Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk?

Objective To study the cardiometabolic profile characteristics and compare the prevalence of cardiovascular (CV) risk factors between women with different polycystic ovary syndrome (PCOS) phenotypes. Design A cross-sectional multicenter study analyzing 2,288 well phenotyped women with PCOS. Setting...

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Published in:Fertility and sterility 2014-11, Vol.102 (5), p.1444-1451.e3
Main Authors: Daan, Nadine M.P., M.D, Louwers, Yvonne V., M.D., Ph.D, Koster, Maria P.H., M.D., Ph.D, Eijkemans, Marinus J.C., Ph.D, de Rijke, Yolanda B., Ph.D, Lentjes, Eef W.G., Ph.D, Fauser, Bart C.J.M., M.D., Ph.D, Laven, Joop S.E., M.D., Ph.D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Cardiovascular Diseases - epidemiology
cardiovascular risk
Comorbidity
Cross-Sectional Studies
Female
Humans
Incidence
Internal Medicine
Metabolic Diseases - epidemiology
Middle Aged
Netherlands - epidemiology
Obesity - epidemiology
Obstetrics and Gynecology
Phenotype
Polycystic ovary syndrome
Polycystic Ovary Syndrome - epidemiology
Risk Factors
Young Adult
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cited_by cdi_FETCH-LOGICAL-c545t-f32f34c7775d34ceb85d124929ae24ebc2d134a278473715d53149a9e53dec543
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container_title Fertility and sterility
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creator Daan, Nadine M.P., M.D
Louwers, Yvonne V., M.D., Ph.D
Koster, Maria P.H., M.D., Ph.D
Eijkemans, Marinus J.C., Ph.D
de Rijke, Yolanda B., Ph.D
Lentjes, Eef W.G., Ph.D
Fauser, Bart C.J.M., M.D., Ph.D
Laven, Joop S.E., M.D., Ph.D
description Objective To study the cardiometabolic profile characteristics and compare the prevalence of cardiovascular (CV) risk factors between women with different polycystic ovary syndrome (PCOS) phenotypes. Design A cross-sectional multicenter study analyzing 2,288 well phenotyped women with PCOS. Setting Specialized reproductive outpatient clinic. Patient(s) Women of reproductive age (18–45 years) diagnosed with PCOS. Intervention(s) Women suspected of oligo- or anovulation underwent a standardized screening consisting of a systematic medical and reproductive history taking, anthropometric measurements, and transvaginal ultrasonography followed by an extensive endocrinologic/metabolic evaluation. Main Outcome Measure(s) Differences in cardiometabolic profile characteristics and CV risk factor prevalence between women with different PCOS phenotypes, i.e., obesity/overweight, hypertension, insulin resistance, dyslipidemia, and metabolic syndrome. Result(s) Women with hyperandrogenic PCOS (n = 1,219; 53.3% of total) presented with a worse cardiometabolic profile and a higher prevalence of CV risk factors, such as obesity and overweight, insulin resistance, and metabolic syndrome, compared with women with nonhyperandrogenic PCOS. In women with nonhyperandrogenic PCOS overweight/obesity (28.5%) and dyslipidemia (low-density lipoprotein cholesterol ≥3.0 mmol/L; 52.2%) were highly prevalent. Conclusion(s) Women with hyperandrogenic PCOS have a worse cardiometabolic profile and higher prevalence of CV risk factors compared with women with nonhyperandrogenic PCOS. However, all women with PCOS should be screened for the presence of CV risk factors, since the frequently found derangements at a young age imply an elevated risk for the development of CV disease later in life.
doi_str_mv 10.1016/j.fertnstert.2014.08.001
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Design A cross-sectional multicenter study analyzing 2,288 well phenotyped women with PCOS. Setting Specialized reproductive outpatient clinic. Patient(s) Women of reproductive age (18–45 years) diagnosed with PCOS. Intervention(s) Women suspected of oligo- or anovulation underwent a standardized screening consisting of a systematic medical and reproductive history taking, anthropometric measurements, and transvaginal ultrasonography followed by an extensive endocrinologic/metabolic evaluation. Main Outcome Measure(s) Differences in cardiometabolic profile characteristics and CV risk factor prevalence between women with different PCOS phenotypes, i.e., obesity/overweight, hypertension, insulin resistance, dyslipidemia, and metabolic syndrome. Result(s) Women with hyperandrogenic PCOS (n = 1,219; 53.3% of total) presented with a worse cardiometabolic profile and a higher prevalence of CV risk factors, such as obesity and overweight, insulin resistance, and metabolic syndrome, compared with women with nonhyperandrogenic PCOS. In women with nonhyperandrogenic PCOS overweight/obesity (28.5%) and dyslipidemia (low-density lipoprotein cholesterol ≥3.0 mmol/L; 52.2%) were highly prevalent. Conclusion(s) Women with hyperandrogenic PCOS have a worse cardiometabolic profile and higher prevalence of CV risk factors compared with women with nonhyperandrogenic PCOS. 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Design A cross-sectional multicenter study analyzing 2,288 well phenotyped women with PCOS. Setting Specialized reproductive outpatient clinic. Patient(s) Women of reproductive age (18–45 years) diagnosed with PCOS. Intervention(s) Women suspected of oligo- or anovulation underwent a standardized screening consisting of a systematic medical and reproductive history taking, anthropometric measurements, and transvaginal ultrasonography followed by an extensive endocrinologic/metabolic evaluation. Main Outcome Measure(s) Differences in cardiometabolic profile characteristics and CV risk factor prevalence between women with different PCOS phenotypes, i.e., obesity/overweight, hypertension, insulin resistance, dyslipidemia, and metabolic syndrome. Result(s) Women with hyperandrogenic PCOS (n = 1,219; 53.3% of total) presented with a worse cardiometabolic profile and a higher prevalence of CV risk factors, such as obesity and overweight, insulin resistance, and metabolic syndrome, compared with women with nonhyperandrogenic PCOS. In women with nonhyperandrogenic PCOS overweight/obesity (28.5%) and dyslipidemia (low-density lipoprotein cholesterol ≥3.0 mmol/L; 52.2%) were highly prevalent. Conclusion(s) Women with hyperandrogenic PCOS have a worse cardiometabolic profile and higher prevalence of CV risk factors compared with women with nonhyperandrogenic PCOS. 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Louwers, Yvonne V., M.D., Ph.D ; Koster, Maria P.H., M.D., Ph.D ; Eijkemans, Marinus J.C., Ph.D ; de Rijke, Yolanda B., Ph.D ; Lentjes, Eef W.G., Ph.D ; Fauser, Bart C.J.M., M.D., Ph.D ; Laven, Joop S.E., M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-f32f34c7775d34ceb85d124929ae24ebc2d134a278473715d53149a9e53dec543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>cardiovascular risk</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Metabolic Diseases - epidemiology</topic><topic>Middle Aged</topic><topic>Netherlands - epidemiology</topic><topic>Obesity - epidemiology</topic><topic>Obstetrics and Gynecology</topic><topic>Phenotype</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - epidemiology</topic><topic>Risk Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daan, Nadine M.P., M.D</creatorcontrib><creatorcontrib>Louwers, Yvonne V., M.D., Ph.D</creatorcontrib><creatorcontrib>Koster, Maria P.H., M.D., Ph.D</creatorcontrib><creatorcontrib>Eijkemans, Marinus J.C., Ph.D</creatorcontrib><creatorcontrib>de Rijke, Yolanda B., Ph.D</creatorcontrib><creatorcontrib>Lentjes, Eef W.G., Ph.D</creatorcontrib><creatorcontrib>Fauser, Bart C.J.M., M.D., Ph.D</creatorcontrib><creatorcontrib>Laven, Joop S.E., M.D., Ph.D</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daan, Nadine M.P., M.D</au><au>Louwers, Yvonne V., M.D., Ph.D</au><au>Koster, Maria P.H., M.D., Ph.D</au><au>Eijkemans, Marinus J.C., Ph.D</au><au>de Rijke, Yolanda B., Ph.D</au><au>Lentjes, Eef W.G., Ph.D</au><au>Fauser, Bart C.J.M., M.D., Ph.D</au><au>Laven, Joop S.E., M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk?</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>102</volume><issue>5</issue><spage>1444</spage><epage>1451.e3</epage><pages>1444-1451.e3</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Objective To study the cardiometabolic profile characteristics and compare the prevalence of cardiovascular (CV) risk factors between women with different polycystic ovary syndrome (PCOS) phenotypes. Design A cross-sectional multicenter study analyzing 2,288 well phenotyped women with PCOS. Setting Specialized reproductive outpatient clinic. Patient(s) Women of reproductive age (18–45 years) diagnosed with PCOS. Intervention(s) Women suspected of oligo- or anovulation underwent a standardized screening consisting of a systematic medical and reproductive history taking, anthropometric measurements, and transvaginal ultrasonography followed by an extensive endocrinologic/metabolic evaluation. Main Outcome Measure(s) Differences in cardiometabolic profile characteristics and CV risk factor prevalence between women with different PCOS phenotypes, i.e., obesity/overweight, hypertension, insulin resistance, dyslipidemia, and metabolic syndrome. Result(s) Women with hyperandrogenic PCOS (n = 1,219; 53.3% of total) presented with a worse cardiometabolic profile and a higher prevalence of CV risk factors, such as obesity and overweight, insulin resistance, and metabolic syndrome, compared with women with nonhyperandrogenic PCOS. In women with nonhyperandrogenic PCOS overweight/obesity (28.5%) and dyslipidemia (low-density lipoprotein cholesterol ≥3.0 mmol/L; 52.2%) were highly prevalent. Conclusion(s) Women with hyperandrogenic PCOS have a worse cardiometabolic profile and higher prevalence of CV risk factors compared with women with nonhyperandrogenic PCOS. However, all women with PCOS should be screened for the presence of CV risk factors, since the frequently found derangements at a young age imply an elevated risk for the development of CV disease later in life.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25239303</pmid><doi>10.1016/j.fertnstert.2014.08.001</doi><oa>free_for_read</oa></addata></record>
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subjects Adolescent
Adult
Cardiovascular Diseases - epidemiology
cardiovascular risk
Comorbidity
Cross-Sectional Studies
Female
Humans
Incidence
Internal Medicine
Metabolic Diseases - epidemiology
Middle Aged
Netherlands - epidemiology
Obesity - epidemiology
Obstetrics and Gynecology
Phenotype
Polycystic ovary syndrome
Polycystic Ovary Syndrome - epidemiology
Risk Factors
Young Adult
title Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk?
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