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Comparative Analysis of Midtrimester Amniotic Fluid Cytokine Levels to Predict Spontaneous Very Pre-term Birth in Patients with Cervical Insufficiency
Problem Few studies have investigated the roles of cytokines and chemokines in women with cervical insufficiency, and those that have done so evaluated only a limited number of cytokines in amniotic fluid. Method of study A retrospective cohort study enrolled 71 patients undergoing physical examinat...
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| Published in: | American journal of reproductive immunology (1989) 2016-02, Vol.75 (2), p.155-161 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4941-af115478d5f55919846df8494064bf621905141b1a31e0390d281701f37581a63 |
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| cites | cdi_FETCH-LOGICAL-c4941-af115478d5f55919846df8494064bf621905141b1a31e0390d281701f37581a63 |
| container_end_page | 161 |
| container_issue | 2 |
| container_start_page | 155 |
| container_title | American journal of reproductive immunology (1989) |
| container_volume | 75 |
| creator | Son, Ga-Hyun You, Young-Ah Kwon, Eun-Jin Lee, Keun-Young Kim, Young Ju |
| description | Problem
Few studies have investigated the roles of cytokines and chemokines in women with cervical insufficiency, and those that have done so evaluated only a limited number of cytokines in amniotic fluid.
Method of study
A retrospective cohort study enrolled 71 patients undergoing physical examination‐indicated cerclage to determine whether expanded amniotic fluid cytokine levels predict spontaneous very pre‐term birth (≤32 weeks of gestation) in patients with cervical insufficiency. Analysis of multiple cytokines and chemokines was performed with the multiplex immunoassay.
Results
Sixty‐seven amniotic fluid samples were available for analysis and assayed for 15 cytokines. Thirty‐eight (56.7%) patients delivered pre‐term. Of these, 26 (38.8%) were spontaneous very pre‐term births. Most cytokine levels were significantly increased in the amniotic fluid from the study group when compared with those from controls. The levels of interleukin‐1β (IL‐1β), IL‐ 6, IL‐ 7, IL‐15, IL‐17α, tumour necrosis factor‐α (TNF‐α), MIP‐1α, and MIP‐1β were higher in patients with a very pre‐term delivery than in those with a late pre‐term delivery. IL‐1β, IL‐6, IL‐7, IL‐17α, TNF‐α, and cervical dilation were independently associated with a very pre‐term birth.
Conclusion
Intra‐amniotic inflammation may contribute to cervical insufficiency, and the severity of inflammation is associated with a very pre‐term birth in women with cervical insufficiency. |
| doi_str_mv | 10.1111/aji.12451 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1776669093</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1760857303</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4941-af115478d5f55919846df8494064bf621905141b1a31e0390d281701f37581a63</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhSMEoqWw4AWQJTawSOub-C_LIaLtVAMMKtCl5Ukc4WkSD7YzbV6kz4tD2i6QkPDG1j3fPda9J0leAz6GeE7U1hxDRig8SQ6BYZxiUfCn8Y0JSznB4iB54f0W41jP-fPkIGNUFJTmh8ldabudciqYvUaLXrWjNx7ZBn0ydXCm0z5ohxZdb2wwFTptB1Ojcgz22vQarfRetx4Fi9ZO16YK6HJn-6B6bQePfmg3TkIaLTr0wbjwE5kereNnug8e3ZhYKLXbm0q1aNn7oWlMFbVqfJk8a1Tr9av7-yj5fvrxW3merr6cLcvFKq1IQSBVDQAlXNS0obSAQhBWNyJKmJFNwzIoMAUCG1A5aJwXuM4EcAxNzqkAxfKj5N3su3P21xCHlZ3xlW7beQQJnDPGClzk_4EyLCjP8YS-_Qvd2sHF5U4U5cCJoBP1fqYqZ713upG7uHDlRglYTrnKmKv8k2tk39w7DptO14_kQ5AROJmBG9Pq8d9OcnGxfLBM5w4TI7597FDuWjIe9yOvPp_Jq6-ZYJcX53Kd_wbssLqv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1757174853</pqid></control><display><type>article</type><title>Comparative Analysis of Midtrimester Amniotic Fluid Cytokine Levels to Predict Spontaneous Very Pre-term Birth in Patients with Cervical Insufficiency</title><source>Wiley Online Library</source><creator>Son, Ga-Hyun ; You, Young-Ah ; Kwon, Eun-Jin ; Lee, Keun-Young ; Kim, Young Ju</creator><creatorcontrib>Son, Ga-Hyun ; You, Young-Ah ; Kwon, Eun-Jin ; Lee, Keun-Young ; Kim, Young Ju</creatorcontrib><description>Problem
Few studies have investigated the roles of cytokines and chemokines in women with cervical insufficiency, and those that have done so evaluated only a limited number of cytokines in amniotic fluid.
Method of study
A retrospective cohort study enrolled 71 patients undergoing physical examination‐indicated cerclage to determine whether expanded amniotic fluid cytokine levels predict spontaneous very pre‐term birth (≤32 weeks of gestation) in patients with cervical insufficiency. Analysis of multiple cytokines and chemokines was performed with the multiplex immunoassay.
Results
Sixty‐seven amniotic fluid samples were available for analysis and assayed for 15 cytokines. Thirty‐eight (56.7%) patients delivered pre‐term. Of these, 26 (38.8%) were spontaneous very pre‐term births. Most cytokine levels were significantly increased in the amniotic fluid from the study group when compared with those from controls. The levels of interleukin‐1β (IL‐1β), IL‐ 6, IL‐ 7, IL‐15, IL‐17α, tumour necrosis factor‐α (TNF‐α), MIP‐1α, and MIP‐1β were higher in patients with a very pre‐term delivery than in those with a late pre‐term delivery. IL‐1β, IL‐6, IL‐7, IL‐17α, TNF‐α, and cervical dilation were independently associated with a very pre‐term birth.
Conclusion
Intra‐amniotic inflammation may contribute to cervical insufficiency, and the severity of inflammation is associated with a very pre‐term birth in women with cervical insufficiency.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/aji.12451</identifier><identifier>PMID: 26589553</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adult ; Amniotic fluid ; Amniotic Fluid - immunology ; cervical insufficiency ; Chemokines ; cytokine ; Cytokines ; Cytokines - immunology ; Female ; Humans ; Pregnancy ; Pregnancy Trimester, Second - immunology ; Premature Birth - immunology ; Prenatal development ; Retrospective Studies ; Tumor necrosis factor-TNF ; Uterine Cervical Incompetence - immunology</subject><ispartof>American journal of reproductive immunology (1989), 2016-02, Vol.75 (2), p.155-161</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4941-af115478d5f55919846df8494064bf621905141b1a31e0390d281701f37581a63</citedby><cites>FETCH-LOGICAL-c4941-af115478d5f55919846df8494064bf621905141b1a31e0390d281701f37581a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faji.12451$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faji.12451$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26589553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Son, Ga-Hyun</creatorcontrib><creatorcontrib>You, Young-Ah</creatorcontrib><creatorcontrib>Kwon, Eun-Jin</creatorcontrib><creatorcontrib>Lee, Keun-Young</creatorcontrib><creatorcontrib>Kim, Young Ju</creatorcontrib><title>Comparative Analysis of Midtrimester Amniotic Fluid Cytokine Levels to Predict Spontaneous Very Pre-term Birth in Patients with Cervical Insufficiency</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>Problem
Few studies have investigated the roles of cytokines and chemokines in women with cervical insufficiency, and those that have done so evaluated only a limited number of cytokines in amniotic fluid.
Method of study
A retrospective cohort study enrolled 71 patients undergoing physical examination‐indicated cerclage to determine whether expanded amniotic fluid cytokine levels predict spontaneous very pre‐term birth (≤32 weeks of gestation) in patients with cervical insufficiency. Analysis of multiple cytokines and chemokines was performed with the multiplex immunoassay.
Results
Sixty‐seven amniotic fluid samples were available for analysis and assayed for 15 cytokines. Thirty‐eight (56.7%) patients delivered pre‐term. Of these, 26 (38.8%) were spontaneous very pre‐term births. Most cytokine levels were significantly increased in the amniotic fluid from the study group when compared with those from controls. The levels of interleukin‐1β (IL‐1β), IL‐ 6, IL‐ 7, IL‐15, IL‐17α, tumour necrosis factor‐α (TNF‐α), MIP‐1α, and MIP‐1β were higher in patients with a very pre‐term delivery than in those with a late pre‐term delivery. IL‐1β, IL‐6, IL‐7, IL‐17α, TNF‐α, and cervical dilation were independently associated with a very pre‐term birth.
Conclusion
Intra‐amniotic inflammation may contribute to cervical insufficiency, and the severity of inflammation is associated with a very pre‐term birth in women with cervical insufficiency.</description><subject>Adult</subject><subject>Amniotic fluid</subject><subject>Amniotic Fluid - immunology</subject><subject>cervical insufficiency</subject><subject>Chemokines</subject><subject>cytokine</subject><subject>Cytokines</subject><subject>Cytokines - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second - immunology</subject><subject>Premature Birth - immunology</subject><subject>Prenatal development</subject><subject>Retrospective Studies</subject><subject>Tumor necrosis factor-TNF</subject><subject>Uterine Cervical Incompetence - immunology</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAUhSMEoqWw4AWQJTawSOub-C_LIaLtVAMMKtCl5Ukc4WkSD7YzbV6kz4tD2i6QkPDG1j3fPda9J0leAz6GeE7U1hxDRig8SQ6BYZxiUfCn8Y0JSznB4iB54f0W41jP-fPkIGNUFJTmh8ldabudciqYvUaLXrWjNx7ZBn0ydXCm0z5ohxZdb2wwFTptB1Ojcgz22vQarfRetx4Fi9ZO16YK6HJn-6B6bQePfmg3TkIaLTr0wbjwE5kereNnug8e3ZhYKLXbm0q1aNn7oWlMFbVqfJk8a1Tr9av7-yj5fvrxW3merr6cLcvFKq1IQSBVDQAlXNS0obSAQhBWNyJKmJFNwzIoMAUCG1A5aJwXuM4EcAxNzqkAxfKj5N3su3P21xCHlZ3xlW7beQQJnDPGClzk_4EyLCjP8YS-_Qvd2sHF5U4U5cCJoBP1fqYqZ713upG7uHDlRglYTrnKmKv8k2tk39w7DptO14_kQ5AROJmBG9Pq8d9OcnGxfLBM5w4TI7597FDuWjIe9yOvPp_Jq6-ZYJcX53Kd_wbssLqv</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Son, Ga-Hyun</creator><creator>You, Young-Ah</creator><creator>Kwon, Eun-Jin</creator><creator>Lee, Keun-Young</creator><creator>Kim, Young Ju</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201602</creationdate><title>Comparative Analysis of Midtrimester Amniotic Fluid Cytokine Levels to Predict Spontaneous Very Pre-term Birth in Patients with Cervical Insufficiency</title><author>Son, Ga-Hyun ; You, Young-Ah ; Kwon, Eun-Jin ; Lee, Keun-Young ; Kim, Young Ju</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4941-af115478d5f55919846df8494064bf621905141b1a31e0390d281701f37581a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Amniotic fluid</topic><topic>Amniotic Fluid - immunology</topic><topic>cervical insufficiency</topic><topic>Chemokines</topic><topic>cytokine</topic><topic>Cytokines</topic><topic>Cytokines - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second - immunology</topic><topic>Premature Birth - immunology</topic><topic>Prenatal development</topic><topic>Retrospective Studies</topic><topic>Tumor necrosis factor-TNF</topic><topic>Uterine Cervical Incompetence - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Son, Ga-Hyun</creatorcontrib><creatorcontrib>You, Young-Ah</creatorcontrib><creatorcontrib>Kwon, Eun-Jin</creatorcontrib><creatorcontrib>Lee, Keun-Young</creatorcontrib><creatorcontrib>Kim, Young Ju</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Son, Ga-Hyun</au><au>You, Young-Ah</au><au>Kwon, Eun-Jin</au><au>Lee, Keun-Young</au><au>Kim, Young Ju</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Analysis of Midtrimester Amniotic Fluid Cytokine Levels to Predict Spontaneous Very Pre-term Birth in Patients with Cervical Insufficiency</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2016-02</date><risdate>2016</risdate><volume>75</volume><issue>2</issue><spage>155</spage><epage>161</epage><pages>155-161</pages><issn>1046-7408</issn><eissn>1600-0897</eissn><notes>istex:94EDD0F4CE42381C11AD8EC92EFCE0D8062AB7D8</notes><notes>ark:/67375/WNG-WQ286SJH-P</notes><notes>Ministry of Health & Welfare, Republic of Korea - No. HI14C0306</notes><notes>ArticleID:AJI12451</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Problem
Few studies have investigated the roles of cytokines and chemokines in women with cervical insufficiency, and those that have done so evaluated only a limited number of cytokines in amniotic fluid.
Method of study
A retrospective cohort study enrolled 71 patients undergoing physical examination‐indicated cerclage to determine whether expanded amniotic fluid cytokine levels predict spontaneous very pre‐term birth (≤32 weeks of gestation) in patients with cervical insufficiency. Analysis of multiple cytokines and chemokines was performed with the multiplex immunoassay.
Results
Sixty‐seven amniotic fluid samples were available for analysis and assayed for 15 cytokines. Thirty‐eight (56.7%) patients delivered pre‐term. Of these, 26 (38.8%) were spontaneous very pre‐term births. Most cytokine levels were significantly increased in the amniotic fluid from the study group when compared with those from controls. The levels of interleukin‐1β (IL‐1β), IL‐ 6, IL‐ 7, IL‐15, IL‐17α, tumour necrosis factor‐α (TNF‐α), MIP‐1α, and MIP‐1β were higher in patients with a very pre‐term delivery than in those with a late pre‐term delivery. IL‐1β, IL‐6, IL‐7, IL‐17α, TNF‐α, and cervical dilation were independently associated with a very pre‐term birth.
Conclusion
Intra‐amniotic inflammation may contribute to cervical insufficiency, and the severity of inflammation is associated with a very pre‐term birth in women with cervical insufficiency.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>26589553</pmid><doi>10.1111/aji.12451</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1046-7408 |
| ispartof | American journal of reproductive immunology (1989), 2016-02, Vol.75 (2), p.155-161 |
| issn | 1046-7408 1600-0897 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1776669093 |
| source | Wiley Online Library |
| subjects | Adult Amniotic fluid Amniotic Fluid - immunology cervical insufficiency Chemokines cytokine Cytokines Cytokines - immunology Female Humans Pregnancy Pregnancy Trimester, Second - immunology Premature Birth - immunology Prenatal development Retrospective Studies Tumor necrosis factor-TNF Uterine Cervical Incompetence - immunology |
| title | Comparative Analysis of Midtrimester Amniotic Fluid Cytokine Levels to Predict Spontaneous Very Pre-term Birth in Patients with Cervical Insufficiency |
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