High expression of M3 muscarinic acetylcholine receptor is a novel biomarker of poor prognostic in patients with non-small cell lung cancer

We assessed the expression of M3 receptor in non-small cell lung cancer (NSCLC) and determined its relationship with clinicopathological features and its impact on patient outcome. Specimens from 192 patients with NSCLC were investigated by immunohistochemistry for M3 receptor and Ki67 expression. C...

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Bibliographic Details
Published in:Tumor biology 2013-12, Vol.34 (6), p.3939-3944
Main Authors: Wu, Jun, Zhou, Jinxu, Yao, Lei, Lang, Yaoguo, Liang, Yingnan, Chen, Lantao, Zhang, Jinfeng, Wang, Fengjiao, Wang, Yanbo, Chen, He, Ma, Jianqun
Format: Article
Language:English
Subjects:
Acetylcholine receptors (muscarinic)
Biomarkers
Biomarkers, Tumor - biosynthesis
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinoma, Non-Small-Cell Lung - metabolism
Carcinoma, Non-Small-Cell Lung - pathology
Disease-Free Survival
Female
Humans
Immunohistochemistry
Immunohistochemistry - statistics & numerical data
Ki-67 Antigen - biosynthesis
Lung cancer
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Male
Medical prognosis
Middle Aged
Multivariate Analysis
Neoplasm Staging
Prognosis
Proportional Hazards Models
Receptor, Muscarinic M3 - biosynthesis
Research Article
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Summary:We assessed the expression of M3 receptor in non-small cell lung cancer (NSCLC) and determined its relationship with clinicopathological features and its impact on patient outcome. Specimens from 192 patients with NSCLC were investigated by immunohistochemistry for M3 receptor and Ki67 expression. Correlation between the expression of M3 receptor and Ki67 and various clinicopathological features of NSCLC patients was analyzed. We found that M3 receptor expression was gradually elevated from normal to metaplasia/dysplasia tissues to cancer tissues. Furthermore, there was a similar trend for Ki67 expression. Statistical analysis revealed that M3 receptor expression in tumor cells were correlated significantly with stage ( P  
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-013-0982-x