Single cell genotyping of exome sequencing-identified mutations to characterize the clonal composition and evolution of inv(16) AML in a CBL mutated clonal hematopoiesis

Highlights • Genetics provide insights into evolution of inv(16) AML in CBL mutated hematopoiesis. • Single cell genotyping verifies clonal architecture derived from bulk genetic analyses. • Mutated PTPRT may contribute to inv(16) AML at later stage by enhancing proliferation.

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Bibliographic Details
Published in:Leukemia research 2016-08, Vol.47, p.41-46
Main Authors: Niemöller, Christoph, Renz, Nathalie, Bleul, Sabine, Blagitko-Dorfs, Nadja, Greil, Christine, Yoshida, Kenichi, Pfeifer, Dietmar, Follo, Marie, Duyster, Justus, Claus, Rainer, Ogawa, Seishi, Lübbert, Michael, Becker, Heiko
Format: Article
Language:English
Subjects:
AML
CBL
Cell Proliferation
Clonal hematopoiesis
Clone Cells - pathology
Exome - genetics
Genotype
Guanine Nucleotide Exchange Factors - genetics
Hematology, Oncology and Palliative Medicine
Hematopoiesis
inv
Leukemia, Myeloid, Acute - etiology
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - pathology
Mutation
Oncogene Proteins, Fusion
PTPRT
Receptor-Like Protein Tyrosine Phosphatases, Class 2 - genetics
Single cell
Single-Cell Analysis - methods
Transcription Factors - genetics
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Description
Summary:Highlights • Genetics provide insights into evolution of inv(16) AML in CBL mutated hematopoiesis. • Single cell genotyping verifies clonal architecture derived from bulk genetic analyses. • Mutated PTPRT may contribute to inv(16) AML at later stage by enhancing proliferation.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2016.05.008