Papain-induced experimental pulmonary emphysema in male and female mice

Highlights • Papain-induced lung injury disclosed male and female differences in BALB/c mice. • Treated mice showed lung mechanical harm, oxidative stress, larger alveoli and FRC. • Treated mice had more inflammatory cells and reduced collagen and elastic fibers. • Treated males showed larger lung m...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2014-08, Vol.200, p.90-96
Main Authors: Machado, Mariana Nascimento, Figueirôa, Silviane Fernandes da Silva, Mazzoli-Rocha, Flavia, Valença, Samuel dos Santos, Zin, Walter Araújo
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Elastance
Female
Histology
Lung - pathology
Lung - physiopathology
Lung mechanics
Male
Medical Education
Mice, Inbred BALB C
Oxidative stress
Oxidative Stress - physiology
Papain
Pulmonary emphysema
Pulmonary Emphysema - pathology
Pulmonary Emphysema - physiopathology
Pulmonary/Respiratory
Random Allocation
Respiratory Mechanics - physiology
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Summary:Highlights • Papain-induced lung injury disclosed male and female differences in BALB/c mice. • Treated mice showed lung mechanical harm, oxidative stress, larger alveoli and FRC. • Treated mice had more inflammatory cells and reduced collagen and elastic fibers. • Treated males showed larger lung mechanical harm and FRC than females. • Treated females were more susceptible to oxidative stress than males.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2014.06.005