Influence of body temperature on the evoked activity in mouse visual cortex

Optical imaging of intrinsic signals and conventional electrophysiological methods were used to investigate the correlation between the evoked activity in mouse visual cortex and core body temperature. The results show that hypothermia (25–36 °C) decreases the intensity of optical imaging in the vis...

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Published in:Brain imaging and behavior 2013-06, Vol.7 (2), p.177-187
Main Authors: Tang, Bin, Kalatsky, Valery A.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Body temperature
Body Temperature - physiology
Brain research
Cameras
Evoked Potentials, Visual - physiology
Female
Fever
Fever - physiopathology
Hyperthermia
Hypothermia
Hypothermia - physiopathology
Male
Medical imaging
Medical research
Metabolism
Mice
Mice, Inbred C57BL
Nervous system
Neuroimaging
Neurons - physiology
Neuropsychology
Neuroradiology
Neurosciences
Optical Imaging
Original Research
Photic Stimulation
Physiology
Psychiatry
Software
Visual Cortex - physiology
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Kalatsky, Valery A.
description Optical imaging of intrinsic signals and conventional electrophysiological methods were used to investigate the correlation between the evoked activity in mouse visual cortex and core body temperature. The results show that hypothermia (25–36 °C) decreases the intensity of optical imaging in the visual cortex and the imaging signal reversibly disappears at 25 °C. Hyperthermia (39–41 °C) increases the intensity but decreases the quality of cortical imaging when body temperature is above 40 °C. The change of optical imaging was in line with that of neuronal activities and local field potentials (LFPs) directly recorded from the visual cortex at 25–39 °C. Hypothermia decreases neuron firing rate and LFPs amplitude. Most of the recorded neurons ceased firing to visual stimulation at 25 °C. Hyperthermia increases neuronal firing rate and LFPs amplitude. Both are reduced when body temperature is above 40 °C, though neither change was statistically significant. These results suggest: (1) Body temperature has an important impact on the visual cortical evoked activities and optical imaging generally reflects these effects when body temperature is between 25 and 39 °C; (2) Optical imaging may not properly reflect the neuronal activity when body temperature is over 40 °C. It is important to maintain core body temperature within 3 °C of the normal body temperature to obtain verifiable results.
doi_str_mv 10.1007/s11682-012-9212-1
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The results show that hypothermia (25–36 °C) decreases the intensity of optical imaging in the visual cortex and the imaging signal reversibly disappears at 25 °C. Hyperthermia (39–41 °C) increases the intensity but decreases the quality of cortical imaging when body temperature is above 40 °C. The change of optical imaging was in line with that of neuronal activities and local field potentials (LFPs) directly recorded from the visual cortex at 25–39 °C. Hypothermia decreases neuron firing rate and LFPs amplitude. Most of the recorded neurons ceased firing to visual stimulation at 25 °C. Hyperthermia increases neuronal firing rate and LFPs amplitude. Both are reduced when body temperature is above 40 °C, though neither change was statistically significant. These results suggest: (1) Body temperature has an important impact on the visual cortical evoked activities and optical imaging generally reflects these effects when body temperature is between 25 and 39 °C; (2) Optical imaging may not properly reflect the neuronal activity when body temperature is over 40 °C. It is important to maintain core body temperature within 3 °C of the normal body temperature to obtain verifiable results.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>23232799</pmid><doi>10.1007/s11682-012-9212-1</doi><tpages>11</tpages></addata></record>
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subjects Animals
Biomedical and Life Sciences
Biomedicine
Body temperature
Body Temperature - physiology
Brain research
Cameras
Evoked Potentials, Visual - physiology
Female
Fever
Fever - physiopathology
Hyperthermia
Hypothermia
Hypothermia - physiopathology
Male
Medical imaging
Medical research
Metabolism
Mice
Mice, Inbred C57BL
Nervous system
Neuroimaging
Neurons - physiology
Neuropsychology
Neuroradiology
Neurosciences
Optical Imaging
Original Research
Photic Stimulation
Physiology
Psychiatry
Software
Visual Cortex - physiology
title Influence of body temperature on the evoked activity in mouse visual cortex
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