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Mass spectrometry strategies for mycotoxins analysis in European beers
In this work, an existent solid-phase extraction (SPE) procedure was used to study the occurrence of mycotoxins in different European beers. HPLC-QqQ-MS/MS and ultra high resolution mass analyser have been optimized for the analysis of 18 mycotoxins: the methods were validated according to the EU Co...
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| Published in: | Food control 2013-03, Vol.30 (1), p.122-128 |
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| cites | cdi_FETCH-LOGICAL-c399t-fe84cae0d5dca7fc778be6dea5d0d624ebe7f655b6d93112f62a7a644037f8af3 |
| container_end_page | 128 |
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| container_title | Food control |
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| creator | Rubert, J. Soler, C. Marín, R. James, K.J. Mañes, J. |
| description | In this work, an existent solid-phase extraction (SPE) procedure was used to study the occurrence of mycotoxins in different European beers. HPLC-QqQ-MS/MS and ultra high resolution mass analyser have been optimized for the analysis of 18 mycotoxins: the methods were validated according to the EU Commission Decision 2002/657/EC guidelines. In this sense, matrix-matched calibration was performed for each type of beer, obtaining an effective quantification. The recoveries ranged from 63 to 91% and repeatability and reproducibility expressed as relative standard deviation (RSD%) were lower than 17%. On one hand, HPLC-LTQ-Orbitrap® was used for unambiguous identification of target mycotoxins, as well as for screening non-target mycotoxins, such as enniatins, fusaproliferin and deoxynivalenol-3-glucoside. On the other hand, the quantification was carried out using HPLC-QqQ-MS/MS instrument. At the end, Ochratoxin A, fumonisins, HT-2 and T-2 toxins were detected and quantified in European beers. Moreover, pale lager beer showed higher mycotoxin incidence than the other studied beers.
► SPE-HPLC-MS/MS method was applied to quantify 18 mycotoxins in beer. ► The applicability of Orbitrap showed an excellent mass accuracy and confirmation. ► The first monitoring in beer using HPLC-MS/MS and HPLC-LTQ-Orbitrap®. ► HT-2, T-2, FB1, FB2 and OTA were detected in European beer samples. |
| doi_str_mv | 10.1016/j.foodcont.2012.06.035 |
| format | article |
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► SPE-HPLC-MS/MS method was applied to quantify 18 mycotoxins in beer. ► The applicability of Orbitrap showed an excellent mass accuracy and confirmation. ► The first monitoring in beer using HPLC-MS/MS and HPLC-LTQ-Orbitrap®. ► HT-2, T-2, FB1, FB2 and OTA were detected in European beer samples.</description><identifier>ISSN: 0956-7135</identifier><identifier>EISSN: 1873-7129</identifier><identifier>DOI: 10.1016/j.foodcont.2012.06.035</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Beer ; Beers ; Biological and medical sciences ; deoxynivalenol-3-glucoside ; European Union ; Fermented food industries ; Food industries ; Food toxicology ; fumonisins ; Fundamental and applied biological sciences. Psychology ; guidelines ; mass spectrometry ; Mycotoxins ; ochratoxin A ; Orbitrap ; screening ; solid phase extraction ; SPE ; Triple quadrupole</subject><ispartof>Food control, 2013-03, Vol.30 (1), p.122-128</ispartof><rights>2012 Elsevier Ltd</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-fe84cae0d5dca7fc778be6dea5d0d624ebe7f655b6d93112f62a7a644037f8af3</citedby><cites>FETCH-LOGICAL-c399t-fe84cae0d5dca7fc778be6dea5d0d624ebe7f655b6d93112f62a7a644037f8af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26905799$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Rubert, J.</creatorcontrib><creatorcontrib>Soler, C.</creatorcontrib><creatorcontrib>Marín, R.</creatorcontrib><creatorcontrib>James, K.J.</creatorcontrib><creatorcontrib>Mañes, J.</creatorcontrib><title>Mass spectrometry strategies for mycotoxins analysis in European beers</title><title>Food control</title><description>In this work, an existent solid-phase extraction (SPE) procedure was used to study the occurrence of mycotoxins in different European beers. HPLC-QqQ-MS/MS and ultra high resolution mass analyser have been optimized for the analysis of 18 mycotoxins: the methods were validated according to the EU Commission Decision 2002/657/EC guidelines. In this sense, matrix-matched calibration was performed for each type of beer, obtaining an effective quantification. The recoveries ranged from 63 to 91% and repeatability and reproducibility expressed as relative standard deviation (RSD%) were lower than 17%. On one hand, HPLC-LTQ-Orbitrap® was used for unambiguous identification of target mycotoxins, as well as for screening non-target mycotoxins, such as enniatins, fusaproliferin and deoxynivalenol-3-glucoside. On the other hand, the quantification was carried out using HPLC-QqQ-MS/MS instrument. At the end, Ochratoxin A, fumonisins, HT-2 and T-2 toxins were detected and quantified in European beers. Moreover, pale lager beer showed higher mycotoxin incidence than the other studied beers.
► SPE-HPLC-MS/MS method was applied to quantify 18 mycotoxins in beer. ► The applicability of Orbitrap showed an excellent mass accuracy and confirmation. ► The first monitoring in beer using HPLC-MS/MS and HPLC-LTQ-Orbitrap®. ► HT-2, T-2, FB1, FB2 and OTA were detected in European beer samples.</description><subject>Beer</subject><subject>Beers</subject><subject>Biological and medical sciences</subject><subject>deoxynivalenol-3-glucoside</subject><subject>European Union</subject><subject>Fermented food industries</subject><subject>Food industries</subject><subject>Food toxicology</subject><subject>fumonisins</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>guidelines</subject><subject>mass spectrometry</subject><subject>Mycotoxins</subject><subject>ochratoxin A</subject><subject>Orbitrap</subject><subject>screening</subject><subject>solid phase extraction</subject><subject>SPE</subject><subject>Triple quadrupole</subject><issn>0956-7135</issn><issn>1873-7129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkMFuEzEQhi0EEqH0FWAvSFyyjHfX9voGqtqCVMSB9mxN7HHlaLMOng0ib4-jtFw5zRy-_5_RJ8Q7Ca0EqT9t25hz8Hle2g5k14JuoVcvxEqOpl8b2dmXYgVW6br36rV4w7wFkAYkrMTNd2RueE9-KXlHSzk2vBRc6DERNzGXZnf0ecl_0swNzjgdOXGT5ub6UPKecG42RIXfilcRJ6bLp3khHm6u76--ru9-3H67-nK39r21yzrSOHgkCCp4NNEbM25IB0IVIOhuoA2ZqJXa6GB7KbuoOzSohwF6E0eM_YX4eO7dl_zrQLy4XWJP04Qz5QM7qdWg9WBHXVF9Rn3JzIWi25e0w3J0EtxJnNu6Z3HuJM6BdlVcDX54uoHscYoFZ5_4X7rTFpSxtnLvz1zE7PCxVObhZy1SAKCHEU5Nn88EVSW_ExXHPtHsKaRShbuQ0_-e-Qt5RJKA</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Rubert, J.</creator><creator>Soler, C.</creator><creator>Marín, R.</creator><creator>James, K.J.</creator><creator>Mañes, J.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20130301</creationdate><title>Mass spectrometry strategies for mycotoxins analysis in European beers</title><author>Rubert, J. ; Soler, C. ; Marín, R. ; James, K.J. ; Mañes, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-fe84cae0d5dca7fc778be6dea5d0d624ebe7f655b6d93112f62a7a644037f8af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Beer</topic><topic>Beers</topic><topic>Biological and medical sciences</topic><topic>deoxynivalenol-3-glucoside</topic><topic>European Union</topic><topic>Fermented food industries</topic><topic>Food industries</topic><topic>Food toxicology</topic><topic>fumonisins</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>guidelines</topic><topic>mass spectrometry</topic><topic>Mycotoxins</topic><topic>ochratoxin A</topic><topic>Orbitrap</topic><topic>screening</topic><topic>solid phase extraction</topic><topic>SPE</topic><topic>Triple quadrupole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rubert, J.</creatorcontrib><creatorcontrib>Soler, C.</creatorcontrib><creatorcontrib>Marín, R.</creatorcontrib><creatorcontrib>James, K.J.</creatorcontrib><creatorcontrib>Mañes, J.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rubert, J.</au><au>Soler, C.</au><au>Marín, R.</au><au>James, K.J.</au><au>Mañes, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mass spectrometry strategies for mycotoxins analysis in European beers</atitle><jtitle>Food control</jtitle><date>2013-03-01</date><risdate>2013</risdate><volume>30</volume><issue>1</issue><spage>122</spage><epage>128</epage><pages>122-128</pages><issn>0956-7135</issn><eissn>1873-7129</eissn><notes>http://dx.doi.org/10.1016/j.foodcont.2012.06.035</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>In this work, an existent solid-phase extraction (SPE) procedure was used to study the occurrence of mycotoxins in different European beers. HPLC-QqQ-MS/MS and ultra high resolution mass analyser have been optimized for the analysis of 18 mycotoxins: the methods were validated according to the EU Commission Decision 2002/657/EC guidelines. In this sense, matrix-matched calibration was performed for each type of beer, obtaining an effective quantification. The recoveries ranged from 63 to 91% and repeatability and reproducibility expressed as relative standard deviation (RSD%) were lower than 17%. On one hand, HPLC-LTQ-Orbitrap® was used for unambiguous identification of target mycotoxins, as well as for screening non-target mycotoxins, such as enniatins, fusaproliferin and deoxynivalenol-3-glucoside. On the other hand, the quantification was carried out using HPLC-QqQ-MS/MS instrument. At the end, Ochratoxin A, fumonisins, HT-2 and T-2 toxins were detected and quantified in European beers. Moreover, pale lager beer showed higher mycotoxin incidence than the other studied beers.
► SPE-HPLC-MS/MS method was applied to quantify 18 mycotoxins in beer. ► The applicability of Orbitrap showed an excellent mass accuracy and confirmation. ► The first monitoring in beer using HPLC-MS/MS and HPLC-LTQ-Orbitrap®. ► HT-2, T-2, FB1, FB2 and OTA were detected in European beer samples.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.foodcont.2012.06.035</doi><tpages>7</tpages></addata></record> |
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| ispartof | Food control, 2013-03, Vol.30 (1), p.122-128 |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Beer Beers Biological and medical sciences deoxynivalenol-3-glucoside European Union Fermented food industries Food industries Food toxicology fumonisins Fundamental and applied biological sciences. Psychology guidelines mass spectrometry Mycotoxins ochratoxin A Orbitrap screening solid phase extraction SPE Triple quadrupole |
| title | Mass spectrometry strategies for mycotoxins analysis in European beers |
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