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Ghrelin and motilin levels in hyperemesis gravidarum
Purpose Ghrelin, an endogenous ligand for the growth hormone secratogogue receptor, and its receptors are found in the reproductive organs and placenta. Motilin is produced from the endocrine cells of the duodeno jejunal mucosa and considered to be a regulator of interdigestive migrating contraction...
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| Published in: | Archives of gynecology and obstetrics 2013-06, Vol.287 (6), p.1087-1092 |
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| container_end_page | 1092 |
| container_issue | 6 |
| container_start_page | 1087 |
| container_title | Archives of gynecology and obstetrics |
| container_volume | 287 |
| creator | Oruç, Ayla Sargın Mert, Ismail Akturk, Mujde Aslan, Ebru Polat, Belgin Buyukkagnıcı, Umran Danışman, Nuri |
| description | Purpose
Ghrelin, an endogenous ligand for the growth hormone secratogogue receptor, and its receptors are found in the reproductive organs and placenta. Motilin is produced from the endocrine cells of the duodeno jejunal mucosa and considered to be a regulator of interdigestive migrating contractions. Aim of this study is to investigate ghrelin and motilin levels in patients with hyperemesis gravidarum.
Methods
A total of 56 patients with singleton pregnancies in the first trimester were recruited in the study, 39 with hyperemezis gravidarum and 17 normal pregnant women. Patients with medical complications and body mass index 25 were excluded. Fasting plasma ghrelin and motilin concentrations were measured. Fasting blood glucose, liver enzymes, blood urea nitrogen, creatinin, estradiol, progesterone, human chorionic gonadotropin, and thyroid function tests were also investigated.
Results
Ghrelin levels were significantly higher in patients with hyperemesis group than the normal pregnant women (
p
= 0.025). Serum estradiol levels were also higher in the hyperemesis group (
p
= 0.001). No significant difference was observed in plasma motilin levels between the two groups. In correlation analyses, maternal ghrelin was positively correlated with estradiol (
r
= 0.29,
p
= 0.029) in the whole cohort.
Conclusion
There are a few studies about the course of circulating ghrelin levels during human pregnancy. Ghrelin administration increases food intake through central mechanisms but its effects on appetite in relation to human pregnancy is unknown. The increased levels of ghrelin in hyperemesis gravidarum might be a compensatory mechanism to restore the energy metabolism of the pregnant women. |
| doi_str_mv | 10.1007/s00404-012-2705-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1353039285</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2261877365</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-85779cc86c73a84fbd5618b80f903fb188fae3ae93083360e5d84aded4f5dada3</originalsourceid><addsrcrecordid>eNp1kE1Lw0AQhhdRbK3-AC8S8OIlOvuR7OYoRatQ8KLnZZOdtCn5qLtNof_eDakKgqd9YZ95Z3gIuaZwTwHkgwcQIGKgLGYSklidkCkVnMUgKT0lU8iGDKmckAvvNxBApdJzMmGcZalIkykRi7XDumoj09qo6XbVkGvcY-2jkNaHLTps0Fc-Wjmzr6xxfXNJzkpTe7w6vjPy8fz0Pn-Jl2-L1_njMi4EV7tYJVJmRaHSQnKjRJnbJKUqV1BmwMucKlUa5AYzDorzFDCxShiLVpSJNdbwGbkbe7eu--zR73RT-QLr2rTY9V5TnnDgGVNJQG__oJuud224TjMWtkrJ04GiI1W4znuHpd66qjHuoCnoQakelepgSg9KtQozN8fmPm_Q_kx8OwwAGwEfvtoVut_V_7d-AQU8f_4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261877365</pqid></control><display><type>article</type><title>Ghrelin and motilin levels in hyperemesis gravidarum</title><source>Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List</source><creator>Oruç, Ayla Sargın ; Mert, Ismail ; Akturk, Mujde ; Aslan, Ebru ; Polat, Belgin ; Buyukkagnıcı, Umran ; Danışman, Nuri</creator><creatorcontrib>Oruç, Ayla Sargın ; Mert, Ismail ; Akturk, Mujde ; Aslan, Ebru ; Polat, Belgin ; Buyukkagnıcı, Umran ; Danışman, Nuri</creatorcontrib><description>Purpose
Ghrelin, an endogenous ligand for the growth hormone secratogogue receptor, and its receptors are found in the reproductive organs and placenta. Motilin is produced from the endocrine cells of the duodeno jejunal mucosa and considered to be a regulator of interdigestive migrating contractions. Aim of this study is to investigate ghrelin and motilin levels in patients with hyperemesis gravidarum.
Methods
A total of 56 patients with singleton pregnancies in the first trimester were recruited in the study, 39 with hyperemezis gravidarum and 17 normal pregnant women. Patients with medical complications and body mass index <18 or >25 were excluded. Fasting plasma ghrelin and motilin concentrations were measured. Fasting blood glucose, liver enzymes, blood urea nitrogen, creatinin, estradiol, progesterone, human chorionic gonadotropin, and thyroid function tests were also investigated.
Results
Ghrelin levels were significantly higher in patients with hyperemesis group than the normal pregnant women (
p
= 0.025). Serum estradiol levels were also higher in the hyperemesis group (
p
= 0.001). No significant difference was observed in plasma motilin levels between the two groups. In correlation analyses, maternal ghrelin was positively correlated with estradiol (
r
= 0.29,
p
= 0.029) in the whole cohort.
Conclusion
There are a few studies about the course of circulating ghrelin levels during human pregnancy. Ghrelin administration increases food intake through central mechanisms but its effects on appetite in relation to human pregnancy is unknown. The increased levels of ghrelin in hyperemesis gravidarum might be a compensatory mechanism to restore the energy metabolism of the pregnant women.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-012-2705-8</identifier><identifier>PMID: 23296465</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Blood Glucose - analysis ; Endocrinology ; Energy Metabolism - physiology ; Estradiol - blood ; Fasting - blood ; Female ; Gestational Age ; Ghrelin - blood ; Gynecology ; Human Genetics ; Humans ; Hyperemesis Gravidarum - blood ; Maternal-Fetal Medicine ; Medicine ; Medicine & Public Health ; Motilin - blood ; Obstetrics/Perinatology/Midwifery ; Pregnancy ; Progesterone - blood ; Thyrotropin - blood</subject><ispartof>Archives of gynecology and obstetrics, 2013-06, Vol.287 (6), p.1087-1092</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2013). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-85779cc86c73a84fbd5618b80f903fb188fae3ae93083360e5d84aded4f5dada3</citedby><cites>FETCH-LOGICAL-c438t-85779cc86c73a84fbd5618b80f903fb188fae3ae93083360e5d84aded4f5dada3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23296465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oruç, Ayla Sargın</creatorcontrib><creatorcontrib>Mert, Ismail</creatorcontrib><creatorcontrib>Akturk, Mujde</creatorcontrib><creatorcontrib>Aslan, Ebru</creatorcontrib><creatorcontrib>Polat, Belgin</creatorcontrib><creatorcontrib>Buyukkagnıcı, Umran</creatorcontrib><creatorcontrib>Danışman, Nuri</creatorcontrib><title>Ghrelin and motilin levels in hyperemesis gravidarum</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
Ghrelin, an endogenous ligand for the growth hormone secratogogue receptor, and its receptors are found in the reproductive organs and placenta. Motilin is produced from the endocrine cells of the duodeno jejunal mucosa and considered to be a regulator of interdigestive migrating contractions. Aim of this study is to investigate ghrelin and motilin levels in patients with hyperemesis gravidarum.
Methods
A total of 56 patients with singleton pregnancies in the first trimester were recruited in the study, 39 with hyperemezis gravidarum and 17 normal pregnant women. Patients with medical complications and body mass index <18 or >25 were excluded. Fasting plasma ghrelin and motilin concentrations were measured. Fasting blood glucose, liver enzymes, blood urea nitrogen, creatinin, estradiol, progesterone, human chorionic gonadotropin, and thyroid function tests were also investigated.
Results
Ghrelin levels were significantly higher in patients with hyperemesis group than the normal pregnant women (
p
= 0.025). Serum estradiol levels were also higher in the hyperemesis group (
p
= 0.001). No significant difference was observed in plasma motilin levels between the two groups. In correlation analyses, maternal ghrelin was positively correlated with estradiol (
r
= 0.29,
p
= 0.029) in the whole cohort.
Conclusion
There are a few studies about the course of circulating ghrelin levels during human pregnancy. Ghrelin administration increases food intake through central mechanisms but its effects on appetite in relation to human pregnancy is unknown. The increased levels of ghrelin in hyperemesis gravidarum might be a compensatory mechanism to restore the energy metabolism of the pregnant women.</description><subject>Adult</subject><subject>Blood Glucose - analysis</subject><subject>Endocrinology</subject><subject>Energy Metabolism - physiology</subject><subject>Estradiol - blood</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Ghrelin - blood</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Hyperemesis Gravidarum - blood</subject><subject>Maternal-Fetal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Motilin - blood</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Pregnancy</subject><subject>Progesterone - blood</subject><subject>Thyrotropin - blood</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kE1Lw0AQhhdRbK3-AC8S8OIlOvuR7OYoRatQ8KLnZZOdtCn5qLtNof_eDakKgqd9YZ95Z3gIuaZwTwHkgwcQIGKgLGYSklidkCkVnMUgKT0lU8iGDKmckAvvNxBApdJzMmGcZalIkykRi7XDumoj09qo6XbVkGvcY-2jkNaHLTps0Fc-Wjmzr6xxfXNJzkpTe7w6vjPy8fz0Pn-Jl2-L1_njMi4EV7tYJVJmRaHSQnKjRJnbJKUqV1BmwMucKlUa5AYzDorzFDCxShiLVpSJNdbwGbkbe7eu--zR73RT-QLr2rTY9V5TnnDgGVNJQG__oJuud224TjMWtkrJ04GiI1W4znuHpd66qjHuoCnoQakelepgSg9KtQozN8fmPm_Q_kx8OwwAGwEfvtoVut_V_7d-AQU8f_4</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Oruç, Ayla Sargın</creator><creator>Mert, Ismail</creator><creator>Akturk, Mujde</creator><creator>Aslan, Ebru</creator><creator>Polat, Belgin</creator><creator>Buyukkagnıcı, Umran</creator><creator>Danışman, Nuri</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Ghrelin and motilin levels in hyperemesis gravidarum</title><author>Oruç, Ayla Sargın ; Mert, Ismail ; Akturk, Mujde ; Aslan, Ebru ; Polat, Belgin ; Buyukkagnıcı, Umran ; Danışman, Nuri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-85779cc86c73a84fbd5618b80f903fb188fae3ae93083360e5d84aded4f5dada3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Blood Glucose - analysis</topic><topic>Endocrinology</topic><topic>Energy Metabolism - physiology</topic><topic>Estradiol - blood</topic><topic>Fasting - blood</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Ghrelin - blood</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Hyperemesis Gravidarum - blood</topic><topic>Maternal-Fetal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Motilin - blood</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Pregnancy</topic><topic>Progesterone - blood</topic><topic>Thyrotropin - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oruç, Ayla Sargın</creatorcontrib><creatorcontrib>Mert, Ismail</creatorcontrib><creatorcontrib>Akturk, Mujde</creatorcontrib><creatorcontrib>Aslan, Ebru</creatorcontrib><creatorcontrib>Polat, Belgin</creatorcontrib><creatorcontrib>Buyukkagnıcı, Umran</creatorcontrib><creatorcontrib>Danışman, Nuri</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oruç, Ayla Sargın</au><au>Mert, Ismail</au><au>Akturk, Mujde</au><au>Aslan, Ebru</au><au>Polat, Belgin</au><au>Buyukkagnıcı, Umran</au><au>Danışman, Nuri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ghrelin and motilin levels in hyperemesis gravidarum</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>287</volume><issue>6</issue><spage>1087</spage><epage>1092</epage><pages>1087-1092</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Purpose
Ghrelin, an endogenous ligand for the growth hormone secratogogue receptor, and its receptors are found in the reproductive organs and placenta. Motilin is produced from the endocrine cells of the duodeno jejunal mucosa and considered to be a regulator of interdigestive migrating contractions. Aim of this study is to investigate ghrelin and motilin levels in patients with hyperemesis gravidarum.
Methods
A total of 56 patients with singleton pregnancies in the first trimester were recruited in the study, 39 with hyperemezis gravidarum and 17 normal pregnant women. Patients with medical complications and body mass index <18 or >25 were excluded. Fasting plasma ghrelin and motilin concentrations were measured. Fasting blood glucose, liver enzymes, blood urea nitrogen, creatinin, estradiol, progesterone, human chorionic gonadotropin, and thyroid function tests were also investigated.
Results
Ghrelin levels were significantly higher in patients with hyperemesis group than the normal pregnant women (
p
= 0.025). Serum estradiol levels were also higher in the hyperemesis group (
p
= 0.001). No significant difference was observed in plasma motilin levels between the two groups. In correlation analyses, maternal ghrelin was positively correlated with estradiol (
r
= 0.29,
p
= 0.029) in the whole cohort.
Conclusion
There are a few studies about the course of circulating ghrelin levels during human pregnancy. Ghrelin administration increases food intake through central mechanisms but its effects on appetite in relation to human pregnancy is unknown. The increased levels of ghrelin in hyperemesis gravidarum might be a compensatory mechanism to restore the energy metabolism of the pregnant women.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23296465</pmid><doi>10.1007/s00404-012-2705-8</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2013-06, Vol.287 (6), p.1087-1092 |
| issn | 0932-0067 1432-0711 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1353039285 |
| source | Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List |
| subjects | Adult Blood Glucose - analysis Endocrinology Energy Metabolism - physiology Estradiol - blood Fasting - blood Female Gestational Age Ghrelin - blood Gynecology Human Genetics Humans Hyperemesis Gravidarum - blood Maternal-Fetal Medicine Medicine Medicine & Public Health Motilin - blood Obstetrics/Perinatology/Midwifery Pregnancy Progesterone - blood Thyrotropin - blood |
| title | Ghrelin and motilin levels in hyperemesis gravidarum |
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