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Effect of hypoglycemic anti-deafness capsules in diabetic patients with deafness and toxicological assessment in rats
OBJECTIVE： Through experiment on animals and clinical trials to explore the safety and efficacy of hypoglycemic anti-deafness capsules on diabetic patients with deafness.METHODS： Total 296 patients with non-insulin dependent diabetes mellitus（NIDDM） were randomly divided into two groups. A treatment...
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| Published in: | Journal of traditional Chinese medicine 2013-10, Vol.33 (5), p.651-657 |
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| creator | Li, Ruiyu Li, Meng Guo, Kaoshan Li, Bin Hou, Jinjie Wu, Liping Liu, Xianyun |
| description | OBJECTIVE： Through experiment on animals and clinical trials to explore the safety and efficacy of hypoglycemic anti-deafness capsules on diabetic patients with deafness.METHODS： Total 296 patients with non-insulin dependent diabetes mellitus（NIDDM） were randomly divided into two groups. A treatment group of 164patients（208 ears） was treated with hypoglycemic anti-deafness capsules based onTCM syndrome differentiation. A control group of 132 patients（184ears） was treated with glibenclamide and conventional drug treatment for deafness. The following were observed： hearing, fasting plasma glucose（FPG）, 2 h postprandial plasma glucose（2hPG）, 24 h urine glucose（24hUG）, improvement of main symptoms, platelet function, and changes in superoxidedismutase（SOD） and lipid peroxide（LPO） levels. In animal studies, Kunming mice, weighing 18-22 g were used. Half of the mice were males and half were females. Wistar rats, weighing 80-120 g were used. Half of the rats were males and half were females. Male Wistar rats, weighing 200-220 g, were also used.Their acute and chronic toxicity was studied.RESULTS： The hearing improvement was 56.7% in the treatment group and 26.6% in the control group. FPG, 2hPG, and 24hUG were improved significantly（P0.05, P0.01, P0.01, respectively） in the treatment group and 2hPG and 24hUG improved significantly in the control group（P0.05,P0.05）. The improvement in 2hPG and 24hUG in the treatment group was significantly greater than that in the control group P0.01）. There was no significant difference in FPG between the two groups（P0.05）. Main symptoms in the treatment group were significantly more improved than those in the control group（P0.05, P0.01）. In the treatment group, platelet adhesion and aggregation, SOD,and LPO were all significantly improved from before treatment（P0.05, P0.01）. However, in the control group, except LOP（P0.05）, there were no significant differences from before treatment to after（P0.05）. In animal studies, no obvious acute or long-term toxicity was observed from capsule administration.CONCLUSION： Through experiment on animals and clinical trials, we can found that hypoglycemic anti-deafness capsules could decrease blood glucose and serum triglycerides of alloxan-induced diabetic rats. This herbal capsule is effective for safely treating diabetic patients with deafness. |
| doi_str_mv | 10.1016/S0254-6272(14)60037-6 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1510402624</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>47663436</cqvip_id><sourcerecordid>1510402624</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-46d6cb2d3397a3e30d3e941017069d6f75aa25f42c2811cc6cb9aa083067da903</originalsourceid><addsrcrecordid>eNo90E1PwzAMBuAcQGwMfgIo3MahkO-2RzSND2kSB-BceUnaBbVJt6SC_XuKNjhZsh9b8ovQFSV3lFB1_0aYFJliOZtTcasI4XmmTtB0bMuMlYxN0HmMn4TIQsriDE2YUIrIkk7RsKxrqxMONd7s-9C0e207pzH45DJjofY2Rqyhj0NrI3YeGwdrm0bSQ3LWp4i_XNrgfwve4BS-nQ5taJyGFkOM46Ab7e_-DlK8QKc1tNFeHusMfTwu3xfP2er16WXxsMq04EXKhDJKr5nhvMyBW04Mt6UYX86JKo2qcwnAZC2YZgWlWo-4BCAFJyo3UBI-Q_PD3X4XtoONqepc1LZtwdswxIpKSgRhiomRXh_psO6sqfqd62C3r_6iGsHNAehN8M3W-ebfiFwpLrjiPwMqdu8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1510402624</pqid></control><display><type>article</type><title>Effect of hypoglycemic anti-deafness capsules in diabetic patients with deafness and toxicological assessment in rats</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><source>ScienceDirect Journals</source><source>EZB Electronic Journals Library</source><creator>Li, Ruiyu ; Li, Meng ; Guo, Kaoshan ; Li, Bin ; Hou, Jinjie ; Wu, Liping ; Liu, Xianyun</creator><creatorcontrib>Li, Ruiyu ; Li, Meng ; Guo, Kaoshan ; Li, Bin ; Hou, Jinjie ; Wu, Liping ; Liu, Xianyun</creatorcontrib><description>OBJECTIVE： Through experiment on animals and clinical trials to explore the safety and efficacy of hypoglycemic anti-deafness capsules on diabetic patients with deafness.METHODS： Total 296 patients with non-insulin dependent diabetes mellitus（NIDDM） were randomly divided into two groups. A treatment group of 164patients（208 ears） was treated with hypoglycemic anti-deafness capsules based onTCM syndrome differentiation. A control group of 132 patients（184ears） was treated with glibenclamide and conventional drug treatment for deafness. The following were observed： hearing, fasting plasma glucose（FPG）, 2 h postprandial plasma glucose（2hPG）, 24 h urine glucose（24hUG）, improvement of main symptoms, platelet function, and changes in superoxidedismutase（SOD） and lipid peroxide（LPO） levels. In animal studies, Kunming mice, weighing 18-22 g were used. Half of the mice were males and half were females. Wistar rats, weighing 80-120 g were used. Half of the rats were males and half were females. Male Wistar rats, weighing 200-220 g, were also used.Their acute and chronic toxicity was studied.RESULTS： The hearing improvement was 56.7% in the treatment group and 26.6% in the control group. FPG, 2hPG, and 24hUG were improved significantly（P0.05, P0.01, P0.01, respectively） in the treatment group and 2hPG and 24hUG improved significantly in the control group（P0.05,P0.05）. The improvement in 2hPG and 24hUG in the treatment group was significantly greater than that in the control group P0.01）. There was no significant difference in FPG between the two groups（P0.05）. Main symptoms in the treatment group were significantly more improved than those in the control group（P0.05, P0.01）. In the treatment group, platelet adhesion and aggregation, SOD,and LPO were all significantly improved from before treatment（P0.05, P0.01）. However, in the control group, except LOP（P0.05）, there were no significant differences from before treatment to after（P0.05）. In animal studies, no obvious acute or long-term toxicity was observed from capsule administration.CONCLUSION： Through experiment on animals and clinical trials, we can found that hypoglycemic anti-deafness capsules could decrease blood glucose and serum triglycerides of alloxan-induced diabetic rats. This herbal capsule is effective for safely treating diabetic patients with deafness.</description><identifier>ISSN: 0255-2922</identifier><identifier>DOI: 10.1016/S0254-6272(14)60037-6</identifier><identifier>PMID: 24660591</identifier><language>eng</language><publisher>China</publisher><subject>Adult ; Aged ; Animals ; Blood Glucose - metabolism ; Capsules - administration & dosage ; Deafness - drug therapy ; Deafness - etiology ; Deafness - metabolism ; Deafness - physiopathology ; Deafness - prevention & control ; Diabetes Complications - drug therapy ; Diabetes Complications - etiology ; Diabetes Complications - metabolism ; Diabetes Complications - physiopathology ; Diabetes Complications - prevention & control ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - metabolism ; Drugs, Chinese Herbal - administration & dosage ; Drugs, Chinese Herbal - adverse effects ; Female ; Hearing - drug effects ; Humans ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - adverse effects ; Male ; Mice ; Middle Aged ; Rats ; Rats, Wistar ; Wistar大鼠 ; 患者 ; 毒理学评价 ; 糖尿病大鼠 ; 耳聋 ; 胶囊 ; 药物治疗 ; 降糖</subject><ispartof>Journal of traditional Chinese medicine, 2013-10, Vol.33 (5), p.651-657</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-46d6cb2d3397a3e30d3e941017069d6f75aa25f42c2811cc6cb9aa083067da903</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/86801X/86801X.jpg</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24660591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Ruiyu</creatorcontrib><creatorcontrib>Li, Meng</creatorcontrib><creatorcontrib>Guo, Kaoshan</creatorcontrib><creatorcontrib>Li, Bin</creatorcontrib><creatorcontrib>Hou, Jinjie</creatorcontrib><creatorcontrib>Wu, Liping</creatorcontrib><creatorcontrib>Liu, Xianyun</creatorcontrib><title>Effect of hypoglycemic anti-deafness capsules in diabetic patients with deafness and toxicological assessment in rats</title><title>Journal of traditional Chinese medicine</title><addtitle>Journal of Traditional Chinese Medicine</addtitle><description>OBJECTIVE： Through experiment on animals and clinical trials to explore the safety and efficacy of hypoglycemic anti-deafness capsules on diabetic patients with deafness.METHODS： Total 296 patients with non-insulin dependent diabetes mellitus（NIDDM） were randomly divided into two groups. A treatment group of 164patients（208 ears） was treated with hypoglycemic anti-deafness capsules based onTCM syndrome differentiation. A control group of 132 patients（184ears） was treated with glibenclamide and conventional drug treatment for deafness. The following were observed： hearing, fasting plasma glucose（FPG）, 2 h postprandial plasma glucose（2hPG）, 24 h urine glucose（24hUG）, improvement of main symptoms, platelet function, and changes in superoxidedismutase（SOD） and lipid peroxide（LPO） levels. In animal studies, Kunming mice, weighing 18-22 g were used. Half of the mice were males and half were females. Wistar rats, weighing 80-120 g were used. Half of the rats were males and half were females. Male Wistar rats, weighing 200-220 g, were also used.Their acute and chronic toxicity was studied.RESULTS： The hearing improvement was 56.7% in the treatment group and 26.6% in the control group. FPG, 2hPG, and 24hUG were improved significantly（P0.05, P0.01, P0.01, respectively） in the treatment group and 2hPG and 24hUG improved significantly in the control group（P0.05,P0.05）. The improvement in 2hPG and 24hUG in the treatment group was significantly greater than that in the control group P0.01）. There was no significant difference in FPG between the two groups（P0.05）. Main symptoms in the treatment group were significantly more improved than those in the control group（P0.05, P0.01）. In the treatment group, platelet adhesion and aggregation, SOD,and LPO were all significantly improved from before treatment（P0.05, P0.01）. However, in the control group, except LOP（P0.05）, there were no significant differences from before treatment to after（P0.05）. In animal studies, no obvious acute or long-term toxicity was observed from capsule administration.CONCLUSION： Through experiment on animals and clinical trials, we can found that hypoglycemic anti-deafness capsules could decrease blood glucose and serum triglycerides of alloxan-induced diabetic rats. This herbal capsule is effective for safely treating diabetic patients with deafness.</description><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Blood Glucose - metabolism</subject><subject>Capsules - administration & dosage</subject><subject>Deafness - drug therapy</subject><subject>Deafness - etiology</subject><subject>Deafness - metabolism</subject><subject>Deafness - physiopathology</subject><subject>Deafness - prevention & control</subject><subject>Diabetes Complications - drug therapy</subject><subject>Diabetes Complications - etiology</subject><subject>Diabetes Complications - metabolism</subject><subject>Diabetes Complications - physiopathology</subject><subject>Diabetes Complications - prevention & control</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Drugs, Chinese Herbal - adverse effects</subject><subject>Female</subject><subject>Hearing - drug effects</subject><subject>Humans</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - adverse effects</subject><subject>Male</subject><subject>Mice</subject><subject>Middle Aged</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Wistar大鼠</subject><subject>患者</subject><subject>毒理学评价</subject><subject>糖尿病大鼠</subject><subject>耳聋</subject><subject>胶囊</subject><subject>药物治疗</subject><subject>降糖</subject><issn>0255-2922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNo90E1PwzAMBuAcQGwMfgIo3MahkO-2RzSND2kSB-BceUnaBbVJt6SC_XuKNjhZsh9b8ovQFSV3lFB1_0aYFJliOZtTcasI4XmmTtB0bMuMlYxN0HmMn4TIQsriDE2YUIrIkk7RsKxrqxMONd7s-9C0e207pzH45DJjofY2Rqyhj0NrI3YeGwdrm0bSQ3LWp4i_XNrgfwve4BS-nQ5taJyGFkOM46Ab7e_-DlK8QKc1tNFeHusMfTwu3xfP2er16WXxsMq04EXKhDJKr5nhvMyBW04Mt6UYX86JKo2qcwnAZC2YZgWlWo-4BCAFJyo3UBI-Q_PD3X4XtoONqepc1LZtwdswxIpKSgRhiomRXh_psO6sqfqd62C3r_6iGsHNAehN8M3W-ebfiFwpLrjiPwMqdu8</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Li, Ruiyu</creator><creator>Li, Meng</creator><creator>Guo, Kaoshan</creator><creator>Li, Bin</creator><creator>Hou, Jinjie</creator><creator>Wu, Liping</creator><creator>Liu, Xianyun</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20131001</creationdate><title>Effect of hypoglycemic anti-deafness capsules in diabetic patients with deafness and toxicological assessment in rats</title><author>Li, Ruiyu ; Li, Meng ; Guo, Kaoshan ; Li, Bin ; Hou, Jinjie ; Wu, Liping ; Liu, Xianyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-46d6cb2d3397a3e30d3e941017069d6f75aa25f42c2811cc6cb9aa083067da903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Animals</topic><topic>Blood Glucose - metabolism</topic><topic>Capsules - administration & dosage</topic><topic>Deafness - drug therapy</topic><topic>Deafness - etiology</topic><topic>Deafness - metabolism</topic><topic>Deafness - physiopathology</topic><topic>Deafness - prevention & control</topic><topic>Diabetes Complications - drug therapy</topic><topic>Diabetes Complications - etiology</topic><topic>Diabetes Complications - metabolism</topic><topic>Diabetes Complications - physiopathology</topic><topic>Diabetes Complications - prevention & control</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Drugs, Chinese Herbal - adverse effects</topic><topic>Female</topic><topic>Hearing - drug effects</topic><topic>Humans</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - adverse effects</topic><topic>Male</topic><topic>Mice</topic><topic>Middle Aged</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Wistar大鼠</topic><topic>患者</topic><topic>毒理学评价</topic><topic>糖尿病大鼠</topic><topic>耳聋</topic><topic>胶囊</topic><topic>药物治疗</topic><topic>降糖</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ruiyu</creatorcontrib><creatorcontrib>Li, Meng</creatorcontrib><creatorcontrib>Guo, Kaoshan</creatorcontrib><creatorcontrib>Li, Bin</creatorcontrib><creatorcontrib>Hou, Jinjie</creatorcontrib><creatorcontrib>Wu, Liping</creatorcontrib><creatorcontrib>Liu, Xianyun</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of traditional Chinese medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ruiyu</au><au>Li, Meng</au><au>Guo, Kaoshan</au><au>Li, Bin</au><au>Hou, Jinjie</au><au>Wu, Liping</au><au>Liu, Xianyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of hypoglycemic anti-deafness capsules in diabetic patients with deafness and toxicological assessment in rats</atitle><jtitle>Journal of traditional Chinese medicine</jtitle><addtitle>Journal of Traditional Chinese Medicine</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>33</volume><issue>5</issue><spage>651</spage><epage>657</epage><pages>651-657</pages><issn>0255-2922</issn><notes>Deafness Hearing Diabetes mellitus Hypoglycemic anti-deafness capsules Pharmacodynamics test Toxicology</notes><notes>11-2167/R</notes><notes>OBJECTIVE： Through experiment on animals and clinical trials to explore the safety and efficacy of hypoglycemic anti-deafness capsules on diabetic patients with deafness.METHODS： Total 296 patients with non-insulin dependent diabetes mellitus（NIDDM） were randomly divided into two groups. A treatment group of 164patients（208 ears） was treated with hypoglycemic anti-deafness capsules based onTCM syndrome differentiation. A control group of 132 patients（184ears） was treated with glibenclamide and conventional drug treatment for deafness. The following were observed： hearing, fasting plasma glucose（FPG）, 2 h postprandial plasma glucose（2hPG）, 24 h urine glucose（24hUG）, improvement of main symptoms, platelet function, and changes in superoxidedismutase（SOD） and lipid peroxide（LPO） levels. In animal studies, Kunming mice, weighing 18-22 g were used. Half of the mice were males and half were females. Wistar rats, weighing 80-120 g were used. Half of the rats were males and half were females. Male Wistar rats, weighing 200-220 g, were also used.Their acute and chronic toxicity was studied.RESULTS： The hearing improvement was 56.7% in the treatment group and 26.6% in the control group. FPG, 2hPG, and 24hUG were improved significantly（P0.05, P0.01, P0.01, respectively） in the treatment group and 2hPG and 24hUG improved significantly in the control group（P0.05,P0.05）. The improvement in 2hPG and 24hUG in the treatment group was significantly greater than that in the control group P0.01）. There was no significant difference in FPG between the two groups（P0.05）. Main symptoms in the treatment group were significantly more improved than those in the control group（P0.05, P0.01）. In the treatment group, platelet adhesion and aggregation, SOD,and LPO were all significantly improved from before treatment（P0.05, P0.01）. However, in the control group, except LOP（P0.05）, there were no significant differences from before treatment to after（P0.05）. In animal studies, no obvious acute or long-term toxicity was observed from capsule administration.CONCLUSION： Through experiment on animals and clinical trials, we can found that hypoglycemic anti-deafness capsules could decrease blood glucose and serum triglycerides of alloxan-induced diabetic rats. This herbal capsule is effective for safely treating diabetic patients with deafness.</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-News-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><abstract>OBJECTIVE： Through experiment on animals and clinical trials to explore the safety and efficacy of hypoglycemic anti-deafness capsules on diabetic patients with deafness.METHODS： Total 296 patients with non-insulin dependent diabetes mellitus（NIDDM） were randomly divided into two groups. A treatment group of 164patients（208 ears） was treated with hypoglycemic anti-deafness capsules based onTCM syndrome differentiation. A control group of 132 patients（184ears） was treated with glibenclamide and conventional drug treatment for deafness. The following were observed： hearing, fasting plasma glucose（FPG）, 2 h postprandial plasma glucose（2hPG）, 24 h urine glucose（24hUG）, improvement of main symptoms, platelet function, and changes in superoxidedismutase（SOD） and lipid peroxide（LPO） levels. In animal studies, Kunming mice, weighing 18-22 g were used. Half of the mice were males and half were females. Wistar rats, weighing 80-120 g were used. Half of the rats were males and half were females. Male Wistar rats, weighing 200-220 g, were also used.Their acute and chronic toxicity was studied.RESULTS： The hearing improvement was 56.7% in the treatment group and 26.6% in the control group. FPG, 2hPG, and 24hUG were improved significantly（P0.05, P0.01, P0.01, respectively） in the treatment group and 2hPG and 24hUG improved significantly in the control group（P0.05,P0.05）. The improvement in 2hPG and 24hUG in the treatment group was significantly greater than that in the control group P0.01）. There was no significant difference in FPG between the two groups（P0.05）. Main symptoms in the treatment group were significantly more improved than those in the control group（P0.05, P0.01）. In the treatment group, platelet adhesion and aggregation, SOD,and LPO were all significantly improved from before treatment（P0.05, P0.01）. However, in the control group, except LOP（P0.05）, there were no significant differences from before treatment to after（P0.05）. In animal studies, no obvious acute or long-term toxicity was observed from capsule administration.CONCLUSION： Through experiment on animals and clinical trials, we can found that hypoglycemic anti-deafness capsules could decrease blood glucose and serum triglycerides of alloxan-induced diabetic rats. This herbal capsule is effective for safely treating diabetic patients with deafness.</abstract><cop>China</cop><pmid>24660591</pmid><doi>10.1016/S0254-6272(14)60037-6</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0255-2922 |
| ispartof | Journal of traditional Chinese medicine, 2013-10, Vol.33 (5), p.651-657 |
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| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS; ScienceDirect Journals; EZB Electronic Journals Library |
| subjects | Adult Aged Animals Blood Glucose - metabolism Capsules - administration & dosage Deafness - drug therapy Deafness - etiology Deafness - metabolism Deafness - physiopathology Deafness - prevention & control Diabetes Complications - drug therapy Diabetes Complications - etiology Diabetes Complications - metabolism Diabetes Complications - physiopathology Diabetes Complications - prevention & control Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - adverse effects Female Hearing - drug effects Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - adverse effects Male Mice Middle Aged Rats Rats, Wistar Wistar大鼠 患者 毒理学评价 糖尿病大鼠 耳聋 胶囊 药物治疗 降糖 |
| title | Effect of hypoglycemic anti-deafness capsules in diabetic patients with deafness and toxicological assessment in rats |
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