Loading…
An Oscillatory Hierarchy Controlling Neuronal Excitability and Stimulus Processing in the Auditory Cortex
1 Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, New York; 2 Institute for Psychology, Hungarian Academy of Sciences, Budapest, Hungary; 3 Computational Sciences Division, National Aeronautics and Space Administration Ames Research Center, Moffett Field, Califo...
Saved in:
| Published in: | Journal of neurophysiology 2005-09, Vol.94 (3), p.1904-1911 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c547t-2fbcad04335277e7548b6e2e5abe98b5c08a3f7ee464f9628282b5dc9990c7193 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c547t-2fbcad04335277e7548b6e2e5abe98b5c08a3f7ee464f9628282b5dc9990c7193 |
| container_end_page | 1911 |
| container_issue | 3 |
| container_start_page | 1904 |
| container_title | Journal of neurophysiology |
| container_volume | 94 |
| creator | Lakatos, Peter Shah, Ankoor S Knuth, Kevin H Ulbert, Istvan Karmos, George Schroeder, Charles E |
| description | 1 Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, New York; 2 Institute for Psychology, Hungarian Academy of Sciences, Budapest, Hungary; 3 Computational Sciences Division, National Aeronautics and Space Administration Ames Research Center, Moffett Field, California; and 4 Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York
Submitted 11 March 2005;
accepted in final form 6 May 2005
EEG oscillations are hypothesized to reflect cyclical variations in the neuronal excitability, with particular frequency bands reflecting differing spatial scales of brain operation. However, despite decades of clinical and scientific investigation, there is no unifying theory of EEG organization, and the role of ongoing activity in sensory processing remains controversial. This study analyzed laminar profiles of synaptic activity [current source density CSD] and multiunit activity (MUA), both spontaneous and stimulus-driven, in primary auditory cortex of awake macaque monkeys. Our results reveal that the EEG is hierarchically organized; delta (14 Hz) phase modulates theta (410 Hz) amplitude, and theta phase modulates gamma (3050 Hz) amplitude. This oscillatory hierarchy controls baseline excitability and thus stimulus-related responses in a neuronal ensemble. We propose that the hierarchical organization of ambient oscillatory activity allows auditory cortex to structure its temporal activity pattern so as to optimize the processing of rhythmic inputs.
Address for reprint requests and other correspondence: C. E. Schroeder, Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Inst., Orangeburg, NY 10962 (E-mail: schrod{at}nki.rfmh.org ) |
| doi_str_mv | 10.1152/jn.00263.2005 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17402100</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17402100</sourcerecordid><originalsourceid>FETCH-LOGICAL-c547t-2fbcad04335277e7548b6e2e5abe98b5c08a3f7ee464f9628282b5dc9990c7193</originalsourceid><addsrcrecordid>eNqFkUGP0zAQhS0EYkvhyBX5BKeUsR3HybGqdlmkFYvEcrYcx2lcuXGxHW3z73G3FXtCqzmMNO-bJ808hD4SWBHC6dfduAKgFVtRAP4KLfKMFoQ39Wu0yAItGAhxhd7FuAMAwYG-RVdZByIqWCC7HvF91NY5lXyY8a01QQU9zHjjxxS8c3bc4h9mCn5UDl8ftU2qtc6mGauxw7-S3U9uivhn8NrEeKLtiNNg8Hrq7JPnxodkju_Rm165aD5c-hL9vrl-2NwWd_ffvm_Wd4XmpUgF7VutOigZ41QII3hZt5WhhqvWNHXLNdSK9cKYsir7pqJ1rpZ3umka0II0bIk-n30Pwf-ZTExyb6M2-cDR-CnKqi5rAZy9CBJRAiUAGSzOoA4-xmB6eQh2r8IsCchTCHI3yqcQ5CmEzH-6GE_t3nTP9OXrGfhyBga7HR5tMPIwzNF657fzyaspJZOkyU9YIvZ_8mZy7sEcU175tyEPXc_-ArMeo7E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17402100</pqid></control><display><type>article</type><title>An Oscillatory Hierarchy Controlling Neuronal Excitability and Stimulus Processing in the Auditory Cortex</title><source>American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list)</source><source>American Physiological Society Free</source><creator>Lakatos, Peter ; Shah, Ankoor S ; Knuth, Kevin H ; Ulbert, Istvan ; Karmos, George ; Schroeder, Charles E</creator><creatorcontrib>Lakatos, Peter ; Shah, Ankoor S ; Knuth, Kevin H ; Ulbert, Istvan ; Karmos, George ; Schroeder, Charles E</creatorcontrib><description>1 Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, New York; 2 Institute for Psychology, Hungarian Academy of Sciences, Budapest, Hungary; 3 Computational Sciences Division, National Aeronautics and Space Administration Ames Research Center, Moffett Field, California; and 4 Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York
Submitted 11 March 2005;
accepted in final form 6 May 2005
EEG oscillations are hypothesized to reflect cyclical variations in the neuronal excitability, with particular frequency bands reflecting differing spatial scales of brain operation. However, despite decades of clinical and scientific investigation, there is no unifying theory of EEG organization, and the role of ongoing activity in sensory processing remains controversial. This study analyzed laminar profiles of synaptic activity [current source density CSD] and multiunit activity (MUA), both spontaneous and stimulus-driven, in primary auditory cortex of awake macaque monkeys. Our results reveal that the EEG is hierarchically organized; delta (14 Hz) phase modulates theta (410 Hz) amplitude, and theta phase modulates gamma (3050 Hz) amplitude. This oscillatory hierarchy controls baseline excitability and thus stimulus-related responses in a neuronal ensemble. We propose that the hierarchical organization of ambient oscillatory activity allows auditory cortex to structure its temporal activity pattern so as to optimize the processing of rhythmic inputs.
Address for reprint requests and other correspondence: C. E. Schroeder, Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Inst., Orangeburg, NY 10962 (E-mail: schrod{at}nki.rfmh.org )</description><identifier>ISSN: 0022-3077</identifier><identifier>EISSN: 1522-1598</identifier><identifier>DOI: 10.1152/jn.00263.2005</identifier><identifier>PMID: 15901760</identifier><language>eng</language><publisher>United States: Am Phys Soc</publisher><subject>Acoustic Stimulation - methods ; Animals ; Auditory Cortex - cytology ; Auditory Cortex - physiology ; Auditory Perception - physiology ; Brain Mapping ; Cortical Synchronization ; Evoked Potentials, Auditory - physiology ; Macaca ; Macaca mulatta ; Male ; Neurons - physiology ; Spectrum Analysis ; Time Factors</subject><ispartof>Journal of neurophysiology, 2005-09, Vol.94 (3), p.1904-1911</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-2fbcad04335277e7548b6e2e5abe98b5c08a3f7ee464f9628282b5dc9990c7193</citedby><cites>FETCH-LOGICAL-c547t-2fbcad04335277e7548b6e2e5abe98b5c08a3f7ee464f9628282b5dc9990c7193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15901760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lakatos, Peter</creatorcontrib><creatorcontrib>Shah, Ankoor S</creatorcontrib><creatorcontrib>Knuth, Kevin H</creatorcontrib><creatorcontrib>Ulbert, Istvan</creatorcontrib><creatorcontrib>Karmos, George</creatorcontrib><creatorcontrib>Schroeder, Charles E</creatorcontrib><title>An Oscillatory Hierarchy Controlling Neuronal Excitability and Stimulus Processing in the Auditory Cortex</title><title>Journal of neurophysiology</title><addtitle>J Neurophysiol</addtitle><description>1 Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, New York; 2 Institute for Psychology, Hungarian Academy of Sciences, Budapest, Hungary; 3 Computational Sciences Division, National Aeronautics and Space Administration Ames Research Center, Moffett Field, California; and 4 Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York
Submitted 11 March 2005;
accepted in final form 6 May 2005
EEG oscillations are hypothesized to reflect cyclical variations in the neuronal excitability, with particular frequency bands reflecting differing spatial scales of brain operation. However, despite decades of clinical and scientific investigation, there is no unifying theory of EEG organization, and the role of ongoing activity in sensory processing remains controversial. This study analyzed laminar profiles of synaptic activity [current source density CSD] and multiunit activity (MUA), both spontaneous and stimulus-driven, in primary auditory cortex of awake macaque monkeys. Our results reveal that the EEG is hierarchically organized; delta (14 Hz) phase modulates theta (410 Hz) amplitude, and theta phase modulates gamma (3050 Hz) amplitude. This oscillatory hierarchy controls baseline excitability and thus stimulus-related responses in a neuronal ensemble. We propose that the hierarchical organization of ambient oscillatory activity allows auditory cortex to structure its temporal activity pattern so as to optimize the processing of rhythmic inputs.
Address for reprint requests and other correspondence: C. E. Schroeder, Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Inst., Orangeburg, NY 10962 (E-mail: schrod{at}nki.rfmh.org )</description><subject>Acoustic Stimulation - methods</subject><subject>Animals</subject><subject>Auditory Cortex - cytology</subject><subject>Auditory Cortex - physiology</subject><subject>Auditory Perception - physiology</subject><subject>Brain Mapping</subject><subject>Cortical Synchronization</subject><subject>Evoked Potentials, Auditory - physiology</subject><subject>Macaca</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Neurons - physiology</subject><subject>Spectrum Analysis</subject><subject>Time Factors</subject><issn>0022-3077</issn><issn>1522-1598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkUGP0zAQhS0EYkvhyBX5BKeUsR3HybGqdlmkFYvEcrYcx2lcuXGxHW3z73G3FXtCqzmMNO-bJ808hD4SWBHC6dfduAKgFVtRAP4KLfKMFoQ39Wu0yAItGAhxhd7FuAMAwYG-RVdZByIqWCC7HvF91NY5lXyY8a01QQU9zHjjxxS8c3bc4h9mCn5UDl8ftU2qtc6mGauxw7-S3U9uivhn8NrEeKLtiNNg8Hrq7JPnxodkju_Rm165aD5c-hL9vrl-2NwWd_ffvm_Wd4XmpUgF7VutOigZ41QII3hZt5WhhqvWNHXLNdSK9cKYsir7pqJ1rpZ3umka0II0bIk-n30Pwf-ZTExyb6M2-cDR-CnKqi5rAZy9CBJRAiUAGSzOoA4-xmB6eQh2r8IsCchTCHI3yqcQ5CmEzH-6GE_t3nTP9OXrGfhyBga7HR5tMPIwzNF657fzyaspJZOkyU9YIvZ_8mZy7sEcU175tyEPXc_-ArMeo7E</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Lakatos, Peter</creator><creator>Shah, Ankoor S</creator><creator>Knuth, Kevin H</creator><creator>Ulbert, Istvan</creator><creator>Karmos, George</creator><creator>Schroeder, Charles E</creator><general>Am Phys Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>An Oscillatory Hierarchy Controlling Neuronal Excitability and Stimulus Processing in the Auditory Cortex</title><author>Lakatos, Peter ; Shah, Ankoor S ; Knuth, Kevin H ; Ulbert, Istvan ; Karmos, George ; Schroeder, Charles E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-2fbcad04335277e7548b6e2e5abe98b5c08a3f7ee464f9628282b5dc9990c7193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acoustic Stimulation - methods</topic><topic>Animals</topic><topic>Auditory Cortex - cytology</topic><topic>Auditory Cortex - physiology</topic><topic>Auditory Perception - physiology</topic><topic>Brain Mapping</topic><topic>Cortical Synchronization</topic><topic>Evoked Potentials, Auditory - physiology</topic><topic>Macaca</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>Neurons - physiology</topic><topic>Spectrum Analysis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lakatos, Peter</creatorcontrib><creatorcontrib>Shah, Ankoor S</creatorcontrib><creatorcontrib>Knuth, Kevin H</creatorcontrib><creatorcontrib>Ulbert, Istvan</creatorcontrib><creatorcontrib>Karmos, George</creatorcontrib><creatorcontrib>Schroeder, Charles E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lakatos, Peter</au><au>Shah, Ankoor S</au><au>Knuth, Kevin H</au><au>Ulbert, Istvan</au><au>Karmos, George</au><au>Schroeder, Charles E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Oscillatory Hierarchy Controlling Neuronal Excitability and Stimulus Processing in the Auditory Cortex</atitle><jtitle>Journal of neurophysiology</jtitle><addtitle>J Neurophysiol</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>94</volume><issue>3</issue><spage>1904</spage><epage>1911</epage><pages>1904-1911</pages><issn>0022-3077</issn><eissn>1522-1598</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>1 Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, New York; 2 Institute for Psychology, Hungarian Academy of Sciences, Budapest, Hungary; 3 Computational Sciences Division, National Aeronautics and Space Administration Ames Research Center, Moffett Field, California; and 4 Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York
Submitted 11 March 2005;
accepted in final form 6 May 2005
EEG oscillations are hypothesized to reflect cyclical variations in the neuronal excitability, with particular frequency bands reflecting differing spatial scales of brain operation. However, despite decades of clinical and scientific investigation, there is no unifying theory of EEG organization, and the role of ongoing activity in sensory processing remains controversial. This study analyzed laminar profiles of synaptic activity [current source density CSD] and multiunit activity (MUA), both spontaneous and stimulus-driven, in primary auditory cortex of awake macaque monkeys. Our results reveal that the EEG is hierarchically organized; delta (14 Hz) phase modulates theta (410 Hz) amplitude, and theta phase modulates gamma (3050 Hz) amplitude. This oscillatory hierarchy controls baseline excitability and thus stimulus-related responses in a neuronal ensemble. We propose that the hierarchical organization of ambient oscillatory activity allows auditory cortex to structure its temporal activity pattern so as to optimize the processing of rhythmic inputs.
Address for reprint requests and other correspondence: C. E. Schroeder, Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Inst., Orangeburg, NY 10962 (E-mail: schrod{at}nki.rfmh.org )</abstract><cop>United States</cop><pub>Am Phys Soc</pub><pmid>15901760</pmid><doi>10.1152/jn.00263.2005</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3077 |
| ispartof | Journal of neurophysiology, 2005-09, Vol.94 (3), p.1904-1911 |
| issn | 0022-3077 1522-1598 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17402100 |
| source | American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list); American Physiological Society Free |
| subjects | Acoustic Stimulation - methods Animals Auditory Cortex - cytology Auditory Cortex - physiology Auditory Perception - physiology Brain Mapping Cortical Synchronization Evoked Potentials, Auditory - physiology Macaca Macaca mulatta Male Neurons - physiology Spectrum Analysis Time Factors |
| title | An Oscillatory Hierarchy Controlling Neuronal Excitability and Stimulus Processing in the Auditory Cortex |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T17%3A33%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20Oscillatory%20Hierarchy%20Controlling%20Neuronal%20Excitability%20and%20Stimulus%20Processing%20in%20the%20Auditory%20Cortex&rft.jtitle=Journal%20of%20neurophysiology&rft.au=Lakatos,%20Peter&rft.date=2005-09-01&rft.volume=94&rft.issue=3&rft.spage=1904&rft.epage=1911&rft.pages=1904-1911&rft.issn=0022-3077&rft.eissn=1522-1598&rft_id=info:doi/10.1152/jn.00263.2005&rft_dat=%3Cproquest_cross%3E17402100%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c547t-2fbcad04335277e7548b6e2e5abe98b5c08a3f7ee464f9628282b5dc9990c7193%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=17402100&rft_id=info:pmid/15901760&rfr_iscdi=true |