Preliminary study of the in vitro antiproliferative effect of a hydroethanolic extract from the subtropical seaweed Turbinaria ornata (Turner J. Agardh) on a human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6)

The Phaeophyceae alga Turbinaria ornata, reported to be invading coral reefs in French Polynesia in the 1980s, has exhibited cytotoxic effects against human colon carcinoma cells. T. ornata extracts were tested for antiproliferative effects on asynchronous cells of a human non-small-cell bronchopulm...

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Bibliographic Details
Published in:Journal of applied phycology 2000-10, Vol.12 (3-5), p.257-262
Main Authors: DESLANDES, E, PONDAVEN, P, AUPERIN, T, ROUSSAKIS C, C, GUEZENNEC, J, STIGER, V, PAYRI, C
Format: Article
Language:English
Subjects:
Antineoplastic drugs. Cytokines
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Production of active biomolecules
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Summary:The Phaeophyceae alga Turbinaria ornata, reported to be invading coral reefs in French Polynesia in the 1980s, has exhibited cytotoxic effects against human colon carcinoma cells. T. ornata extracts were tested for antiproliferative effects on asynchronous cells of a human non-small-cell bronchopulmonary carcinoma line. The mechanism of action on the cell cycle was examined using flowcytometry. A sulfated fucan-like polysaccharide-containing aminosugar constituent was isolated as the antiproliferative agent. Cell growth is inhibited in the G1 phase. Results suggest a triggering of the terminal differentiation of cancerous cells by this polysaccharide. The structural diversity and mechanism of action of this agent are complex.
ISSN:0921-8971
1573-5176
DOI:10.1023/a:1008114831862