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Memory Enhancement of Acteoside (Verbascoside) in a Senescent Mice Model Induced by a Combination of d-gal and AlCl3
Acteoside, also known as verbascoside or orobanchin, is a common compound found in many important medicinal plants including the Chinese herb Cistanche deserticola Y. C. Ma, which is used for its neuroprotective and memory enhancement properties. We have investigated the effects of acteoside using a...
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| Published in: | Phytotherapy research 2015-08, Vol.29 (8), p.1131-1136 |
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| creator | Gao, Li Peng, Xiao-Ming Huo, Shi-Xia Liu, Xin-Ming Yan, Ming |
| description | Acteoside, also known as verbascoside or orobanchin, is a common compound found in many important medicinal plants including the Chinese herb Cistanche deserticola Y. C. Ma, which is used for its neuroprotective and memory enhancement properties. We have investigated the effects of acteoside using a senescent mouse model induced by a combination of chronic intraperitoneal administration of d‐gal (60 mg/kg/day) and oral administration AlCl3 (5 mg/kg/day) once daily for 90 days. After 60 days, acteoside (30, 60, and 120 mg/kg/day) was orally administered once daily for 30 days. The memory enhancing effects of acteoside were evaluated using the Morris water maze test. The results showed that 30–120 mg/kg/day of acteoside reduced the escape latency in finding the platform, and increased the number of crossings of the platform. A 30–120 mg/kg/day of acteoside increased significantly the expression of nerve growth factor and tropomycin receptor kinase A mRNA and protein in the hippocampus, measured using real‐time RT‐PCR, immunohistochemical analysis, and western blotting. These results support the use of C. deserticola for memory enhancement and indicate that the effects of acteoside are induced via promotion of nerve growth factor and tropomycin receptor kinase A expression. Copyright © 2015 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.5357 |
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C. Ma, which is used for its neuroprotective and memory enhancement properties. We have investigated the effects of acteoside using a senescent mouse model induced by a combination of chronic intraperitoneal administration of d‐gal (60 mg/kg/day) and oral administration AlCl3 (5 mg/kg/day) once daily for 90 days. After 60 days, acteoside (30, 60, and 120 mg/kg/day) was orally administered once daily for 30 days. The memory enhancing effects of acteoside were evaluated using the Morris water maze test. The results showed that 30–120 mg/kg/day of acteoside reduced the escape latency in finding the platform, and increased the number of crossings of the platform. A 30–120 mg/kg/day of acteoside increased significantly the expression of nerve growth factor and tropomycin receptor kinase A mRNA and protein in the hippocampus, measured using real‐time RT‐PCR, immunohistochemical analysis, and western blotting. These results support the use of C. deserticola for memory enhancement and indicate that the effects of acteoside are induced via promotion of nerve growth factor and tropomycin receptor kinase A expression. Copyright © 2015 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.5357</identifier><identifier>PMID: 25900014</identifier><identifier>CODEN: PHYREH</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>acteoside ; Administration, Oral ; Aging ; AlCl3 ; Aluminum Compounds ; Animals ; Basal Forebrain Cholinergic Neurons ; Chlorides ; Cognition Disorders - chemically induced ; Cognition Disorders - drug therapy ; d-galactose ; Disease Models, Animal ; Galactose ; Glucosides - pharmacology ; Hippocampus - drug effects ; Hippocampus - metabolism ; Memory - drug effects ; Memory Disorders - chemically induced ; Memory Disorders - drug therapy ; Mice ; Morris water maze ; Nerve Growth Factors - metabolism ; Nerve Growth Factors - pharmacology ; Phenols - pharmacology ; Receptor, trkA - metabolism ; TrkA</subject><ispartof>Phytotherapy research, 2015-08, Vol.29 (8), p.1131-1136</ispartof><rights>Copyright © 2015 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.5357$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.5357$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25900014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Li</creatorcontrib><creatorcontrib>Peng, Xiao-Ming</creatorcontrib><creatorcontrib>Huo, Shi-Xia</creatorcontrib><creatorcontrib>Liu, Xin-Ming</creatorcontrib><creatorcontrib>Yan, Ming</creatorcontrib><title>Memory Enhancement of Acteoside (Verbascoside) in a Senescent Mice Model Induced by a Combination of d-gal and AlCl3</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Acteoside, also known as verbascoside or orobanchin, is a common compound found in many important medicinal plants including the Chinese herb Cistanche deserticola Y. C. Ma, which is used for its neuroprotective and memory enhancement properties. We have investigated the effects of acteoside using a senescent mouse model induced by a combination of chronic intraperitoneal administration of d‐gal (60 mg/kg/day) and oral administration AlCl3 (5 mg/kg/day) once daily for 90 days. After 60 days, acteoside (30, 60, and 120 mg/kg/day) was orally administered once daily for 30 days. The memory enhancing effects of acteoside were evaluated using the Morris water maze test. The results showed that 30–120 mg/kg/day of acteoside reduced the escape latency in finding the platform, and increased the number of crossings of the platform. A 30–120 mg/kg/day of acteoside increased significantly the expression of nerve growth factor and tropomycin receptor kinase A mRNA and protein in the hippocampus, measured using real‐time RT‐PCR, immunohistochemical analysis, and western blotting. These results support the use of C. deserticola for memory enhancement and indicate that the effects of acteoside are induced via promotion of nerve growth factor and tropomycin receptor kinase A expression. Copyright © 2015 John Wiley & Sons, Ltd.</description><subject>acteoside</subject><subject>Administration, Oral</subject><subject>Aging</subject><subject>AlCl3</subject><subject>Aluminum Compounds</subject><subject>Animals</subject><subject>Basal Forebrain Cholinergic Neurons</subject><subject>Chlorides</subject><subject>Cognition Disorders - chemically induced</subject><subject>Cognition Disorders - drug therapy</subject><subject>d-galactose</subject><subject>Disease Models, Animal</subject><subject>Galactose</subject><subject>Glucosides - pharmacology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Memory - drug effects</subject><subject>Memory Disorders - chemically induced</subject><subject>Memory Disorders - drug therapy</subject><subject>Mice</subject><subject>Morris water maze</subject><subject>Nerve Growth Factors - metabolism</subject><subject>Nerve Growth Factors - pharmacology</subject><subject>Phenols - pharmacology</subject><subject>Receptor, trkA - metabolism</subject><subject>TrkA</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpd0Utv1DAQB3ALgehSkPgEyBKXckixY8eJj6tVX9BtESyPm-XHBFwSexsngv32OH0h9TQazU-jsf8IvabkkBJSvt-Ow2HFqvoJWlAiZUGrmj1FCyIrWnDa_NhDL1K6IoTIkvDnaK-sZG4oX6BxDX0cdvgo_NLBQg9hxLHFSztCTN4BPvgGg9HJ3nTvsA9Y4y8QINmZrr0FvI4OOnwW3GTBYbPLYhV744MefQzzOlf81B3WweFlt-rYS_Ss1V2CV3d1H309PtqsTovzy5Oz1fK88Cy_oOCEsbYqRVNarS2tKyoMp6A58KbVeeSc0IZbLairmWAcwGhtSmMIbZ2UbB8d3O7dDvF6gjSq3ue7u04HiFNStCalEKSkTaZvH9GrOA0hXzcrKrkgjcjqzZ2aTA9ObQff62Gn7v8zg-IW_PEd7B7mlKg5J5VzUnNO6tPm81z_e59G-Pvg9fBbiZrVlfp-caLWm4tTIj8eqw_sH-sHkl8</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Gao, Li</creator><creator>Peng, Xiao-Ming</creator><creator>Huo, Shi-Xia</creator><creator>Liu, Xin-Ming</creator><creator>Yan, Ming</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201508</creationdate><title>Memory Enhancement of Acteoside (Verbascoside) in a Senescent Mice Model Induced by a Combination of d-gal and AlCl3</title><author>Gao, Li ; Peng, Xiao-Ming ; Huo, Shi-Xia ; Liu, Xin-Ming ; Yan, Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3157-4033f52682caac17516b41ea4e48fa3f5dd6ab4ca61d73634eebaab2bb01fd993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>acteoside</topic><topic>Administration, Oral</topic><topic>Aging</topic><topic>AlCl3</topic><topic>Aluminum Compounds</topic><topic>Animals</topic><topic>Basal Forebrain Cholinergic Neurons</topic><topic>Chlorides</topic><topic>Cognition Disorders - chemically induced</topic><topic>Cognition Disorders - drug therapy</topic><topic>d-galactose</topic><topic>Disease Models, Animal</topic><topic>Galactose</topic><topic>Glucosides - pharmacology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Memory - drug effects</topic><topic>Memory Disorders - chemically induced</topic><topic>Memory Disorders - drug therapy</topic><topic>Mice</topic><topic>Morris water maze</topic><topic>Nerve Growth Factors - metabolism</topic><topic>Nerve Growth Factors - pharmacology</topic><topic>Phenols - pharmacology</topic><topic>Receptor, trkA - metabolism</topic><topic>TrkA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Li</creatorcontrib><creatorcontrib>Peng, Xiao-Ming</creatorcontrib><creatorcontrib>Huo, Shi-Xia</creatorcontrib><creatorcontrib>Liu, Xin-Ming</creatorcontrib><creatorcontrib>Yan, Ming</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Li</au><au>Peng, Xiao-Ming</au><au>Huo, Shi-Xia</au><au>Liu, Xin-Ming</au><au>Yan, Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Memory Enhancement of Acteoside (Verbascoside) in a Senescent Mice Model Induced by a Combination of d-gal and AlCl3</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2015-08</date><risdate>2015</risdate><volume>29</volume><issue>8</issue><spage>1131</spage><epage>1136</epage><pages>1131-1136</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><coden>PHYREH</coden><notes>istex:7FFACFF192890BF38F6E7E0C4F9BFB957205EF77</notes><notes>Xinjiang Uygur Autonomous Region - No. 201110104</notes><notes>ark:/67375/WNG-MTNH09KF-J</notes><notes>ArticleID:PTR5357</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Acteoside, also known as verbascoside or orobanchin, is a common compound found in many important medicinal plants including the Chinese herb Cistanche deserticola Y. C. Ma, which is used for its neuroprotective and memory enhancement properties. We have investigated the effects of acteoside using a senescent mouse model induced by a combination of chronic intraperitoneal administration of d‐gal (60 mg/kg/day) and oral administration AlCl3 (5 mg/kg/day) once daily for 90 days. After 60 days, acteoside (30, 60, and 120 mg/kg/day) was orally administered once daily for 30 days. The memory enhancing effects of acteoside were evaluated using the Morris water maze test. The results showed that 30–120 mg/kg/day of acteoside reduced the escape latency in finding the platform, and increased the number of crossings of the platform. A 30–120 mg/kg/day of acteoside increased significantly the expression of nerve growth factor and tropomycin receptor kinase A mRNA and protein in the hippocampus, measured using real‐time RT‐PCR, immunohistochemical analysis, and western blotting. These results support the use of C. deserticola for memory enhancement and indicate that the effects of acteoside are induced via promotion of nerve growth factor and tropomycin receptor kinase A expression. Copyright © 2015 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25900014</pmid><doi>10.1002/ptr.5357</doi><tpages>6</tpages></addata></record> |
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| ispartof | Phytotherapy research, 2015-08, Vol.29 (8), p.1131-1136 |
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| subjects | acteoside Administration, Oral Aging AlCl3 Aluminum Compounds Animals Basal Forebrain Cholinergic Neurons Chlorides Cognition Disorders - chemically induced Cognition Disorders - drug therapy d-galactose Disease Models, Animal Galactose Glucosides - pharmacology Hippocampus - drug effects Hippocampus - metabolism Memory - drug effects Memory Disorders - chemically induced Memory Disorders - drug therapy Mice Morris water maze Nerve Growth Factors - metabolism Nerve Growth Factors - pharmacology Phenols - pharmacology Receptor, trkA - metabolism TrkA |
| title | Memory Enhancement of Acteoside (Verbascoside) in a Senescent Mice Model Induced by a Combination of d-gal and AlCl3 |
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