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Assessment of antidiabetogenic potential of fermented soybean extracts in streptozotocin-induced diabetic rat
► We isolated Bacillus subtilis MORI-fermented soybean extracts (BTD-1). ► BTD-1 decreased the glucose level via the increment of insulin in diabetic rat. ► BTD-1 attenuates the production of ROS via the antioxidative activity. ► BTD-1 ameliorates the vascular contraction and relaxation responses in...
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| Published in: | Food and chemical toxicology 2012-11, Vol.50 (11), p.3941-3948 |
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| creator | Lim, Kyu Hee Han, Ji-Hui Lee, Jae Yeon Park, Young Shik Cho, Yong Seok Kang, Kyung-Don Yuk, Won Jeong Hwang, Kyo Yeol Seong, Su-Il Kim, Bumseok Kwon, JungKee Kang, Chang-Won Kim, Jong-Hoon |
| description | ► We isolated Bacillus subtilis MORI-fermented soybean extracts (BTD-1). ► BTD-1 decreased the glucose level via the increment of insulin in diabetic rat. ► BTD-1 attenuates the production of ROS via the antioxidative activity. ► BTD-1 ameliorates the vascular contraction and relaxation responses in rats aorta.
Most of the available drugs for the treatment of diabetes mellitus (DM) produce detrimental side effects, which has prompted an ongoing search for plant with the antidiabetic potential. The present study investigated the effect of soybean extracts fermented with Bacillus subtilis MORI, fermented soybean extracts (BTD-1) was investigated in streptozotocin (STZ)-induced diabetic rats. The possible effects of BTD-1 against hyperglycemia and free radical-mediated oxidative stress was investigated by assaying the plasma glucose level and the activity of enzymatic antioxidants, such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and malondialdehyde (MDA). A significant increase in the levels of both plasma glucose and reactive oxygen species (ROS) was observed in the diabetic rats when compared to normal control group. After administration of BTD-1 (500 and 1000mg/kg/day), the elevated plasma glucose level was significantly reduced while the plasma insulin level and the activities of SOD, GSH-Px, CAT and MDA were significantly increased. The results suggest that administration of BTD-1 can inhibit hyperglycemia and free radical-mediated oxidative stress. The administration of BTD-1 also inhibited the contractile response by norepinephrine (10−10–10−5M) in the presence of endothelium, and caused significant relaxation by carbachol (10−8–10−5M) in rat aorta. These findings indicate that BTD-1 improves vascular functions on STZ-induced diabetic rats. Therefore, subchronic administration of BTD-1 could prevent the functional changes in vascular reactivity in STZ-induced diabetic rats. The collective findings support that administration of BTD-1 may prevent some diabetes-related changes in vascular reactivity directly and/or indirectly due to its hypoglycaemic effect and inhibition of production of ROS. |
| doi_str_mv | 10.1016/j.fct.2012.08.036 |
| format | article |
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Most of the available drugs for the treatment of diabetes mellitus (DM) produce detrimental side effects, which has prompted an ongoing search for plant with the antidiabetic potential. The present study investigated the effect of soybean extracts fermented with Bacillus subtilis MORI, fermented soybean extracts (BTD-1) was investigated in streptozotocin (STZ)-induced diabetic rats. The possible effects of BTD-1 against hyperglycemia and free radical-mediated oxidative stress was investigated by assaying the plasma glucose level and the activity of enzymatic antioxidants, such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and malondialdehyde (MDA). A significant increase in the levels of both plasma glucose and reactive oxygen species (ROS) was observed in the diabetic rats when compared to normal control group. After administration of BTD-1 (500 and 1000mg/kg/day), the elevated plasma glucose level was significantly reduced while the plasma insulin level and the activities of SOD, GSH-Px, CAT and MDA were significantly increased. The results suggest that administration of BTD-1 can inhibit hyperglycemia and free radical-mediated oxidative stress. The administration of BTD-1 also inhibited the contractile response by norepinephrine (10−10–10−5M) in the presence of endothelium, and caused significant relaxation by carbachol (10−8–10−5M) in rat aorta. These findings indicate that BTD-1 improves vascular functions on STZ-induced diabetic rats. Therefore, subchronic administration of BTD-1 could prevent the functional changes in vascular reactivity in STZ-induced diabetic rats. The collective findings support that administration of BTD-1 may prevent some diabetes-related changes in vascular reactivity directly and/or indirectly due to its hypoglycaemic effect and inhibition of production of ROS.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2012.08.036</identifier><identifier>PMID: 22943971</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>adverse effects ; Animals ; Antioxidants ; aorta ; Aorta - drug effects ; Bacillus subtilis ; Biological and medical sciences ; blood glucose ; Blood Glucose - analysis ; Body Weight - drug effects ; carbachol ; catalase ; Catalase - metabolism ; Diabetes mellitus ; Diabetes Mellitus, Experimental - diet therapy ; Diabetes Mellitus, Experimental - metabolism ; Diabetes. Impaired glucose tolerance ; Drinking - drug effects ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; endothelium ; enzyme activity ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fermentation ; Fermented soybean extracts ; glutathione peroxidase ; Glutathione Peroxidase - metabolism ; glycemic effect ; Glycine max - chemistry ; Glycine max - microbiology ; hyperglycemia ; Hypoglycemic Agents - pharmacology ; In Vitro Techniques ; insulin ; Male ; malondialdehyde ; Malondialdehyde - analysis ; Medical sciences ; norepinephrine ; Norepinephrine - pharmacology ; Oxidative stress ; Oxidative Stress - drug effects ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar ; reactive oxygen species ; Reactive Oxygen Species - metabolism ; soybeans ; Streptozocin ; Streptozotocin ; superoxide dismutase ; Superoxide Dismutase - metabolism ; Toxicology ; Vascular responsiveness ; Vasodilator Agents - pharmacology</subject><ispartof>Food and chemical toxicology, 2012-11, Vol.50 (11), p.3941-3948</ispartof><rights>2012 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-e9b339de77af5195a6b86ebd6688f8df4d2f51b3f8f66c9ff74b39dc995aca33</citedby><cites>FETCH-LOGICAL-c506t-e9b339de77af5195a6b86ebd6688f8df4d2f51b3f8f66c9ff74b39dc995aca33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26464270$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22943971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, Kyu Hee</creatorcontrib><creatorcontrib>Han, Ji-Hui</creatorcontrib><creatorcontrib>Lee, Jae Yeon</creatorcontrib><creatorcontrib>Park, Young Shik</creatorcontrib><creatorcontrib>Cho, Yong Seok</creatorcontrib><creatorcontrib>Kang, Kyung-Don</creatorcontrib><creatorcontrib>Yuk, Won Jeong</creatorcontrib><creatorcontrib>Hwang, Kyo Yeol</creatorcontrib><creatorcontrib>Seong, Su-Il</creatorcontrib><creatorcontrib>Kim, Bumseok</creatorcontrib><creatorcontrib>Kwon, JungKee</creatorcontrib><creatorcontrib>Kang, Chang-Won</creatorcontrib><creatorcontrib>Kim, Jong-Hoon</creatorcontrib><title>Assessment of antidiabetogenic potential of fermented soybean extracts in streptozotocin-induced diabetic rat</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>► We isolated Bacillus subtilis MORI-fermented soybean extracts (BTD-1). ► BTD-1 decreased the glucose level via the increment of insulin in diabetic rat. ► BTD-1 attenuates the production of ROS via the antioxidative activity. ► BTD-1 ameliorates the vascular contraction and relaxation responses in rats aorta.
Most of the available drugs for the treatment of diabetes mellitus (DM) produce detrimental side effects, which has prompted an ongoing search for plant with the antidiabetic potential. The present study investigated the effect of soybean extracts fermented with Bacillus subtilis MORI, fermented soybean extracts (BTD-1) was investigated in streptozotocin (STZ)-induced diabetic rats. The possible effects of BTD-1 against hyperglycemia and free radical-mediated oxidative stress was investigated by assaying the plasma glucose level and the activity of enzymatic antioxidants, such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and malondialdehyde (MDA). A significant increase in the levels of both plasma glucose and reactive oxygen species (ROS) was observed in the diabetic rats when compared to normal control group. After administration of BTD-1 (500 and 1000mg/kg/day), the elevated plasma glucose level was significantly reduced while the plasma insulin level and the activities of SOD, GSH-Px, CAT and MDA were significantly increased. The results suggest that administration of BTD-1 can inhibit hyperglycemia and free radical-mediated oxidative stress. The administration of BTD-1 also inhibited the contractile response by norepinephrine (10−10–10−5M) in the presence of endothelium, and caused significant relaxation by carbachol (10−8–10−5M) in rat aorta. These findings indicate that BTD-1 improves vascular functions on STZ-induced diabetic rats. Therefore, subchronic administration of BTD-1 could prevent the functional changes in vascular reactivity in STZ-induced diabetic rats. The collective findings support that administration of BTD-1 may prevent some diabetes-related changes in vascular reactivity directly and/or indirectly due to its hypoglycaemic effect and inhibition of production of ROS.</description><subject>adverse effects</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>aorta</subject><subject>Aorta - drug effects</subject><subject>Bacillus subtilis</subject><subject>Biological and medical sciences</subject><subject>blood glucose</subject><subject>Blood Glucose - analysis</subject><subject>Body Weight - drug effects</subject><subject>carbachol</subject><subject>catalase</subject><subject>Catalase - metabolism</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - diet therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Drinking - drug effects</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>endothelium</subject><subject>enzyme activity</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fermentation</subject><subject>Fermented soybean extracts</subject><subject>glutathione peroxidase</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>glycemic effect</subject><subject>Glycine max - chemistry</subject><subject>Glycine max - microbiology</subject><subject>hyperglycemia</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>In Vitro Techniques</subject><subject>insulin</subject><subject>Male</subject><subject>malondialdehyde</subject><subject>Malondialdehyde - analysis</subject><subject>Medical sciences</subject><subject>norepinephrine</subject><subject>Norepinephrine - pharmacology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>soybeans</subject><subject>Streptozocin</subject><subject>Streptozotocin</subject><subject>superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Toxicology</subject><subject>Vascular responsiveness</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqF0U1vFSEUBmBibOy1-gPc6GxM3MwIwwwfcdU0fjRp4sK6JgwcGm5m4ApcY_31ZTJX3Vk2JPCcAzkvQq8I7ggm7P2-c6Z0PSZ9h0WHKXuCdkRw2jI6kqdoh3suWibJeI6e57zHGHPC2TN03vdyoJKTHVouc4acFwilia7RoXjr9QQl3kHwpjnEUq-8ntdbB2mFYJsc7yfQoYFfJWlTcuNDk0uCQ4m_Y4nGh9YHezSVbu1qq6TLC3Tm9Jzh5Wm_QLefPt5efWlvvn6-vrq8ac2IWWlBTpRKC5xrNxI5ajYJBpNlTAgnrBtsX88n6oRjzEjn-DBVb2SlRlN6gd5tbQ8p_jhCLmrx2cA86wDxmBVhfJ0Q5eRxWpcYJZO8UrJRk2LOCZw6JL_odK8IVmseaq9qHmrNQ2Ghah615vWp_XFawP6t-BNABW9PQGejZ5d0MD7_c2xgQ89xdW8253RU-i5V8_1bfWnEmPCe4lV82ATUwf70kFQ2HkKNwCeo37LR_-ejD2X0s-c</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Lim, Kyu Hee</creator><creator>Han, Ji-Hui</creator><creator>Lee, Jae Yeon</creator><creator>Park, Young Shik</creator><creator>Cho, Yong Seok</creator><creator>Kang, Kyung-Don</creator><creator>Yuk, Won Jeong</creator><creator>Hwang, Kyo Yeol</creator><creator>Seong, Su-Il</creator><creator>Kim, Bumseok</creator><creator>Kwon, JungKee</creator><creator>Kang, Chang-Won</creator><creator>Kim, Jong-Hoon</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20121101</creationdate><title>Assessment of antidiabetogenic potential of fermented soybean extracts in streptozotocin-induced diabetic rat</title><author>Lim, Kyu Hee ; Han, Ji-Hui ; Lee, Jae Yeon ; Park, Young Shik ; Cho, Yong Seok ; Kang, Kyung-Don ; Yuk, Won Jeong ; Hwang, Kyo Yeol ; Seong, Su-Il ; Kim, Bumseok ; Kwon, JungKee ; Kang, Chang-Won ; Kim, Jong-Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-e9b339de77af5195a6b86ebd6688f8df4d2f51b3f8f66c9ff74b39dc995aca33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>adverse effects</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>aorta</topic><topic>Aorta - drug effects</topic><topic>Bacillus subtilis</topic><topic>Biological and medical sciences</topic><topic>blood glucose</topic><topic>Blood Glucose - analysis</topic><topic>Body Weight - drug effects</topic><topic>carbachol</topic><topic>catalase</topic><topic>Catalase - metabolism</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - diet therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Drinking - drug effects</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>endothelium</topic><topic>enzyme activity</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fermentation</topic><topic>Fermented soybean extracts</topic><topic>glutathione peroxidase</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>glycemic effect</topic><topic>Glycine max - chemistry</topic><topic>Glycine max - microbiology</topic><topic>hyperglycemia</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>In Vitro Techniques</topic><topic>insulin</topic><topic>Male</topic><topic>malondialdehyde</topic><topic>Malondialdehyde - analysis</topic><topic>Medical sciences</topic><topic>norepinephrine</topic><topic>Norepinephrine - pharmacology</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>soybeans</topic><topic>Streptozocin</topic><topic>Streptozotocin</topic><topic>superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Toxicology</topic><topic>Vascular responsiveness</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, Kyu Hee</creatorcontrib><creatorcontrib>Han, Ji-Hui</creatorcontrib><creatorcontrib>Lee, Jae Yeon</creatorcontrib><creatorcontrib>Park, Young Shik</creatorcontrib><creatorcontrib>Cho, Yong Seok</creatorcontrib><creatorcontrib>Kang, Kyung-Don</creatorcontrib><creatorcontrib>Yuk, Won Jeong</creatorcontrib><creatorcontrib>Hwang, Kyo Yeol</creatorcontrib><creatorcontrib>Seong, Su-Il</creatorcontrib><creatorcontrib>Kim, Bumseok</creatorcontrib><creatorcontrib>Kwon, JungKee</creatorcontrib><creatorcontrib>Kang, Chang-Won</creatorcontrib><creatorcontrib>Kim, Jong-Hoon</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lim, Kyu Hee</au><au>Han, Ji-Hui</au><au>Lee, Jae Yeon</au><au>Park, Young Shik</au><au>Cho, Yong Seok</au><au>Kang, Kyung-Don</au><au>Yuk, Won Jeong</au><au>Hwang, Kyo Yeol</au><au>Seong, Su-Il</au><au>Kim, Bumseok</au><au>Kwon, JungKee</au><au>Kang, Chang-Won</au><au>Kim, Jong-Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of antidiabetogenic potential of fermented soybean extracts in streptozotocin-induced diabetic rat</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>50</volume><issue>11</issue><spage>3941</spage><epage>3948</epage><pages>3941-3948</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><notes>http://dx.doi.org/10.1016/j.fct.2012.08.036</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>► We isolated Bacillus subtilis MORI-fermented soybean extracts (BTD-1). ► BTD-1 decreased the glucose level via the increment of insulin in diabetic rat. ► BTD-1 attenuates the production of ROS via the antioxidative activity. ► BTD-1 ameliorates the vascular contraction and relaxation responses in rats aorta.
Most of the available drugs for the treatment of diabetes mellitus (DM) produce detrimental side effects, which has prompted an ongoing search for plant with the antidiabetic potential. The present study investigated the effect of soybean extracts fermented with Bacillus subtilis MORI, fermented soybean extracts (BTD-1) was investigated in streptozotocin (STZ)-induced diabetic rats. The possible effects of BTD-1 against hyperglycemia and free radical-mediated oxidative stress was investigated by assaying the plasma glucose level and the activity of enzymatic antioxidants, such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and malondialdehyde (MDA). A significant increase in the levels of both plasma glucose and reactive oxygen species (ROS) was observed in the diabetic rats when compared to normal control group. After administration of BTD-1 (500 and 1000mg/kg/day), the elevated plasma glucose level was significantly reduced while the plasma insulin level and the activities of SOD, GSH-Px, CAT and MDA were significantly increased. The results suggest that administration of BTD-1 can inhibit hyperglycemia and free radical-mediated oxidative stress. The administration of BTD-1 also inhibited the contractile response by norepinephrine (10−10–10−5M) in the presence of endothelium, and caused significant relaxation by carbachol (10−8–10−5M) in rat aorta. These findings indicate that BTD-1 improves vascular functions on STZ-induced diabetic rats. Therefore, subchronic administration of BTD-1 could prevent the functional changes in vascular reactivity in STZ-induced diabetic rats. The collective findings support that administration of BTD-1 may prevent some diabetes-related changes in vascular reactivity directly and/or indirectly due to its hypoglycaemic effect and inhibition of production of ROS.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>22943971</pmid><doi>10.1016/j.fct.2012.08.036</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 2012-11, Vol.50 (11), p.3941-3948 |
| issn | 0278-6915 1873-6351 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1676351371 |
| source | ScienceDirect Freedom Collection |
| subjects | adverse effects Animals Antioxidants aorta Aorta - drug effects Bacillus subtilis Biological and medical sciences blood glucose Blood Glucose - analysis Body Weight - drug effects carbachol catalase Catalase - metabolism Diabetes mellitus Diabetes Mellitus, Experimental - diet therapy Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Drinking - drug effects Endocrine pancreas. Apud cells (diseases) Endocrinopathies endothelium enzyme activity Etiopathogenesis. Screening. Investigations. Target tissue resistance Fermentation Fermented soybean extracts glutathione peroxidase Glutathione Peroxidase - metabolism glycemic effect Glycine max - chemistry Glycine max - microbiology hyperglycemia Hypoglycemic Agents - pharmacology In Vitro Techniques insulin Male malondialdehyde Malondialdehyde - analysis Medical sciences norepinephrine Norepinephrine - pharmacology Oxidative stress Oxidative Stress - drug effects Plant Extracts - pharmacology Rats Rats, Wistar reactive oxygen species Reactive Oxygen Species - metabolism soybeans Streptozocin Streptozotocin superoxide dismutase Superoxide Dismutase - metabolism Toxicology Vascular responsiveness Vasodilator Agents - pharmacology |
| title | Assessment of antidiabetogenic potential of fermented soybean extracts in streptozotocin-induced diabetic rat |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T02%3A00%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20antidiabetogenic%20potential%20of%20fermented%20soybean%20extracts%20in%20streptozotocin-induced%20diabetic%20rat&rft.jtitle=Food%20and%20chemical%20toxicology&rft.au=Lim,%20Kyu%20Hee&rft.date=2012-11-01&rft.volume=50&rft.issue=11&rft.spage=3941&rft.epage=3948&rft.pages=3941-3948&rft.issn=0278-6915&rft.eissn=1873-6351&rft.coden=FCTOD7&rft_id=info:doi/10.1016/j.fct.2012.08.036&rft_dat=%3Cproquest_cross%3E1111859697%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c506t-e9b339de77af5195a6b86ebd6688f8df4d2f51b3f8f66c9ff74b39dc995aca33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1111859697&rft_id=info:pmid/22943971&rfr_iscdi=true |