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Birth weight and polycystic ovary syndrome in adult life: a register-based study on 523,757 Danish women born 1973–1991
Objective To study the association between birth weight and polycystic ovary syndrome (PCOS) in adult life in Danish women born 1973–1991. Design Register study. Setting Data were extracted from the Danish Medical Birth Register and the Danish National Patient Register (NPR). Patient(s) All female c...
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| Published in: | Fertility and sterility 2013-03, Vol.99 (3), p.777-782 |
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| creator | Mumm, Hanne, M.D Kamper-Jørgensen, Mads, M.Sc., Ph.D Nybo Andersen, Anne-Marie, M.D., Ph.D Glintborg, Dorte, M.D., Ph.D Andersen, Marianne, M.D., Ph.D |
| description | Objective To study the association between birth weight and polycystic ovary syndrome (PCOS) in adult life in Danish women born 1973–1991. Design Register study. Setting Data were extracted from the Danish Medical Birth Register and the Danish National Patient Register (NPR). Patient(s) All female children born of Danish mothers in Denmark between 1973 and 1991 were included (n = 523,757) and followed for a total of 4,739,547 person-years at risk. Intervention(s) None. Main Outcome Measure(s) Information on birth weight was extracted from the Danish Medical Birth Register. The cohort was followed up in the NPR for PCOS diagnoses from age 15 years until the end of 2006. Furthermore, information on maternal diabetes diagnoses was extracted from the NPR. Result(s) The risk of PCOS was significantly increased in women with birth weight ≥4,500 g (incidence rate ratio, 1.57; 95% confidence interval 1.21–2.03) compared to women with birth weight 3,000–3,499 g. All women with birth weight ≥4,500 g were born large for gestational age and a birth weight of 4,500 g represented the 98.5th percentile of the birth weights. Women born of mothers diagnosed with diabetes were at increased risk of PCOS. In these women the risk of PCOS increased with decreasing birth weight. Conclusion(s) The risk of PCOS was increased in women born with birth weight ≥4,500 g. In women of diabetic mothers we found an increased risk of PCOS, which was inversely related to birth weight. |
| doi_str_mv | 10.1016/j.fertnstert.2012.11.004 |
| format | article |
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Design Register study. Setting Data were extracted from the Danish Medical Birth Register and the Danish National Patient Register (NPR). Patient(s) All female children born of Danish mothers in Denmark between 1973 and 1991 were included (n = 523,757) and followed for a total of 4,739,547 person-years at risk. Intervention(s) None. Main Outcome Measure(s) Information on birth weight was extracted from the Danish Medical Birth Register. The cohort was followed up in the NPR for PCOS diagnoses from age 15 years until the end of 2006. Furthermore, information on maternal diabetes diagnoses was extracted from the NPR. Result(s) The risk of PCOS was significantly increased in women with birth weight ≥4,500 g (incidence rate ratio, 1.57; 95% confidence interval 1.21–2.03) compared to women with birth weight 3,000–3,499 g. All women with birth weight ≥4,500 g were born large for gestational age and a birth weight of 4,500 g represented the 98.5th percentile of the birth weights. Women born of mothers diagnosed with diabetes were at increased risk of PCOS. In these women the risk of PCOS increased with decreasing birth weight. Conclusion(s) The risk of PCOS was increased in women born with birth weight ≥4,500 g. In women of diabetic mothers we found an increased risk of PCOS, which was inversely related to birth weight.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2012.11.004</identifier><identifier>PMID: 23200688</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; adults ; animal ovaries ; Birth Weight ; children ; Cohort Studies ; confidence interval ; Denmark - epidemiology ; diabetes ; Diabetes Mellitus, Type 1 - epidemiology ; Diabetes Mellitus, Type 2 - epidemiology ; Female ; Humans ; Incidence ; Internal Medicine ; large for gestational age ; maternal diabetes ; mothers ; Obstetrics and Gynecology ; patients ; polycystic ovary syndrome ; Polycystic Ovary Syndrome - epidemiology ; Pregnancy ; Pregnancy in Diabetics - epidemiology ; Registries - statistics & numerical data ; risk ; Risk Factors ; women ; Young Adult</subject><ispartof>Fertility and sterility, 2013-03, Vol.99 (3), p.777-782</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2013 American Society for Reproductive Medicine</rights><rights>Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-288ba29b0b4f5c1f6303c3e39c9acc4c6d53ae597df6f1c6f1f15b5171219ff43</citedby><cites>FETCH-LOGICAL-c503t-288ba29b0b4f5c1f6303c3e39c9acc4c6d53ae597df6f1c6f1f15b5171219ff43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028212023989$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,786,790,3568,27957,27958,45815</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23200688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mumm, Hanne, M.D</creatorcontrib><creatorcontrib>Kamper-Jørgensen, Mads, M.Sc., Ph.D</creatorcontrib><creatorcontrib>Nybo Andersen, Anne-Marie, M.D., Ph.D</creatorcontrib><creatorcontrib>Glintborg, Dorte, M.D., Ph.D</creatorcontrib><creatorcontrib>Andersen, Marianne, M.D., Ph.D</creatorcontrib><title>Birth weight and polycystic ovary syndrome in adult life: a register-based study on 523,757 Danish women born 1973–1991</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To study the association between birth weight and polycystic ovary syndrome (PCOS) in adult life in Danish women born 1973–1991. Design Register study. Setting Data were extracted from the Danish Medical Birth Register and the Danish National Patient Register (NPR). Patient(s) All female children born of Danish mothers in Denmark between 1973 and 1991 were included (n = 523,757) and followed for a total of 4,739,547 person-years at risk. Intervention(s) None. Main Outcome Measure(s) Information on birth weight was extracted from the Danish Medical Birth Register. The cohort was followed up in the NPR for PCOS diagnoses from age 15 years until the end of 2006. Furthermore, information on maternal diabetes diagnoses was extracted from the NPR. Result(s) The risk of PCOS was significantly increased in women with birth weight ≥4,500 g (incidence rate ratio, 1.57; 95% confidence interval 1.21–2.03) compared to women with birth weight 3,000–3,499 g. All women with birth weight ≥4,500 g were born large for gestational age and a birth weight of 4,500 g represented the 98.5th percentile of the birth weights. Women born of mothers diagnosed with diabetes were at increased risk of PCOS. In these women the risk of PCOS increased with decreasing birth weight. Conclusion(s) The risk of PCOS was increased in women born with birth weight ≥4,500 g. In women of diabetic mothers we found an increased risk of PCOS, which was inversely related to birth weight.</description><subject>Adult</subject><subject>adults</subject><subject>animal ovaries</subject><subject>Birth Weight</subject><subject>children</subject><subject>Cohort Studies</subject><subject>confidence interval</subject><subject>Denmark - epidemiology</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Type 1 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>large for gestational age</subject><subject>maternal diabetes</subject><subject>mothers</subject><subject>Obstetrics and Gynecology</subject><subject>patients</subject><subject>polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - epidemiology</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics - epidemiology</subject><subject>Registries - statistics & numerical data</subject><subject>risk</subject><subject>Risk Factors</subject><subject>women</subject><subject>Young Adult</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNks1u1DAUhSMEokPhFcBLFiT42nESs0Bqy69UiUXp2nKc66mHjD3YSVF2vANvyJPgaApIrFj4Z3HOudefb1EQoBVQaF7uKotx8mnKe8UosAqgorS-V2xAiKYUjeD3iw2lIErKOnZSPEppRyltoGUPixPGWb533aZYzl2cbsg3dNubiWg_kEMYF7OkyRkSbnVcSFr8EMMeifNED_M4kdFZfEU0ibh1aw9lrxMOJE3zsJDgiWD8RSta8kZ7l3J4NnvSh-gJyJb__P4DpITHxQOrx4RP7s7T4vrd288XH8rLT-8_XpxdlkZQPpWs63rNZE_72goDtuGUG45cGqmNqU0zCK5RyHawjQWTlwXRC2iBgbS25qfF82PuIYavM6ZJ7V0yOI7aY5iTAi4aKWrZNVnaHaUmhpQiWnWIbp8ZKKBqBa926i94tYJXACqDz9and1Xmfo_DH-Nv0lnw7CiwOii9jS6p66ucIPIn5TcCZMX5UYGZxq3DqJJx6A0OLqKZ1BDc__Tx-p8QMzrvjB6_4IJpF-boM20FKjFF1dU6IuuEAKOMy07yX1H8t5o</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Mumm, Hanne, M.D</creator><creator>Kamper-Jørgensen, Mads, M.Sc., Ph.D</creator><creator>Nybo Andersen, Anne-Marie, M.D., Ph.D</creator><creator>Glintborg, Dorte, M.D., Ph.D</creator><creator>Andersen, Marianne, M.D., Ph.D</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130301</creationdate><title>Birth weight and polycystic ovary syndrome in adult life: a register-based study on 523,757 Danish women born 1973–1991</title><author>Mumm, Hanne, M.D ; Kamper-Jørgensen, Mads, M.Sc., Ph.D ; Nybo Andersen, Anne-Marie, M.D., Ph.D ; Glintborg, Dorte, M.D., Ph.D ; Andersen, Marianne, M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-288ba29b0b4f5c1f6303c3e39c9acc4c6d53ae597df6f1c6f1f15b5171219ff43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>adults</topic><topic>animal ovaries</topic><topic>Birth Weight</topic><topic>children</topic><topic>Cohort Studies</topic><topic>confidence interval</topic><topic>Denmark - epidemiology</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Type 1 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>large for gestational age</topic><topic>maternal diabetes</topic><topic>mothers</topic><topic>Obstetrics and Gynecology</topic><topic>patients</topic><topic>polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - epidemiology</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics - epidemiology</topic><topic>Registries - statistics & numerical data</topic><topic>risk</topic><topic>Risk Factors</topic><topic>women</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mumm, Hanne, M.D</creatorcontrib><creatorcontrib>Kamper-Jørgensen, Mads, M.Sc., Ph.D</creatorcontrib><creatorcontrib>Nybo Andersen, Anne-Marie, M.D., Ph.D</creatorcontrib><creatorcontrib>Glintborg, Dorte, M.D., Ph.D</creatorcontrib><creatorcontrib>Andersen, Marianne, M.D., Ph.D</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mumm, Hanne, M.D</au><au>Kamper-Jørgensen, Mads, M.Sc., Ph.D</au><au>Nybo Andersen, Anne-Marie, M.D., Ph.D</au><au>Glintborg, Dorte, M.D., Ph.D</au><au>Andersen, Marianne, M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Birth weight and polycystic ovary syndrome in adult life: a register-based study on 523,757 Danish women born 1973–1991</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>99</volume><issue>3</issue><spage>777</spage><epage>782</epage><pages>777-782</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><notes>http://dx.doi.org/10.1016/j.fertnstert.2012.11.004</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Objective To study the association between birth weight and polycystic ovary syndrome (PCOS) in adult life in Danish women born 1973–1991. Design Register study. Setting Data were extracted from the Danish Medical Birth Register and the Danish National Patient Register (NPR). Patient(s) All female children born of Danish mothers in Denmark between 1973 and 1991 were included (n = 523,757) and followed for a total of 4,739,547 person-years at risk. Intervention(s) None. Main Outcome Measure(s) Information on birth weight was extracted from the Danish Medical Birth Register. The cohort was followed up in the NPR for PCOS diagnoses from age 15 years until the end of 2006. Furthermore, information on maternal diabetes diagnoses was extracted from the NPR. Result(s) The risk of PCOS was significantly increased in women with birth weight ≥4,500 g (incidence rate ratio, 1.57; 95% confidence interval 1.21–2.03) compared to women with birth weight 3,000–3,499 g. All women with birth weight ≥4,500 g were born large for gestational age and a birth weight of 4,500 g represented the 98.5th percentile of the birth weights. Women born of mothers diagnosed with diabetes were at increased risk of PCOS. In these women the risk of PCOS increased with decreasing birth weight. Conclusion(s) The risk of PCOS was increased in women born with birth weight ≥4,500 g. In women of diabetic mothers we found an increased risk of PCOS, which was inversely related to birth weight.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23200688</pmid><doi>10.1016/j.fertnstert.2012.11.004</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 2013-03, Vol.99 (3), p.777-782 |
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| source | ScienceDirect® |
| subjects | Adult adults animal ovaries Birth Weight children Cohort Studies confidence interval Denmark - epidemiology diabetes Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 2 - epidemiology Female Humans Incidence Internal Medicine large for gestational age maternal diabetes mothers Obstetrics and Gynecology patients polycystic ovary syndrome Polycystic Ovary Syndrome - epidemiology Pregnancy Pregnancy in Diabetics - epidemiology Registries - statistics & numerical data risk Risk Factors women Young Adult |
| title | Birth weight and polycystic ovary syndrome in adult life: a register-based study on 523,757 Danish women born 1973–1991 |
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