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Total extract of Yupingfeng attenuates bleomycin-induced pulmonary fibrosis in rats
Yupingfeng is a Chinese herbal compound used efficaciously to treat respiratory tract diseases. Total glucosides of Yupingfeng have been proven effective in anti-inflammation and immunoregulation. Nevertheless, the role of total extract of Yupingfeng (YTE) in pulmonary fibrosis (PF), a severe lung d...
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| Published in: | Phytomedicine (Stuttgart) 2015-01, Vol.22 (1), p.111-119 |
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| creator | Li, Liucheng Li, Delin Xu, Liang Zhao, Ping Deng, Ziyu Mo, Xiaoting Li, Ping Qi, Lianwen Li, Jun Gao, Jian |
| description | Yupingfeng is a Chinese herbal compound used efficaciously to treat respiratory tract diseases. Total glucosides of Yupingfeng have been proven effective in anti-inflammation and immunoregulation. Nevertheless, the role of total extract of Yupingfeng (YTE) in pulmonary fibrosis (PF), a severe lung disease with no substantial therapies, remains unknown. Present study was conducted to elucidate the anti-fibrotic activity of YTE. The rat PF model was induced by intratracheal administration of bleomycin (BLM, 5 mg/kg), and YTE (12 mg/kg/d) was gavaged from the second day. At 14 and 28 days, the lungs were harvested and stained with H&E and Masson's trichrome. The content of hydroxyproline (HYP) and type I collagen (Col-I) were detected, while the protein expression of high-mobility group box 1 (HMGB1), transforming growth factor-beta 1 (TGF-β1), Col-I and α-smooth muscle actin (α-SMA) were analyzed by immunohistochemistry or Western blot. As observed, YTE treatment attenuated the alveolitis and fibrosis induced by BLM, reduced the loss of body weight and increase of lung coefficient. Meanwhile, YTE strongly decreased the levels of HYP and Col-I, and reduced the over-expression of HMGB1, TGF-β1, Col-I and α-SMA. In conclusion, YTE could ameliorate BLM-induced lung fibrosis by alleviating HMGB1 activity and TGF-β1 activation, suggesting therapeutic potential for PF.
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| doi_str_mv | 10.1016/j.phymed.2014.10.011 |
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[Display omitted]</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2014.10.011</identifier><identifier>PMID: 25636879</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Actins - metabolism ; Animals ; Astragalus membranaceus ; Bleomycin ; Bleomycin - pharmacology ; Care and treatment ; Collagen Type I - metabolism ; Complications and side effects ; Disease Models, Animal ; Drugs, Chinese Herbal ; Female ; High-mobility group box 1 ; HMGB1 Protein - metabolism ; Hydroxyproline - metabolism ; Lung - drug effects ; Lung - pathology ; Medicine, Chinese ; Pulmonary fibrosis ; Pulmonary Fibrosis - chemically induced ; Pulmonary Fibrosis - drug therapy ; Rats, Sprague-Dawley ; Total extract of Yupingfeng ; Transforming Growth Factor beta1 - metabolism ; Transforming growth factor-beta 1</subject><ispartof>Phytomedicine (Stuttgart), 2015-01, Vol.22 (1), p.111-119</ispartof><rights>2014 Elsevier GmbH</rights><rights>Copyright © 2014 Elsevier GmbH. All rights reserved.</rights><rights>COPYRIGHT 2015 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-bd1f15b5a6e0076b099eaa567b549369d0b4946624b01dfe4d2269a88ee909113</citedby><cites>FETCH-LOGICAL-c533t-bd1f15b5a6e0076b099eaa567b549369d0b4946624b01dfe4d2269a88ee909113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25636879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Liucheng</creatorcontrib><creatorcontrib>Li, Delin</creatorcontrib><creatorcontrib>Xu, Liang</creatorcontrib><creatorcontrib>Zhao, Ping</creatorcontrib><creatorcontrib>Deng, Ziyu</creatorcontrib><creatorcontrib>Mo, Xiaoting</creatorcontrib><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Qi, Lianwen</creatorcontrib><creatorcontrib>Li, Jun</creatorcontrib><creatorcontrib>Gao, Jian</creatorcontrib><title>Total extract of Yupingfeng attenuates bleomycin-induced pulmonary fibrosis in rats</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>Yupingfeng is a Chinese herbal compound used efficaciously to treat respiratory tract diseases. Total glucosides of Yupingfeng have been proven effective in anti-inflammation and immunoregulation. Nevertheless, the role of total extract of Yupingfeng (YTE) in pulmonary fibrosis (PF), a severe lung disease with no substantial therapies, remains unknown. Present study was conducted to elucidate the anti-fibrotic activity of YTE. The rat PF model was induced by intratracheal administration of bleomycin (BLM, 5 mg/kg), and YTE (12 mg/kg/d) was gavaged from the second day. At 14 and 28 days, the lungs were harvested and stained with H&E and Masson's trichrome. The content of hydroxyproline (HYP) and type I collagen (Col-I) were detected, while the protein expression of high-mobility group box 1 (HMGB1), transforming growth factor-beta 1 (TGF-β1), Col-I and α-smooth muscle actin (α-SMA) were analyzed by immunohistochemistry or Western blot. As observed, YTE treatment attenuated the alveolitis and fibrosis induced by BLM, reduced the loss of body weight and increase of lung coefficient. Meanwhile, YTE strongly decreased the levels of HYP and Col-I, and reduced the over-expression of HMGB1, TGF-β1, Col-I and α-SMA. In conclusion, YTE could ameliorate BLM-induced lung fibrosis by alleviating HMGB1 activity and TGF-β1 activation, suggesting therapeutic potential for PF.
[Display omitted]</description><subject>Actins - metabolism</subject><subject>Animals</subject><subject>Astragalus membranaceus</subject><subject>Bleomycin</subject><subject>Bleomycin - pharmacology</subject><subject>Care and treatment</subject><subject>Collagen Type I - metabolism</subject><subject>Complications and side effects</subject><subject>Disease Models, Animal</subject><subject>Drugs, Chinese Herbal</subject><subject>Female</subject><subject>High-mobility group box 1</subject><subject>HMGB1 Protein - metabolism</subject><subject>Hydroxyproline - metabolism</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Medicine, Chinese</subject><subject>Pulmonary fibrosis</subject><subject>Pulmonary Fibrosis - chemically induced</subject><subject>Pulmonary Fibrosis - drug therapy</subject><subject>Rats, Sprague-Dawley</subject><subject>Total extract of Yupingfeng</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><subject>Transforming growth factor-beta 1</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kU-L1TAUxYMoznP0G4gE3LhpTdo0fdkIwzD-gQEXjqCrkDQ3zzzapCap-L69qZ1ZCA_JInDzOzeccxB6SUlNCeVvj_X84zSBqRtCWRnVhNJHaEc53VdEdN8eox0RjFU9pe0FepbSkRRQ9OQpumg63vJ9L3boy13IasTwO0c1ZBws_r7Mzh8s-ANWOYNfVIaE9QhhOg3OV86bZQCD52WcglfxhK3TMSSXsPM4qpyeoydWjQle3N-X6Ov7m7vrj9Xt5w-frq9uq6Fr21xpQy3tdKc4ENJzTYQApTre646JlgtDNBOM84ZpQo0FZpqGC7XfAwgiiqtL9GbbO8fwc4GU5eTSAOOoPIQlScq7hlFB2r6grzf0oEaQztuw-l1xecUIY4z3bF1YnaEO4CGqMXiwroz_4eszfDkGJjecFbBNMJTAUgQr5-imkqGkRK6tyqPcWpVrq-uU_DX66t7oote3B9FDjQV4twFQ4v7lIMo0OPClJhdhyNIE9_8f_gCGDbOK</recordid><startdate>20150115</startdate><enddate>20150115</enddate><creator>Li, Liucheng</creator><creator>Li, Delin</creator><creator>Xu, Liang</creator><creator>Zhao, Ping</creator><creator>Deng, Ziyu</creator><creator>Mo, Xiaoting</creator><creator>Li, Ping</creator><creator>Qi, Lianwen</creator><creator>Li, Jun</creator><creator>Gao, Jian</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150115</creationdate><title>Total extract of Yupingfeng attenuates bleomycin-induced pulmonary fibrosis in rats</title><author>Li, Liucheng ; Li, Delin ; Xu, Liang ; Zhao, Ping ; Deng, Ziyu ; Mo, Xiaoting ; Li, Ping ; Qi, Lianwen ; Li, Jun ; Gao, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-bd1f15b5a6e0076b099eaa567b549369d0b4946624b01dfe4d2269a88ee909113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Actins - metabolism</topic><topic>Animals</topic><topic>Astragalus membranaceus</topic><topic>Bleomycin</topic><topic>Bleomycin - pharmacology</topic><topic>Care and treatment</topic><topic>Collagen Type I - metabolism</topic><topic>Complications and side effects</topic><topic>Disease Models, Animal</topic><topic>Drugs, Chinese Herbal</topic><topic>Female</topic><topic>High-mobility group box 1</topic><topic>HMGB1 Protein - metabolism</topic><topic>Hydroxyproline - metabolism</topic><topic>Lung - drug effects</topic><topic>Lung - pathology</topic><topic>Medicine, Chinese</topic><topic>Pulmonary fibrosis</topic><topic>Pulmonary Fibrosis - chemically induced</topic><topic>Pulmonary Fibrosis - drug therapy</topic><topic>Rats, Sprague-Dawley</topic><topic>Total extract of Yupingfeng</topic><topic>Transforming Growth Factor beta1 - metabolism</topic><topic>Transforming growth factor-beta 1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Liucheng</creatorcontrib><creatorcontrib>Li, Delin</creatorcontrib><creatorcontrib>Xu, Liang</creatorcontrib><creatorcontrib>Zhao, Ping</creatorcontrib><creatorcontrib>Deng, Ziyu</creatorcontrib><creatorcontrib>Mo, Xiaoting</creatorcontrib><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Qi, Lianwen</creatorcontrib><creatorcontrib>Li, Jun</creatorcontrib><creatorcontrib>Gao, Jian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Liucheng</au><au>Li, Delin</au><au>Xu, Liang</au><au>Zhao, Ping</au><au>Deng, Ziyu</au><au>Mo, Xiaoting</au><au>Li, Ping</au><au>Qi, Lianwen</au><au>Li, Jun</au><au>Gao, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Total extract of Yupingfeng attenuates bleomycin-induced pulmonary fibrosis in rats</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2015-01-15</date><risdate>2015</risdate><volume>22</volume><issue>1</issue><spage>111</spage><epage>119</epage><pages>111-119</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Yupingfeng is a Chinese herbal compound used efficaciously to treat respiratory tract diseases. Total glucosides of Yupingfeng have been proven effective in anti-inflammation and immunoregulation. Nevertheless, the role of total extract of Yupingfeng (YTE) in pulmonary fibrosis (PF), a severe lung disease with no substantial therapies, remains unknown. Present study was conducted to elucidate the anti-fibrotic activity of YTE. The rat PF model was induced by intratracheal administration of bleomycin (BLM, 5 mg/kg), and YTE (12 mg/kg/d) was gavaged from the second day. At 14 and 28 days, the lungs were harvested and stained with H&E and Masson's trichrome. The content of hydroxyproline (HYP) and type I collagen (Col-I) were detected, while the protein expression of high-mobility group box 1 (HMGB1), transforming growth factor-beta 1 (TGF-β1), Col-I and α-smooth muscle actin (α-SMA) were analyzed by immunohistochemistry or Western blot. As observed, YTE treatment attenuated the alveolitis and fibrosis induced by BLM, reduced the loss of body weight and increase of lung coefficient. Meanwhile, YTE strongly decreased the levels of HYP and Col-I, and reduced the over-expression of HMGB1, TGF-β1, Col-I and α-SMA. In conclusion, YTE could ameliorate BLM-induced lung fibrosis by alleviating HMGB1 activity and TGF-β1 activation, suggesting therapeutic potential for PF.
[Display omitted]</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>25636879</pmid><doi>10.1016/j.phymed.2014.10.011</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0944-7113 |
| ispartof | Phytomedicine (Stuttgart), 2015-01, Vol.22 (1), p.111-119 |
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| subjects | Actins - metabolism Animals Astragalus membranaceus Bleomycin Bleomycin - pharmacology Care and treatment Collagen Type I - metabolism Complications and side effects Disease Models, Animal Drugs, Chinese Herbal Female High-mobility group box 1 HMGB1 Protein - metabolism Hydroxyproline - metabolism Lung - drug effects Lung - pathology Medicine, Chinese Pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - drug therapy Rats, Sprague-Dawley Total extract of Yupingfeng Transforming Growth Factor beta1 - metabolism Transforming growth factor-beta 1 |
| title | Total extract of Yupingfeng attenuates bleomycin-induced pulmonary fibrosis in rats |
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