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Cyclic AMP and protein kinase A rhythmicity in the mammalian suprachiasmatic nuclei
The levels of cyclic AMP and protein kinase A, as well as the activity of this enzyme, were measured in the hamster suprachiasmatic nuclei at different time points throughout the daily or circadian cycle. Significant diurnal variations for levels of AMPc and the catalytic subunit of protein kinase A...
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| Published in: | Brain research 2000-03, Vol.858 (1), p.33-39 |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c390t-b669fcab0bb9b3a0556b3b85d949ee00aba675606363c5dc12886367d90c56183 |
| container_end_page | 39 |
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| container_start_page | 33 |
| container_title | Brain research |
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| creator | Ferreyra, Gabriela A Golombek, Diego A |
| description | The levels of cyclic AMP and protein kinase A, as well as the activity of this enzyme, were measured in the hamster suprachiasmatic nuclei at different time points throughout the daily or circadian cycle. Significant diurnal variations for levels of AMPc and the catalytic subunit of protein kinase A and the activity of this enzyme were found. All of these parameters tended to increase throughout the nocturnal phase, reaching higher values at the end of the night and the beginning of the day and minimal values around the time of lights off. This rhythmicity appears to be under exogenous control, since constant darkness abolished fluctuations throughout the circadian cycle. In vitro incubation in the presence of melatonin during the day significantly decreased cyclic AMP levels and basal protein kinase A activity in the SCN, while neither neuropeptide Y nor light pulses affected these parameters. These results suggest a significant diurnal regulation of the cyclic AMP-dependent system in the hamster circadian clock. |
| doi_str_mv | 10.1016/S0006-8993(99)02390-2 |
| format | article |
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Significant diurnal variations for levels of AMPc and the catalytic subunit of protein kinase A and the activity of this enzyme were found. All of these parameters tended to increase throughout the nocturnal phase, reaching higher values at the end of the night and the beginning of the day and minimal values around the time of lights off. This rhythmicity appears to be under exogenous control, since constant darkness abolished fluctuations throughout the circadian cycle. In vitro incubation in the presence of melatonin during the day significantly decreased cyclic AMP levels and basal protein kinase A activity in the SCN, while neither neuropeptide Y nor light pulses affected these parameters. 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Significant diurnal variations for levels of AMPc and the catalytic subunit of protein kinase A and the activity of this enzyme were found. All of these parameters tended to increase throughout the nocturnal phase, reaching higher values at the end of the night and the beginning of the day and minimal values around the time of lights off. This rhythmicity appears to be under exogenous control, since constant darkness abolished fluctuations throughout the circadian cycle. In vitro incubation in the presence of melatonin during the day significantly decreased cyclic AMP levels and basal protein kinase A activity in the SCN, while neither neuropeptide Y nor light pulses affected these parameters. These results suggest a significant diurnal regulation of the cyclic AMP-dependent system in the hamster circadian clock.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Clocks - drug effects</subject><subject>Biological Clocks - radiation effects</subject><subject>Blotting, Western</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - physiology</subject><subject>Cricetinae</subject><subject>Cyclic AMP</subject><subject>Cyclic AMP - metabolism</subject><subject>Cyclic AMP-Dependent Protein Kinases - metabolism</subject><subject>Darkness</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>In Vitro Techniques</subject><subject>Light</subject><subject>Male</subject><subject>Melatonin</subject><subject>Melatonin - metabolism</subject><subject>Melatonin - pharmacology</subject><subject>Mesocricetus</subject><subject>Mesocricetus auratus</subject><subject>Neuropeptide Y - metabolism</subject><subject>Neuropeptide Y - pharmacology</subject><subject>Periodicity</subject><subject>Photic Stimulation</subject><subject>Protein kinase A</subject><subject>Suprachiasmatic nuclei</subject><subject>Suprachiasmatic Nucleus - enzymology</subject><subject>Vertebrates: endocrinology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkMFuEzEQhq0KRNPCIxT5gBAcFsbrrHd9qqKIAlJRKxXO1nh2orjd3aT2LlLeHqeJKDdO47G-mfn1CXGh4JMCZT7fAYApGmv1B2s_QqktFOWJmKmmLgtTzuGFmP1FTsVZSve51Rl7JU4V1ACV1TNxt9xRF0guftxKHFq5jZuRwyAfwoCJ5ULG9W5c94HCuJP5f1yz7LHvsQs4yDRtI9I6YOpxzFuGiToOr8XLFXaJ3xzrufh19eXn8ltxffP1-3JxXVBOMRbeGLsi9OC99RqhqozXvqlaO7fMAOjR1JUBo42mqiVVNk1-160Fqoxq9Ll4f9ibQz9OnEbXh0TcdTjwZkpO1XM7r02ZweoAUtykFHnltjH0GHdOgdvbdE823V6Vs9Y92XT7ubfHA5Pvuf1n6qAvA--OACbCbhVxoJCeudJCo2zGLg8YZxu_A0eXKPBA3IbINLp2E_6T5A_oHpBr</recordid><startdate>20000306</startdate><enddate>20000306</enddate><creator>Ferreyra, Gabriela A</creator><creator>Golombek, Diego A</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20000306</creationdate><title>Cyclic AMP and protein kinase A rhythmicity in the mammalian suprachiasmatic nuclei</title><author>Ferreyra, Gabriela A ; Golombek, Diego A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-b669fcab0bb9b3a0556b3b85d949ee00aba675606363c5dc12886367d90c56183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Clocks - drug effects</topic><topic>Biological Clocks - radiation effects</topic><topic>Blotting, Western</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - physiology</topic><topic>Cricetinae</topic><topic>Cyclic AMP</topic><topic>Cyclic AMP - metabolism</topic><topic>Cyclic AMP-Dependent Protein Kinases - metabolism</topic><topic>Darkness</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus. Hypophysis. Epiphysis. 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Significant diurnal variations for levels of AMPc and the catalytic subunit of protein kinase A and the activity of this enzyme were found. All of these parameters tended to increase throughout the nocturnal phase, reaching higher values at the end of the night and the beginning of the day and minimal values around the time of lights off. This rhythmicity appears to be under exogenous control, since constant darkness abolished fluctuations throughout the circadian cycle. In vitro incubation in the presence of melatonin during the day significantly decreased cyclic AMP levels and basal protein kinase A activity in the SCN, while neither neuropeptide Y nor light pulses affected these parameters. These results suggest a significant diurnal regulation of the cyclic AMP-dependent system in the hamster circadian clock.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>10700593</pmid><doi>10.1016/S0006-8993(99)02390-2</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| source | ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Biological Clocks - drug effects Biological Clocks - radiation effects Blotting, Western Circadian rhythm Circadian Rhythm - physiology Cricetinae Cyclic AMP Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Darkness Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis In Vitro Techniques Light Male Melatonin Melatonin - metabolism Melatonin - pharmacology Mesocricetus Mesocricetus auratus Neuropeptide Y - metabolism Neuropeptide Y - pharmacology Periodicity Photic Stimulation Protein kinase A Suprachiasmatic nuclei Suprachiasmatic Nucleus - enzymology Vertebrates: endocrinology |
| title | Cyclic AMP and protein kinase A rhythmicity in the mammalian suprachiasmatic nuclei |
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