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Current or recent pregnancy is associated with adverse pathologic features but not impaired survival in early breast cancer
BACKGROUND: Pregnancy‐associated breast cancer (PABC) may be defined as breast cancer diagnosed during pregnancy or within 1 year of giving birth. Conflicting data exist regarding the impact of pregnancy on clinical features and prognosis of breast cancer. METHODS: A single‐institution retrospective...
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| Published in: | Cancer 2012-07, Vol.118 (13), p.3254-3259 |
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| container_end_page | 3259 |
| container_issue | 13 |
| container_start_page | 3254 |
| container_title | Cancer |
| container_volume | 118 |
| creator | Murphy, Conleth G. Mallam, Divya Stein, Samantha Patil, Sujata Howard, Jane Sklarin, Nancy Hudis, Clifford A. Gemignani, Mary L. Seidman, Andrew D. |
| description | BACKGROUND:
Pregnancy‐associated breast cancer (PABC) may be defined as breast cancer diagnosed during pregnancy or within 1 year of giving birth. Conflicting data exist regarding the impact of pregnancy on clinical features and prognosis of breast cancer.
METHODS:
A single‐institution retrospective chart review was performed of 99 patients identified with PABC between 1992 and 2007. Non‐PABC controls were matched 2:1 to PABC cases by year of diagnosis and age. The differences in clinical features were compared between cases and controls using chi‐square tests. Univariate and multivariate analyses were performed to assess the effect of PABC on survival.
RESULTS:
Of the 99 PABC cases, breast cancer was diagnosed during pregnancy in 36 patients, and after delivery in 63. PABC cases were more likely than controls to be negative for estrogen receptor (59% vs 31%, P < .0001) and negative for progesterone receptor (72% vs 40%, P < .0001). Cases were also more likely to have advanced T class (P = .0271) and N class (P = .0104) and higher grade tumors (P = .0115). With a median follow‐up of 6.3 years for cases and 4.7 years for controls, overall survival did not differ between cases and controls (P = .0787). On multivariate analysis, the independent prognostic factors for overall survival were estrogen receptor status (P = .0031) and N class (P = .0003). The diagnosis of PABC was not an independent prognostic factor (P = .1317).
CONCLUSIONS:
PABC is associated with more adverse tumor features than non‐PABC matched for age and year of diagnosis. After correcting for pathologic features, the diagnosis of PABC is not in itself an adverse prognostic factor for survival. Cancer 2011. © 2011 American Cancer Society.
We compared the clinical features and survival of 99 women diagnosed with pregnancy‐associated breast cancer (PABC) and 186 control patients matched for age and year of diagnosis. Although PABC was associated with more adverse pathologic features, the diagnosis of PABC was not itself an independent adverse prognostic feature. |
| doi_str_mv | 10.1002/cncr.26654 |
| format | article |
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Pregnancy‐associated breast cancer (PABC) may be defined as breast cancer diagnosed during pregnancy or within 1 year of giving birth. Conflicting data exist regarding the impact of pregnancy on clinical features and prognosis of breast cancer.
METHODS:
A single‐institution retrospective chart review was performed of 99 patients identified with PABC between 1992 and 2007. Non‐PABC controls were matched 2:1 to PABC cases by year of diagnosis and age. The differences in clinical features were compared between cases and controls using chi‐square tests. Univariate and multivariate analyses were performed to assess the effect of PABC on survival.
RESULTS:
Of the 99 PABC cases, breast cancer was diagnosed during pregnancy in 36 patients, and after delivery in 63. PABC cases were more likely than controls to be negative for estrogen receptor (59% vs 31%, P < .0001) and negative for progesterone receptor (72% vs 40%, P < .0001). Cases were also more likely to have advanced T class (P = .0271) and N class (P = .0104) and higher grade tumors (P = .0115). With a median follow‐up of 6.3 years for cases and 4.7 years for controls, overall survival did not differ between cases and controls (P = .0787). On multivariate analysis, the independent prognostic factors for overall survival were estrogen receptor status (P = .0031) and N class (P = .0003). The diagnosis of PABC was not an independent prognostic factor (P = .1317).
CONCLUSIONS:
PABC is associated with more adverse tumor features than non‐PABC matched for age and year of diagnosis. After correcting for pathologic features, the diagnosis of PABC is not in itself an adverse prognostic factor for survival. Cancer 2011. © 2011 American Cancer Society.
We compared the clinical features and survival of 99 women diagnosed with pregnancy‐associated breast cancer (PABC) and 186 control patients matched for age and year of diagnosis. Although PABC was associated with more adverse pathologic features, the diagnosis of PABC was not itself an independent adverse prognostic feature.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.26654</identifier><identifier>PMID: 22086863</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Biological and medical sciences ; breast cancer ; Breast Neoplasms - metabolism ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical sciences ; Middle Aged ; pathologic features ; post‐partum ; Pregnancy ; Pregnancy Complications, Neoplastic - metabolism ; Pregnancy Complications, Neoplastic - mortality ; Pregnancy Complications, Neoplastic - pathology ; prognosis ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; survival ; Tumors ; Young Adult</subject><ispartof>Cancer, 2012-07, Vol.118 (13), p.3254-3259</ispartof><rights>Copyright © 2011 American Cancer Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3954-aaa948d0e62e58f1378fc75bf821f365ed163905362e9215f65c46fd752317be3</citedby><cites>FETCH-LOGICAL-c3954-aaa948d0e62e58f1378fc75bf821f365ed163905362e9215f65c46fd752317be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,783,787,27936,27937</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26029531$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22086863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murphy, Conleth G.</creatorcontrib><creatorcontrib>Mallam, Divya</creatorcontrib><creatorcontrib>Stein, Samantha</creatorcontrib><creatorcontrib>Patil, Sujata</creatorcontrib><creatorcontrib>Howard, Jane</creatorcontrib><creatorcontrib>Sklarin, Nancy</creatorcontrib><creatorcontrib>Hudis, Clifford A.</creatorcontrib><creatorcontrib>Gemignani, Mary L.</creatorcontrib><creatorcontrib>Seidman, Andrew D.</creatorcontrib><title>Current or recent pregnancy is associated with adverse pathologic features but not impaired survival in early breast cancer</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND:
Pregnancy‐associated breast cancer (PABC) may be defined as breast cancer diagnosed during pregnancy or within 1 year of giving birth. Conflicting data exist regarding the impact of pregnancy on clinical features and prognosis of breast cancer.
METHODS:
A single‐institution retrospective chart review was performed of 99 patients identified with PABC between 1992 and 2007. Non‐PABC controls were matched 2:1 to PABC cases by year of diagnosis and age. The differences in clinical features were compared between cases and controls using chi‐square tests. Univariate and multivariate analyses were performed to assess the effect of PABC on survival.
RESULTS:
Of the 99 PABC cases, breast cancer was diagnosed during pregnancy in 36 patients, and after delivery in 63. PABC cases were more likely than controls to be negative for estrogen receptor (59% vs 31%, P < .0001) and negative for progesterone receptor (72% vs 40%, P < .0001). Cases were also more likely to have advanced T class (P = .0271) and N class (P = .0104) and higher grade tumors (P = .0115). With a median follow‐up of 6.3 years for cases and 4.7 years for controls, overall survival did not differ between cases and controls (P = .0787). On multivariate analysis, the independent prognostic factors for overall survival were estrogen receptor status (P = .0031) and N class (P = .0003). The diagnosis of PABC was not an independent prognostic factor (P = .1317).
CONCLUSIONS:
PABC is associated with more adverse tumor features than non‐PABC matched for age and year of diagnosis. After correcting for pathologic features, the diagnosis of PABC is not in itself an adverse prognostic factor for survival. Cancer 2011. © 2011 American Cancer Society.
We compared the clinical features and survival of 99 women diagnosed with pregnancy‐associated breast cancer (PABC) and 186 control patients matched for age and year of diagnosis. Although PABC was associated with more adverse pathologic features, the diagnosis of PABC was not itself an independent adverse prognostic feature.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>breast cancer</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>pathologic features</subject><subject>post‐partum</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Neoplastic - metabolism</subject><subject>Pregnancy Complications, Neoplastic - mortality</subject><subject>Pregnancy Complications, Neoplastic - pathology</subject><subject>prognosis</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>survival</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kE2L1EAQhhtR3HH14g-QvggiZLc_0p3kKMEvWFxYFLyFSqd6tyWTxOrOLIN_fnucUW-eqop66n2pl7GXUlxIIdSlmxxdKGtN-YhtpGiqQshSPWYbIURdmFJ_P2PPYvyRx0oZ_ZSdKSVqW1u9Yb_alQinxGfihO7QLYS3E0xuz0PkEOPsAiQc-H1IdxyGHVJEvkC6m8f5NjjuEdJKGHm_Jj7NiYftAoHyRVxpF3Yw8jBxBBr3vCeEmLjL8kjP2RMPY8QXp3rOvn14_7X9VFxdf_zcvrsqnG5MWQBAU9aDQKvQ1F7qqvauMr2vlfTaGhyk1Y0wOu8bJY23xpXWD5VRWlY96nP25qi70PxzxZi6bYgOxxEmnNfYSaGkMlUtZUbfHlFHc4yEvlsobIH2GeoOYXeHsLvfYWf41Ul37bc4_EX_pJuB1ycAooPRU347xH-cFaox-uAqj9x9GHH_H8uu_dLeHM0fAFbYmHo</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Murphy, Conleth G.</creator><creator>Mallam, Divya</creator><creator>Stein, Samantha</creator><creator>Patil, Sujata</creator><creator>Howard, Jane</creator><creator>Sklarin, Nancy</creator><creator>Hudis, Clifford A.</creator><creator>Gemignani, Mary L.</creator><creator>Seidman, Andrew D.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Current or recent pregnancy is associated with adverse pathologic features but not impaired survival in early breast cancer</title><author>Murphy, Conleth G. ; Mallam, Divya ; Stein, Samantha ; Patil, Sujata ; Howard, Jane ; Sklarin, Nancy ; Hudis, Clifford A. ; Gemignani, Mary L. ; Seidman, Andrew D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3954-aaa948d0e62e58f1378fc75bf821f365ed163905362e9215f65c46fd752317be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>breast cancer</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>pathologic features</topic><topic>post‐partum</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Neoplastic - metabolism</topic><topic>Pregnancy Complications, Neoplastic - mortality</topic><topic>Pregnancy Complications, Neoplastic - pathology</topic><topic>prognosis</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>survival</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murphy, Conleth G.</creatorcontrib><creatorcontrib>Mallam, Divya</creatorcontrib><creatorcontrib>Stein, Samantha</creatorcontrib><creatorcontrib>Patil, Sujata</creatorcontrib><creatorcontrib>Howard, Jane</creatorcontrib><creatorcontrib>Sklarin, Nancy</creatorcontrib><creatorcontrib>Hudis, Clifford A.</creatorcontrib><creatorcontrib>Gemignani, Mary L.</creatorcontrib><creatorcontrib>Seidman, Andrew D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murphy, Conleth G.</au><au>Mallam, Divya</au><au>Stein, Samantha</au><au>Patil, Sujata</au><au>Howard, Jane</au><au>Sklarin, Nancy</au><au>Hudis, Clifford A.</au><au>Gemignani, Mary L.</au><au>Seidman, Andrew D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current or recent pregnancy is associated with adverse pathologic features but not impaired survival in early breast cancer</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>118</volume><issue>13</issue><spage>3254</spage><epage>3259</epage><pages>3254-3259</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND:
Pregnancy‐associated breast cancer (PABC) may be defined as breast cancer diagnosed during pregnancy or within 1 year of giving birth. Conflicting data exist regarding the impact of pregnancy on clinical features and prognosis of breast cancer.
METHODS:
A single‐institution retrospective chart review was performed of 99 patients identified with PABC between 1992 and 2007. Non‐PABC controls were matched 2:1 to PABC cases by year of diagnosis and age. The differences in clinical features were compared between cases and controls using chi‐square tests. Univariate and multivariate analyses were performed to assess the effect of PABC on survival.
RESULTS:
Of the 99 PABC cases, breast cancer was diagnosed during pregnancy in 36 patients, and after delivery in 63. PABC cases were more likely than controls to be negative for estrogen receptor (59% vs 31%, P < .0001) and negative for progesterone receptor (72% vs 40%, P < .0001). Cases were also more likely to have advanced T class (P = .0271) and N class (P = .0104) and higher grade tumors (P = .0115). With a median follow‐up of 6.3 years for cases and 4.7 years for controls, overall survival did not differ between cases and controls (P = .0787). On multivariate analysis, the independent prognostic factors for overall survival were estrogen receptor status (P = .0031) and N class (P = .0003). The diagnosis of PABC was not an independent prognostic factor (P = .1317).
CONCLUSIONS:
PABC is associated with more adverse tumor features than non‐PABC matched for age and year of diagnosis. After correcting for pathologic features, the diagnosis of PABC is not in itself an adverse prognostic factor for survival. Cancer 2011. © 2011 American Cancer Society.
We compared the clinical features and survival of 99 women diagnosed with pregnancy‐associated breast cancer (PABC) and 186 control patients matched for age and year of diagnosis. Although PABC was associated with more adverse pathologic features, the diagnosis of PABC was not itself an independent adverse prognostic feature.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22086863</pmid><doi>10.1002/cncr.26654</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Biological and medical sciences breast cancer Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Female Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Middle Aged pathologic features post‐partum Pregnancy Pregnancy Complications, Neoplastic - metabolism Pregnancy Complications, Neoplastic - mortality Pregnancy Complications, Neoplastic - pathology prognosis Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism survival Tumors Young Adult |
| title | Current or recent pregnancy is associated with adverse pathologic features but not impaired survival in early breast cancer |
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