Outcomes After Percutaneous Coronary Intervention or Bypass Surgery in Patients With Unprotected Left Main Disease
Abstract Background Currently available randomized data on the comparison between percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) for the treatment of unprotected left main coronary disease (LMD) lacks statistical power due to low numbers of patients enrolled. Object...
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Outcomes After Percutaneous Coronary Intervention or Bypass Surgery in Patients With Unprotected Left Main Disease |
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Cavalcante, Rafael, MD, PhD Sotomi, Yohei, MD Lee, Cheol W., MD Ahn, Jung-Min, MD Farooq, Vasim, MD, PhD Tateishi, Hiroki, MD, PhD Tenekecioglu, Erhan, MD Zeng, Yaping, MD, PhD Suwannasom, Pannipa, MD Collet, Carlos, MD Albuquerque, Felipe N., MD Onuma, Yoshinobu, MD, PhD Park, Seung-Jung, MD, PhD Serruys, Patrick W., MD, PhD |
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Cardiovascular Cardiovascular disease Chronic obstructive pulmonary disease Clinical trials Confidence intervals Coronary Artery Bypass - adverse effects coronary artery bypass graft surgery Coronary Artery Disease - pathology Coronary Artery Disease - surgery Coronary vessels Female Heart attacks Heart surgery Humans Internal Medicine Ischemia left main coronary artery disease long-term outcomes Male Middle Aged Mortality Patients percutaneous coronary intervention Percutaneous Coronary Intervention - adverse effects Population Postoperative Complications - epidemiology Postoperative Complications - etiology randomized controlled trials Stents Stroke Taxus Treatment Outcome |
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Journal of the American College of Cardiology, 2016-09, Vol.68 (10), p.999-1009 |
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Abstract Background Currently available randomized data on the comparison between percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) for the treatment of unprotected left main coronary disease (LMD) lacks statistical power due to low numbers of patients enrolled. Objectives This study assessed long-term outcomes of PCI and CABG for the treatment of LMD in specific subgroups according to disease anatomic complexity. Methods We conducted a pooled analysis of individual patient-level data of the LMD patients included in the PRECOMBAT (Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease) and SYNTAX (Synergy Between PCI With TAXUS and Cardiac Surgery) trials. Incidences of major adverse cardiac events were assessed at 5 years follow-up. Results Study population comprised 1,305 patients. The incidence of major adverse cardiac and cerebrovascular events at 5 years was 28.3% in the PCI group and 23.0% in the CABG group (hazard ratio [HR]: 1.23; 95% confidence interval [CI]: 1.01 to 1.55; p = 0.045). This difference is mainly driven by a higher rate of repeat revascularization associated with PCI (HR: 1.85; 95% CI: 1.38 to 2.47; p < 0.001). The 2 strategies showed similar rates of the safety composite endpoint of death, myocardial infarction, or stroke (p = 0.45). In patients with isolated LM or LM + 1-vessel disease, PCI was associated with a 60% reduction in all-cause mortality (HR: 0.40; 95% CI: 0.20 to 0.83; p = 0.029) and 67% reduction in cardiac mortality (HR: 0.33; 95% CI: 0.12 to 0.88; p = 0.025) when compared with CABG. Conclusions In patients with unprotected LMD, CABG, and PCI result in similar rates of the safety composite endpoint of death, myocardial infarction, or stroke. In patients with isolated LM or LM + 1-vessel disease, PCI is associated with lower all-cause and cardiac mortality when compared to CABG. |
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<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1819138794</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0735109716336737</els_id><sourcerecordid>4169441001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c586t-944e93d7c740260bbc162deecca55ac45a3e7ba9f751b292f4ae2bb1bc5705f3</originalsourceid><addsrcrecordid>eNqNkk2LFDEQhoMo7rj6BzxIwIuXHvPRSbpBhHX8WhjZhV3xGNLpak3bk4xJemH-vWlnVdiDCAUJ1FNFvW8VQk8pWVNC5ctxPRpr16z816QEq--hFRWiqbho1X20IoqLipJWnaBHKY2EENnQ9iE6YUo0QhC-QvFizjbsIOGzIUPElxDtnI2HMCe8CTF4Ew_43JfcDfjsgsch4jeHvUkJX83xK5S08_jSZFfyCX9x-Rv-7PcxZLAZeryFIeNPpjBvXQKT4DF6MJgpwZPb9xRdv393vflYbS8-nG_OtpUVjcxVW9fQ8l5ZVRMmSddZKlkPYK0RwthaGA6qM-2gBO1Yy4baAOs62lmhiBj4KXpxbFtG-TFDynrnkoVpOorTtFhBeaPa-n9QKblgrSro8zvoGOboi45fFJdSKFoodqRsDClFGPQ-ul1xUlOil93pUS-708vuNCnBlime3baeux30f0p-L6sAr44AFNduHESdbDHdQu9i8Vr3wf27_-s75XZy3lkzfYcDpL86dGKa6KvlepbjKaq4VFzxnyFSwAQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><isCDI>true</isCDI><recordtype>article</recordtype><pqid>1816366571</pqid></control><display><type>article</type><title>Outcomes After Percutaneous Coronary Intervention or Bypass Surgery in Patients With Unprotected Left Main Disease</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><source>ScienceDirect - Connect here FIRST to enable access</source><creator>Cavalcante, Rafael, MD, PhD ; Sotomi, Yohei, MD ; Lee, Cheol W., MD ; Ahn, Jung-Min, MD ; Farooq, Vasim, MD, PhD ; Tateishi, Hiroki, MD, PhD ; Tenekecioglu, Erhan, MD ; Zeng, Yaping, MD, PhD ; Suwannasom, Pannipa, MD ; Collet, Carlos, MD ; Albuquerque, Felipe N., MD ; Onuma, Yoshinobu, MD, PhD ; Park, Seung-Jung, MD, PhD ; Serruys, Patrick W., MD, PhD</creator><creatorcontrib>Cavalcante, Rafael, MD, PhD ; Sotomi, Yohei, MD ; Lee, Cheol W., MD ; Ahn, Jung-Min, MD ; Farooq, Vasim, MD, PhD ; Tateishi, Hiroki, MD, PhD ; Tenekecioglu, Erhan, MD ; Zeng, Yaping, MD, PhD ; Suwannasom, Pannipa, MD ; Collet, Carlos, MD ; Albuquerque, Felipe N., MD ; Onuma, Yoshinobu, MD, PhD ; Park, Seung-Jung, MD, PhD ; Serruys, Patrick W., MD, PhD</creatorcontrib><description>Abstract Background Currently available randomized data on the comparison between percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) for the treatment of unprotected left main coronary disease (LMD) lacks statistical power due to low numbers of patients enrolled. Objectives This study assessed long-term outcomes of PCI and CABG for the treatment of LMD in specific subgroups according to disease anatomic complexity. Methods We conducted a pooled analysis of individual patient-level data of the LMD patients included in the PRECOMBAT (Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease) and SYNTAX (Synergy Between PCI With TAXUS and Cardiac Surgery) trials. Incidences of major adverse cardiac events were assessed at 5 years follow-up. Results Study population comprised 1,305 patients. The incidence of major adverse cardiac and cerebrovascular events at 5 years was 28.3% in the PCI group and 23.0% in the CABG group (hazard ratio [HR]: 1.23; 95% confidence interval [CI]: 1.01 to 1.55; p = 0.045). This difference is mainly driven by a higher rate of repeat revascularization associated with PCI (HR: 1.85; 95% CI: 1.38 to 2.47; p < 0.001). The 2 strategies showed similar rates of the safety composite endpoint of death, myocardial infarction, or stroke (p = 0.45). In patients with isolated LM or LM + 1-vessel disease, PCI was associated with a 60% reduction in all-cause mortality (HR: 0.40; 95% CI: 0.20 to 0.83; p = 0.029) and 67% reduction in cardiac mortality (HR: 0.33; 95% CI: 0.12 to 0.88; p = 0.025) when compared with CABG. Conclusions In patients with unprotected LMD, CABG, and PCI result in similar rates of the safety composite endpoint of death, myocardial infarction, or stroke. In patients with isolated LM or LM + 1-vessel disease, PCI is associated with lower all-cause and cardiac mortality when compared to CABG.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2016.06.024</identifier><identifier>PMID: 27585503</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cardiovascular ; Cardiovascular disease ; Chronic obstructive pulmonary disease ; Clinical trials ; Confidence intervals ; Coronary Artery Bypass - adverse effects ; coronary artery bypass graft surgery ; Coronary Artery Disease - pathology ; Coronary Artery Disease - surgery ; Coronary vessels ; Female ; Heart attacks ; Heart surgery ; Humans ; Internal Medicine ; Ischemia ; left main coronary artery disease ; long-term outcomes ; Male ; Middle Aged ; Mortality ; Patients ; percutaneous coronary intervention ; Percutaneous Coronary Intervention - adverse effects ; Population ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; randomized controlled trials ; Stents ; Stroke ; Taxus ; Treatment Outcome</subject><ispartof>Journal of the American College of Cardiology, 2016-09, Vol.68 (10), p.999-1009</ispartof><rights>American College of Cardiology Foundation</rights><rights>2016 American College of Cardiology Foundation</rights><rights>Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Sep 6, 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c586t-944e93d7c740260bbc162deecca55ac45a3e7ba9f751b292f4ae2bb1bc5705f3</citedby><cites>FETCH-LOGICAL-c586t-944e93d7c740260bbc162deecca55ac45a3e7ba9f751b292f4ae2bb1bc5705f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0735109716336737$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,787,791,3569,27985,27986,46162</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27585503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cavalcante, Rafael, MD, PhD</creatorcontrib><creatorcontrib>Sotomi, Yohei, MD</creatorcontrib><creatorcontrib>Lee, Cheol W., MD</creatorcontrib><creatorcontrib>Ahn, Jung-Min, MD</creatorcontrib><creatorcontrib>Farooq, Vasim, MD, PhD</creatorcontrib><creatorcontrib>Tateishi, Hiroki, MD, PhD</creatorcontrib><creatorcontrib>Tenekecioglu, Erhan, MD</creatorcontrib><creatorcontrib>Zeng, Yaping, MD, PhD</creatorcontrib><creatorcontrib>Suwannasom, Pannipa, MD</creatorcontrib><creatorcontrib>Collet, Carlos, MD</creatorcontrib><creatorcontrib>Albuquerque, Felipe N., MD</creatorcontrib><creatorcontrib>Onuma, Yoshinobu, MD, PhD</creatorcontrib><creatorcontrib>Park, Seung-Jung, MD, PhD</creatorcontrib><creatorcontrib>Serruys, Patrick W., MD, PhD</creatorcontrib><title>Outcomes After Percutaneous Coronary Intervention or Bypass Surgery in Patients With Unprotected Left Main Disease</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Abstract Background Currently available randomized data on the comparison between percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) for the treatment of unprotected left main coronary disease (LMD) lacks statistical power due to low numbers of patients enrolled. Objectives This study assessed long-term outcomes of PCI and CABG for the treatment of LMD in specific subgroups according to disease anatomic complexity. Methods We conducted a pooled analysis of individual patient-level data of the LMD patients included in the PRECOMBAT (Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease) and SYNTAX (Synergy Between PCI With TAXUS and Cardiac Surgery) trials. Incidences of major adverse cardiac events were assessed at 5 years follow-up. Results Study population comprised 1,305 patients. The incidence of major adverse cardiac and cerebrovascular events at 5 years was 28.3% in the PCI group and 23.0% in the CABG group (hazard ratio [HR]: 1.23; 95% confidence interval [CI]: 1.01 to 1.55; p = 0.045). This difference is mainly driven by a higher rate of repeat revascularization associated with PCI (HR: 1.85; 95% CI: 1.38 to 2.47; p < 0.001). The 2 strategies showed similar rates of the safety composite endpoint of death, myocardial infarction, or stroke (p = 0.45). In patients with isolated LM or LM + 1-vessel disease, PCI was associated with a 60% reduction in all-cause mortality (HR: 0.40; 95% CI: 0.20 to 0.83; p = 0.029) and 67% reduction in cardiac mortality (HR: 0.33; 95% CI: 0.12 to 0.88; p = 0.025) when compared with CABG. Conclusions In patients with unprotected LMD, CABG, and PCI result in similar rates of the safety composite endpoint of death, myocardial infarction, or stroke. In patients with isolated LM or LM + 1-vessel disease, PCI is associated with lower all-cause and cardiac mortality when compared to CABG.</description><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Clinical trials</subject><subject>Confidence intervals</subject><subject>Coronary Artery Bypass - adverse effects</subject><subject>coronary artery bypass graft surgery</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary Artery Disease - surgery</subject><subject>Coronary vessels</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Ischemia</subject><subject>left main coronary artery disease</subject><subject>long-term outcomes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patients</subject><subject>percutaneous coronary intervention</subject><subject>Percutaneous Coronary Intervention - adverse effects</subject><subject>Population</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>randomized controlled trials</subject><subject>Stents</subject><subject>Stroke</subject><subject>Taxus</subject><subject>Treatment Outcome</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkk2LFDEQhoMo7rj6BzxIwIuXHvPRSbpBhHX8WhjZhV3xGNLpak3bk4xJemH-vWlnVdiDCAUJ1FNFvW8VQk8pWVNC5ctxPRpr16z816QEq--hFRWiqbho1X20IoqLipJWnaBHKY2EENnQ9iE6YUo0QhC-QvFizjbsIOGzIUPElxDtnI2HMCe8CTF4Ew_43JfcDfjsgsch4jeHvUkJX83xK5S08_jSZFfyCX9x-Rv-7PcxZLAZeryFIeNPpjBvXQKT4DF6MJgpwZPb9xRdv393vflYbS8-nG_OtpUVjcxVW9fQ8l5ZVRMmSddZKlkPYK0RwthaGA6qM-2gBO1Yy4baAOs62lmhiBj4KXpxbFtG-TFDynrnkoVpOorTtFhBeaPa-n9QKblgrSro8zvoGOboi45fFJdSKFoodqRsDClFGPQ-ul1xUlOil93pUS-708vuNCnBlime3baeux30f0p-L6sAr44AFNduHESdbDHdQu9i8Vr3wf27_-s75XZy3lkzfYcDpL86dGKa6KvlepbjKaq4VFzxnyFSwAQ</recordid><startdate>20160906</startdate><enddate>20160906</enddate><creator>Cavalcante, Rafael, MD, PhD</creator><creator>Sotomi, Yohei, MD</creator><creator>Lee, Cheol W., MD</creator><creator>Ahn, Jung-Min, MD</creator><creator>Farooq, Vasim, MD, PhD</creator><creator>Tateishi, Hiroki, MD, PhD</creator><creator>Tenekecioglu, Erhan, MD</creator><creator>Zeng, Yaping, MD, PhD</creator><creator>Suwannasom, Pannipa, MD</creator><creator>Collet, Carlos, MD</creator><creator>Albuquerque, Felipe N., MD</creator><creator>Onuma, Yoshinobu, MD, PhD</creator><creator>Park, Seung-Jung, MD, PhD</creator><creator>Serruys, Patrick W., MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20160906</creationdate><title>Outcomes After Percutaneous Coronary Intervention or Bypass Surgery in Patients With Unprotected Left Main Disease</title><author>Cavalcante, Rafael, MD, PhD ; Sotomi, Yohei, MD ; Lee, Cheol W., MD ; Ahn, Jung-Min, MD ; Farooq, Vasim, MD, PhD ; Tateishi, Hiroki, MD, PhD ; Tenekecioglu, Erhan, MD ; Zeng, Yaping, MD, PhD ; Suwannasom, Pannipa, MD ; Collet, Carlos, MD ; Albuquerque, Felipe N., MD ; Onuma, Yoshinobu, MD, PhD ; Park, Seung-Jung, MD, PhD ; Serruys, Patrick W., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c586t-944e93d7c740260bbc162deecca55ac45a3e7ba9f751b292f4ae2bb1bc5705f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Clinical trials</topic><topic>Confidence intervals</topic><topic>Coronary Artery Bypass - adverse effects</topic><topic>coronary artery bypass graft surgery</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary Artery Disease - surgery</topic><topic>Coronary vessels</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Heart surgery</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Ischemia</topic><topic>left main coronary artery disease</topic><topic>long-term outcomes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Patients</topic><topic>percutaneous coronary intervention</topic><topic>Percutaneous Coronary Intervention - adverse effects</topic><topic>Population</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>randomized controlled trials</topic><topic>Stents</topic><topic>Stroke</topic><topic>Taxus</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cavalcante, Rafael, MD, PhD</creatorcontrib><creatorcontrib>Sotomi, Yohei, MD</creatorcontrib><creatorcontrib>Lee, Cheol W., MD</creatorcontrib><creatorcontrib>Ahn, Jung-Min, MD</creatorcontrib><creatorcontrib>Farooq, Vasim, MD, PhD</creatorcontrib><creatorcontrib>Tateishi, Hiroki, MD, PhD</creatorcontrib><creatorcontrib>Tenekecioglu, Erhan, MD</creatorcontrib><creatorcontrib>Zeng, Yaping, MD, PhD</creatorcontrib><creatorcontrib>Suwannasom, Pannipa, MD</creatorcontrib><creatorcontrib>Collet, Carlos, MD</creatorcontrib><creatorcontrib>Albuquerque, Felipe N., MD</creatorcontrib><creatorcontrib>Onuma, Yoshinobu, MD, PhD</creatorcontrib><creatorcontrib>Park, Seung-Jung, MD, PhD</creatorcontrib><creatorcontrib>Serruys, Patrick W., MD, PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cavalcante, Rafael, MD, PhD</au><au>Sotomi, Yohei, MD</au><au>Lee, Cheol W., MD</au><au>Ahn, Jung-Min, MD</au><au>Farooq, Vasim, MD, PhD</au><au>Tateishi, Hiroki, MD, PhD</au><au>Tenekecioglu, Erhan, MD</au><au>Zeng, Yaping, MD, PhD</au><au>Suwannasom, Pannipa, MD</au><au>Collet, Carlos, MD</au><au>Albuquerque, Felipe N., MD</au><au>Onuma, Yoshinobu, MD, PhD</au><au>Park, Seung-Jung, MD, PhD</au><au>Serruys, Patrick W., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes After Percutaneous Coronary Intervention or Bypass Surgery in Patients With Unprotected Left Main Disease</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2016-09-06</date><risdate>2016</risdate><volume>68</volume><issue>10</issue><spage>999</spage><epage>1009</epage><pages>999-1009</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-News-2</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Feature-2</notes><abstract>Abstract Background Currently available randomized data on the comparison between percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) for the treatment of unprotected left main coronary disease (LMD) lacks statistical power due to low numbers of patients enrolled. Objectives This study assessed long-term outcomes of PCI and CABG for the treatment of LMD in specific subgroups according to disease anatomic complexity. Methods We conducted a pooled analysis of individual patient-level data of the LMD patients included in the PRECOMBAT (Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease) and SYNTAX (Synergy Between PCI With TAXUS and Cardiac Surgery) trials. Incidences of major adverse cardiac events were assessed at 5 years follow-up. Results Study population comprised 1,305 patients. The incidence of major adverse cardiac and cerebrovascular events at 5 years was 28.3% in the PCI group and 23.0% in the CABG group (hazard ratio [HR]: 1.23; 95% confidence interval [CI]: 1.01 to 1.55; p = 0.045). This difference is mainly driven by a higher rate of repeat revascularization associated with PCI (HR: 1.85; 95% CI: 1.38 to 2.47; p < 0.001). The 2 strategies showed similar rates of the safety composite endpoint of death, myocardial infarction, or stroke (p = 0.45). In patients with isolated LM or LM + 1-vessel disease, PCI was associated with a 60% reduction in all-cause mortality (HR: 0.40; 95% CI: 0.20 to 0.83; p = 0.029) and 67% reduction in cardiac mortality (HR: 0.33; 95% CI: 0.12 to 0.88; p = 0.025) when compared with CABG. Conclusions In patients with unprotected LMD, CABG, and PCI result in similar rates of the safety composite endpoint of death, myocardial infarction, or stroke. In patients with isolated LM or LM + 1-vessel disease, PCI is associated with lower all-cause and cardiac mortality when compared to CABG.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27585503</pmid><doi>10.1016/j.jacc.2016.06.024</doi><oa>free_for_read</oa></addata></record> |