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Small for gestational age and exposure to particulate air pollution in the early-life environment of twins
Several studies in singletons have shown that maternal exposure to ambient air pollutants is associated with restricted fetal growth. About half of twins have low birth weight compared with six percent in singletons. So far, no studies have investigated maternal air pollution exposure in association...
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| Published in: | Environmental research 2016-07, Vol.148, p.39-45 |
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| container_title | Environmental research |
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| creator | Bijnens, Esmée M. Derom, Catherine Gielen, Marij Winckelmans, Ellen Fierens, Frans Vlietinck, Robert Zeegers, Maurice P. Nawrot, Tim S. |
| description | Several studies in singletons have shown that maternal exposure to ambient air pollutants is associated with restricted fetal growth. About half of twins have low birth weight compared with six percent in singletons. So far, no studies have investigated maternal air pollution exposure in association with birth weight and small for gestational age in twins.
We examined 4760 twins of the East Flanders Prospective Twins Survey (2002–2013), to study the association between in utero exposure to air pollution with birth weight and small for gestational age. Maternal particulate air pollution (PM10) and nitric dioxide (NO2) exposure was estimated using a spatial temporal interpolation method over various time windows during pregnancy.
In the total group of twins, we observed that higher PM10 and NO2 exposure during the third trimester was significantly associated with a lower birth weight and higher risk of small for gestational age. However, the association was driven by moderate to late preterm twins (32–36 weeks of gestation). In these twins born between 32 and 36 weeks of gestation, birth weight decreased by 40.2g (95% CI: −69.0 to −11.3; p=0.006) and by 27.3g (95% CI: −52.9 to −1.7; p=0.04) in association for each 10µg/m³ increment in PM10 and NO2 concentration during the third trimester. The corresponding odds ratio for small for gestational age were 1.68 (95% CI: 1.27–2.33; p=0.0003) and 1.51 (95% CI: 1.18–1.95; p=0.001) for PM10 or NO2, respectively. No associations between air pollution and birth weight or small for gestational age were observed among term born twins. Finally, in all twins, we found that for each 10µg/m³ increase in PM10 during the last month of pregnancy the within-pair birth weight difference increased by 19.6g (95% CI: 3.7–35.4; p=0.02).
Assuming causality, an achievement of a 10µg/m³ decrease of particulate air pollution may account for a reduction by 40% in small for gestational age, in twins born moderate to late preterm.
•Exposure to air pollution is associated with restricted fetal growth in singletons.•No studies have investigated the association of air pollution with birth weight and small for gestational age in twins.•Maternal air pollution (PM10 and NO2) exposure was estimated over various time windows during pregnancy in 4,760 twins.•Air pollution is associated with small for gestational age and birth weight in moderate to late preterm born twins.•The within-pair difference in birth weight increases with higher air pollution |
| doi_str_mv | 10.1016/j.envres.2016.03.006 |
| format | article |
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We examined 4760 twins of the East Flanders Prospective Twins Survey (2002–2013), to study the association between in utero exposure to air pollution with birth weight and small for gestational age. Maternal particulate air pollution (PM10) and nitric dioxide (NO2) exposure was estimated using a spatial temporal interpolation method over various time windows during pregnancy.
In the total group of twins, we observed that higher PM10 and NO2 exposure during the third trimester was significantly associated with a lower birth weight and higher risk of small for gestational age. However, the association was driven by moderate to late preterm twins (32–36 weeks of gestation). In these twins born between 32 and 36 weeks of gestation, birth weight decreased by 40.2g (95% CI: −69.0 to −11.3; p=0.006) and by 27.3g (95% CI: −52.9 to −1.7; p=0.04) in association for each 10µg/m³ increment in PM10 and NO2 concentration during the third trimester. The corresponding odds ratio for small for gestational age were 1.68 (95% CI: 1.27–2.33; p=0.0003) and 1.51 (95% CI: 1.18–1.95; p=0.001) for PM10 or NO2, respectively. No associations between air pollution and birth weight or small for gestational age were observed among term born twins. Finally, in all twins, we found that for each 10µg/m³ increase in PM10 during the last month of pregnancy the within-pair birth weight difference increased by 19.6g (95% CI: 3.7–35.4; p=0.02).
Assuming causality, an achievement of a 10µg/m³ decrease of particulate air pollution may account for a reduction by 40% in small for gestational age, in twins born moderate to late preterm.
•Exposure to air pollution is associated with restricted fetal growth in singletons.•No studies have investigated the association of air pollution with birth weight and small for gestational age in twins.•Maternal air pollution (PM10 and NO2) exposure was estimated over various time windows during pregnancy in 4,760 twins.•Air pollution is associated with small for gestational age and birth weight in moderate to late preterm born twins.•The within-pair difference in birth weight increases with higher air pollution exposure during the last month of pregnancy.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/j.envres.2016.03.006</identifier><identifier>PMID: 27003124</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adult ; Air Pollutants - analysis ; Air pollution ; Air Pollution - analysis ; Belgium - epidemiology ; Birth Weight ; Female ; Gestational Age ; Humans ; Male ; Maternal Exposure ; Nitrogen Dioxide - analysis ; Particulate matter ; Particulate Matter - analysis ; Pregnancy ; Small for gestational age ; Twin ; Twins ; Young Adult</subject><ispartof>Environmental research, 2016-07, Vol.148, p.39-45</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-3436becccbada810df1fd6fc57a2d60c42ae189b58a25605c2ee1874faf3490e3</citedby><cites>FETCH-LOGICAL-c441t-3436becccbada810df1fd6fc57a2d60c42ae189b58a25605c2ee1874faf3490e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27003124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bijnens, Esmée M.</creatorcontrib><creatorcontrib>Derom, Catherine</creatorcontrib><creatorcontrib>Gielen, Marij</creatorcontrib><creatorcontrib>Winckelmans, Ellen</creatorcontrib><creatorcontrib>Fierens, Frans</creatorcontrib><creatorcontrib>Vlietinck, Robert</creatorcontrib><creatorcontrib>Zeegers, Maurice P.</creatorcontrib><creatorcontrib>Nawrot, Tim S.</creatorcontrib><title>Small for gestational age and exposure to particulate air pollution in the early-life environment of twins</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>Several studies in singletons have shown that maternal exposure to ambient air pollutants is associated with restricted fetal growth. About half of twins have low birth weight compared with six percent in singletons. So far, no studies have investigated maternal air pollution exposure in association with birth weight and small for gestational age in twins.
We examined 4760 twins of the East Flanders Prospective Twins Survey (2002–2013), to study the association between in utero exposure to air pollution with birth weight and small for gestational age. Maternal particulate air pollution (PM10) and nitric dioxide (NO2) exposure was estimated using a spatial temporal interpolation method over various time windows during pregnancy.
In the total group of twins, we observed that higher PM10 and NO2 exposure during the third trimester was significantly associated with a lower birth weight and higher risk of small for gestational age. However, the association was driven by moderate to late preterm twins (32–36 weeks of gestation). In these twins born between 32 and 36 weeks of gestation, birth weight decreased by 40.2g (95% CI: −69.0 to −11.3; p=0.006) and by 27.3g (95% CI: −52.9 to −1.7; p=0.04) in association for each 10µg/m³ increment in PM10 and NO2 concentration during the third trimester. The corresponding odds ratio for small for gestational age were 1.68 (95% CI: 1.27–2.33; p=0.0003) and 1.51 (95% CI: 1.18–1.95; p=0.001) for PM10 or NO2, respectively. No associations between air pollution and birth weight or small for gestational age were observed among term born twins. Finally, in all twins, we found that for each 10µg/m³ increase in PM10 during the last month of pregnancy the within-pair birth weight difference increased by 19.6g (95% CI: 3.7–35.4; p=0.02).
Assuming causality, an achievement of a 10µg/m³ decrease of particulate air pollution may account for a reduction by 40% in small for gestational age, in twins born moderate to late preterm.
•Exposure to air pollution is associated with restricted fetal growth in singletons.•No studies have investigated the association of air pollution with birth weight and small for gestational age in twins.•Maternal air pollution (PM10 and NO2) exposure was estimated over various time windows during pregnancy in 4,760 twins.•Air pollution is associated with small for gestational age and birth weight in moderate to late preterm born twins.•The within-pair difference in birth weight increases with higher air pollution exposure during the last month of pregnancy.</description><subject>Adult</subject><subject>Air Pollutants - analysis</subject><subject>Air pollution</subject><subject>Air Pollution - analysis</subject><subject>Belgium - epidemiology</subject><subject>Birth Weight</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Male</subject><subject>Maternal Exposure</subject><subject>Nitrogen Dioxide - analysis</subject><subject>Particulate matter</subject><subject>Particulate Matter - analysis</subject><subject>Pregnancy</subject><subject>Small for gestational age</subject><subject>Twin</subject><subject>Twins</subject><subject>Young Adult</subject><issn>0013-9351</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkUFvFCEUx4nR2G3rNzCGo5cZHwMzO1xMTFO1SZMeas-EZR6VDQMjMKv99rLZ6lFPvH_4PV54P0LeMmgZsOHDvsVwSJjbrqYWeAswvCAbBnJoQPb8JdkAMN5I3rMzcp7zvkbWc3hNzrotAGed2JD9_ay9pzYm-oi56OJi0J7qR6Q6TBR_LTGvCWmJdNGpOLN6XeqdS3SJ3q9HnrpAy3ekqJN_aryztQwHl2KYMRQaLS0_XciX5JXVPuOb5_OCPHy-_nb1tbm9-3Jz9em2MUKw0nDBhx0aY3Z60iODyTI7Ddb0W91NAxjRaWSj3PWj7voBetNhzVthteVCAvIL8v707pLij7V-Ss0uG_ReB4xrVmyEcehlP8r_o1sJYuiEPKLihJoUc05o1ZLcrNOTYqCOQtRenYSooxAFXFUhte3d84R1N-P0t-mPgQp8PAFYV3JwmFQ2DoPBySU0RU3R_XvCb_bZoAk</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Bijnens, Esmée M.</creator><creator>Derom, Catherine</creator><creator>Gielen, Marij</creator><creator>Winckelmans, Ellen</creator><creator>Fierens, Frans</creator><creator>Vlietinck, Robert</creator><creator>Zeegers, Maurice P.</creator><creator>Nawrot, Tim S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7ST</scope><scope>7TV</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>201607</creationdate><title>Small for gestational age and exposure to particulate air pollution in the early-life environment of twins</title><author>Bijnens, Esmée M. ; Derom, Catherine ; Gielen, Marij ; Winckelmans, Ellen ; Fierens, Frans ; Vlietinck, Robert ; Zeegers, Maurice P. ; Nawrot, Tim S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-3436becccbada810df1fd6fc57a2d60c42ae189b58a25605c2ee1874faf3490e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Air Pollutants - analysis</topic><topic>Air pollution</topic><topic>Air Pollution - analysis</topic><topic>Belgium - epidemiology</topic><topic>Birth Weight</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Male</topic><topic>Maternal Exposure</topic><topic>Nitrogen Dioxide - analysis</topic><topic>Particulate matter</topic><topic>Particulate Matter - analysis</topic><topic>Pregnancy</topic><topic>Small for gestational age</topic><topic>Twin</topic><topic>Twins</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bijnens, Esmée M.</creatorcontrib><creatorcontrib>Derom, Catherine</creatorcontrib><creatorcontrib>Gielen, Marij</creatorcontrib><creatorcontrib>Winckelmans, Ellen</creatorcontrib><creatorcontrib>Fierens, Frans</creatorcontrib><creatorcontrib>Vlietinck, Robert</creatorcontrib><creatorcontrib>Zeegers, Maurice P.</creatorcontrib><creatorcontrib>Nawrot, Tim S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bijnens, Esmée M.</au><au>Derom, Catherine</au><au>Gielen, Marij</au><au>Winckelmans, Ellen</au><au>Fierens, Frans</au><au>Vlietinck, Robert</au><au>Zeegers, Maurice P.</au><au>Nawrot, Tim S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small for gestational age and exposure to particulate air pollution in the early-life environment of twins</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>2016-07</date><risdate>2016</risdate><volume>148</volume><spage>39</spage><epage>45</epage><pages>39-45</pages><issn>0013-9351</issn><eissn>1096-0953</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Several studies in singletons have shown that maternal exposure to ambient air pollutants is associated with restricted fetal growth. About half of twins have low birth weight compared with six percent in singletons. So far, no studies have investigated maternal air pollution exposure in association with birth weight and small for gestational age in twins.
We examined 4760 twins of the East Flanders Prospective Twins Survey (2002–2013), to study the association between in utero exposure to air pollution with birth weight and small for gestational age. Maternal particulate air pollution (PM10) and nitric dioxide (NO2) exposure was estimated using a spatial temporal interpolation method over various time windows during pregnancy.
In the total group of twins, we observed that higher PM10 and NO2 exposure during the third trimester was significantly associated with a lower birth weight and higher risk of small for gestational age. However, the association was driven by moderate to late preterm twins (32–36 weeks of gestation). In these twins born between 32 and 36 weeks of gestation, birth weight decreased by 40.2g (95% CI: −69.0 to −11.3; p=0.006) and by 27.3g (95% CI: −52.9 to −1.7; p=0.04) in association for each 10µg/m³ increment in PM10 and NO2 concentration during the third trimester. The corresponding odds ratio for small for gestational age were 1.68 (95% CI: 1.27–2.33; p=0.0003) and 1.51 (95% CI: 1.18–1.95; p=0.001) for PM10 or NO2, respectively. No associations between air pollution and birth weight or small for gestational age were observed among term born twins. Finally, in all twins, we found that for each 10µg/m³ increase in PM10 during the last month of pregnancy the within-pair birth weight difference increased by 19.6g (95% CI: 3.7–35.4; p=0.02).
Assuming causality, an achievement of a 10µg/m³ decrease of particulate air pollution may account for a reduction by 40% in small for gestational age, in twins born moderate to late preterm.
•Exposure to air pollution is associated with restricted fetal growth in singletons.•No studies have investigated the association of air pollution with birth weight and small for gestational age in twins.•Maternal air pollution (PM10 and NO2) exposure was estimated over various time windows during pregnancy in 4,760 twins.•Air pollution is associated with small for gestational age and birth weight in moderate to late preterm born twins.•The within-pair difference in birth weight increases with higher air pollution exposure during the last month of pregnancy.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>27003124</pmid><doi>10.1016/j.envres.2016.03.006</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Air Pollutants - analysis Air pollution Air Pollution - analysis Belgium - epidemiology Birth Weight Female Gestational Age Humans Male Maternal Exposure Nitrogen Dioxide - analysis Particulate matter Particulate Matter - analysis Pregnancy Small for gestational age Twin Twins Young Adult |
| title | Small for gestational age and exposure to particulate air pollution in the early-life environment of twins |
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