The prevalence and trends of transfusion-transmissible infectious pathogens among first-time, voluntary blood donors in Xi’an, China between 1999 and 2009

Summary Objectives The prevalence of infectious diseases is increasing in developing countries, and this may threaten the biological safety of donated blood. This study analyzed trends in the prevalence of transfusion-transmissible infectious pathogens among Chinese, first-time, voluntary blood dono...

Full description

Saved in:
Bibliographic Details
Published in:International journal of infectious diseases 2013-04, Vol.17 (4), p.e259-e262
Main Authors: Ji, Zhao-Hua, Li, Cui-Ying, Lv, Yong-Gang, Cao, Wei, Chen, Yao-Zhen, Chen, Xiao-Peng, Tian, Min, Li, Jing-Hua, An, Qun-Xing, Shao, Zhong-Jun
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Blood Donors - psychology
Blood Safety
Blood-borne pathogens
China - epidemiology
Communicable Diseases - transmission
Disease Transmission, Infectious - statistics & numerical data
Enzyme-Linked Immunosorbent Assay
Female
Hepatitis
Hepatitis B - epidemiology
Hepatitis C - epidemiology
HIV Infections - epidemiology
Human immunodeficiency virus
Humans
Infectious Disease
Male
Middle Aged
Prevalence
Pulmonary/Respiratory
Sex Factors
Syphilis
Transfusion
Transfusion Reaction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Objectives The prevalence of infectious diseases is increasing in developing countries, and this may threaten the biological safety of donated blood. This study analyzed trends in the prevalence of transfusion-transmissible infectious pathogens among Chinese, first-time, voluntary blood donors from 1999 to 2009 to evaluate the potential for disease transmission. Methods From 1999 to 2009, all first-time donors at the Xi’an Blood Service (XBS) were screened for hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and syphilis infections using enzyme-linked immunosorbent assays (ELISA); results were confirmed using alternative commercial kits. The prevalence and temporal trends were analyzed using the Cochran–Armitage trend test and other appropriate methods. Results From 1999 to 2009, 263 299 first-time blood donors were analyzed. The overall prevalence rates were 1.16% for HBV, 0.51% for HCV, 0.02% for HIV, and 0.31% for syphilis. There was a significant decrease in the trend for HBV and HCV infections, while a significant increase was found for syphilis. The prevalence of HIV infection remained low and stable during the study period. Conclusions These findings suggest that HBV infection is the primary threat to blood safety, while the increasing prevalence of syphilis might also be a potential threat.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2012.10.006