Loading…
Liver fibrosis, microbial translocation and immune activation markers in HIV and HCV infections and in HIV/HCV co-infection
Abstract Background Liver fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C viruses. Aims We investigated the correlation between liver fibrosis, immune activation and microbial translocation. Methods This cross-sectional study included patients with h...
Saved in:
| Published in: | Digestive and liver disease 2015-03, Vol.47 (3), p.218-225 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c521t-7cd45e4010af553566f7a30ef83af46b3faf9789ee5fc03b4a0b5a3021e3d3283 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c521t-7cd45e4010af553566f7a30ef83af46b3faf9789ee5fc03b4a0b5a3021e3d3283 |
| container_end_page | 225 |
| container_issue | 3 |
| container_start_page | 218 |
| container_title | Digestive and liver disease |
| container_volume | 47 |
| creator | Sacchi, Paolo Cima, Serena Corbella, Marta Comolli, Giuditta Chiesa, Antonella Baldanti, Fausto Klersy, Catherine Novati, Stefano Mulatto, Patrizia Mariconti, Mara Bazzocchi, Chiara Puoti, Massimo Pagani, Laura Filice, Gaetano Bruno, Raffaele |
| description | Abstract Background Liver fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C viruses. Aims We investigated the correlation between liver fibrosis, immune activation and microbial translocation. Methods This cross-sectional study included patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) mono-infections, HIV/HCV co-infection, and healthy controls (20 subjects/group). Peripheral blood was analysed to determine the levels of Forkhead box 3 (Foxp3) T cells, TGF-β1, CD14 (soluble and surface isoforms), IL-17 and bacterial translocation products. These measurements were correlated to the severity of liver fibrosis, measured with the FIB-4 score and transient elastography. Results Foxp3T cell levels were significantly elevated in HIV mono-infected and co-infected groups ( p < 0.0005). FIB-4 and liver stiffness values inversely correlated with TGF-β1 ( p = 0.0155 and p = 0.0498). Bacterial DNA differed significantly in the HIV-positive compared to the other groups: HIV/HCV co-infected subjects had significantly higher serum levels of bacterial translocation products, CD14, and IL-17 levels ( p < 0.001). Conclusions Fibrosis stage in HIV/HCV co-infection may be influenced by immune activation due either by viral infections or to bacterial translocation. |
| doi_str_mv | 10.1016/j.dld.2014.11.012 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1658415389</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S159086581400807X</els_id><sourcerecordid>1658415389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c521t-7cd45e4010af553566f7a30ef83af46b3faf9789ee5fc03b4a0b5a3021e3d3283</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhi1ERUvhB3BBOXIgqccfiVdISGhV2EorcQAqbpbjjCVvk7jYyUpV_zxOU3rg0JM_5nlHmmcIeQe0Agr1xaHq-q5iFEQFUFFgL8gZqEaVXNbsZb7LDS1VLdUpeZ3SgVIGtaSvyCmTUohaNmfkfu-PGAvn2xiSTx-LwdsYWm_6YopmTH2wZvJhLMzYFX4Y5hELYyd_XH8HE28wpsKPxe7q-gHaba_z06FdgLTmHqoXS8WG8qn4hpw40yd8-3iek19fL39ud-X--7er7Zd9aSWDqWxsJyQKCtQ4KfNotWsMp-gUN07ULXfGbRq1QZTOUt4KQ1uZAQbIO84UPycf1r63MfyZMU168Mli35sRw5x0lqIESK42GYUVzRJSiuj0bfR5yDsNVC_O9UFn53pxrgF0dp4z7x_bz-2A3VPin-QMfFoBzEMePUadrMfRYudjNqG74J9t__m_tO396K3pb_AO0yHMccz2NOjENNU_lqUvOwdBqaLNb_4XQ8-m5g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1658415389</pqid></control><display><type>article</type><title>Liver fibrosis, microbial translocation and immune activation markers in HIV and HCV infections and in HIV/HCV co-infection</title><source>ScienceDirect Journals</source><creator>Sacchi, Paolo ; Cima, Serena ; Corbella, Marta ; Comolli, Giuditta ; Chiesa, Antonella ; Baldanti, Fausto ; Klersy, Catherine ; Novati, Stefano ; Mulatto, Patrizia ; Mariconti, Mara ; Bazzocchi, Chiara ; Puoti, Massimo ; Pagani, Laura ; Filice, Gaetano ; Bruno, Raffaele</creator><creatorcontrib>Sacchi, Paolo ; Cima, Serena ; Corbella, Marta ; Comolli, Giuditta ; Chiesa, Antonella ; Baldanti, Fausto ; Klersy, Catherine ; Novati, Stefano ; Mulatto, Patrizia ; Mariconti, Mara ; Bazzocchi, Chiara ; Puoti, Massimo ; Pagani, Laura ; Filice, Gaetano ; Bruno, Raffaele</creatorcontrib><description>Abstract Background Liver fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C viruses. Aims We investigated the correlation between liver fibrosis, immune activation and microbial translocation. Methods This cross-sectional study included patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) mono-infections, HIV/HCV co-infection, and healthy controls (20 subjects/group). Peripheral blood was analysed to determine the levels of Forkhead box 3 (Foxp3) T cells, TGF-β1, CD14 (soluble and surface isoforms), IL-17 and bacterial translocation products. These measurements were correlated to the severity of liver fibrosis, measured with the FIB-4 score and transient elastography. Results Foxp3T cell levels were significantly elevated in HIV mono-infected and co-infected groups ( p < 0.0005). FIB-4 and liver stiffness values inversely correlated with TGF-β1 ( p = 0.0155 and p = 0.0498). Bacterial DNA differed significantly in the HIV-positive compared to the other groups: HIV/HCV co-infected subjects had significantly higher serum levels of bacterial translocation products, CD14, and IL-17 levels ( p < 0.001). Conclusions Fibrosis stage in HIV/HCV co-infection may be influenced by immune activation due either by viral infections or to bacterial translocation.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/j.dld.2014.11.012</identifier><identifier>PMID: 25544657</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Bacterial Translocation ; Biomarkers - blood ; Case-Control Studies ; CD4-Positive T-Lymphocytes - cytology ; Coinfection ; Cross-Sectional Studies ; DNA, Bacterial - genetics ; Elasticity Imaging Techniques ; Female ; Gastroenterology and Hepatology ; Hepacivirus ; Hepatitis C - immunology ; HIV immunity ; HIV Infections - immunology ; HIV/HCV co-infection ; Humans ; Interleukin-17 - blood ; Linear Models ; Lipopolysaccharide Receptors - blood ; Liver Cirrhosis - diagnosis ; Liver Cirrhosis - virology ; Liver fibrosis ; Male ; Middle Aged ; RNA, Viral - genetics ; Transforming Growth Factor beta1 - blood</subject><ispartof>Digestive and liver disease, 2015-03, Vol.47 (3), p.218-225</ispartof><rights>Editrice Gastroenterologica Italiana S.r.l.</rights><rights>2014 Editrice Gastroenterologica Italiana S.r.l.</rights><rights>Copyright © 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-7cd45e4010af553566f7a30ef83af46b3faf9789ee5fc03b4a0b5a3021e3d3283</citedby><cites>FETCH-LOGICAL-c521t-7cd45e4010af553566f7a30ef83af46b3faf9789ee5fc03b4a0b5a3021e3d3283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25544657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sacchi, Paolo</creatorcontrib><creatorcontrib>Cima, Serena</creatorcontrib><creatorcontrib>Corbella, Marta</creatorcontrib><creatorcontrib>Comolli, Giuditta</creatorcontrib><creatorcontrib>Chiesa, Antonella</creatorcontrib><creatorcontrib>Baldanti, Fausto</creatorcontrib><creatorcontrib>Klersy, Catherine</creatorcontrib><creatorcontrib>Novati, Stefano</creatorcontrib><creatorcontrib>Mulatto, Patrizia</creatorcontrib><creatorcontrib>Mariconti, Mara</creatorcontrib><creatorcontrib>Bazzocchi, Chiara</creatorcontrib><creatorcontrib>Puoti, Massimo</creatorcontrib><creatorcontrib>Pagani, Laura</creatorcontrib><creatorcontrib>Filice, Gaetano</creatorcontrib><creatorcontrib>Bruno, Raffaele</creatorcontrib><title>Liver fibrosis, microbial translocation and immune activation markers in HIV and HCV infections and in HIV/HCV co-infection</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>Abstract Background Liver fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C viruses. Aims We investigated the correlation between liver fibrosis, immune activation and microbial translocation. Methods This cross-sectional study included patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) mono-infections, HIV/HCV co-infection, and healthy controls (20 subjects/group). Peripheral blood was analysed to determine the levels of Forkhead box 3 (Foxp3) T cells, TGF-β1, CD14 (soluble and surface isoforms), IL-17 and bacterial translocation products. These measurements were correlated to the severity of liver fibrosis, measured with the FIB-4 score and transient elastography. Results Foxp3T cell levels were significantly elevated in HIV mono-infected and co-infected groups ( p < 0.0005). FIB-4 and liver stiffness values inversely correlated with TGF-β1 ( p = 0.0155 and p = 0.0498). Bacterial DNA differed significantly in the HIV-positive compared to the other groups: HIV/HCV co-infected subjects had significantly higher serum levels of bacterial translocation products, CD14, and IL-17 levels ( p < 0.001). Conclusions Fibrosis stage in HIV/HCV co-infection may be influenced by immune activation due either by viral infections or to bacterial translocation.</description><subject>Adult</subject><subject>Bacterial Translocation</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>CD4-Positive T-Lymphocytes - cytology</subject><subject>Coinfection</subject><subject>Cross-Sectional Studies</subject><subject>DNA, Bacterial - genetics</subject><subject>Elasticity Imaging Techniques</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Hepacivirus</subject><subject>Hepatitis C - immunology</subject><subject>HIV immunity</subject><subject>HIV Infections - immunology</subject><subject>HIV/HCV co-infection</subject><subject>Humans</subject><subject>Interleukin-17 - blood</subject><subject>Linear Models</subject><subject>Lipopolysaccharide Receptors - blood</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver Cirrhosis - virology</subject><subject>Liver fibrosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>RNA, Viral - genetics</subject><subject>Transforming Growth Factor beta1 - blood</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kU1v1DAQhi1ERUvhB3BBOXIgqccfiVdISGhV2EorcQAqbpbjjCVvk7jYyUpV_zxOU3rg0JM_5nlHmmcIeQe0Agr1xaHq-q5iFEQFUFFgL8gZqEaVXNbsZb7LDS1VLdUpeZ3SgVIGtaSvyCmTUohaNmfkfu-PGAvn2xiSTx-LwdsYWm_6YopmTH2wZvJhLMzYFX4Y5hELYyd_XH8HE28wpsKPxe7q-gHaba_z06FdgLTmHqoXS8WG8qn4hpw40yd8-3iek19fL39ud-X--7er7Zd9aSWDqWxsJyQKCtQ4KfNotWsMp-gUN07ULXfGbRq1QZTOUt4KQ1uZAQbIO84UPycf1r63MfyZMU168Mli35sRw5x0lqIESK42GYUVzRJSiuj0bfR5yDsNVC_O9UFn53pxrgF0dp4z7x_bz-2A3VPin-QMfFoBzEMePUadrMfRYudjNqG74J9t__m_tO396K3pb_AO0yHMccz2NOjENNU_lqUvOwdBqaLNb_4XQ8-m5g</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Sacchi, Paolo</creator><creator>Cima, Serena</creator><creator>Corbella, Marta</creator><creator>Comolli, Giuditta</creator><creator>Chiesa, Antonella</creator><creator>Baldanti, Fausto</creator><creator>Klersy, Catherine</creator><creator>Novati, Stefano</creator><creator>Mulatto, Patrizia</creator><creator>Mariconti, Mara</creator><creator>Bazzocchi, Chiara</creator><creator>Puoti, Massimo</creator><creator>Pagani, Laura</creator><creator>Filice, Gaetano</creator><creator>Bruno, Raffaele</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>Liver fibrosis, microbial translocation and immune activation markers in HIV and HCV infections and in HIV/HCV co-infection</title><author>Sacchi, Paolo ; Cima, Serena ; Corbella, Marta ; Comolli, Giuditta ; Chiesa, Antonella ; Baldanti, Fausto ; Klersy, Catherine ; Novati, Stefano ; Mulatto, Patrizia ; Mariconti, Mara ; Bazzocchi, Chiara ; Puoti, Massimo ; Pagani, Laura ; Filice, Gaetano ; Bruno, Raffaele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-7cd45e4010af553566f7a30ef83af46b3faf9789ee5fc03b4a0b5a3021e3d3283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Bacterial Translocation</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>CD4-Positive T-Lymphocytes - cytology</topic><topic>Coinfection</topic><topic>Cross-Sectional Studies</topic><topic>DNA, Bacterial - genetics</topic><topic>Elasticity Imaging Techniques</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Hepacivirus</topic><topic>Hepatitis C - immunology</topic><topic>HIV immunity</topic><topic>HIV Infections - immunology</topic><topic>HIV/HCV co-infection</topic><topic>Humans</topic><topic>Interleukin-17 - blood</topic><topic>Linear Models</topic><topic>Lipopolysaccharide Receptors - blood</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Liver Cirrhosis - virology</topic><topic>Liver fibrosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>RNA, Viral - genetics</topic><topic>Transforming Growth Factor beta1 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sacchi, Paolo</creatorcontrib><creatorcontrib>Cima, Serena</creatorcontrib><creatorcontrib>Corbella, Marta</creatorcontrib><creatorcontrib>Comolli, Giuditta</creatorcontrib><creatorcontrib>Chiesa, Antonella</creatorcontrib><creatorcontrib>Baldanti, Fausto</creatorcontrib><creatorcontrib>Klersy, Catherine</creatorcontrib><creatorcontrib>Novati, Stefano</creatorcontrib><creatorcontrib>Mulatto, Patrizia</creatorcontrib><creatorcontrib>Mariconti, Mara</creatorcontrib><creatorcontrib>Bazzocchi, Chiara</creatorcontrib><creatorcontrib>Puoti, Massimo</creatorcontrib><creatorcontrib>Pagani, Laura</creatorcontrib><creatorcontrib>Filice, Gaetano</creatorcontrib><creatorcontrib>Bruno, Raffaele</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sacchi, Paolo</au><au>Cima, Serena</au><au>Corbella, Marta</au><au>Comolli, Giuditta</au><au>Chiesa, Antonella</au><au>Baldanti, Fausto</au><au>Klersy, Catherine</au><au>Novati, Stefano</au><au>Mulatto, Patrizia</au><au>Mariconti, Mara</au><au>Bazzocchi, Chiara</au><au>Puoti, Massimo</au><au>Pagani, Laura</au><au>Filice, Gaetano</au><au>Bruno, Raffaele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liver fibrosis, microbial translocation and immune activation markers in HIV and HCV infections and in HIV/HCV co-infection</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>47</volume><issue>3</issue><spage>218</spage><epage>225</epage><pages>218-225</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Abstract Background Liver fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C viruses. Aims We investigated the correlation between liver fibrosis, immune activation and microbial translocation. Methods This cross-sectional study included patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) mono-infections, HIV/HCV co-infection, and healthy controls (20 subjects/group). Peripheral blood was analysed to determine the levels of Forkhead box 3 (Foxp3) T cells, TGF-β1, CD14 (soluble and surface isoforms), IL-17 and bacterial translocation products. These measurements were correlated to the severity of liver fibrosis, measured with the FIB-4 score and transient elastography. Results Foxp3T cell levels were significantly elevated in HIV mono-infected and co-infected groups ( p < 0.0005). FIB-4 and liver stiffness values inversely correlated with TGF-β1 ( p = 0.0155 and p = 0.0498). Bacterial DNA differed significantly in the HIV-positive compared to the other groups: HIV/HCV co-infected subjects had significantly higher serum levels of bacterial translocation products, CD14, and IL-17 levels ( p < 0.001). Conclusions Fibrosis stage in HIV/HCV co-infection may be influenced by immune activation due either by viral infections or to bacterial translocation.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>25544657</pmid><doi>10.1016/j.dld.2014.11.012</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1590-8658 |
| ispartof | Digestive and liver disease, 2015-03, Vol.47 (3), p.218-225 |
| issn | 1590-8658 1878-3562 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1658415389 |
| source | ScienceDirect Journals |
| subjects | Adult Bacterial Translocation Biomarkers - blood Case-Control Studies CD4-Positive T-Lymphocytes - cytology Coinfection Cross-Sectional Studies DNA, Bacterial - genetics Elasticity Imaging Techniques Female Gastroenterology and Hepatology Hepacivirus Hepatitis C - immunology HIV immunity HIV Infections - immunology HIV/HCV co-infection Humans Interleukin-17 - blood Linear Models Lipopolysaccharide Receptors - blood Liver Cirrhosis - diagnosis Liver Cirrhosis - virology Liver fibrosis Male Middle Aged RNA, Viral - genetics Transforming Growth Factor beta1 - blood |
| title | Liver fibrosis, microbial translocation and immune activation markers in HIV and HCV infections and in HIV/HCV co-infection |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T20%3A31%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Liver%20fibrosis,%20microbial%20translocation%20and%20immune%20activation%20markers%20in%20HIV%20and%20HCV%20infections%20and%20in%20HIV/HCV%20co-infection&rft.jtitle=Digestive%20and%20liver%20disease&rft.au=Sacchi,%20Paolo&rft.date=2015-03-01&rft.volume=47&rft.issue=3&rft.spage=218&rft.epage=225&rft.pages=218-225&rft.issn=1590-8658&rft.eissn=1878-3562&rft_id=info:doi/10.1016/j.dld.2014.11.012&rft_dat=%3Cproquest_cross%3E1658415389%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c521t-7cd45e4010af553566f7a30ef83af46b3faf9789ee5fc03b4a0b5a3021e3d3283%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1658415389&rft_id=info:pmid/25544657&rfr_iscdi=true |