Imaging of ex vivo nonmelanoma skin cancers in the optical and terahertz spectral regions Optical and Terahertz skin cancers imaging

We tested the hypothesis that polarization sensitive optical and terahertz imaging may be combined for accurate nonmelanoma skin cancer (NMSC) delineation. Nine NMSC specimens were imaged. 513 μm and 440 nm wavelengths were used for terahertz and optical imaging, respectively. Histopathology was pro...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biophotonics 2014-05, Vol.7 (5), p.295-303
Main Authors: Joseph, Cecil S., Patel, Rakesh, Neel, Victor A., Giles, Robert H., Yaroslavsky, Anna N.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Female
Humans
Male
nonmelanoma skin cancer
optical imaging
Optical Imaging - methods
polarization
Sensitivity and Specificity
Skin Neoplasms - diagnosis
Skin Neoplasms - pathology
terahertz imaging
Terahertz Imaging - methods
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We tested the hypothesis that polarization sensitive optical and terahertz imaging may be combined for accurate nonmelanoma skin cancer (NMSC) delineation. Nine NMSC specimens were imaged. 513 μm and 440 nm wavelengths were used for terahertz and optical imaging, respectively. Histopathology was processed for evaluation. Terahertz reflectance of NMSC was quantified. Our results demonstrate that cross‐polarized terahertz images correctly identified location of the tumours, whereas cross‐polarized and polarization difference optical images accurately presented morphological features. Cross‐polarized terahertz images exhibited lower reflectivity values in cancer as compared to normal tissue. Combination of optical and terahertz imaging shows promise for intraoperative delineation of NMSC (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
ISSN:1864-063X
1864-0648
DOI:10.1002/jbio.201200111