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The role of super(18)F-fluorodeoxyglucose positron emission tomography/computed tomography in the primary staging of rectal cancer
Background: In this study we aimed to determine the need for super(18)F-flourodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in the preoperative staging of rectal carcinoma in our large patient group according to level and location of tumor. Method: Totally, 97 patients...
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| Published in: | World journal of surgical oncology 2014-01, Vol.12 (1), p.26-26 |
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| container_title | World journal of surgical oncology |
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| creator | Ozis, Salih Erpulat Soydal, Cigdem Akyol, Cihangir Can, Nalan Kucuk, Ozlem Nuriye Yagci, Cemil Erkek, Ayhan Bulent Kuzu, Mehmet Ayhan |
| description | Background: In this study we aimed to determine the need for super(18)F-flourodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in the preoperative staging of rectal carcinoma in our large patient group according to level and location of tumor. Method: Totally, 97 patients diagnosed with primary rectal adenocarcinoma between May 2009 and July 2011 were included in the study. Preoperative staging was performed by evaluating contrast-enhanced thoracic, abdominal, and pelvic computed tomographies. After staging by conventional methods, all patients underwent an super(18)F-FDG PET/CT. In all cases, the relationship between super(18)F-FDG uptake and gender, tumor height at the anal canal, localization in the rectal wall, plasma carcinoembryonic antigen levels, histopathological tumor type, and tumor stage were examined. Results: While the ceCT was normal in 4 (4%) patients, it was positive for the rectum in 93 (95%), pelvic lymph nodes in 22 (22%), and distant metastases in 14 (14%) (liver (8), lung (8), bone (2), distant lymph nodes (6), and uterus (1)). Using computed tomography, disease stages were determined as stage 0, 1, 2, 3, and 4 in 4, 8, 48, 23, and 14 patients, respectively; super(18)F-FDG PET/CT was normal in two (2%) patients. The mean SUVmax of FDG-positive rectal tumors was calculated as 17.31 plus or minus 9.37. Additionally, 18F-FDG uptake was seen in pelvic lymph nodes in 15 (15%) patients and in distant organs in 24 (24%) patients (liver (9), lung (12), bone (5), distant lymph nodes (11), uterus (1), and sigmoid colon (1)). According to an super(18)F-FDG PET/CT, 2, 7, 47, 20, and 21 patients were staged as stage 0, 1, 2, 3, and 4, respectively. In 14 patients (14.4%), the stage of the disease was either changed, and there was a need to make adjustments to the patient's treatment strategy (n = 10), or the type of operation was changed (n = 4). In seven patients (0.7%), findings from super(18)F-FDG PET/CT images did not require any changes of the treatment plan. Conclusion: F-FDG PET/CT provides new findings in addition to conventional techniques in the staging of primary rectal cancer. These findings could change the patients' treatment strategies. |
| doi_str_mv | 10.1186/1477-7819-12-26 |
| format | article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_1746896251</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1746896251</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_17468962513</originalsourceid><addsrcrecordid>eNqVjU1PwzAQRC0EEuXjzNXHcnCbTdokPSMqfkDvleVuUiMna3ZtiVz55QQJoV45zdPTaEapJyhWAG29hk3TmKaFnYHSlPWVWvyZ6wu-VXci70VRVtW2Wqivwxk1U0BNnZYckZfQPu9NFzIxnZA-pz5kR4I6kvjENGocvIifIdFAPdt4ntaOhpgTni6c9nNjXo_sB8uTlmR7P_Y_R4wu2aCdHR3yg7rpbBB8_M17tdy_Hl7eTGT6yCjpOP85DMGOSFmO0GzqdleXW6j-Uf0GeBhcvg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1746896251</pqid></control><display><type>article</type><title>The role of super(18)F-fluorodeoxyglucose positron emission tomography/computed tomography in the primary staging of rectal cancer</title><source>Publicly Available Content Database</source><source>PubMed</source><creator>Ozis, Salih Erpulat ; Soydal, Cigdem ; Akyol, Cihangir ; Can, Nalan ; Kucuk, Ozlem Nuriye ; Yagci, Cemil ; Erkek, Ayhan Bulent ; Kuzu, Mehmet Ayhan</creator><creatorcontrib>Ozis, Salih Erpulat ; Soydal, Cigdem ; Akyol, Cihangir ; Can, Nalan ; Kucuk, Ozlem Nuriye ; Yagci, Cemil ; Erkek, Ayhan Bulent ; Kuzu, Mehmet Ayhan</creatorcontrib><description>Background: In this study we aimed to determine the need for super(18)F-flourodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in the preoperative staging of rectal carcinoma in our large patient group according to level and location of tumor. Method: Totally, 97 patients diagnosed with primary rectal adenocarcinoma between May 2009 and July 2011 were included in the study. Preoperative staging was performed by evaluating contrast-enhanced thoracic, abdominal, and pelvic computed tomographies. After staging by conventional methods, all patients underwent an super(18)F-FDG PET/CT. In all cases, the relationship between super(18)F-FDG uptake and gender, tumor height at the anal canal, localization in the rectal wall, plasma carcinoembryonic antigen levels, histopathological tumor type, and tumor stage were examined. Results: While the ceCT was normal in 4 (4%) patients, it was positive for the rectum in 93 (95%), pelvic lymph nodes in 22 (22%), and distant metastases in 14 (14%) (liver (8), lung (8), bone (2), distant lymph nodes (6), and uterus (1)). Using computed tomography, disease stages were determined as stage 0, 1, 2, 3, and 4 in 4, 8, 48, 23, and 14 patients, respectively; super(18)F-FDG PET/CT was normal in two (2%) patients. The mean SUVmax of FDG-positive rectal tumors was calculated as 17.31 plus or minus 9.37. Additionally, 18F-FDG uptake was seen in pelvic lymph nodes in 15 (15%) patients and in distant organs in 24 (24%) patients (liver (9), lung (12), bone (5), distant lymph nodes (11), uterus (1), and sigmoid colon (1)). According to an super(18)F-FDG PET/CT, 2, 7, 47, 20, and 21 patients were staged as stage 0, 1, 2, 3, and 4, respectively. In 14 patients (14.4%), the stage of the disease was either changed, and there was a need to make adjustments to the patient's treatment strategy (n = 10), or the type of operation was changed (n = 4). In seven patients (0.7%), findings from super(18)F-FDG PET/CT images did not require any changes of the treatment plan. Conclusion: F-FDG PET/CT provides new findings in addition to conventional techniques in the staging of primary rectal cancer. These findings could change the patients' treatment strategies.</description><identifier>ISSN: 1477-7819</identifier><identifier>EISSN: 1477-7819</identifier><identifier>DOI: 10.1186/1477-7819-12-26</identifier><language>eng</language><ispartof>World journal of surgical oncology, 2014-01, Vol.12 (1), p.26-26</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958,37048</link.rule.ids></links><search><creatorcontrib>Ozis, Salih Erpulat</creatorcontrib><creatorcontrib>Soydal, Cigdem</creatorcontrib><creatorcontrib>Akyol, Cihangir</creatorcontrib><creatorcontrib>Can, Nalan</creatorcontrib><creatorcontrib>Kucuk, Ozlem Nuriye</creatorcontrib><creatorcontrib>Yagci, Cemil</creatorcontrib><creatorcontrib>Erkek, Ayhan Bulent</creatorcontrib><creatorcontrib>Kuzu, Mehmet Ayhan</creatorcontrib><title>The role of super(18)F-fluorodeoxyglucose positron emission tomography/computed tomography in the primary staging of rectal cancer</title><title>World journal of surgical oncology</title><description>Background: In this study we aimed to determine the need for super(18)F-flourodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in the preoperative staging of rectal carcinoma in our large patient group according to level and location of tumor. Method: Totally, 97 patients diagnosed with primary rectal adenocarcinoma between May 2009 and July 2011 were included in the study. Preoperative staging was performed by evaluating contrast-enhanced thoracic, abdominal, and pelvic computed tomographies. After staging by conventional methods, all patients underwent an super(18)F-FDG PET/CT. In all cases, the relationship between super(18)F-FDG uptake and gender, tumor height at the anal canal, localization in the rectal wall, plasma carcinoembryonic antigen levels, histopathological tumor type, and tumor stage were examined. Results: While the ceCT was normal in 4 (4%) patients, it was positive for the rectum in 93 (95%), pelvic lymph nodes in 22 (22%), and distant metastases in 14 (14%) (liver (8), lung (8), bone (2), distant lymph nodes (6), and uterus (1)). Using computed tomography, disease stages were determined as stage 0, 1, 2, 3, and 4 in 4, 8, 48, 23, and 14 patients, respectively; super(18)F-FDG PET/CT was normal in two (2%) patients. The mean SUVmax of FDG-positive rectal tumors was calculated as 17.31 plus or minus 9.37. Additionally, 18F-FDG uptake was seen in pelvic lymph nodes in 15 (15%) patients and in distant organs in 24 (24%) patients (liver (9), lung (12), bone (5), distant lymph nodes (11), uterus (1), and sigmoid colon (1)). According to an super(18)F-FDG PET/CT, 2, 7, 47, 20, and 21 patients were staged as stage 0, 1, 2, 3, and 4, respectively. In 14 patients (14.4%), the stage of the disease was either changed, and there was a need to make adjustments to the patient's treatment strategy (n = 10), or the type of operation was changed (n = 4). In seven patients (0.7%), findings from super(18)F-FDG PET/CT images did not require any changes of the treatment plan. Conclusion: F-FDG PET/CT provides new findings in addition to conventional techniques in the staging of primary rectal cancer. These findings could change the patients' treatment strategies.</description><issn>1477-7819</issn><issn>1477-7819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqVjU1PwzAQRC0EEuXjzNXHcnCbTdokPSMqfkDvleVuUiMna3ZtiVz55QQJoV45zdPTaEapJyhWAG29hk3TmKaFnYHSlPWVWvyZ6wu-VXci70VRVtW2Wqivwxk1U0BNnZYckZfQPu9NFzIxnZA-pz5kR4I6kvjENGocvIifIdFAPdt4ntaOhpgTni6c9nNjXo_sB8uTlmR7P_Y_R4wu2aCdHR3yg7rpbBB8_M17tdy_Hl7eTGT6yCjpOP85DMGOSFmO0GzqdleXW6j-Uf0GeBhcvg</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Ozis, Salih Erpulat</creator><creator>Soydal, Cigdem</creator><creator>Akyol, Cihangir</creator><creator>Can, Nalan</creator><creator>Kucuk, Ozlem Nuriye</creator><creator>Yagci, Cemil</creator><creator>Erkek, Ayhan Bulent</creator><creator>Kuzu, Mehmet Ayhan</creator><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20140101</creationdate><title>The role of super(18)F-fluorodeoxyglucose positron emission tomography/computed tomography in the primary staging of rectal cancer</title><author>Ozis, Salih Erpulat ; Soydal, Cigdem ; Akyol, Cihangir ; Can, Nalan ; Kucuk, Ozlem Nuriye ; Yagci, Cemil ; Erkek, Ayhan Bulent ; Kuzu, Mehmet Ayhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_17468962513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozis, Salih Erpulat</creatorcontrib><creatorcontrib>Soydal, Cigdem</creatorcontrib><creatorcontrib>Akyol, Cihangir</creatorcontrib><creatorcontrib>Can, Nalan</creatorcontrib><creatorcontrib>Kucuk, Ozlem Nuriye</creatorcontrib><creatorcontrib>Yagci, Cemil</creatorcontrib><creatorcontrib>Erkek, Ayhan Bulent</creatorcontrib><creatorcontrib>Kuzu, Mehmet Ayhan</creatorcontrib><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>World journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozis, Salih Erpulat</au><au>Soydal, Cigdem</au><au>Akyol, Cihangir</au><au>Can, Nalan</au><au>Kucuk, Ozlem Nuriye</au><au>Yagci, Cemil</au><au>Erkek, Ayhan Bulent</au><au>Kuzu, Mehmet Ayhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of super(18)F-fluorodeoxyglucose positron emission tomography/computed tomography in the primary staging of rectal cancer</atitle><jtitle>World journal of surgical oncology</jtitle><date>2014-01-01</date><risdate>2014</risdate><volume>12</volume><issue>1</issue><spage>26</spage><epage>26</epage><pages>26-26</pages><issn>1477-7819</issn><eissn>1477-7819</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>content type line 23</notes><notes>ObjectType-Feature-2</notes><abstract>Background: In this study we aimed to determine the need for super(18)F-flourodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in the preoperative staging of rectal carcinoma in our large patient group according to level and location of tumor. Method: Totally, 97 patients diagnosed with primary rectal adenocarcinoma between May 2009 and July 2011 were included in the study. Preoperative staging was performed by evaluating contrast-enhanced thoracic, abdominal, and pelvic computed tomographies. After staging by conventional methods, all patients underwent an super(18)F-FDG PET/CT. In all cases, the relationship between super(18)F-FDG uptake and gender, tumor height at the anal canal, localization in the rectal wall, plasma carcinoembryonic antigen levels, histopathological tumor type, and tumor stage were examined. Results: While the ceCT was normal in 4 (4%) patients, it was positive for the rectum in 93 (95%), pelvic lymph nodes in 22 (22%), and distant metastases in 14 (14%) (liver (8), lung (8), bone (2), distant lymph nodes (6), and uterus (1)). Using computed tomography, disease stages were determined as stage 0, 1, 2, 3, and 4 in 4, 8, 48, 23, and 14 patients, respectively; super(18)F-FDG PET/CT was normal in two (2%) patients. The mean SUVmax of FDG-positive rectal tumors was calculated as 17.31 plus or minus 9.37. Additionally, 18F-FDG uptake was seen in pelvic lymph nodes in 15 (15%) patients and in distant organs in 24 (24%) patients (liver (9), lung (12), bone (5), distant lymph nodes (11), uterus (1), and sigmoid colon (1)). According to an super(18)F-FDG PET/CT, 2, 7, 47, 20, and 21 patients were staged as stage 0, 1, 2, 3, and 4, respectively. In 14 patients (14.4%), the stage of the disease was either changed, and there was a need to make adjustments to the patient's treatment strategy (n = 10), or the type of operation was changed (n = 4). In seven patients (0.7%), findings from super(18)F-FDG PET/CT images did not require any changes of the treatment plan. Conclusion: F-FDG PET/CT provides new findings in addition to conventional techniques in the staging of primary rectal cancer. These findings could change the patients' treatment strategies.</abstract><doi>10.1186/1477-7819-12-26</doi></addata></record> |
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| title | The role of super(18)F-fluorodeoxyglucose positron emission tomography/computed tomography in the primary staging of rectal cancer |
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