Dysanaptic growth of lung and airway in children with post-infectious bronchiolitis obliterans

Rationale Post‐infectious bronchiolitis obliterans (PBO) is a rare form of chronic obstructive lung disease associated with small airway fibrosis following a severe insult to the lower respiratory tract. It has been suggested that PBO is a non‐progressive disease. However, evidence supporting this s...

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Bibliographic Details
Published in:The clinical respiratory journal 2014-01, Vol.8 (1), p.63-71
Main Authors: Mosquera, Ricardo A., Hashmi, Syed S., Pacheco, Susan E., Reverdin, Alexandra, Chevallier, Justyna, Colasurdo, Giuseppe N.
Format: Article
Language:English
Subjects:
Adolescent
Airway management
bronchiolitis obliterans
Bronchiolitis Obliterans - diagnostic imaging
Bronchiolitis Obliterans - etiology
Bronchiolitis Obliterans - pathology
Bronchiolitis Obliterans - physiopathology
Child
Disease Progression
dysanaptic growth
Female
Forced Expiratory Volume
Humans
immunomodulation
Inflammation - pathology
Inflammation - physiopathology
inhaled corticosteroids
Lung - pathology
Lung - physiopathology
Male
pulmonary function test
Respiratory diseases
Respiratory Function Tests
Respiratory Tract Infections - complications
Tomography, X-Ray Computed - methods
Vital Capacity
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Summary:Rationale Post‐infectious bronchiolitis obliterans (PBO) is a rare form of chronic obstructive lung disease associated with small airway fibrosis following a severe insult to the lower respiratory tract. It has been suggested that PBO is a non‐progressive disease. However, evidence supporting this statement is limited. In this case series, we sought to determine the changes of pulmonary function tests (PFT) over time in children with PBO. Methods Seven children with PBO, ages 6–15 years old, were retrospectively studied between 1994 and 2012. Spirometry and lung volumes tests were performed in accordance with American Thoracic Society (ATS) guidelines and were monitored over time. The average rate of change was calculated using generalized linear mixed models. Results The median baseline values for forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), the FEV1/FVC ratio and forced expiratory flow 25%–75% (FEF25%–75%) were 57%, 50%, 87% and 29%, respectively. FVC increased at a rate of 1.8% per year (P = 0.008). There was no significant change in FEV1 over time (P = 0.112). However, the FEV1/FVC ratio decreased by 2.6% per year (P 
ISSN:1752-6981
1752-699X
DOI:10.1111/crj.12037