</date><risdate>2001</risdate><volume>70</volume><issue>5</issue><spage>691</spage><epage>698</epage><pages>691-698</pages><issn>0741-5400</issn><eissn>1938-3673</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>ObjectType-Review-3</notes><notes>content type line 23</notes><abstract>Eosinophils remain among the most enigmatic of cells, as our appreciation of their detrimental activities—e.g., asthma and allergic disease—far outweighs our understanding of their beneficial effects. Among the major secretory effector proteins of eosinophils are the ribonucleases eosinophil‐derived neurotoxin (EDN) and eosinophil cationic protein (ECP) in primates and their orthologs, the eosinophil‐associated ribonucleases (EARs) in rodents. The rapid diversification observed among these ribonucleases suggested that the ultimate target(s) might be similarly efficient at generating sequence diversity while maintaining an unalterable susceptibility to ribonucleolytic cleavage. This has prompted us to consider a role for these proteins and by extension, for eosinophils, in host defense against single‐stranded RNA virus pathogens. We detail our studies of the antiviral activity of eosinophils and eosinophil ribonucleases against respiratory syncytial virus (RSV) in vitro and the related, natural rodent pathogen, pneumonia virus of mice (PVM), in vivo, and consider the possibility that antiviral host defense and the dysregulated responses leading to asthma represent opposing sides of an eosinophil‐mediated double‐edged sword.</abstract><cop>United States</cop><pub>Society for Leukocyte Biology</pub><pmid>11698487</pmid><doi>10.1189/jlb.70.5.691</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of leukocyte biology, 2001-11, Vol.70 (5), p.691-698 |
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| source | Wiley; OUP_牛津大学出版社现刊 |
| subjects | Animals Asthma - etiology Asthma - immunology Blood Proteins - physiology Chemotaxis Child Cytoplasmic Granules - enzymology Disease Susceptibility Eosinophil Granule Proteins eosinophil ribonuclease Eosinophil-Derived Neurotoxin Eosinophils - enzymology Eosinophils - physiology Evolution, Molecular Humans Infant major basic protein Mice Murine pneumonia virus - immunology pneumonia virus of mice Pneumovirus Infections - immunology Pneumovirus Infections - virology Primates Pulmonary Eosinophilia - immunology Pulmonary Eosinophilia - virology Recombinant Proteins - pharmacology Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Tract Infections - immunology Respiratory Tract Infections - virology Ribonucleases - genetics Ribonucleases - pharmacology Ribonucleases - physiology Rodentia Species Specificity Virus Diseases - immunology |
| title | Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens |
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