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Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents
Natural products are rich sources of gene modulators that may be useful in prevention and treatment of cancer. Recently, nonsteroidal anti-inflammatory drug (NSAID) activated gene-1 (NAG-1) has been focused as a target of action against diverse cancers like colorectal, pancreatic, prostate, and brea...
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| Published in: | Life sciences (1973) 2014-04, Vol.100 (2), p.75-84 |
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| creator | Yang, Min Hye Kim, Jinwoong Khan, Ikhlas A. Walker, Larry A. Khan, Shabana I. |
| description | Natural products are rich sources of gene modulators that may be useful in prevention and treatment of cancer. Recently, nonsteroidal anti-inflammatory drug (NSAID) activated gene-1 (NAG-1) has been focused as a target of action against diverse cancers like colorectal, pancreatic, prostate, and breast. A variety of natural agents have been reported to play a pivotal role in regulation of NAG-1 through multiple transcriptional mechanisms. The aim of this paper is to review the NAG-1 modulators derived from natural products including plants, marine organisms, and microorganisms. Plant extracts belonging to the families of Fabaceae (Astragalus membranaceus), Ranunculaceae (Coptis chinensis), Menispermaceae (Coscinium fenestratum), Umbelliferae (Pleurospermum kamtschaticum), Lamiaceae (Marubium vulgare), and Rosaceae (Prunus serotina) increased the protein expression of NAG-1 in human colon cancer or hepatocarcinoma cells. Phytochemicals in the class of flavonoids (apigenin, quercetin, isoliquiritigenin, and 2′-hydroxyflavanone), isoflavonoids (formononetin and genistein), catechins (epigallocatechin gallate and epicatechin gallate), stilbenoids (resveratrol and pinosylvin), phenolics (6-gingerol), phloroglucinols (rottlerin and aspidin PB), terpenoids (18α-glycyrrhetinic acid, platycodin D, pseudolaric acid B, and xanthorrhizol), alkaloids (berberine, capsaicin, and indole-3-carbinol), lignans (isochaihulactone), anthraquinones (damnacanthal), and allyl sulfides (diallyl disulfide) elicited NAG-1 overexpression in various cancer cells. Pectenotoxin-2 from marine organisms and prodigiosin and anisomycin from microorganisms were also reported as NAG-1 modulators. Several transcription factors including EGR-1, p53, ATF-3, Sp1 and PPARγ were involved in natural products-induced NAG-1 transcriptional signaling pathway.
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| doi_str_mv | 10.1016/j.lfs.2014.01.075 |
| format | article |
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[Display omitted]</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2014.01.075</identifier><identifier>PMID: 24530873</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - metabolism ; Antineoplastic Agents - therapeutic use ; Astragalus ; Biological Products - therapeutic use ; Cancer ; Coptis ; Fabaceae ; Growth Differentiation Factor 15 - metabolism ; Humans ; Lamiaceae ; Marine organism ; Menispermaceae ; Microorganism ; NAG-1 transcriptional pathway ; Neoplasms - drug therapy ; Neoplasms - metabolism ; Phytochemical ; Plant extract ; Prunus serotina ; Ranunculaceae ; Rosaceae</subject><ispartof>Life sciences (1973), 2014-04, Vol.100 (2), p.75-84</ispartof><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-22edd4f6a1252a03e5156afa0203f21d2635ee7b4353ff6cf4a7b1594770f8203</citedby><cites>FETCH-LOGICAL-c452t-22edd4f6a1252a03e5156afa0203f21d2635ee7b4353ff6cf4a7b1594770f8203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24530873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Min Hye</creatorcontrib><creatorcontrib>Kim, Jinwoong</creatorcontrib><creatorcontrib>Khan, Ikhlas A.</creatorcontrib><creatorcontrib>Walker, Larry A.</creatorcontrib><creatorcontrib>Khan, Shabana I.</creatorcontrib><title>Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Natural products are rich sources of gene modulators that may be useful in prevention and treatment of cancer. Recently, nonsteroidal anti-inflammatory drug (NSAID) activated gene-1 (NAG-1) has been focused as a target of action against diverse cancers like colorectal, pancreatic, prostate, and breast. A variety of natural agents have been reported to play a pivotal role in regulation of NAG-1 through multiple transcriptional mechanisms. The aim of this paper is to review the NAG-1 modulators derived from natural products including plants, marine organisms, and microorganisms. Plant extracts belonging to the families of Fabaceae (Astragalus membranaceus), Ranunculaceae (Coptis chinensis), Menispermaceae (Coscinium fenestratum), Umbelliferae (Pleurospermum kamtschaticum), Lamiaceae (Marubium vulgare), and Rosaceae (Prunus serotina) increased the protein expression of NAG-1 in human colon cancer or hepatocarcinoma cells. Phytochemicals in the class of flavonoids (apigenin, quercetin, isoliquiritigenin, and 2′-hydroxyflavanone), isoflavonoids (formononetin and genistein), catechins (epigallocatechin gallate and epicatechin gallate), stilbenoids (resveratrol and pinosylvin), phenolics (6-gingerol), phloroglucinols (rottlerin and aspidin PB), terpenoids (18α-glycyrrhetinic acid, platycodin D, pseudolaric acid B, and xanthorrhizol), alkaloids (berberine, capsaicin, and indole-3-carbinol), lignans (isochaihulactone), anthraquinones (damnacanthal), and allyl sulfides (diallyl disulfide) elicited NAG-1 overexpression in various cancer cells. Pectenotoxin-2 from marine organisms and prodigiosin and anisomycin from microorganisms were also reported as NAG-1 modulators. Several transcription factors including EGR-1, p53, ATF-3, Sp1 and PPARγ were involved in natural products-induced NAG-1 transcriptional signaling pathway.
[Display omitted]</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - metabolism</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Astragalus</subject><subject>Biological Products - therapeutic use</subject><subject>Cancer</subject><subject>Coptis</subject><subject>Fabaceae</subject><subject>Growth Differentiation Factor 15 - metabolism</subject><subject>Humans</subject><subject>Lamiaceae</subject><subject>Marine organism</subject><subject>Menispermaceae</subject><subject>Microorganism</subject><subject>NAG-1 transcriptional pathway</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - metabolism</subject><subject>Phytochemical</subject><subject>Plant extract</subject><subject>Prunus serotina</subject><subject>Ranunculaceae</subject><subject>Rosaceae</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkT1vFDEQhi0EIpfAD6BBLkOxy4w_1hdRRREEpCg0UFs-exz5tB_B9kbKv49PF1IiqinmeR-N5mXsA0KPgMPnfT_G0gtA1QP2YPQrtsGtuehgkPiabQCE6qQAfcJOS9kDgNZGvmUnQmkJWyM3rNwuc6mUlxTcyN1cU5fmOLppcnXJjzzk9Y47X9ODqxT4Hc3UIT-_vbzu8BOflrCOB7DwmJeJz66uuXnuc1v4WrgrR6d3s6fMXcvX8o69iW4s9P55nrHf377-uvre3fy8_nF1edN5pUXthKAQVBwcCi0cSNKoBxcdCJBRYBCD1ERmp6SWMQ4-Kmd2qC-UMRC3DTpj50dvO-fPSqXaKRVP4-hmWtZiUQulAAbc_g8KRiqUBxSPqM9LKZmivc9pcvnRIthDLXZvWy32UIsFtK2Wlvn4rF93E4WXxN8eGvDlCFD7x0OibItP1H4WUiZfbVjSP_RP7u2dEQ</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Yang, Min Hye</creator><creator>Kim, Jinwoong</creator><creator>Khan, Ikhlas A.</creator><creator>Walker, Larry A.</creator><creator>Khan, Shabana I.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20140401</creationdate><title>Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents</title><author>Yang, Min Hye ; Kim, Jinwoong ; Khan, Ikhlas A. ; Walker, Larry A. ; Khan, Shabana I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-22edd4f6a1252a03e5156afa0203f21d2635ee7b4353ff6cf4a7b1594770f8203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - metabolism</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Astragalus</topic><topic>Biological Products - therapeutic use</topic><topic>Cancer</topic><topic>Coptis</topic><topic>Fabaceae</topic><topic>Growth Differentiation Factor 15 - metabolism</topic><topic>Humans</topic><topic>Lamiaceae</topic><topic>Marine organism</topic><topic>Menispermaceae</topic><topic>Microorganism</topic><topic>NAG-1 transcriptional pathway</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - metabolism</topic><topic>Phytochemical</topic><topic>Plant extract</topic><topic>Prunus serotina</topic><topic>Ranunculaceae</topic><topic>Rosaceae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Min Hye</creatorcontrib><creatorcontrib>Kim, Jinwoong</creatorcontrib><creatorcontrib>Khan, Ikhlas A.</creatorcontrib><creatorcontrib>Walker, Larry A.</creatorcontrib><creatorcontrib>Khan, Shabana I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Min Hye</au><au>Kim, Jinwoong</au><au>Khan, Ikhlas A.</au><au>Walker, Larry A.</au><au>Khan, Shabana I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>100</volume><issue>2</issue><spage>75</spage><epage>84</epage><pages>75-84</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-2</notes><notes>ObjectType-Feature-2</notes><abstract>Natural products are rich sources of gene modulators that may be useful in prevention and treatment of cancer. Recently, nonsteroidal anti-inflammatory drug (NSAID) activated gene-1 (NAG-1) has been focused as a target of action against diverse cancers like colorectal, pancreatic, prostate, and breast. A variety of natural agents have been reported to play a pivotal role in regulation of NAG-1 through multiple transcriptional mechanisms. The aim of this paper is to review the NAG-1 modulators derived from natural products including plants, marine organisms, and microorganisms. Plant extracts belonging to the families of Fabaceae (Astragalus membranaceus), Ranunculaceae (Coptis chinensis), Menispermaceae (Coscinium fenestratum), Umbelliferae (Pleurospermum kamtschaticum), Lamiaceae (Marubium vulgare), and Rosaceae (Prunus serotina) increased the protein expression of NAG-1 in human colon cancer or hepatocarcinoma cells. Phytochemicals in the class of flavonoids (apigenin, quercetin, isoliquiritigenin, and 2′-hydroxyflavanone), isoflavonoids (formononetin and genistein), catechins (epigallocatechin gallate and epicatechin gallate), stilbenoids (resveratrol and pinosylvin), phenolics (6-gingerol), phloroglucinols (rottlerin and aspidin PB), terpenoids (18α-glycyrrhetinic acid, platycodin D, pseudolaric acid B, and xanthorrhizol), alkaloids (berberine, capsaicin, and indole-3-carbinol), lignans (isochaihulactone), anthraquinones (damnacanthal), and allyl sulfides (diallyl disulfide) elicited NAG-1 overexpression in various cancer cells. Pectenotoxin-2 from marine organisms and prodigiosin and anisomycin from microorganisms were also reported as NAG-1 modulators. Several transcription factors including EGR-1, p53, ATF-3, Sp1 and PPARγ were involved in natural products-induced NAG-1 transcriptional signaling pathway.
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| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - metabolism Antineoplastic Agents - therapeutic use Astragalus Biological Products - therapeutic use Cancer Coptis Fabaceae Growth Differentiation Factor 15 - metabolism Humans Lamiaceae Marine organism Menispermaceae Microorganism NAG-1 transcriptional pathway Neoplasms - drug therapy Neoplasms - metabolism Phytochemical Plant extract Prunus serotina Ranunculaceae Rosaceae |
| title | Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents |
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