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The rhizobacterium Arthrobacter agilis produces dimethylhexadecylamine, a compound that inhibits growth of phytopathogenic fungi in vitro
Plant diseases caused by fungal pathogens such as Botrytis cinerea and the oomycete Phytophthora cinnamomi affect agricultural production worldwide. Control of these pests can be done by the use of fungicides such as captan, which may have deleterious effects on human health. This study demonstrates...
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| Published in: | Protoplasma 2013-12, Vol.250 (6), p.1251-1262 |
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| Main Authors: | , , , , , , |
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| creator | Velázquez-Becerra, Crisanto Macías-Rodríguez, Lourdes I. López-Bucio, José Flores-Cortez, Idolina Santoyo, Gustavo Hernández-Soberano, Christian Valencia-Cantero, Eduardo |
| description | Plant diseases caused by fungal pathogens such as
Botrytis cinerea
and the oomycete
Phytophthora cinnamomi
affect agricultural production worldwide. Control of these pests can be done by the use of fungicides such as captan, which may have deleterious effects on human health. This study demonstrates that the rhizobacterium
Arthrobacter agilis
UMCV2 produces volatile organic compounds that inhibit the growth of
B
.
cinerea
in vitro. A single compound from the volatile blends, namely dimethylhexadecylamine (DMHDA), could inhibit the growth of both
B
.
cinerea
and
P
.
cinnamomi
when supplied to the growth medium in low concentrations. DMHDA also inhibited the growth of beneficial fungi
Trichoderma virens
and
Trichoderma atroviride
but at much higher concentrations. DMHDA-related aminolipids containing 4, 8, 10, 12, and 14 carbons in the alkyl chain were tested for their inhibitory effect on the growth of the pathogens. The results show that the most active compound from those tested was dimethyldodecylamine. This effect correlates with a decrease in the number of membrane lipids present in the mycelium of the pathogen including eicosanoic acid, (
Z
)-9-hexadecenoic acid, methyl ester, and (
Z
)-9-octadecenoic acid, methyl ester. Strawberry leaflets treated with DMHDA were not injured by the compound. These data indicate that DMHDA and related compounds, which can be produced by microorganisms may effectively inhibit the proliferation of certain plant pathogens. |
| doi_str_mv | 10.1007/s00709-013-0506-y |
| format | article |
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Botrytis cinerea
and the oomycete
Phytophthora cinnamomi
affect agricultural production worldwide. Control of these pests can be done by the use of fungicides such as captan, which may have deleterious effects on human health. This study demonstrates that the rhizobacterium
Arthrobacter agilis
UMCV2 produces volatile organic compounds that inhibit the growth of
B
.
cinerea
in vitro. A single compound from the volatile blends, namely dimethylhexadecylamine (DMHDA), could inhibit the growth of both
B
.
cinerea
and
P
.
cinnamomi
when supplied to the growth medium in low concentrations. DMHDA also inhibited the growth of beneficial fungi
Trichoderma virens
and
Trichoderma atroviride
but at much higher concentrations. DMHDA-related aminolipids containing 4, 8, 10, 12, and 14 carbons in the alkyl chain were tested for their inhibitory effect on the growth of the pathogens. The results show that the most active compound from those tested was dimethyldodecylamine. This effect correlates with a decrease in the number of membrane lipids present in the mycelium of the pathogen including eicosanoic acid, (
Z
)-9-hexadecenoic acid, methyl ester, and (
Z
)-9-octadecenoic acid, methyl ester. Strawberry leaflets treated with DMHDA were not injured by the compound. These data indicate that DMHDA and related compounds, which can be produced by microorganisms may effectively inhibit the proliferation of certain plant pathogens.</description><identifier>ISSN: 0033-183X</identifier><identifier>EISSN: 1615-6102</identifier><identifier>DOI: 10.1007/s00709-013-0506-y</identifier><identifier>PMID: 23674267</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Amines - chemistry ; Amines - pharmacology ; Antifungal Agents - pharmacology ; Arthrobacter - chemistry ; Biomedical and Life Sciences ; Botrytis - drug effects ; Botrytis - growth & development ; Cell Biology ; Culture Media - pharmacology ; Fragaria - microbiology ; Fungi - drug effects ; Fungi - growth & development ; Humans ; Hydrocarbons - chemistry ; Hydrocarbons - pharmacology ; Life Sciences ; Methylamines - chemistry ; Methylamines - pharmacology ; Original Article ; Phospholipids - metabolism ; Phytophthora - drug effects ; Phytophthora - growth & development ; Plant Sciences ; Trichoderma - drug effects ; Trichoderma - growth & development ; Zoology</subject><ispartof>Protoplasma, 2013-12, Vol.250 (6), p.1251-1262</ispartof><rights>Springer-Verlag Wien 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-29931f773e8b2439350a871d00ad6da407fae4e6b87feab7eeb40d5f1311b1993</citedby><cites>FETCH-LOGICAL-c420t-29931f773e8b2439350a871d00ad6da407fae4e6b87feab7eeb40d5f1311b1993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23674267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Velázquez-Becerra, Crisanto</creatorcontrib><creatorcontrib>Macías-Rodríguez, Lourdes I.</creatorcontrib><creatorcontrib>López-Bucio, José</creatorcontrib><creatorcontrib>Flores-Cortez, Idolina</creatorcontrib><creatorcontrib>Santoyo, Gustavo</creatorcontrib><creatorcontrib>Hernández-Soberano, Christian</creatorcontrib><creatorcontrib>Valencia-Cantero, Eduardo</creatorcontrib><title>The rhizobacterium Arthrobacter agilis produces dimethylhexadecylamine, a compound that inhibits growth of phytopathogenic fungi in vitro</title><title>Protoplasma</title><addtitle>Protoplasma</addtitle><addtitle>Protoplasma</addtitle><description>Plant diseases caused by fungal pathogens such as
Botrytis cinerea
and the oomycete
Phytophthora cinnamomi
affect agricultural production worldwide. Control of these pests can be done by the use of fungicides such as captan, which may have deleterious effects on human health. This study demonstrates that the rhizobacterium
Arthrobacter agilis
UMCV2 produces volatile organic compounds that inhibit the growth of
B
.
cinerea
in vitro. A single compound from the volatile blends, namely dimethylhexadecylamine (DMHDA), could inhibit the growth of both
B
.
cinerea
and
P
.
cinnamomi
when supplied to the growth medium in low concentrations. DMHDA also inhibited the growth of beneficial fungi
Trichoderma virens
and
Trichoderma atroviride
but at much higher concentrations. DMHDA-related aminolipids containing 4, 8, 10, 12, and 14 carbons in the alkyl chain were tested for their inhibitory effect on the growth of the pathogens. The results show that the most active compound from those tested was dimethyldodecylamine. This effect correlates with a decrease in the number of membrane lipids present in the mycelium of the pathogen including eicosanoic acid, (
Z
)-9-hexadecenoic acid, methyl ester, and (
Z
)-9-octadecenoic acid, methyl ester. Strawberry leaflets treated with DMHDA were not injured by the compound. These data indicate that DMHDA and related compounds, which can be produced by microorganisms may effectively inhibit the proliferation of certain plant pathogens.</description><subject>Amines - chemistry</subject><subject>Amines - pharmacology</subject><subject>Antifungal Agents - pharmacology</subject><subject>Arthrobacter - chemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Botrytis - drug effects</subject><subject>Botrytis - growth & development</subject><subject>Cell Biology</subject><subject>Culture Media - pharmacology</subject><subject>Fragaria - microbiology</subject><subject>Fungi - drug effects</subject><subject>Fungi - growth & development</subject><subject>Humans</subject><subject>Hydrocarbons - chemistry</subject><subject>Hydrocarbons - pharmacology</subject><subject>Life Sciences</subject><subject>Methylamines - chemistry</subject><subject>Methylamines - pharmacology</subject><subject>Original Article</subject><subject>Phospholipids - metabolism</subject><subject>Phytophthora - drug effects</subject><subject>Phytophthora - growth & development</subject><subject>Plant Sciences</subject><subject>Trichoderma - drug effects</subject><subject>Trichoderma - growth & development</subject><subject>Zoology</subject><issn>0033-183X</issn><issn>1615-6102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kV9r1TAYh4M43NnRD-CNBLzxws43TdM_l2M4Jwy8meBdSJu3TUbb1CSddt_Ab23mOYoI3iSEPL_fm_AQ8pLBOQOo3oW0QJMB4xkIKLPtCdmxkomsZJA_JTsAzjNW8y-n5CyEOwAQOYhn5DTnZVXkZbUjP24NUm_sg2tVF9HbdaIXPhp_PFM12NEGunin1w4D1XbCaLbR4HelsdtGNdkZ31JFOzctbp01jUZFamdjWxsDHbz7Fg11PV3MFt2ionEDzraj_ToPNoH03kbvnpOTXo0BXxz3Pfl89f728jq7-fTh4-XFTdYVOcQsbxrO-qriWLd5wRsuQNUV0wBKl1oVUPUKCyzbuupRtRViW4AWPeOMtSyF9-TNoTd96euKIcrJhg7HUc3o1iBZUTJeMJFG7Mnrf9A7t_o5vS5RomlEXf4qZAeq8y4Ej71cvJ2U3yQD-ehJHjzJ5Ek-epJbyrw6Nq_thPpP4reYBOQHIKSreUD_1-j_tv4EyKuhUg</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Velázquez-Becerra, Crisanto</creator><creator>Macías-Rodríguez, Lourdes I.</creator><creator>López-Bucio, José</creator><creator>Flores-Cortez, Idolina</creator><creator>Santoyo, Gustavo</creator><creator>Hernández-Soberano, Christian</creator><creator>Valencia-Cantero, Eduardo</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20131201</creationdate><title>The rhizobacterium Arthrobacter agilis produces dimethylhexadecylamine, a compound that inhibits growth of phytopathogenic fungi in vitro</title><author>Velázquez-Becerra, Crisanto ; Macías-Rodríguez, Lourdes I. ; López-Bucio, José ; Flores-Cortez, Idolina ; Santoyo, Gustavo ; Hernández-Soberano, Christian ; Valencia-Cantero, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-29931f773e8b2439350a871d00ad6da407fae4e6b87feab7eeb40d5f1311b1993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Amines - chemistry</topic><topic>Amines - pharmacology</topic><topic>Antifungal Agents - pharmacology</topic><topic>Arthrobacter - chemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Botrytis - drug effects</topic><topic>Botrytis - growth & development</topic><topic>Cell Biology</topic><topic>Culture Media - pharmacology</topic><topic>Fragaria - microbiology</topic><topic>Fungi - drug effects</topic><topic>Fungi - growth & development</topic><topic>Humans</topic><topic>Hydrocarbons - chemistry</topic><topic>Hydrocarbons - pharmacology</topic><topic>Life Sciences</topic><topic>Methylamines - chemistry</topic><topic>Methylamines - pharmacology</topic><topic>Original Article</topic><topic>Phospholipids - metabolism</topic><topic>Phytophthora - drug effects</topic><topic>Phytophthora - growth & development</topic><topic>Plant Sciences</topic><topic>Trichoderma - drug effects</topic><topic>Trichoderma - growth & development</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Velázquez-Becerra, Crisanto</creatorcontrib><creatorcontrib>Macías-Rodríguez, Lourdes I.</creatorcontrib><creatorcontrib>López-Bucio, José</creatorcontrib><creatorcontrib>Flores-Cortez, Idolina</creatorcontrib><creatorcontrib>Santoyo, Gustavo</creatorcontrib><creatorcontrib>Hernández-Soberano, Christian</creatorcontrib><creatorcontrib>Valencia-Cantero, Eduardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Protoplasma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Velázquez-Becerra, Crisanto</au><au>Macías-Rodríguez, Lourdes I.</au><au>López-Bucio, José</au><au>Flores-Cortez, Idolina</au><au>Santoyo, Gustavo</au><au>Hernández-Soberano, Christian</au><au>Valencia-Cantero, Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The rhizobacterium Arthrobacter agilis produces dimethylhexadecylamine, a compound that inhibits growth of phytopathogenic fungi in vitro</atitle><jtitle>Protoplasma</jtitle><stitle>Protoplasma</stitle><addtitle>Protoplasma</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>250</volume><issue>6</issue><spage>1251</spage><epage>1262</epage><pages>1251-1262</pages><issn>0033-183X</issn><eissn>1615-6102</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Plant diseases caused by fungal pathogens such as
Botrytis cinerea
and the oomycete
Phytophthora cinnamomi
affect agricultural production worldwide. Control of these pests can be done by the use of fungicides such as captan, which may have deleterious effects on human health. This study demonstrates that the rhizobacterium
Arthrobacter agilis
UMCV2 produces volatile organic compounds that inhibit the growth of
B
.
cinerea
in vitro. A single compound from the volatile blends, namely dimethylhexadecylamine (DMHDA), could inhibit the growth of both
B
.
cinerea
and
P
.
cinnamomi
when supplied to the growth medium in low concentrations. DMHDA also inhibited the growth of beneficial fungi
Trichoderma virens
and
Trichoderma atroviride
but at much higher concentrations. DMHDA-related aminolipids containing 4, 8, 10, 12, and 14 carbons in the alkyl chain were tested for their inhibitory effect on the growth of the pathogens. The results show that the most active compound from those tested was dimethyldodecylamine. This effect correlates with a decrease in the number of membrane lipids present in the mycelium of the pathogen including eicosanoic acid, (
Z
)-9-hexadecenoic acid, methyl ester, and (
Z
)-9-octadecenoic acid, methyl ester. Strawberry leaflets treated with DMHDA were not injured by the compound. These data indicate that DMHDA and related compounds, which can be produced by microorganisms may effectively inhibit the proliferation of certain plant pathogens.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>23674267</pmid><doi>10.1007/s00709-013-0506-y</doi><tpages>12</tpages></addata></record> |
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| ispartof | Protoplasma, 2013-12, Vol.250 (6), p.1251-1262 |
| issn | 0033-183X 1615-6102 |
| language | eng |
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| source | Springer Link |
| subjects | Amines - chemistry Amines - pharmacology Antifungal Agents - pharmacology Arthrobacter - chemistry Biomedical and Life Sciences Botrytis - drug effects Botrytis - growth & development Cell Biology Culture Media - pharmacology Fragaria - microbiology Fungi - drug effects Fungi - growth & development Humans Hydrocarbons - chemistry Hydrocarbons - pharmacology Life Sciences Methylamines - chemistry Methylamines - pharmacology Original Article Phospholipids - metabolism Phytophthora - drug effects Phytophthora - growth & development Plant Sciences Trichoderma - drug effects Trichoderma - growth & development Zoology |
| title | The rhizobacterium Arthrobacter agilis produces dimethylhexadecylamine, a compound that inhibits growth of phytopathogenic fungi in vitro |
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