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Cell Phone Use and Parotid Salivary Gland Alterations: No Molecular Evidence
The association between cell phone use and the development of parotid tumors is controversial. Because there is unequivocal evidence that the microenvironment is important for tumor formation, we investigated in the parotid glands whether cell phone use alters the expression of gene products related...
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Published in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2014-07, Vol.23 (7), p.1428-1431 |
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creator | DE SOUZA, Fabrício T. A CORREIA-SILVA, Jeane F FERREIRA, Efigênia F SIQUEIRA, Elisa C DUARTE, Alessandra P GOMEZ, Marcus Vinícius GOMEZ, Ricardo S GOMES, Carolina C |
description | The association between cell phone use and the development of parotid tumors is controversial. Because there is unequivocal evidence that the microenvironment is important for tumor formation, we investigated in the parotid glands whether cell phone use alters the expression of gene products related to cellular stress.
We used the saliva produced by the parotid glands of 62 individuals to assess molecular alterations compatible with cellular stress, comparing the saliva from the gland exposed to cell phone radiation (ipsilateral) to the saliva from the opposite, unexposed parotid gland (contralateral) of each individual. We compared salivary flow, total protein concentration, p53, p21, reactive oxygen species (ROS), and salivary levels of glutathione (GSH), heat shock proteins 27 and 70, and IgA between the ipsilateral and contralateral parotids.
No difference was found for any of these parameters, even when grouping individuals by period of cell phone use in years or by monthly average calls in minutes.
We provide molecular evidence that the exposure of parotid glands to cell phone use does not alter parotid salivary flow, protein concentration, or levels of proteins of genes that are directly or indirectly affected by heat-induced cellular stress. |
doi_str_mv | 10.1158/1055-9965.EPI-13-1357 |
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We used the saliva produced by the parotid glands of 62 individuals to assess molecular alterations compatible with cellular stress, comparing the saliva from the gland exposed to cell phone radiation (ipsilateral) to the saliva from the opposite, unexposed parotid gland (contralateral) of each individual. We compared salivary flow, total protein concentration, p53, p21, reactive oxygen species (ROS), and salivary levels of glutathione (GSH), heat shock proteins 27 and 70, and IgA between the ipsilateral and contralateral parotids.
No difference was found for any of these parameters, even when grouping individuals by period of cell phone use in years or by monthly average calls in minutes.
We provide molecular evidence that the exposure of parotid glands to cell phone use does not alter parotid salivary flow, protein concentration, or levels of proteins of genes that are directly or indirectly affected by heat-induced cellular stress.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-13-1357</identifier><identifier>PMID: 24753545</identifier><identifier>CODEN: CEBPE4</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Biological and medical sciences ; Cell Phone ; Female ; Humans ; Male ; Medical sciences ; Parotid Gland ; Saliva ; Tumors ; Young Adult</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2014-07, Vol.23 (7), p.1428-1431</ispartof><rights>2015 INIST-CNRS</rights><rights>2014 American Association for Cancer Research.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-49e08e24b371e3fbc257aaf3633ab6488cd069236cbc8d4c581c5e7d501bb0993</citedby><cites>FETCH-LOGICAL-c339t-49e08e24b371e3fbc257aaf3633ab6488cd069236cbc8d4c581c5e7d501bb0993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28663730$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24753545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DE SOUZA, Fabrício T. A</creatorcontrib><creatorcontrib>CORREIA-SILVA, Jeane F</creatorcontrib><creatorcontrib>FERREIRA, Efigênia F</creatorcontrib><creatorcontrib>SIQUEIRA, Elisa C</creatorcontrib><creatorcontrib>DUARTE, Alessandra P</creatorcontrib><creatorcontrib>GOMEZ, Marcus Vinícius</creatorcontrib><creatorcontrib>GOMEZ, Ricardo S</creatorcontrib><creatorcontrib>GOMES, Carolina C</creatorcontrib><title>Cell Phone Use and Parotid Salivary Gland Alterations: No Molecular Evidence</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>The association between cell phone use and the development of parotid tumors is controversial. Because there is unequivocal evidence that the microenvironment is important for tumor formation, we investigated in the parotid glands whether cell phone use alters the expression of gene products related to cellular stress.
We used the saliva produced by the parotid glands of 62 individuals to assess molecular alterations compatible with cellular stress, comparing the saliva from the gland exposed to cell phone radiation (ipsilateral) to the saliva from the opposite, unexposed parotid gland (contralateral) of each individual. We compared salivary flow, total protein concentration, p53, p21, reactive oxygen species (ROS), and salivary levels of glutathione (GSH), heat shock proteins 27 and 70, and IgA between the ipsilateral and contralateral parotids.
No difference was found for any of these parameters, even when grouping individuals by period of cell phone use in years or by monthly average calls in minutes.
We provide molecular evidence that the exposure of parotid glands to cell phone use does not alter parotid salivary flow, protein concentration, or levels of proteins of genes that are directly or indirectly affected by heat-induced cellular stress.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cell Phone</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parotid Gland</subject><subject>Saliva</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpFkFFLwzAQgIMobk5_gpIXwZfOpNdrGt_GmFOYOtA9hzRNsZK1M-kG_ntbtikc3HF8d8d9hFxzNuYcs3vOECMpUxzPls8Rhy5QnJAhR8giIRBPu_rIDMhFCF-MMSERz8kgTgQCJjgki6l1ji4_m9rSVbBU1wVdat-0VUHftat22v_QuevbE9dar9uqqcMDfW3oS-Os2Trt6WxXFbY29pKcldoFe3XII7J6nH1Mn6LF2_x5OllEBkC2USIty2yc5CC4hTI3MQqtS0gBdJ4mWWYKlsoYUpObrEgMZtygFQUynudMShiRu_3ejW--tza0al0F0z2ia9tsg-KYQCwkS3iH4h41vgnB21JtfLXunlKcqV6k6iWpXpLqRCoOqhfZzd0cTmzztS3-po7mOuD2AOhgtCu9rk0V_rksTUEAg189ZHpg</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>DE SOUZA, Fabrício T. A</creator><creator>CORREIA-SILVA, Jeane F</creator><creator>FERREIRA, Efigênia F</creator><creator>SIQUEIRA, Elisa C</creator><creator>DUARTE, Alessandra P</creator><creator>GOMEZ, Marcus Vinícius</creator><creator>GOMEZ, Ricardo S</creator><creator>GOMES, Carolina C</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140701</creationdate><title>Cell Phone Use and Parotid Salivary Gland Alterations: No Molecular Evidence</title><author>DE SOUZA, Fabrício T. A ; CORREIA-SILVA, Jeane F ; FERREIRA, Efigênia F ; SIQUEIRA, Elisa C ; DUARTE, Alessandra P ; GOMEZ, Marcus Vinícius ; GOMEZ, Ricardo S ; GOMES, Carolina C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-49e08e24b371e3fbc257aaf3633ab6488cd069236cbc8d4c581c5e7d501bb0993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cell Phone</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parotid Gland</topic><topic>Saliva</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE SOUZA, Fabrício T. A</creatorcontrib><creatorcontrib>CORREIA-SILVA, Jeane F</creatorcontrib><creatorcontrib>FERREIRA, Efigênia F</creatorcontrib><creatorcontrib>SIQUEIRA, Elisa C</creatorcontrib><creatorcontrib>DUARTE, Alessandra P</creatorcontrib><creatorcontrib>GOMEZ, Marcus Vinícius</creatorcontrib><creatorcontrib>GOMEZ, Ricardo S</creatorcontrib><creatorcontrib>GOMES, Carolina C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE SOUZA, Fabrício T. A</au><au>CORREIA-SILVA, Jeane F</au><au>FERREIRA, Efigênia F</au><au>SIQUEIRA, Elisa C</au><au>DUARTE, Alessandra P</au><au>GOMEZ, Marcus Vinícius</au><au>GOMEZ, Ricardo S</au><au>GOMES, Carolina C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell Phone Use and Parotid Salivary Gland Alterations: No Molecular Evidence</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>23</volume><issue>7</issue><spage>1428</spage><epage>1431</epage><pages>1428-1431</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><coden>CEBPE4</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The association between cell phone use and the development of parotid tumors is controversial. Because there is unequivocal evidence that the microenvironment is important for tumor formation, we investigated in the parotid glands whether cell phone use alters the expression of gene products related to cellular stress.
We used the saliva produced by the parotid glands of 62 individuals to assess molecular alterations compatible with cellular stress, comparing the saliva from the gland exposed to cell phone radiation (ipsilateral) to the saliva from the opposite, unexposed parotid gland (contralateral) of each individual. We compared salivary flow, total protein concentration, p53, p21, reactive oxygen species (ROS), and salivary levels of glutathione (GSH), heat shock proteins 27 and 70, and IgA between the ipsilateral and contralateral parotids.
No difference was found for any of these parameters, even when grouping individuals by period of cell phone use in years or by monthly average calls in minutes.
We provide molecular evidence that the exposure of parotid glands to cell phone use does not alter parotid salivary flow, protein concentration, or levels of proteins of genes that are directly or indirectly affected by heat-induced cellular stress.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>24753545</pmid><doi>10.1158/1055-9965.EPI-13-1357</doi><tpages>4</tpages></addata></record> |
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subjects | Adult Biological and medical sciences Cell Phone Female Humans Male Medical sciences Parotid Gland Saliva Tumors Young Adult |
title | Cell Phone Use and Parotid Salivary Gland Alterations: No Molecular Evidence |
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