Clinical impact of lung age on postoperative complications in non–small cell lung cancer patients aged >70 y

Abstract Background Surgery for elderly patients with primary lung neoplasms has become relatively common as populations age; however, the high frequency of postoperative complications has prevented its broad application. Recently, the Japanese Respiratory Society proposed lung age (LA) as an index...

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Bibliographic Details
Published in:The Journal of surgical research 2014-05, Vol.188 (2), p.373-380
Main Authors: Ogawa, Fumihiro, MD, Miyata, Satoshi, PhD, Nakashima, Hiroyasu, MD, Matsui, Yoshio, MD, PhD, Shiomi, Kazu, MD, PhD, Iyoda, Akira, MD, PhD, Satoh, Yukitoshi, MD, PhD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age gap
Aged
Aged, 80 and over
Aging - physiology
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - surgery
Female
Humans
Japan - epidemiology
Lung - pathology
Lung - surgery
Lung age
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Male
Middle Aged
Non–small cell lung cancer
Postoperative complications
Postoperative Complications - mortality
Postoperative Complications - pathology
Prognosis
Respiratory function
Retrospective Studies
Surgery
Surgical resection
Treatment Outcome
Young Adult
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Summary:Abstract Background Surgery for elderly patients with primary lung neoplasms has become relatively common as populations age; however, the high frequency of postoperative complications has prevented its broad application. Recently, the Japanese Respiratory Society proposed lung age (LA) as an index of lung function, but reports on the association between LA and the risk factors for postoperative complications with non–small cell lung cancer (NSCLC) surgery have been limited. In this study, we analyzed the clinical applicability of LA for elderly patients with NSCLC. Materials and methods We studied 320 patients aged >70 y underwent curative resections for NSCLC. LA was calculated based on the formula provided by the Japanese Respiratory Society, which depended on the patient's preoperative respiratory function and was divided into four age gap (AG) groups between the LA and the true age (TA). The categorical data were compared among the four groups. Results The numbers of patients in groups A, B, C, and D were 80, 77, 79, and 84, respectively. For the univariate analysis, the preoperative factors for postoperative complications were gender, AG, and smoking ( P  
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2014.01.012