Ghrelin and motilin levels in hyperemesis gravidarum

Purpose Ghrelin, an endogenous ligand for the growth hormone secratogogue receptor, and its receptors are found in the reproductive organs and placenta. Motilin is produced from the endocrine cells of the duodeno jejunal mucosa and considered to be a regulator of interdigestive migrating contraction...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2013-06, Vol.287 (6), p.1087-1092
Main Authors: Oruç, Ayla Sargın, Mert, Ismail, Akturk, Mujde, Aslan, Ebru, Polat, Belgin, Buyukkagnıcı, Umran, Danışman, Nuri
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - analysis
Endocrinology
Energy Metabolism - physiology
Estradiol - blood
Fasting - blood
Female
Gestational Age
Ghrelin - blood
Gynecology
Human Genetics
Humans
Hyperemesis Gravidarum - blood
Maternal-Fetal Medicine
Medicine
Medicine & Public Health
Motilin - blood
Obstetrics/Perinatology/Midwifery
Pregnancy
Progesterone - blood
Thyrotropin - blood
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Summary:Purpose Ghrelin, an endogenous ligand for the growth hormone secratogogue receptor, and its receptors are found in the reproductive organs and placenta. Motilin is produced from the endocrine cells of the duodeno jejunal mucosa and considered to be a regulator of interdigestive migrating contractions. Aim of this study is to investigate ghrelin and motilin levels in patients with hyperemesis gravidarum. Methods A total of 56 patients with singleton pregnancies in the first trimester were recruited in the study, 39 with hyperemezis gravidarum and 17 normal pregnant women. Patients with medical complications and body mass index 25 were excluded. Fasting plasma ghrelin and motilin concentrations were measured. Fasting blood glucose, liver enzymes, blood urea nitrogen, creatinin, estradiol, progesterone, human chorionic gonadotropin, and thyroid function tests were also investigated. Results Ghrelin levels were significantly higher in patients with hyperemesis group than the normal pregnant women ( p  = 0.025). Serum estradiol levels were also higher in the hyperemesis group ( p  = 0.001). No significant difference was observed in plasma motilin levels between the two groups. In correlation analyses, maternal ghrelin was positively correlated with estradiol ( r  = 0.29, p  = 0.029) in the whole cohort. Conclusion There are a few studies about the course of circulating ghrelin levels during human pregnancy. Ghrelin administration increases food intake through central mechanisms but its effects on appetite in relation to human pregnancy is unknown. The increased levels of ghrelin in hyperemesis gravidarum might be a compensatory mechanism to restore the energy metabolism of the pregnant women.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-012-2705-8