Ionic Liquids and Deep Eutectic Solvents in Natural Products Research: Mixtures of Solids as Extraction Solvents

Mixtures of solid chemicals may become liquid under certain conditions. These liquids are characterized by the formation of strong ionic (ionic liquids) or hydrogen bonds (deep eutectic solvents). Due to their extremely low vapor pressure, they are now widely used in polymer chemistry and synthetic...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2013-11, Vol.76 (11), p.2162-2173
Main Authors: Dai, Yuntao, van Spronsen, Jaap, Witkamp, Geert-Jan, Verpoorte, Robert, Choi, Young Hae
Format: Article
Language:English
Subjects:
Biological Products - chemistry
Chemistry, Organic
Hydrogen Bonding
Ionic Liquids - chemistry
Microwaves
Molecular Structure
Osmolar Concentration
Solvents - chemistry
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Summary:Mixtures of solid chemicals may become liquid under certain conditions. These liquids are characterized by the formation of strong ionic (ionic liquids) or hydrogen bonds (deep eutectic solvents). Due to their extremely low vapor pressure, they are now widely used in polymer chemistry and synthetic organic chemistry, yet little attention has been paid to their use as extraction solvents of natural products. This review summarizes the preparation of ionic liquids and deep eutectic solvents with natural product components and recent progress in their applications to the extraction and analysis of natural products as well as the recovery of extracted compounds from their extracts. Additionally, various factors affecting extraction features of ionic liquids and deep eutectic solvents, as well as potential useful technologies including microwave and ultrasound to increase the extraction efficiency, are discussed.
ISSN:0163-3864
1520-6025
DOI:10.1021/np400051w