Ischemic Conditioning: Implications for Emergency Medicine

Ischemic conditioning refers to the ability of brief episodes of controlled hypoperfusion around the time of an acute ischemic event to protect the target organ from reperfusion injury. A considerable body of literature suggests that interventions as simple and safe as repetitively inflating a blood...

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Bibliographic Details
Published in:Annals of emergency medicine 2016-09, Vol.68 (3), p.268-274
Main Authors: Frumkin, Kenneth, MD, PhD, Bloom, Adam S., LT, MC, USN
Format: Article
Language:English
Subjects:
Emergency
Humans
Ischemic Preconditioning - methods
Myocardial Reperfusion Injury - prevention & control
Reperfusion Injury - prevention & control
ST Elevation Myocardial Infarction - complications
ST Elevation Myocardial Infarction - therapy
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Summary:Ischemic conditioning refers to the ability of brief episodes of controlled hypoperfusion around the time of an acute ischemic event to protect the target organ from reperfusion injury. A considerable body of literature suggests that interventions as simple and safe as repetitively inflating a blood pressure cuff could reduce the size and long-term morbidity of myocardial and cerebral infarction. This review introduces and summarizes the body of evidence contributing to these impressions.
ISSN:0196-0644
1097-6760
DOI:10.1016/j.annemergmed.2016.02.020