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Emerging avenues linking inflammation, angiogenesis and Sjögren’s syndrome
► The salivary epithelial cells perpetuate chronic inflammation in Sjögren’s syndrome. ► Sjögren’s syndrome is characterized by the overexpression of inflammatory cytokines. ► Angiogenesis and inflammation are mutually correlated. ► Neovascularization contributes to the perpetuation of inflammation....
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| Published in: | Cytokine (Philadelphia, Pa.) Pa.), 2013-03, Vol.61 (3), p.693-703 |
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| cited_by | cdi_FETCH-LOGICAL-c380t-e5893bb271dbff73dec157107a04a77cec2762e6b601cac186d917464927eda23 |
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| container_title | Cytokine (Philadelphia, Pa.) |
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| creator | Lisi, Sabrina Sisto, Margherita D’Amore, Massimo Lofrumento, Dario Domenico Ribatti, Domenico |
| description | ► The salivary epithelial cells perpetuate chronic inflammation in Sjögren’s syndrome. ► Sjögren’s syndrome is characterized by the overexpression of inflammatory cytokines. ► Angiogenesis and inflammation are mutually correlated. ► Neovascularization contributes to the perpetuation of inflammation. ► The production of angiogenic factors occurs via NF-κB activation.
Sjögren’s syndrome (SS) is an autoimmune disease characterized by an inflammatory mononuclear infiltration and the destruction of epithelial cells of the lachrymal and salivary glands. The aetiology is unknown. The expression “autoimmune epithelitis” has been proposed as an alternative to SS, in view of the emerging central role of the epithelial cells in the disease pathogenesis. At the biomolecular level, the epithelial cells play an important role in triggering the autoimmune condition via antigen presentation, apoptosis, and chemokine and cytokines release. Inflammation and angiogenesis are frequently coupled in the pathological conditions associated to autoimmune diseases, and an angiogenic imbalance contributes to the pathogenesis of a number of inflammatory disorders.
This work reviews the current knowledge of the molecular and cellular mechanisms underlying the pathogenesis of the inflammatory reactions that characterize SS. The literature and our data on the role of angiogenesis in the pathophysiology of the disease are discussed. |
| doi_str_mv | 10.1016/j.cyto.2012.12.021 |
| format | article |
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Sjögren’s syndrome (SS) is an autoimmune disease characterized by an inflammatory mononuclear infiltration and the destruction of epithelial cells of the lachrymal and salivary glands. The aetiology is unknown. The expression “autoimmune epithelitis” has been proposed as an alternative to SS, in view of the emerging central role of the epithelial cells in the disease pathogenesis. At the biomolecular level, the epithelial cells play an important role in triggering the autoimmune condition via antigen presentation, apoptosis, and chemokine and cytokines release. Inflammation and angiogenesis are frequently coupled in the pathological conditions associated to autoimmune diseases, and an angiogenic imbalance contributes to the pathogenesis of a number of inflammatory disorders.
This work reviews the current knowledge of the molecular and cellular mechanisms underlying the pathogenesis of the inflammatory reactions that characterize SS. The literature and our data on the role of angiogenesis in the pathophysiology of the disease are discussed.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/j.cyto.2012.12.021</identifier><identifier>PMID: 23340181</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>angiogenesis ; Animals ; antigen presentation ; apoptosis ; autoimmune diseases ; chemokines ; Chronic Disease ; Chronic inflammation ; epithelial cells ; etiology ; Humans ; inflammation ; Inflammation - complications ; Inflammation - pathology ; Inflammation Mediators - metabolism ; IκBα ; Neovascularization ; Neovascularization, Pathologic - complications ; Neovascularization, Pathologic - pathology ; NF-κB ; pathogenesis ; pathophysiology ; Salivary glands ; Signal Transduction ; Sjogren's Syndrome - complications ; Sjogren's Syndrome - immunology ; Sjogren's Syndrome - pathology ; Sjogren's Syndrome - therapy</subject><ispartof>Cytokine (Philadelphia, Pa.), 2013-03, Vol.61 (3), p.693-703</ispartof><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-e5893bb271dbff73dec157107a04a77cec2762e6b601cac186d917464927eda23</citedby><cites>FETCH-LOGICAL-c380t-e5893bb271dbff73dec157107a04a77cec2762e6b601cac186d917464927eda23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23340181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lisi, Sabrina</creatorcontrib><creatorcontrib>Sisto, Margherita</creatorcontrib><creatorcontrib>D’Amore, Massimo</creatorcontrib><creatorcontrib>Lofrumento, Dario Domenico</creatorcontrib><creatorcontrib>Ribatti, Domenico</creatorcontrib><title>Emerging avenues linking inflammation, angiogenesis and Sjögren’s syndrome</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>► The salivary epithelial cells perpetuate chronic inflammation in Sjögren’s syndrome. ► Sjögren’s syndrome is characterized by the overexpression of inflammatory cytokines. ► Angiogenesis and inflammation are mutually correlated. ► Neovascularization contributes to the perpetuation of inflammation. ► The production of angiogenic factors occurs via NF-κB activation.
Sjögren’s syndrome (SS) is an autoimmune disease characterized by an inflammatory mononuclear infiltration and the destruction of epithelial cells of the lachrymal and salivary glands. The aetiology is unknown. The expression “autoimmune epithelitis” has been proposed as an alternative to SS, in view of the emerging central role of the epithelial cells in the disease pathogenesis. At the biomolecular level, the epithelial cells play an important role in triggering the autoimmune condition via antigen presentation, apoptosis, and chemokine and cytokines release. Inflammation and angiogenesis are frequently coupled in the pathological conditions associated to autoimmune diseases, and an angiogenic imbalance contributes to the pathogenesis of a number of inflammatory disorders.
This work reviews the current knowledge of the molecular and cellular mechanisms underlying the pathogenesis of the inflammatory reactions that characterize SS. The literature and our data on the role of angiogenesis in the pathophysiology of the disease are discussed.</description><subject>angiogenesis</subject><subject>Animals</subject><subject>antigen presentation</subject><subject>apoptosis</subject><subject>autoimmune diseases</subject><subject>chemokines</subject><subject>Chronic Disease</subject><subject>Chronic inflammation</subject><subject>epithelial cells</subject><subject>etiology</subject><subject>Humans</subject><subject>inflammation</subject><subject>Inflammation - complications</subject><subject>Inflammation - pathology</subject><subject>Inflammation Mediators - metabolism</subject><subject>IκBα</subject><subject>Neovascularization</subject><subject>Neovascularization, Pathologic - complications</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>NF-κB</subject><subject>pathogenesis</subject><subject>pathophysiology</subject><subject>Salivary glands</subject><subject>Signal Transduction</subject><subject>Sjogren's Syndrome - complications</subject><subject>Sjogren's Syndrome - immunology</subject><subject>Sjogren's Syndrome - pathology</subject><subject>Sjogren's Syndrome - therapy</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kE1q3TAQx0VpaD7aC3TRetlF_DqSbMmGbkLIF6R0kWYtZGls9GpLqeQXeLtcoxfJBXKTnqQyL8myMDAz8Js_w4-QjxRWFKj4ul6Z7RxWDChb5QJG35ADCq0oARh_u8wVLyshxD45TGkNAC2X8h3ZZ5xXQBt6QL6fTRgH54dC36PfYCpG538tu_P9qKdJzy7440L7wYUBPSaX8mKLm_XT4xDR_334k4q09TaGCd-TvV6PCT889yNye3728_SyvP5xcXV6cl0a3sBcYt20vOuYpLbre8ktGlpLClJDpaU0aJgUDEUngBptaCNsS2UlqpZJtJrxI_Jll3sXw-_89KwmlwyOo_YYNklRTgXUsmIio2yHmhhSitiru-gmHbeKglo0qrVaNKpFo8qVNeajT8_5m25C-3ry4i0Dn3dAr4PSQ3RJ3d7khDo7bmoOC_FtR2D2cO8wqmQceoPWRTSzssH974N_UFKOuw</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Lisi, Sabrina</creator><creator>Sisto, Margherita</creator><creator>D’Amore, Massimo</creator><creator>Lofrumento, Dario Domenico</creator><creator>Ribatti, Domenico</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130301</creationdate><title>Emerging avenues linking inflammation, angiogenesis and Sjögren’s syndrome</title><author>Lisi, Sabrina ; Sisto, Margherita ; D’Amore, Massimo ; Lofrumento, Dario Domenico ; Ribatti, Domenico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-e5893bb271dbff73dec157107a04a77cec2762e6b601cac186d917464927eda23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>angiogenesis</topic><topic>Animals</topic><topic>antigen presentation</topic><topic>apoptosis</topic><topic>autoimmune diseases</topic><topic>chemokines</topic><topic>Chronic Disease</topic><topic>Chronic inflammation</topic><topic>epithelial cells</topic><topic>etiology</topic><topic>Humans</topic><topic>inflammation</topic><topic>Inflammation - complications</topic><topic>Inflammation - pathology</topic><topic>Inflammation Mediators - metabolism</topic><topic>IκBα</topic><topic>Neovascularization</topic><topic>Neovascularization, Pathologic - complications</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>NF-κB</topic><topic>pathogenesis</topic><topic>pathophysiology</topic><topic>Salivary glands</topic><topic>Signal Transduction</topic><topic>Sjogren's Syndrome - complications</topic><topic>Sjogren's Syndrome - immunology</topic><topic>Sjogren's Syndrome - pathology</topic><topic>Sjogren's Syndrome - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lisi, Sabrina</creatorcontrib><creatorcontrib>Sisto, Margherita</creatorcontrib><creatorcontrib>D’Amore, Massimo</creatorcontrib><creatorcontrib>Lofrumento, Dario Domenico</creatorcontrib><creatorcontrib>Ribatti, Domenico</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lisi, Sabrina</au><au>Sisto, Margherita</au><au>D’Amore, Massimo</au><au>Lofrumento, Dario Domenico</au><au>Ribatti, Domenico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emerging avenues linking inflammation, angiogenesis and Sjögren’s syndrome</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><addtitle>Cytokine</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>61</volume><issue>3</issue><spage>693</spage><epage>703</epage><pages>693-703</pages><issn>1043-4666</issn><eissn>1096-0023</eissn><notes>http://dx.doi.org/10.1016/j.cyto.2012.12.021</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-1</notes><abstract>► The salivary epithelial cells perpetuate chronic inflammation in Sjögren’s syndrome. ► Sjögren’s syndrome is characterized by the overexpression of inflammatory cytokines. ► Angiogenesis and inflammation are mutually correlated. ► Neovascularization contributes to the perpetuation of inflammation. ► The production of angiogenic factors occurs via NF-κB activation.
Sjögren’s syndrome (SS) is an autoimmune disease characterized by an inflammatory mononuclear infiltration and the destruction of epithelial cells of the lachrymal and salivary glands. The aetiology is unknown. The expression “autoimmune epithelitis” has been proposed as an alternative to SS, in view of the emerging central role of the epithelial cells in the disease pathogenesis. At the biomolecular level, the epithelial cells play an important role in triggering the autoimmune condition via antigen presentation, apoptosis, and chemokine and cytokines release. Inflammation and angiogenesis are frequently coupled in the pathological conditions associated to autoimmune diseases, and an angiogenic imbalance contributes to the pathogenesis of a number of inflammatory disorders.
This work reviews the current knowledge of the molecular and cellular mechanisms underlying the pathogenesis of the inflammatory reactions that characterize SS. The literature and our data on the role of angiogenesis in the pathophysiology of the disease are discussed.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23340181</pmid><doi>10.1016/j.cyto.2012.12.021</doi><tpages>11</tpages></addata></record> |
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| subjects | angiogenesis Animals antigen presentation apoptosis autoimmune diseases chemokines Chronic Disease Chronic inflammation epithelial cells etiology Humans inflammation Inflammation - complications Inflammation - pathology Inflammation Mediators - metabolism IκBα Neovascularization Neovascularization, Pathologic - complications Neovascularization, Pathologic - pathology NF-κB pathogenesis pathophysiology Salivary glands Signal Transduction Sjogren's Syndrome - complications Sjogren's Syndrome - immunology Sjogren's Syndrome - pathology Sjogren's Syndrome - therapy |
| title | Emerging avenues linking inflammation, angiogenesis and Sjögren’s syndrome |
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