New Developments in Chemical Engineering for the Production of Drug Substances

The pharmaceutical industry is moving towards a profitability gap between increasing costs and decreasing prices. Finally, management has understood that mergers and acquisitions, high throughput screening, and biotechnology alone will not save the companies' earnings. Therefore, classical appr...

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Bibliographic Details
Published in:Engineering in life sciences 2004-01, Vol.4 (1), p.15-24
Main Authors: Behr, A., Brehme, V.A., Ewers, Ch.L.J., Grön, H., Kimmel, T., Küppers, S., Symietz, I.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Chemical engineering
Fundamental and applied biological sciences. Psychology
Miniplants
Plant optimization
Process control
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Summary:The pharmaceutical industry is moving towards a profitability gap between increasing costs and decreasing prices. Finally, management has understood that mergers and acquisitions, high throughput screening, and biotechnology alone will not save the companies' earnings. Therefore, classical approaches like the optimization of production technologies for drug substances, that might help to increase profitability, are receiving increasing attention. This paper shows how the combination of innovative components will guide the way to very efficient and cost‐effective production. The first component is the design and manufacturing of production facilities. The second component is a process streamlining of the production process. The key technologies discussed here are process control and miniplant technology. For these technologies a brief outlook on future trends is given. The pharmaceutical industry is moving towards a profitability gap between increasing costs and decreasing prices. Classical approaches like the optimization of production technologies for drug substances, that might help to increase profitability, are receiving increasing attention. This paper shows how the combination of innovative components will guide the way to very efficient and cost‐effective production.
ISSN:1618-0240
1618-2863
DOI:10.1002/elsc.200406127