Pulmonary function and CT biomarkers as risk factors for cardiovascular events in male lung cancer screening participants: the NELSON study

Objective The objective of this study was to investigate the association of spirometry and pulmonary CT biomarkers with cardiovascular events. Methods In this lung cancer screening trial 3,080 male participants without a prior cardiovascular event were analysed. Fatal and non-fatal cardiovascular ev...

Full description

Saved in:
Bibliographic Details
Published in:European radiology 2015-01, Vol.25 (1), p.65-71
Main Authors: Takx, Richard A. P., Vliegenthart, Rozemarijn, Hoesein, Firdaus A. A. Mohamed, Išgum, Ivana, de Koning, Harry J., Mali, Willem P. Th. M., van der Aalst, Carlijn M., Zanen, Pieter, Lammers, Jan-Willem J., Groen, Harry J. M., van Rikxoort, Eva M., Schmidt, Michael, van Ginneken, Bram, Oudkerk, Matthijs, Leiner, Tim, de Jong, Pim A.
Format: Article
Language:English
Subjects:
Belgium - epidemiology
Biomarkers
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Chest
Chronic obstructive pulmonary disease
Coronary vessels
Diagnostic Radiology
Early Detection of Cancer
Emphysema
Forced Expiratory Volume
Humans
Imaging
Imaging, Three-Dimensional
Incidence
Internal Medicine
Interventional Radiology
Lung cancer
Lung Neoplasms - complications
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - physiopathology
Male
Mass Screening
Medical screening
Medicine
Medicine & Public Health
Middle Aged
Netherlands - epidemiology
Neuroradiology
Prognosis
Pulmonology
Radiology
Risk Factors
Smoking
Spirometry
Tomography
Tomography, X-Ray Computed - methods
Ultrasound
Veins & arteries
Vital Capacity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective The objective of this study was to investigate the association of spirometry and pulmonary CT biomarkers with cardiovascular events. Methods In this lung cancer screening trial 3,080 male participants without a prior cardiovascular event were analysed. Fatal and non-fatal cardiovascular events were included. Spirometry included forced expiratory volume measured in units of one-second percent predicted (FEV 1 %predicted) and FEV 1 divided by forced vital capacity (FVC; FEV 1 /FVC). CT examinations were quantified for coronary artery calcium volume, pulmonary emphysema (perc15) and bronchial wall thickness (pi10). Data were analysed via a Cox proportional hazard analysis, net reclassification improvement (NRI) and C-indices. Results 184 participants experienced a cardiovascular event during a median follow-up of 2.9 years. Age, pack-years and smoking status adjusted hazard ratios were 0.992 (95 % confidence interval (CI) 0.985-0.999) for FEV 1 %predicted, 1.000 (95%CI 0.986-1.015) for FEV 1 /FVC, 1.014 (95%CI 1.005-1.023) for perc15 per 10 HU, and 1.269 (95%CI 1.024-1.573) for pi10 per 1 mm. The incremental C-index (
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-014-3384-6