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Concurrent cytomegalovirus glomerulitis and BK polyomavirus-associated nephropathy in a kidney allograft biopsy
A 58‐year‐old renal transplant recipient underwent biopsy 11 weeks post transplantation for increasing creatinine. The biopsy showed cytomegalovirus (CMV) glomerulitis together with BK polyomavirus (BKPyV)‐associated nephropathy (PVAN). Treatment with intravenous ganciclovir and overall reduction in...
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| Published in: | Transplant infectious disease 2016-04, Vol.18 (2), p.247-250 |
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| cites | cdi_FETCH-LOGICAL-c4268-18a788ea9465b0f9f7a3a672ea3969a32b582b50cecfeb06cf8982f22dfa32f03 |
| container_end_page | 250 |
| container_issue | 2 |
| container_start_page | 247 |
| container_title | Transplant infectious disease |
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| creator | Chikeka, I.O. Paulk, A. Haririan, A. Papadimitriou, J.C. Drachenberg, C.B. |
| description | A 58‐year‐old renal transplant recipient underwent biopsy 11 weeks post transplantation for increasing creatinine. The biopsy showed cytomegalovirus (CMV) glomerulitis together with BK polyomavirus (BKPyV)‐associated nephropathy (PVAN). Treatment with intravenous ganciclovir and overall reduction in maintenance immunosuppression resulted in prompt resolution of the CMV glomerulitis, but with persistence of PVAN in a follow‐up biopsy 4 weeks later. Stable creatinine and BKPyV viral clearance were observed at the last clinical visit 15 months post transplantation. This case exemplifies infectious glomerulitis, which requires differentiation from the more common glomerulitis caused by antibody‐mediated allograft rejection. The morphological similarities and differences between BKPyV and CMV infections are discussed. |
| doi_str_mv | 10.1111/tid.12498 |
| format | article |
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The biopsy showed cytomegalovirus (CMV) glomerulitis together with BK polyomavirus (BKPyV)‐associated nephropathy (PVAN). Treatment with intravenous ganciclovir and overall reduction in maintenance immunosuppression resulted in prompt resolution of the CMV glomerulitis, but with persistence of PVAN in a follow‐up biopsy 4 weeks later. Stable creatinine and BKPyV viral clearance were observed at the last clinical visit 15 months post transplantation. This case exemplifies infectious glomerulitis, which requires differentiation from the more common glomerulitis caused by antibody‐mediated allograft rejection. The morphological similarities and differences between BKPyV and CMV infections are discussed.</description><identifier>ISSN: 1398-2273</identifier><identifier>EISSN: 1399-3062</identifier><identifier>DOI: 10.1111/tid.12498</identifier><identifier>PMID: 26782090</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Biopsy ; BK polyomavirus-associated nephropathy ; BK Virus - isolation & purification ; CMV ; Cytomegalovirus ; Cytomegalovirus - isolation & purification ; Cytomegalovirus Infections - diagnosis ; Cytomegalovirus Infections - pathology ; Cytomegalovirus Infections - virology ; glomerulitis ; Graft Rejection ; Humans ; Immunocompromised Host ; Kidney - pathology ; Kidney - virology ; Kidney Glomerulus - pathology ; Kidney Glomerulus - virology ; Kidney Transplantation - adverse effects ; Male ; Middle Aged ; Polyomavirus Infections - pathology ; Polyomavirus Infections - virology ; Postoperative Complications ; renal biopsy ; SV40 stain ; Tissue Donors ; Transplants & implants ; Tumor Virus Infections - pathology ; Tumor Virus Infections - virology ; viremia</subject><ispartof>Transplant infectious disease, 2016-04, Vol.18 (2), p.247-250</ispartof><rights>2016 John Wiley & Sons A/S. 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Published by John Wiley & Sons Ltd.</rights><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4268-18a788ea9465b0f9f7a3a672ea3969a32b582b50cecfeb06cf8982f22dfa32f03</citedby><cites>FETCH-LOGICAL-c4268-18a788ea9465b0f9f7a3a672ea3969a32b582b50cecfeb06cf8982f22dfa32f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftid.12498$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftid.12498$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26782090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chikeka, I.O.</creatorcontrib><creatorcontrib>Paulk, A.</creatorcontrib><creatorcontrib>Haririan, A.</creatorcontrib><creatorcontrib>Papadimitriou, J.C.</creatorcontrib><creatorcontrib>Drachenberg, C.B.</creatorcontrib><title>Concurrent cytomegalovirus glomerulitis and BK polyomavirus-associated nephropathy in a kidney allograft biopsy</title><title>Transplant infectious disease</title><addtitle>Transpl Infect Dis</addtitle><description>A 58‐year‐old renal transplant recipient underwent biopsy 11 weeks post transplantation for increasing creatinine. The biopsy showed cytomegalovirus (CMV) glomerulitis together with BK polyomavirus (BKPyV)‐associated nephropathy (PVAN). Treatment with intravenous ganciclovir and overall reduction in maintenance immunosuppression resulted in prompt resolution of the CMV glomerulitis, but with persistence of PVAN in a follow‐up biopsy 4 weeks later. Stable creatinine and BKPyV viral clearance were observed at the last clinical visit 15 months post transplantation. This case exemplifies infectious glomerulitis, which requires differentiation from the more common glomerulitis caused by antibody‐mediated allograft rejection. The morphological similarities and differences between BKPyV and CMV infections are discussed.</description><subject>Biopsy</subject><subject>BK polyomavirus-associated nephropathy</subject><subject>BK Virus - isolation & purification</subject><subject>CMV</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - isolation & purification</subject><subject>Cytomegalovirus Infections - diagnosis</subject><subject>Cytomegalovirus Infections - pathology</subject><subject>Cytomegalovirus Infections - virology</subject><subject>glomerulitis</subject><subject>Graft Rejection</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Kidney - pathology</subject><subject>Kidney - virology</subject><subject>Kidney Glomerulus - pathology</subject><subject>Kidney Glomerulus - virology</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polyomavirus Infections - pathology</subject><subject>Polyomavirus Infections - virology</subject><subject>Postoperative Complications</subject><subject>renal biopsy</subject><subject>SV40 stain</subject><subject>Tissue Donors</subject><subject>Transplants & implants</subject><subject>Tumor Virus Infections - pathology</subject><subject>Tumor Virus Infections - virology</subject><subject>viremia</subject><issn>1398-2273</issn><issn>1399-3062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp10U1vFSEUBmBiNLZWF_4BQ-JGF9PyMTPAUq-2VhtdWOOSnJmBW1pmGIFR59-L97ZdmEhCgPCcN4SD0HNKjmkZJ9kNx5TVSj5Ah5QrVXHSsoe7vawYE_wAPUnpmhAqVK0eowPWCsmIIocobMLULzGaKeN-zWE0W_Dhp4tLwltfjnHxLruEYRrw2094Dn4NI-xABSmF3kE2A57MfBXDDPlqxW7CgG_cMJkVg_dhG8Fm3Lkwp_UpemTBJ_Psdj1C307fX24-VBdfzs43by6qvmatrKgEIaUBVbdNR6yyAji0ghngqlXAWdfIMklvems60vZWKsksY4Mtl5bwI_RqnzvH8GMxKevRpd54D5MJS9JUSNpw2ShZ6Mt_6HVY4lRet1OkEXXDi3q9V30MKUVj9RzdCHHVlOi_XdClC3rXhWJf3CYu3WiGe3n37QWc7MEv5836_yR9ef7uLrLaV7iUze_7Cog3uhVcNPr75zMtTgn7Kj4K3fA_oraiNg</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Chikeka, I.O.</creator><creator>Paulk, A.</creator><creator>Haririan, A.</creator><creator>Papadimitriou, J.C.</creator><creator>Drachenberg, C.B.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201604</creationdate><title>Concurrent cytomegalovirus glomerulitis and BK polyomavirus-associated nephropathy in a kidney allograft biopsy</title><author>Chikeka, I.O. ; Paulk, A. ; Haririan, A. ; Papadimitriou, J.C. ; Drachenberg, C.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4268-18a788ea9465b0f9f7a3a672ea3969a32b582b50cecfeb06cf8982f22dfa32f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biopsy</topic><topic>BK polyomavirus-associated nephropathy</topic><topic>BK Virus - isolation & purification</topic><topic>CMV</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus - isolation & purification</topic><topic>Cytomegalovirus Infections - diagnosis</topic><topic>Cytomegalovirus Infections - pathology</topic><topic>Cytomegalovirus Infections - virology</topic><topic>glomerulitis</topic><topic>Graft Rejection</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Kidney - pathology</topic><topic>Kidney - virology</topic><topic>Kidney Glomerulus - pathology</topic><topic>Kidney Glomerulus - virology</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polyomavirus Infections - pathology</topic><topic>Polyomavirus Infections - virology</topic><topic>Postoperative Complications</topic><topic>renal biopsy</topic><topic>SV40 stain</topic><topic>Tissue Donors</topic><topic>Transplants & implants</topic><topic>Tumor Virus Infections - pathology</topic><topic>Tumor Virus Infections - virology</topic><topic>viremia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chikeka, I.O.</creatorcontrib><creatorcontrib>Paulk, A.</creatorcontrib><creatorcontrib>Haririan, A.</creatorcontrib><creatorcontrib>Papadimitriou, J.C.</creatorcontrib><creatorcontrib>Drachenberg, C.B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chikeka, I.O.</au><au>Paulk, A.</au><au>Haririan, A.</au><au>Papadimitriou, J.C.</au><au>Drachenberg, C.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concurrent cytomegalovirus glomerulitis and BK polyomavirus-associated nephropathy in a kidney allograft biopsy</atitle><jtitle>Transplant infectious disease</jtitle><addtitle>Transpl Infect Dis</addtitle><date>2016-04</date><risdate>2016</risdate><volume>18</volume><issue>2</issue><spage>247</spage><epage>250</epage><pages>247-250</pages><issn>1398-2273</issn><eissn>1399-3062</eissn><notes>istex:855D5CB35A5F121ADE08D65EEAA6FBEEA8549007</notes><notes>ark:/67375/WNG-7F02S7J7-5</notes><notes>ArticleID:TID12498</notes><notes>ObjectType-Case Study-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-4</notes><notes>content type line 23</notes><notes>ObjectType-Report-1</notes><notes>ObjectType-Article-3</notes><abstract>A 58‐year‐old renal transplant recipient underwent biopsy 11 weeks post transplantation for increasing creatinine. The biopsy showed cytomegalovirus (CMV) glomerulitis together with BK polyomavirus (BKPyV)‐associated nephropathy (PVAN). Treatment with intravenous ganciclovir and overall reduction in maintenance immunosuppression resulted in prompt resolution of the CMV glomerulitis, but with persistence of PVAN in a follow‐up biopsy 4 weeks later. Stable creatinine and BKPyV viral clearance were observed at the last clinical visit 15 months post transplantation. This case exemplifies infectious glomerulitis, which requires differentiation from the more common glomerulitis caused by antibody‐mediated allograft rejection. The morphological similarities and differences between BKPyV and CMV infections are discussed.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>26782090</pmid><doi>10.1111/tid.12498</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Transplant infectious disease, 2016-04, Vol.18 (2), p.247-250 |
| issn | 1398-2273 1399-3062 |
| language | eng |
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| source | Wiley-Blackwell Journals |
| subjects | Biopsy BK polyomavirus-associated nephropathy BK Virus - isolation & purification CMV Cytomegalovirus Cytomegalovirus - isolation & purification Cytomegalovirus Infections - diagnosis Cytomegalovirus Infections - pathology Cytomegalovirus Infections - virology glomerulitis Graft Rejection Humans Immunocompromised Host Kidney - pathology Kidney - virology Kidney Glomerulus - pathology Kidney Glomerulus - virology Kidney Transplantation - adverse effects Male Middle Aged Polyomavirus Infections - pathology Polyomavirus Infections - virology Postoperative Complications renal biopsy SV40 stain Tissue Donors Transplants & implants Tumor Virus Infections - pathology Tumor Virus Infections - virology viremia |
| title | Concurrent cytomegalovirus glomerulitis and BK polyomavirus-associated nephropathy in a kidney allograft biopsy |
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