Experimental Approaches to Studies of the Role of the Genotype at the TAG 1A Locus of the Dopamine D sub(2) Receptor in Epileptogenesis

The aim of the present work was to study the effects of the genotype at the TAG 1A locus of the dopamine D sub(2) receptor on the characteristics of peak-wave discharges on the EEG of the somatosensory, parietal, and occipital areas of the neocortex. Two groups of WAG-Rij rats (a model of absence ep...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2013-10, Vol.43 (8), p.935-940
Main Authors: Kalimullina, L B, Musina, A M, Kuznetsova, G N
Format: Article
Language:English
Online Access:Get full text
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Summary:The aim of the present work was to study the effects of the genotype at the TAG 1A locus of the dopamine D sub(2) receptor on the characteristics of peak-wave discharges on the EEG of the somatosensory, parietal, and occipital areas of the neocortex. Two groups of WAG-Rij rats (a model of absence epilepsy) differing in the genotype at this locus were studied. Rats with the A1/A1 genotype showed only type 1 generalized peak-wave discharges, while A2/A2 rats showed type 1 peak-wave discharges (41%), type 2 discharges (8%), and atypical discharges (51%). Quantitative analysis showed that type 1 peak-wave discharges in A1/A1 rats were significantly longer-lasting and arose more frequently, leading to significant increase in the peak-wave index in these animals. These results are of clinical interest, creating a theoretical basis for improving the diagnosis of absence epilepsy and selecting anticonvulsants.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-013-9831-z