Lead Bone Toxicity in Growing Rats Exposed to Chronic Intermittent Hypoxia

Lead chronic intoxication under hypoxic conditions revealed growth retardation in growing rats and damages on femoral and mandibular bones that predispose to fractures. These findings aimed us to investigate if bone material and geometric properties, bone mass in terms of histomorphometry or antioxi...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 2012-10, Vol.89 (4), p.693-698
Main Authors: Conti, María I., Bozzini, Clarisa, Facorro, Graciela B., Lee, Ching M., Mandalunis, Patricia M., Piehl, Lidia L., Piñeiro, Adriana E., Terrizzi, Antonela R., Martínez, María P.
Format: Article
Language:English
Subjects:
Adaptability
Animals
Aquatic Pollution
Biomechanics
Bone and Bones - drug effects
Bone and Bones - physiology
Bone Density - drug effects
Bone Development - drug effects
Bones
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental Pollutants - toxicity
Femur - drug effects
Femur - growth & development
Growth Plate
Hypoxia
Hypoxia - veterinary
Lead - toxicity
Lead poisoning
Male
Mandible - drug effects
Mandible - growth & development
Pollution
Rats
Rodents
Soil Science & Conservation
Tibia
Toxicity
Waste Water Technology
Water Management
Water Pollution Control
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Summary:Lead chronic intoxication under hypoxic conditions revealed growth retardation in growing rats and damages on femoral and mandibular bones that predispose to fractures. These findings aimed us to investigate if bone material and geometric properties, bone mass in terms of histomorphometry or antioxidant capacity are also impaired in such experimental model. Combined treatments significantly reduced hemimandible cross sectional geometry and intrinsic stiffness (−16 % and −34 %); tibia and hemimandible bone volume (−45 % and −40 %) and growth plate cartilage thickness (−19 %). These results show a previously unreported toxic effect of lead on mandible however, longer studies should be necessary to evaluate if an adaptation of bone architecture to maintain structural properties may occur and if the oxidative stress can be identified as the primary contributory agent in the pathogenesis of lead poisoning.
ISSN:0007-4861
1432-0800
DOI:10.1007/s00128-012-0753-1