LC–MS-based holistic metabolic profiling. Problems, limitations, advantages, and future perspectives

•A review of the advantages, constrains and issues in MS-based metabolomics.•Perspective for future research seen in six fields.•Design of experiment, analytical developments for quality control-validation, improvement of metabolome coverage, fusion of data, metabolite identification, and data visua...

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Bibliographic Details
Published in:Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2014-09, Vol.966, p.1-6
Main Authors: Gika, Helen G., Wilson, Ian D., Theodoridis, Georgios A.
Format: Article
Language:English
Subjects:
Analytical chemistry
Animals
Chromatography
Chromatography, Liquid - methods
Chromatography, Liquid - standards
Chromatography, Liquid - trends
Computational Biology
Humans
Life sciences
Mass spectrometry
Mass Spectrometry - methods
Mass Spectrometry - standards
Mass Spectrometry - trends
Metabolomics
Metabolomics - methods
Metabolomics - standards
Metabolomics - trends
Metabonomics
Profiling
Quality Control
Scientists
Standardisation
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Summary:•A review of the advantages, constrains and issues in MS-based metabolomics.•Perspective for future research seen in six fields.•Design of experiment, analytical developments for quality control-validation, improvement of metabolome coverage, fusion of data, metabolite identification, and data visualisation. The present review aims to critically discuss some of the major problems and limitations of LC–MS based metabolomics as experienced from an analytical chemistry standpoint. Metabolomics offers distinct advantages to a variety of life sciences. Continuous development of the field has been realised due to intensive efforts from a great many scientists from widely divergent backgrounds and research interests as demonstrated by the contents of this special issue. The aim of this commentary is to describe current hindrances to field's progress, (some unique to metabolomics, some common with other omics fields or with conventional targeted bioanalysis) to propose some potential solutions to overcome these constraints and to provide a future perspective for likely developments in the field.
ISSN:1570-0232
1873-376X
DOI:10.1016/j.jchromb.2014.01.054