Novel t(1;3)(q21,p21) translocation in a basal cell adenocarcinoma of the parotid gland: potential association with tumorigenesis

Summary We report a rare translocation involving chromosomes 1q23 and 3p21 regions in a Basaloid Salivary Carcinoma. Our case together with a previously reported instance of translocation involving chromosome 1q 21–24 region define a specific chromosomal segment that may house a gene associated with...

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Bibliographic Details
Published in:Human pathology 2016-08, Vol.54, p.189-192
Main Authors: Saluja, Karan, MD, Rao, Pulivarthi H., PhD, Myers, Jeffery N., MD, PhD, El-Naggar, Adel K., MD, PhD
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adenoma
Basal cell
Biopsy
Chromosomes
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 3
Cytogenetics
Female
Genetic Predisposition to Disease
Humans
Hybridization
Karyotyping
Lymphatic system
Metastasis
Middle Aged
Parotid Neoplasms - genetics
Parotid Neoplasms - pathology
Parotid Neoplasms - surgery
Pathology
Phenotype
Salivary tumor
Translocation
Translocation, Genetic
Tumorigenesis
Tumors
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Summary:Summary We report a rare translocation involving chromosomes 1q23 and 3p21 regions in a Basaloid Salivary Carcinoma. Our case together with a previously reported instance of translocation involving chromosome 1q 21–24 region define a specific chromosomal segment that may house a gene associated with the development of a subset of basaloid salivary tumors.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2016.03.019