Loading…
Preserved mid-fusiform activation for visual words in a patient with a visual word recognition impairment
Previous functional imaging studies have highlighted the role of left ventral temporal cortex in processing written word forms. We explored activation and anatomical connectivity of this region in HE, a professional writer with alexia as a result of stroke affecting primarily white matter in the lef...
Saved in:
| Published in: | Neuropsychologia 2014-12, Vol.65 (Dec), p.113-124 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c488t-de276b9e74d166c4ceeb33fc2186ba14b562cffe23f7277cf793bf47f3e40aca3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c488t-de276b9e74d166c4ceeb33fc2186ba14b562cffe23f7277cf793bf47f3e40aca3 |
| container_end_page | 124 |
| container_issue | Dec |
| container_start_page | 113 |
| container_title | Neuropsychologia |
| container_volume | 65 |
| creator | Welcome, Suzanne E. Pasquarella, Adrian Chen, Xi Olson, David R. Joanisse, Marc F. |
| description | Previous functional imaging studies have highlighted the role of left ventral temporal cortex in processing written word forms. We explored activation and anatomical connectivity of this region in HE, a professional writer with alexia as a result of stroke affecting primarily white matter in the left inferior temporal lobe. We used a one-back visual recognition task and functional Magnetic Resonance Imaging to elicit automatic activation to various orthographic and non-orthographic stimuli. Surprisingly, HE showed cortical activation in the left mid-fusiform area during the presentation of words and word-like stimuli, suggesting that this region׳s role in processing visual words is intact despite his severely impaired reading. Diffusion Tensor Imaging data further suggest that HE shows an anatomical disconnection between the ventral temporal cortex and posterior middle temporal cortex. Together, these findings suggest that activation of word-specific regions of mid-fusiform gyrus is not sufficient to yield the conscious experience of reading in the absence of activity in downstream regions of the classical reading network.
•A patient with severe reading impairment shows cortical activation in mid-fusiform cortex.•DTI shows a structural disconnection between ventral and middle temporal cortex.•Preserved activation in ventral temporal cortex is not sufficient for typical word recognition. |
| doi_str_mv | 10.1016/j.neuropsychologia.2014.10.012 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1738472377</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0028393214003728</els_id><sourcerecordid>1660396183</sourcerecordid><originalsourceid>FETCH-LOGICAL-c488t-de276b9e74d166c4ceeb33fc2186ba14b562cffe23f7277cf793bf47f3e40aca3</originalsourceid><addsrcrecordid>eNqNkc1u1DAURi1URIfCK1TetOomg_9iOxskVLUUqRIsYG05znXrURKndjJV3x4PM0DFhq6sq-_cz5YPQueUrCmh8sNmPcKS4pSf3H3s412wa0aoKOGaUPYKrahWvOI1FUdoRQjTFW84O0Zvc94QQkTN9Bt0zGohFJF6hcK3BBnSFjo8hK7ySw4-pgFbN4etnUMccZnxNuTF9vgxpi7jMGKLpxLCOOPHMN-X8RmAE7h4N4Zfy2GYbEhDId-h1972Gd4fzhP04_rq--VNdfv185fLT7eVE1rPVQdMybYBJToqpRMOoOXcO0a1bC0VbS2Z8x4Y94op5bxqeOuF8hwEsc7yE3Sx751SfFggz2YI2UHf2xHikg1VXAvFuFL_R6UkvJFU8xegvJTWmtKCftyjLsWcE3gzpTDY9GQoMTuJZmP-lWh2End5kVgKTg93Le0A3Z_139YKcHYAbHa298mOLuS_XENqXou6cDd7Dsp_bwMkk12R5qALxdFsuhhe-qafc5bHXA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1634725811</pqid></control><display><type>article</type><title>Preserved mid-fusiform activation for visual words in a patient with a visual word recognition impairment</title><source>ScienceDirect Freedom Collection</source><source>Linguistics and Language Behavior Abstracts (LLBA)</source><creator>Welcome, Suzanne E. ; Pasquarella, Adrian ; Chen, Xi ; Olson, David R. ; Joanisse, Marc F.</creator><creatorcontrib>Welcome, Suzanne E. ; Pasquarella, Adrian ; Chen, Xi ; Olson, David R. ; Joanisse, Marc F.</creatorcontrib><description>Previous functional imaging studies have highlighted the role of left ventral temporal cortex in processing written word forms. We explored activation and anatomical connectivity of this region in HE, a professional writer with alexia as a result of stroke affecting primarily white matter in the left inferior temporal lobe. We used a one-back visual recognition task and functional Magnetic Resonance Imaging to elicit automatic activation to various orthographic and non-orthographic stimuli. Surprisingly, HE showed cortical activation in the left mid-fusiform area during the presentation of words and word-like stimuli, suggesting that this region׳s role in processing visual words is intact despite his severely impaired reading. Diffusion Tensor Imaging data further suggest that HE shows an anatomical disconnection between the ventral temporal cortex and posterior middle temporal cortex. Together, these findings suggest that activation of word-specific regions of mid-fusiform gyrus is not sufficient to yield the conscious experience of reading in the absence of activity in downstream regions of the classical reading network.
•A patient with severe reading impairment shows cortical activation in mid-fusiform cortex.•DTI shows a structural disconnection between ventral and middle temporal cortex.•Preserved activation in ventral temporal cortex is not sufficient for typical word recognition.</description><identifier>ISSN: 0028-3932</identifier><identifier>EISSN: 1873-3514</identifier><identifier>DOI: 10.1016/j.neuropsychologia.2014.10.012</identifier><identifier>PMID: 25447068</identifier><identifier>CODEN: NUPSA6</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult and adolescent clinical studies ; Aged ; Biological and medical sciences ; Connectivity ; Diffusion Tensor Imaging ; Diffusion tensor imaging (DTI) ; Disconnection syndrome ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Dyslexia - pathology ; Dyslexia - physiopathology ; Functional MRI ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Organic mental disorders. Neuropsychology ; Pattern Recognition, Visual - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Reading ; Temporal Lobe - pathology ; Temporal Lobe - physiopathology ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Neuropsychologia, 2014-12, Vol.65 (Dec), p.113-124</ispartof><rights>2014 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-de276b9e74d166c4ceeb33fc2186ba14b562cffe23f7277cf793bf47f3e40aca3</citedby><cites>FETCH-LOGICAL-c488t-de276b9e74d166c4ceeb33fc2186ba14b562cffe23f7277cf793bf47f3e40aca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958,31305</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=29053545$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25447068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Welcome, Suzanne E.</creatorcontrib><creatorcontrib>Pasquarella, Adrian</creatorcontrib><creatorcontrib>Chen, Xi</creatorcontrib><creatorcontrib>Olson, David R.</creatorcontrib><creatorcontrib>Joanisse, Marc F.</creatorcontrib><title>Preserved mid-fusiform activation for visual words in a patient with a visual word recognition impairment</title><title>Neuropsychologia</title><addtitle>Neuropsychologia</addtitle><description>Previous functional imaging studies have highlighted the role of left ventral temporal cortex in processing written word forms. We explored activation and anatomical connectivity of this region in HE, a professional writer with alexia as a result of stroke affecting primarily white matter in the left inferior temporal lobe. We used a one-back visual recognition task and functional Magnetic Resonance Imaging to elicit automatic activation to various orthographic and non-orthographic stimuli. Surprisingly, HE showed cortical activation in the left mid-fusiform area during the presentation of words and word-like stimuli, suggesting that this region׳s role in processing visual words is intact despite his severely impaired reading. Diffusion Tensor Imaging data further suggest that HE shows an anatomical disconnection between the ventral temporal cortex and posterior middle temporal cortex. Together, these findings suggest that activation of word-specific regions of mid-fusiform gyrus is not sufficient to yield the conscious experience of reading in the absence of activity in downstream regions of the classical reading network.
•A patient with severe reading impairment shows cortical activation in mid-fusiform cortex.•DTI shows a structural disconnection between ventral and middle temporal cortex.•Preserved activation in ventral temporal cortex is not sufficient for typical word recognition.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Connectivity</subject><subject>Diffusion Tensor Imaging</subject><subject>Diffusion tensor imaging (DTI)</subject><subject>Disconnection syndrome</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Dyslexia - pathology</subject><subject>Dyslexia - physiopathology</subject><subject>Functional MRI</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Pattern Recognition, Visual - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Reading</subject><subject>Temporal Lobe - pathology</subject><subject>Temporal Lobe - physiopathology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0028-3932</issn><issn>1873-3514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>7T9</sourceid><recordid>eNqNkc1u1DAURi1URIfCK1TetOomg_9iOxskVLUUqRIsYG05znXrURKndjJV3x4PM0DFhq6sq-_cz5YPQueUrCmh8sNmPcKS4pSf3H3s412wa0aoKOGaUPYKrahWvOI1FUdoRQjTFW84O0Zvc94QQkTN9Bt0zGohFJF6hcK3BBnSFjo8hK7ySw4-pgFbN4etnUMccZnxNuTF9vgxpi7jMGKLpxLCOOPHMN-X8RmAE7h4N4Zfy2GYbEhDId-h1972Gd4fzhP04_rq--VNdfv185fLT7eVE1rPVQdMybYBJToqpRMOoOXcO0a1bC0VbS2Z8x4Y94op5bxqeOuF8hwEsc7yE3Sx751SfFggz2YI2UHf2xHikg1VXAvFuFL_R6UkvJFU8xegvJTWmtKCftyjLsWcE3gzpTDY9GQoMTuJZmP-lWh2End5kVgKTg93Le0A3Z_139YKcHYAbHa298mOLuS_XENqXou6cDd7Dsp_bwMkk12R5qALxdFsuhhe-qafc5bHXA</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Welcome, Suzanne E.</creator><creator>Pasquarella, Adrian</creator><creator>Chen, Xi</creator><creator>Olson, David R.</creator><creator>Joanisse, Marc F.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>7T9</scope></search><sort><creationdate>20141201</creationdate><title>Preserved mid-fusiform activation for visual words in a patient with a visual word recognition impairment</title><author>Welcome, Suzanne E. ; Pasquarella, Adrian ; Chen, Xi ; Olson, David R. ; Joanisse, Marc F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-de276b9e74d166c4ceeb33fc2186ba14b562cffe23f7277cf793bf47f3e40aca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Connectivity</topic><topic>Diffusion Tensor Imaging</topic><topic>Diffusion tensor imaging (DTI)</topic><topic>Disconnection syndrome</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Dyslexia - pathology</topic><topic>Dyslexia - physiopathology</topic><topic>Functional MRI</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Pattern Recognition, Visual - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Reading</topic><topic>Temporal Lobe - pathology</topic><topic>Temporal Lobe - physiopathology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Welcome, Suzanne E.</creatorcontrib><creatorcontrib>Pasquarella, Adrian</creatorcontrib><creatorcontrib>Chen, Xi</creatorcontrib><creatorcontrib>Olson, David R.</creatorcontrib><creatorcontrib>Joanisse, Marc F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Linguistics and Language Behavior Abstracts (LLBA)</collection><jtitle>Neuropsychologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Welcome, Suzanne E.</au><au>Pasquarella, Adrian</au><au>Chen, Xi</au><au>Olson, David R.</au><au>Joanisse, Marc F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preserved mid-fusiform activation for visual words in a patient with a visual word recognition impairment</atitle><jtitle>Neuropsychologia</jtitle><addtitle>Neuropsychologia</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>65</volume><issue>Dec</issue><spage>113</spage><epage>124</epage><pages>113-124</pages><issn>0028-3932</issn><eissn>1873-3514</eissn><coden>NUPSA6</coden><notes>ObjectType-Case Study-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-4</notes><notes>content type line 23</notes><notes>ObjectType-Report-1</notes><notes>ObjectType-Article-3</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>Previous functional imaging studies have highlighted the role of left ventral temporal cortex in processing written word forms. We explored activation and anatomical connectivity of this region in HE, a professional writer with alexia as a result of stroke affecting primarily white matter in the left inferior temporal lobe. We used a one-back visual recognition task and functional Magnetic Resonance Imaging to elicit automatic activation to various orthographic and non-orthographic stimuli. Surprisingly, HE showed cortical activation in the left mid-fusiform area during the presentation of words and word-like stimuli, suggesting that this region׳s role in processing visual words is intact despite his severely impaired reading. Diffusion Tensor Imaging data further suggest that HE shows an anatomical disconnection between the ventral temporal cortex and posterior middle temporal cortex. Together, these findings suggest that activation of word-specific regions of mid-fusiform gyrus is not sufficient to yield the conscious experience of reading in the absence of activity in downstream regions of the classical reading network.
•A patient with severe reading impairment shows cortical activation in mid-fusiform cortex.•DTI shows a structural disconnection between ventral and middle temporal cortex.•Preserved activation in ventral temporal cortex is not sufficient for typical word recognition.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>25447068</pmid><doi>10.1016/j.neuropsychologia.2014.10.012</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-3932 |
| ispartof | Neuropsychologia, 2014-12, Vol.65 (Dec), p.113-124 |
| issn | 0028-3932 1873-3514 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1738472377 |
| source | ScienceDirect Freedom Collection; Linguistics and Language Behavior Abstracts (LLBA) |
| subjects | Adult and adolescent clinical studies Aged Biological and medical sciences Connectivity Diffusion Tensor Imaging Diffusion tensor imaging (DTI) Disconnection syndrome Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Dyslexia - pathology Dyslexia - physiopathology Functional MRI Humans Magnetic Resonance Imaging Male Medical sciences Nervous system (semeiology, syndromes) Neurology Organic mental disorders. Neuropsychology Pattern Recognition, Visual - physiology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reading Temporal Lobe - pathology Temporal Lobe - physiopathology Vascular diseases and vascular malformations of the nervous system |
| title | Preserved mid-fusiform activation for visual words in a patient with a visual word recognition impairment |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-25T06%3A38%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preserved%20mid-fusiform%20activation%20for%20visual%20words%20in%20a%20patient%20with%20a%20visual%20word%20recognition%20impairment&rft.jtitle=Neuropsychologia&rft.au=Welcome,%20Suzanne%20E.&rft.date=2014-12-01&rft.volume=65&rft.issue=Dec&rft.spage=113&rft.epage=124&rft.pages=113-124&rft.issn=0028-3932&rft.eissn=1873-3514&rft.coden=NUPSA6&rft_id=info:doi/10.1016/j.neuropsychologia.2014.10.012&rft_dat=%3Cproquest_cross%3E1660396183%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c488t-de276b9e74d166c4ceeb33fc2186ba14b562cffe23f7277cf793bf47f3e40aca3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1634725811&rft_id=info:pmid/25447068&rfr_iscdi=true |