A probabilistic atlas of the cerebellar white matter

Imaging of the cerebellar cortex, deep cerebellar nuclei and their connectivity are gaining attraction, due to the important role the cerebellum plays in cognition and motor control. Atlases of the cerebellar cortex and nuclei are used to locate regions of interest in clinical and neuroscience studi...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2016-01, Vol.124 (Pt A), p.724-732
Main Authors: van Baarsen, K.M., Kleinnijenhuis, M., Jbabdi, S., Sotiropoulos, S.N., Grotenhuis, J.A., van Cappellen van Walsum, A.M.
Format: Article
Language:English
Subjects:
Adult
Atlases as Topic
Attention deficit hyperactivity disorder
Cerebellar Cortex - anatomy & histology
Cerebellar Cortex - physiology
Cerebellar Nuclei - anatomy & histology
Cerebellar Nuclei - physiology
Cerebellum
Cerebellum - anatomy & histology
Connectome
Diffusion Tensor Imaging
Female
Functional Laterality - physiology
Healthy Volunteers
Human Connectome Project
Humans
Hyperactivity
Imaging, Three-Dimensional
Male
Models, Neurological
Models, Statistical
Multiple sclerosis
Parcellation map
Probabilistic tractography
Studies
White matter
White Matter - anatomy & histology
Young Adult
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Summary:Imaging of the cerebellar cortex, deep cerebellar nuclei and their connectivity are gaining attraction, due to the important role the cerebellum plays in cognition and motor control. Atlases of the cerebellar cortex and nuclei are used to locate regions of interest in clinical and neuroscience studies. However, the white matter that connects these relay stations is of at least similar functional importance. Damage to these cerebellar white matter tracts may lead to serious language, cognitive and emotional disturbances, although the pathophysiological mechanism behind it is still debated. Differences in white matter integrity between patients and controls might shed light on structure–function correlations. A probabilistic parcellation atlas of the cerebellar white matter would help these studies by facilitating automatic segmentation of the cerebellar peduncles, the localization of lesions and the comparison of white matter integrity between patients and controls. In this work a digital three-dimensional probabilistic atlas of the cerebellar white matter is presented, based on high quality 3T, 1.25mm resolution diffusion MRI data from 90 subjects participating in the Human Connectome Project. The white matter tracts were estimated using probabilistic tractography. Results over 90 subjects were symmetrical and trajectories of superior, middle and inferior cerebellar peduncles resembled the anatomy as known from anatomical studies. This atlas will contribute to a better understanding of cerebellar white matter architecture. It may eventually aid in defining structure–function correlations in patients with cerebellar disorders. •Human Connectome data were used to create a new cerebellar white matter atlas.•Probabilistic tractography and high data quality allowed tracking reproducibly across subjects.•Tracts of superior, middle and inferior peduncles strongly resembled known anatomy.•The decussation of the superior cerebellar peduncles is clearly demonstrated.•The atlas will facilitate white matter segmentation in structure–function correlation studies.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2015.09.014