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Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation
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Published in: | Molecular and Cellular Biology 2000-09, Vol.20 (18), p.6945-6957 |
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creator | Shan, Xiaochuan Czar, Michael J. Bunnell, Stephen C. Liu, Pinghu Liu, Yusen Schwartzberg, Pamela L. Wange, Ronald L. |
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doi_str_mv | 10.1128/MCB.20.18.6945-6957.2000 |
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</description><identifier>ISSN: 0270-7306</identifier><identifier>ISSN: 1098-5549</identifier><identifier>EISSN: 1098-5549</identifier><identifier>DOI: 10.1128/MCB.20.18.6945-6957.2000</identifier><identifier>PMID: 10958690</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Animals ; Antigens, Polyomavirus Transforming - genetics ; Base Sequence ; Binding Sites ; Biological Transport ; Blood Proteins - metabolism ; CD3 antigen ; CD3 Complex - metabolism ; CD3 Complex - pharmacology ; Cell Growth and Development ; Cell Membrane - metabolism ; Cytosol ; Enzyme Activation ; Exons ; Humans ; Isoenzymes - metabolism ; Itk protein ; Jurkat Cells ; Molecular Sequence Data ; Mutagenesis ; phosphatidylinositides ; Phosphatidylinositol 3-Kinases - metabolism ; Phosphatidylinositol Phosphates - metabolism ; Phospholipase C gamma ; Phosphoproteins - metabolism ; Phosphoric Monoester Hydrolases - biosynthesis ; Phosphoric Monoester Hydrolases - genetics ; Phosphoric Monoester Hydrolases - physiology ; Phosphorylation ; Protein Serine-Threonine Kinases - metabolism ; Protein Tyrosine Phosphatases - metabolism ; Protein-Tyrosine Kinases - metabolism ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins c-akt ; PTEN Phosphohydrolase ; Rabbits ; T-Lymphocytes - drug effects ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; Transcription, Genetic ; Tumor Cells, Cultured ; Tumor Suppressor Proteins ; Type C Phospholipases - metabolism</subject><ispartof>Molecular and Cellular Biology, 2000-09, Vol.20 (18), p.6945-6957</ispartof><rights>Copyright © 2000 American Society for Microbiology 2000</rights><rights>2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-1c937e96c10dd4a77d0c4dcb77ffe08a5ea8e41146593b0727ce9dde1d4cc1cb3</citedby><cites>FETCH-LOGICAL-c587t-1c937e96c10dd4a77d0c4dcb77ffe08a5ea8e41146593b0727ce9dde1d4cc1cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC88770/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC88770/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10958690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shan, Xiaochuan</creatorcontrib><creatorcontrib>Czar, Michael J.</creatorcontrib><creatorcontrib>Bunnell, Stephen C.</creatorcontrib><creatorcontrib>Liu, Pinghu</creatorcontrib><creatorcontrib>Liu, Yusen</creatorcontrib><creatorcontrib>Schwartzberg, Pamela L.</creatorcontrib><creatorcontrib>Wange, Ronald L.</creatorcontrib><title>Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation</title><title>Molecular and Cellular Biology</title><addtitle>Mol Cell Biol</addtitle><description>Article Usage Stats
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</description><subject>Animals</subject><subject>Antigens, Polyomavirus Transforming - genetics</subject><subject>Base Sequence</subject><subject>Binding Sites</subject><subject>Biological Transport</subject><subject>Blood Proteins - metabolism</subject><subject>CD3 antigen</subject><subject>CD3 Complex - metabolism</subject><subject>CD3 Complex - pharmacology</subject><subject>Cell Growth and Development</subject><subject>Cell Membrane - metabolism</subject><subject>Cytosol</subject><subject>Enzyme Activation</subject><subject>Exons</subject><subject>Humans</subject><subject>Isoenzymes - metabolism</subject><subject>Itk protein</subject><subject>Jurkat Cells</subject><subject>Molecular Sequence Data</subject><subject>Mutagenesis</subject><subject>phosphatidylinositides</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Phosphatidylinositol Phosphates - metabolism</subject><subject>Phospholipase C gamma</subject><subject>Phosphoproteins - metabolism</subject><subject>Phosphoric Monoester Hydrolases - biosynthesis</subject><subject>Phosphoric Monoester Hydrolases - genetics</subject><subject>Phosphoric Monoester Hydrolases - physiology</subject><subject>Phosphorylation</subject><subject>Protein Serine-Threonine Kinases - metabolism</subject><subject>Protein Tyrosine Phosphatases - metabolism</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-akt</subject><subject>PTEN Phosphohydrolase</subject><subject>Rabbits</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>Transcription, Genetic</subject><subject>Tumor Cells, Cultured</subject><subject>Tumor Suppressor Proteins</subject><subject>Type C Phospholipases - metabolism</subject><issn>0270-7306</issn><issn>1098-5549</issn><issn>1098-5549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAUhS0EokPhFZDFgl0GO392JDaQFlo0hUoMa8uxbzqmiT3YTqvhIXhmHFKhYcfqXsvfOde-ByFMyZrSnL-5at-v89Tzdd2UVVY3FUtnQh6hFSUNz6qqbB6jFckZyVhB6hP0LITvCagbUjxFJwmqeOpX6NcZ9EYZsOqAXY-vt-efsbH40-RvZcRb3MIwBNzKKUAqzoZo4hTNHeCNU3IwP2U0zs7Sy3iLo8NxB_h6kGGU-ArGzksLWFqNLw578B7CPnkkuYUQZrw9K_DXaMZp-GP0HD3p5RDgxUM9Rd8-nG_bi2zz5eNl-26TqYqzmFHVFAyaWlGidSkZ00SVWnWM9T0QLiuQHEpKy7pqio6wnClotAaqS6Wo6opT9Hbx3U_dCFqBjV4OYu_NKP1BOGnEvzfW7MSNuxOcM0aS_PWD3LsfE4QoRhNUWlX6rZuCoKzmtCyrBPIFVN6F4KH_O4ISMUcpUpQiTz0Xc5RijlLMUSbpy-MnHgmX7BLQLoCxvfOjvHd-0CLKw-B8n_auTBDFf4x5tbjszM3u3ngQKTsxqu4IL34DY96_cw</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Shan, Xiaochuan</creator><creator>Czar, Michael J.</creator><creator>Bunnell, Stephen C.</creator><creator>Liu, Pinghu</creator><creator>Liu, Yusen</creator><creator>Schwartzberg, Pamela L.</creator><creator>Wange, Ronald L.</creator><general>American Society for Microbiology</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20000901</creationdate><title>Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation</title><author>Shan, Xiaochuan ; 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Mailing address: Gerontology Research Center, MSC-12, 5600 Nathan Shock Dr., Baltimore, MD 21224-6825. Phone: (410) 558-8054. Fax: (410) 558-8107. E-mail: wanger@grc.nia.nih.gov.</notes><abstract>Article Usage Stats
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</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>10958690</pmid><doi>10.1128/MCB.20.18.6945-6957.2000</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Antigens, Polyomavirus Transforming - genetics Base Sequence Binding Sites Biological Transport Blood Proteins - metabolism CD3 antigen CD3 Complex - metabolism CD3 Complex - pharmacology Cell Growth and Development Cell Membrane - metabolism Cytosol Enzyme Activation Exons Humans Isoenzymes - metabolism Itk protein Jurkat Cells Molecular Sequence Data Mutagenesis phosphatidylinositides Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol Phosphates - metabolism Phospholipase C gamma Phosphoproteins - metabolism Phosphoric Monoester Hydrolases - biosynthesis Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - physiology Phosphorylation Protein Serine-Threonine Kinases - metabolism Protein Tyrosine Phosphatases - metabolism Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt PTEN Phosphohydrolase Rabbits T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism Transcription, Genetic Tumor Cells, Cultured Tumor Suppressor Proteins Type C Phospholipases - metabolism |
title | Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation |
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