Dissemination of the mcr-1 colistin resistance gene

Since our first report on plasmid-mediated colistin resistance gene mcr-1,1 strains previously collected in seven countries (Denmark, the Netherlands, Laos, Nigeria, Thailand, France, and the UK) have been found to carry mcr-1.2-6 Furthermore, the sequences in GenBank show that mcr-1 might also be c...

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Bibliographic Details
Published in:The Lancet infectious diseases 2016-03, Vol.16 (3), p.292-293
Main Authors: Zhi, Chanping, Lv, Luchao, Yu, Lin-Feng, Doi, Yohei, Liu, Jian-Hua
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Colistin - therapeutic use
Enterobacteriaceae - drug effects
Enterobacteriaceae Infections - drug therapy
Enterobacteriaceae Infections - immunology
Genes
Humans
Infectious Disease
Infectious diseases
Plasmids
Plasmids - immunology
Polymyxins - therapeutic use
Swine Diseases - drug therapy
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Summary:Since our first report on plasmid-mediated colistin resistance gene mcr-1,1 strains previously collected in seven countries (Denmark, the Netherlands, Laos, Nigeria, Thailand, France, and the UK) have been found to carry mcr-1.2-6 Furthermore, the sequences in GenBank show that mcr-1 might also be circulating in Portugal and Malaysia. Interestingly, the sequence of pHNSHP45-2 is also almost identical to the partial sequence of a salmonalla Sal25 plasmid (GenBank accession number LFCC01000022) carrying mcr-1 from a food sample in Portugal. [...]IncHI2 plasmids carrying mcr-1 seem to have spread among different Enterobacteriaceae species and continents, which further suggests that food plays an important part in the spread of mcr-1 worldwide.
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(16)00063-3